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3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 3-MA. CAS No. 5142-23-4. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-19312.
3-Methyladenine
3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-Methylpurin-6-amine. Product Category: Inhibitors. Appearance: White powder. CAS No. 5142-23-4. Molecular formula: C6H7N5. Mole weight: 149.15. Purity: 0.98. IUPACName: 3-Methyl-7h-purin-6-imine. Canonical SMILES: CN1C=NC(=N)C2=C1N=CN2. Density: 1.60 g/cm³. Product ID: ACM5142234. Alfa Chemistry ISO 9001:2015 Certified. Categories: 3-methyladenine DNA glycosylase II.
3-Methyladenine is an autophagy inhibitor that protects cerebellar granule cells (CGCs) from apoptosis following serum/potassium deprivation. 3-Methyladenine inhibits phosphoinositide 3-kinase (PI3K) activity, which plays a key role in autophagy process. Synonyms: NSC 66389; NSC-66389; NSC66389; 6-Amino-3-methylpurine; 3-MA; 3H-Purin-6-amine, 3-methyl-; 3-Methyl Adenine; 3-Methyl-6-aminopurine; N3-Methyladenine. Grades: ≥98% by HPLC. CAS No. 5142-23-4. Molecular formula: C6H7N5. Mole weight: 149.15.
3-Methyladenine
A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50=4.5mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 and Wortmannin.Autophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Group: Biochemicals. Alternative Names: 3-Methyl-3H-purin-6-amine; 3-Methyl-6-aminopurine; 3-Methyladenine; 6-Amino-3-methylpurine; N3-Methyladenine; NSC 66389. Grades: Highly Purified. CAS No. 5142-23-4. Pack Sizes: 50mg, 100mg, 250mg. Molecular Formula: C6H7N5 0.1H2O, Molecular Weight: 150.95. US Biological Life Sciences.
Worldwide
DNA-3-methyladenine glycosylase I
Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase). Group: Enzymes. Synonyms: deoxyribonucleate 3-methyladenine glycosidase I; 3-methyladenine DNA glycosylase I; DNA-3-methyladenine glycosidase I. Enzyme Commission Number: EC 3.2.2.20. CAS No. 89287-37-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3974; DNA-3-methyladenine glycosylase I; EC 3.2.2.20; 89287-37-6; deoxyribonucleate 3-methyladenine glycosidase I; 3-methyladenine DNA glycosylase I; DNA-3-methyladenine glycosidase I. Cat No: EXWM-3974.
DNA-3-methyladenine glycosylase II
Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase). Group: Enzymes. Synonyms: deoxyribonucleate 3-methyladenine glycosidase II; 3-methyladenine DNA glycosylase II; DNA-3-methyladenine glycosidase II; AlkA. Enzyme Commission Number: EC 3.2.2.21. CAS No. 89287-38-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3975; DNA-3-methyladenine glycosylase II; EC 3.2.2.21; 89287-38-7; deoxyribonucleate 3-methyladenine glycosidase II; 3-methyladenine DNA glycosylase II; DNA-3-methyladenine glycosidase II; AlkA. Cat No: EXWM-3975.
Autophagy Inhibitor IV, Cpd18 (3-methyl-6-(3-methylpiperidin-1-yl)-3H-purine, 3-MA analog, Cpd 18)
A cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K. Shown to block 80% of starvation-induced autophagy at 1 mM (IC50 = 0.67mM, compared with 3-MA at 6 mM). Displays much better solubility than 3-MA (5 times more soluble in water and 30 times more soluble in DMSO). Also found to reduce cell viability by 55% at 1 mM at 12 hours compared with 72% reduction for 3-MA at 10mM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Chloroquine Diphosphate Salt
Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine. Group: Biochemicals. Alternative Names: N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine Diphosphate Salt; Aralen Diphosphate; Aralen Phosphate; Arechin; Avloclor; Bemaphate; Chingamin; Chingamin Phosphate; SN 7618; Sanoquin; Tanakan. Grades: Highly Purified. CAS No. 50-63-5. Pack Sizes: 1g, 5g, 10g, 25g. Molecular Formula: C??H??ClN?O?P?, Molecular Weight: 515.86. US Biological Life Sciences.
Worldwide
Olaquindox
Olaquindox, as one of the antimicrobial growth accelerants, is usually used in livestock production to improve feed efficiency. Olaquindox induced apoptosis of HepG2 cells through a caspase-9 dependent mitochondrial pathway. Besides, Olaquindox also induces autophagy in HepG2 cells and that Olaquindox-induced apoptosis can be enhanced by 3-methyladenine. Olaquindox-induced autophagy in HepG2 cells is upregulated by Beclin 1 but downregulated by ROS-dependent JNK. Uses: Antimicrobial growth accelerant. Synonyms: N-(2-HYDROXYETHYL)-3-METHYL-2-QUINOXALINECARBOXAMIDE 1,4-DIOXIDE;OLAGUINDOX; OLAQUINDOX;2-(n-(2-hydroxyethyl)karbamoyl)-3-methylchinoxalin-1,4-dioxid; 2-quinoxalinecarboxamide,n-(2-hydroxyethyl)-3-methyl-,1,4-dioxide;bayernox;bayonox; bisergon. Grades: >98%. CAS No. 23696-28-8. Molecular formula: C12H13N3O4. Mole weight: 263.25.
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