3-(trifluoromethyl)-5-(phenyl)pyrazole suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
3-(Trifluoromethyl)-5-(phenyl)pyrazole ≥95% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
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3-Trifluoromethyl-5-methyl-1-(phenyl)pyrazole
3-Trifluoromethyl-5-methyl-1-(phenyl)pyrazole. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-TRIFLUOROMETHYL-5-METHYL-1-(PHENYL)PYRAZOLE. Product Category: Heterocyclic Organic Compound. CAS No. 111079-04-0. Molecular formula: C11H9F3N2. Mole weight: 226.2. Product ID: ACM111079040. Alfa Chemistry ISO 9001:2015 Certified.
5-Hydroxy-1-phenyl-3-trifluoro methyl pyrazole. Group: Biochemicals. Alternative Names: 1-Phenyl-3-trifluoromethyl-1H-pyrazol-5-ol; 1-Phenyl-3-trifluoromethyl-5-hydroxypyrazole; 1-Phenyl-3-(trifluoromethyl)-1H-pyrazol-5-ol. Grades: Highly Purified. CAS No. 96145-98-1. Pack Sizes: 1g. Molecular Formula: C10H7F3N2O, Molecular Weight: 228.17. US Biological Life Sciences.
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Berotralstat
Berotralstat is a kallikrein inhibitor for treatment of hereditary angioedema. Synonyms: Orladeyo; BCX7353; BCX-7353; 1-[3-(aminomethyl)phenyl]-N-(5-{(R)-(3-cyanophenyl)[(cyclopropylmethyl)amino]methyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide. CAS No. 1809010-50-1. Molecular formula: C30H26F4N6O. Mole weight: 562.56.
DPC 423
DPC 423. Group: Biochemicals. Alternative Names: 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide hydrochloride; 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide monohydrochloride. Grades: Highly Purified. CAS No. 292135-59-2. Pack Sizes: 10mg. Molecular Formula: C25H21ClF4N4O3S. US Biological Life Sciences.
Ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate is involved in the regulation of immune response and inflammation by inhibiting the NF-κB signaling pathway, in the regulation of antioxidant response by activating the Nrf2 signaling pathway, and in the regulation of cell survival and proliferation by inhibiting the Akt signaling pathway. Synonyms: 1H-Pyrazole-4-carboxylic acid, 1-[3,5-bis(trifluoromethyl)phenyl]-2,5-dihydro-5-oxo-, ethyl ester; Ethyl 1-[3,5-bis(trifluoromethyl)phenyl]-2,5-dihydro-5-oxo-1H-pyrazole-4-carboxylate. Grade: ≥95%. CAS No. 1878204-21-7. Molecular formula: C14H10F6N2O3. Mole weight: 368.23.
Fipronil
A broad spectrum insecticide which actively disrupts the CNS of contacted insects by blocking the passage of chloride ions through GABA receptors. Group: Biochemicals. Alternative Names: 5-Amino-1-[2, 6-dichloro-4- (trifluoromethyl) phenyl]-4-[ (trifluoromethyl) sulfinyl]-1H-pyrazole-3-carbonitrile; (+/-)-Fipronil; 1- (2, 6-Dichloro-4-trifluoro methyl phenyl) -3-cyano-5-amino-4- (trifluoro methyl sulfinyl) pyrazole; Fluocyanobenpyrazole; Frontline Spot-on; Frontline Spray; Frontline Top Spot; Goliath gel; Granedo MC; Grenade MC; Maxforce FC; Maxforce FC Select Roach Killer Bait Gel; Over'n Out; Regent; Regent TS; Termidor; Termidor 80WG; TopChoice. Grades: Highly Purified. CAS No. 120068-37-3. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
Fipronil
Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gated chloride channels and glutamate-gated chloride channels, resulting in central nervous system toxicity. Fipronil can be used to kill parasites such as fleas and lice on cats and dogs. Synonyms: Fluocyanobenpyrazole; (RS)-5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)pyrazole-3-carbonitrile; 5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile; (+/-)-Fipronil; 1-(2,6-Dichloro-4-trifluoromethylphenyl)-3-cyano-5-amino-4-(trifluoromethylsulfinyl)pyrazole; Frontline Spot-on; Frontline Spray; Frontline Top Spot; Goliath gel; Granedo MC; Grenade MC; Maxforce FC; Maxforce FC Select Roach Killer Bait Gel; Over'n Out; Regent; Regent TS; Termidor; Termidor 80WG; TopChoice; RM 1601; NSC-758960. Grade: > 95%. CAS No. 120068-37-3. Molecular formula: C12H4Cl2F6N4OS. Mole weight: 437.15.
An impurity of Fipronil. Fipronil is a broad-spectrum insecticide. Synonyms: 1-(2,6-Dichloro-4-trifluoromethylphenyl)-3-carboxamido-5-aminopyrazole; 5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-Pyrazole-3-carboxamide. Grade: > 95%. CAS No. 270564-31-3. Molecular formula: C11H7Cl2F3N4O. Mole weight: 339.11.
Flufiprole
Flufiprole is a non-systemic phenylpyrazole insecticide targeting the GABA receptor. It is used in the rice field and performs well in controlling a variety of pests. Synonyms: 1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-5-[(2-methyl-2-propen-1-yl)amino]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile; Butene-fipronil; Butylene-fipronil; Flupiprole; Rizazole; 1-(2,6-Dichloro-α,α,α-trifluoro-p-tolyl)-5-(2-methylallylamino)-4-(trifluoromethylsulfinyl)pyrazole-3-carbonitrile. Grade: ≥95%. CAS No. 704886-18-0. Molecular formula: C16H10Cl2F6N4OS. Mole weight: 491.24.
2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-amine
2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-amine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-PHENYL-5-TRIFLUOROMETHYL-2H-PYRAZOL-3-YLAMINE;2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-amine. Product Category: Heterocyclic Organic Compound. CAS No. 182923-55-3. Molecular formula: C10H8F3N3. Mole weight: 227.19. Product ID: ACM182923553. Alfa Chemistry ISO 9001:2015 Certified.
2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ylamine
2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ylamine. Group: Biochemicals. Grades: Highly Purified. CAS No. 182923-55-3. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. US Biological Life Sciences.
5-(4-Methylsulfanyl-phenyl)-1-(4-trifluoromethyl-phenyl)-1H-pyrazole-3-carboxylic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1017781-23-5, 5-(4-METHYLSULFANYL-PHENYL)-1-(4-TRIFLUOROMETHYL-PHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID. Product Category: Heterocyclic Organic Compound. CAS No. 1017781-23-5. Molecular formula: C18H13F3N2O2S. Mole weight: 378.3681. Purity: 0.97. IUPACName: 5-(4-methylsulfanylphenyl)-1-[4-(trifluoromethyl)phenyl]pyrazole-3-carboxylic acid. Canonical SMILES: CSC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)C(F)(F)F)C(=O)O. Product ID: ACM1017781235. Alfa Chemistry ISO 9001:2015 Certified.
A01
A01 is a high affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM), which attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Study showed that it potentiated BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells. Synonyms: Smurf1-IN-A01; Smurf1INA01; Smurf1 IN A01; Smurf1 inhibitor A01; Smurf1-inhibitor-A01; A01; A 01; A-01; [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone; SMURF1 inhibitor A01. Grade: ≥98% by HPLC. CAS No. 1007647-73-5. Molecular formula: C22H20ClF3N4O3S. Mole weight: 512.93.
Bamocaftor
Bamocaftor, a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore the function of F508del-CFtr protein, can be used in combination with Tezacaftor and Ivacaftor in cystic fibrosis studies. Synonyms: VX-659; (S)-N-(phenylsulfonyl)-6-(3-(2-(1-(trifluoromethyl)cyclopropyl)ethoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinamide; 3-Pyridinecarboxamide, N-(phenylsulfonyl)-6-(3-(2-(1-(trifluoromethyl)cyclopropyl)ethoxy)-1H-pyrazol-1-yl)-2-((4S)-2,2,4-trimethyl-1-pyrrolidinyl)-; N-(Phenylsulfonyl)-6-(3-{2-[1-(trifluoromethyl)cyclopropyl]ethoxy}-1H-pyrazol-1-yl)-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]nicotinamide. Grade: ≥95%. CAS No. 2204245-48-5. Molecular formula: C28H32F3N5O4S. Mole weight: 591.64.
BMT-145027
BMT-145027 is a potent mGluR5 PAM without inherent agonist activity with an EC50 of 47 nM. BMT-145027 is a non-MPEP site PAM to demonstrate in vivo efficacy. Synonyms: BMT-145027; BMT 145027; BMT145027; 3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile. CAS No. 2018282-44-3. Molecular formula: C23H14ClF3N4. Mole weight: 438.83.
ELND006
ELND006 is one of the newest molecules to be reported on regarding the testing of the β-amyloid hypothesis. ELND006 is a novel oral γ-secretase inhibitor. At the 2010 Alzheimer's Association International Conference on Alzheimer's Disease in which ELND006 was reported to have an in vitro IC50 = 0.34 nM against APP and IC50 = 5.3 nM versus Notch signaling. Synonyms: ELND006; ELND-006; ELND 006. (4R)-4-cyclopropyl-7,8-difluoro-5-[4-(trifluoromethyl)phenyl]sulfonyl-1,4-dihydropyrazolo[4,3-c]quinoline; UNII-7F5QGV49GL; ELND006; ELND-006; 959997-22-9; (R)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo(4,3-c)quinoline; (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline; 7F5QGV49GL; SCHEMBL486044; GTPL7337; CHEMBL2396778. CAS No. 1333990-84-3. Molecular formula: C20H14F5N3O2S. Mole weight: 455.07.
FGFR1/DDR2 inhibitor 1
FGFR1/DDR2 inhibitor 1 is an orally active fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2) inhibitor, with IC50s of 31.1 and 3.2 nM, respectively. It has antitumor activity. Synonyms: 3-(3-(1-Cyclopropyl-1H-pyrazol-4-yl)-1H-indazol-6-yl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide; Benzamide, 3-[3-(1-cyclopropyl-1H-pyrazol-4-yl)-1H-indazol-6-yl]-4-methyl-N-[3-(trifluoromethyl)phenyl]-. Grade: ≥95%. CAS No. 2308497-58-5. Molecular formula: C28H22F3N5O. Mole weight: 501.50.
GSK-7975A
This active molecular is a calcium release-activated calcium modulator (ORAI1) inhibitor. GSK-7975A inhibited toxin-induced activation of ORAI1 and/or activation of Ca(2+) currents after Ca(2+) release in mouse and human pancreatic acinar cells. GSK-7975A may be used for the treatment of pancreatitis in the future. Uses: Pancreatitis. Synonyms: GSK-7975A; GSK 7975A; GSK7975A; GSK-7975; GSK 7975; GSK7975. SCHEMBL705705; AOB4124; CPYTVBALBFSXSH-UHFFFAOYSA-N; 2,6-difluoro-N-[1-[[4-hydroxy-2-(trifluoromethyl)phenyl]methyl]pyrazol-3-yl]benzamide. Grade: 98%. CAS No. 1253186-56-9. Molecular formula: C18H12F5N3O2. Mole weight: 397.31.
GZD824 Dimesylate
GZD824 Dimesylate is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively. Synonyms: Olverembatinib dimesylate; HQP1351 dimesylate; GZD 824 Dimesylate; GZD-824 Dimesylate; 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide dimethanesulfonate; Benzamide, 4-methyl-N-(4-((4-methyl-1-piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(1H-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)-, methanesulfonate (1:2). Grade: ≥99%. CAS No. 1421783-64-3. Molecular formula: C29H27F3N6O.2CH4O3S. Mole weight: 724.77.
A cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC50=600nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC50=1 to 2.5uM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C30H30F3N5O, Molecular Weight: 553.6. US Biological Life Sciences.
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KSQ-4279
KSQ-4279 is a USP1 and PARP inhibitor. KSQ-4279 showed anti-proliferative effects in a subset of cell lines, often characterized by the presence of homologous recombination deficiencies (HRD), including mutations in BRCA1/2. The combination of KSQ-4279 with olaparib was able to induce strong and durable regressions across a number of ovarian and TNBC PDX models. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KSQ-4279; KSQ 4279; KSQ4279. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2446480-97-1. Molecular formula: C27H25F3N8O. Mole weight: 534.55. Purity: >98%. IUPACName: 1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-. Canonical SMILES: FC(C1=CN(C(C)C)C(C2=CC=C(CN3N=CC4=CN=C(C5=C(OC)N=CN=C5C6CC6)N=C43)C=C2)=N1)(F)F. Product ID: ACM2446480971. Alfa Chemistry ISO 9001:2015 Certified.
Methyl 5-(4-methylsulfanylphenyl)-1-(4-trifluoromethyl-phenyl)-1H-pyrazole-3-carboxylate. Group: Biochemicals. Grades: Highly Purified. CAS No. 641639-55-6. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
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PHTPP
Selective estrogen ER β receptor antagonist that displays 36-fold selectivity over ERα. Exhibits full antagonism at ER β in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ERα. Group: Biochemicals. Alternative Names: 4-[2-Phenyl-5, 7-bis (trifluoromethyl) pyrazolo[1, 5-a]pyrimidin-3-yl]phenol. Grades: Highly Purified. CAS No. 805239-56-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.