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| Product | Description | |
|---|---|---|
| 2-methoxyestradiol | 2-methoxyestradiol, also known as 2-ME, is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis. Uses: Antineoplastic agents. Synonyms: 2-ME; 2-Methoxy Estradiol. US brand name: Panzem. Abbreviation: 2ME2. Chemical structure name: (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol. Grades: 0.98. CAS No. 362-07-2. Molecular formula: C19H26O3. Mole weight: 302.414. |  |
| 2-Methoxyestradiol | 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-ME2; NSC-659853. CAS No. 362-07-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12033. |  |
| 2-Methoxyestradiol | 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-Me2. Product Category: Inhibitors. Appearance: Off-white solid. CAS No. 362-07-2. Molecular formula: C19H26O3. Mole weight: 302.41. Purity: 95%+. IUPACName: (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol. Canonical SMILES: CC12CCC3C(C1CCC2O)CCC4=CC(=C(C=C34)OC)O. Density: 1.178g/cm³. Product ID: ACM362072. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 2-Methoxyestradiol | Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly. Group: Biochemicals. Grades: Highly Purified. CAS No. 362-07-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| 2-Methoxyestradiol (2-Methoxy-3,17B-dihydroxyestra-1,3,5(10)-triene) | A natural meta. Group: Biochemicals. Alternative Names: 2-Methoxy-3,17B-dihydroxyestra-1,3,5(10)-triene. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 2-Methoxyestradiol (2- methoxy- estra- 1, 3, 5(10)- triene- 3, 17beta- diol, 2-Hydroxyestradiol 2-methyl ether, NSC659853, 2-ME2, Panzem) | 2-Methoxyestradiol (2-ME) is major estradiol metabolite that acts as a potent inhibitor of endothelial cell proliferation and angiogenesis. It displays little affinity for classical estrogen receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 362-07-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 1, 3, 5(10)-ESTRATRIEN-2, 3, 17β-TRIOL-6-ONE-6-CAROXYMETHYLOXIME:BSA-2-METHYL ETHER | 1, 3, 5(10)-ESTRATRIEN-2, 3, 17β-TRIOL-6-ONE-6-CAROXYMETHYLOXIME:BSA-2-METHYL ETHER. Group: Biochemicals. Alternative Names: 2-METHOXYESTRADIOL-6-CMO:BSA2,3,17β-TRIHYDROXY-1,3,5(10)-ESTRATRIENE-6-ONE-CMO:BSA- 2-METHYL ETHER. US Biological Life Sciences. | Worldwide |
| 18a-Methylestrone | 18a-Methylestrone is an reactant in the synthesis of 2-methoxyestradiol (M262625), a natural metabolite of 17 β-Estradiol which is devoid of estrogenic activity. Group: Biochemicals. Alternative Names: 3-Hydroxy-13-ethylgona-1,3,5(10)-trien-17-one; 18a-Homoestrone; 13-Ethyl-3-hydroxygona-1,3,5(10)-trien-17-one. Grades: Highly Purified. CAS No. 6544-68-9. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Angiogenesis related Compound Library | A unique collection of 1370 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high throughput screening (HTS) and high content screening (HCS); - Targets include angiogenesis signaling, and related targets such as S1P, VEGFR, PDGF, etc. ; - Includes approved drugs targeting angiogenesis, such as Sunitinib Malate, Lenalidomide, sorafenib, Erlotinib; drugs in clinical development with the most potential targeting angiogenesis, such as Vatalanib, Orantinib, 2-Methoxyestradiol (Panzem), Celecoxib; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L4800. Categories: Angiogenesis related Compounds Libraries. |  |
| ENMD-1198 | ENMD-1198 is an analog of 2-methoxyestradiol (2ME2) with antiproliferative and antiangiogenic activity. ENMD-1198 is a novel tubulin-binding agent that reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells. Synonyms: IRC-110160; 2-methoxyoestra-1,3,5(10),16-tetraene-3-carboxamide. Grades: 98%. CAS No. 864668-87-1. Molecular formula: C20H25NO2. Mole weight: 311.42. | |
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