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| Product | Description | |
|---|---|---|
| 4'-Hydroxytamoxifen | 4'-Hydroxytamoxifen is a metabolite of Tamoxifen. 4'-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4'-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 82413-23-8. Pack Sizes: 1 mg. Product ID: HY-124414. |  |
| 4'-Hydroxytamoxifen | One of the impurities of Tamoxifen, which is an estrogen response modifier as well as protein kinase C inhibitor. Uses: Either first generation because they demonstrate estrogen agonist properties in the endometrium or second generation based on their patterns of tissue specificity. (horm res 1997;48:155-63) (see all compounds cselective estrogen receptor modulators. Synonyms: 4'-Hydroxy Tamoxifen; 4- [ (1Z) -1- [ [4- [2- (Dimethylamino) ethoxy] phenyl] phenylmethylene] propyl] phenol. Grades: > 95%. CAS No. 82413-23-8. Molecular formula: C26H29NO2. Mole weight: 387.53. |  |
| 4-Hydroxytamoxifen | 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator ( SERM ). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) induces CRISPR/Cas9 systems based on ER mediated nucleus translocation. 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is also the active metabolic form of Tamoxifen (HY-13757A) in vivo and can be used to induce gene knockout in transgenic mice expressing CreER [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; (Z)-Afimoxifene. CAS No. 68047-06-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16950. | |
| a-Hydroxytamoxifen (trans- (Z) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-1, 2-diphenyl-1-butene-3-ol) | A metabolite of the chemotherapeutic drug tamoxifen. Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Also active as an intramembranous inhibitor of lipid peroxidation. Group: Biochemicals. Alternative Names: trans- (Z) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-1, 2-diphenyl-1-butene-3-ol. Grades: Highly Purified. CAS No. 97151-02-5Mol. Formula: »C26H29 NO2MoreDetails»Order». Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| b-Hydroxytamoxifen (trans- (Z) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-1, 2-diphenyl-1-butene-4-ol) | A hydroxylated analogue of tamoxifen with anti-estrogenic properties. Group: Biochemicals. Alternative Names: trans- (Z) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-1, 2-diphenyl-1-butene-4-ol. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| cis-a-Hydroxytamoxifen ( (E) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-1, 2-diphenyl-1-butene-3-ol) | A hydroxylated analogue of tamoxifen with anti-estrogenic properties. Group: Biochemicals. Alternative Names: (E) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-1, 2-diphenyl-1-butene-3-ol. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| cis-b-Hydroxytamoxifen (cis- (E) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-1, 2-diphenyl-1-butene-4-ol) | A hydroxylated analog of tamoxifen with anti-estrogenic properties. Group: Biochemicals. Alternative Names: cis- (E) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-1, 2-diphenyl-1-butene-4-ol. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (E/Z)-4-Hydroxytamoxifen | A selective estrogen receptor modulator. Group: Biochemicals. Alternative Names: 4-[1-[4-[2- (Dimethylamino) ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (E/Z)-4-Hydroxytamoxifen; 4-Hydroxytamoxifen. Grades: Highly Purified. CAS No. 68392-35-8. Pack Sizes: 5mg. Molecular Formula: C26H29NO2, Molecular Weight: 387.51. US Biological Life Sciences. | Worldwide |
| (E/Z)-4-Hydroxytamoxifen | (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. (E/Z)-4-Hydroxytamoxifen is a selective estrogen receptor modulator with mixed estrogenic and antiestrogenic activity, which is also an active metabolite of Tamoxifen (HY-13757A). (E/Z)-4-Hydroxytamoxifen is an agonist of the G protein-coupled estrogen receptor ( GPER ) with relatively low affinity (100-1000 nM). (E/Z)-4-Hydroxytamoxifen is promising for research of cyclical mastalgia, such as breast pain, tenderness, and nodularity [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Afimoxifene; 4-OHT. CAS No. 68392-35-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16950A. | |
| N-Demethyl-3-methoxy-4-hydroxytamoxifen-d3 Hydrochloride. (Z,E mixture) | N-Demethyl-3-methoxy-4-hydroxytamoxifen-d3 Hydrochloride (Z,E mixture). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C26H27D3ClNO3, Molecular Weight: 442.99. US Biological Life Sciences. | Worldwide |
| N-Demethyl-3-methoxy-4-hydroxytamoxifen Hydrochloride. (Z,E mixture) | N-Demethyl-3-methoxy-4-hydroxytamoxifen Hydrochloride (Z,E mixture). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C26H30ClNO3, Molecular Weight: 439.97. US Biological Life Sciences. | Worldwide |
| N-Desmethyl-4-hydroxytamoxifen (1:1 E/Z Mixture) (E/Z Endoxifen) | A metabolite of the anti-cancer drug Tamoxifen. Group: Biochemicals. Alternative Names: E/Z Endoxifen, 4OHNDtam, 4-[1-[4-[2- (methylamino) ethoxy]phenyl]-2-phenyl-1-butenyl]phenol. Grades: Highly Purified. CAS No. 110025-28-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| N-Desmethyl-4-hydroxytamoxifen-ethyl-d5 (1:1 E/Z Mixture) (E/Z Endoxifen-d5) | A labeled metabolite of the anti-cancer drug Tamoxifen. Group: Biochemicals. Alternative Names: E/Z Endoxifen-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (Z)-4-Hydroxytamoxifen | tamoxifen metabolite, anti-estrogen, see Tamoxifen 1,01038. CAS No. 68047-06-3. Product ID: 1-01039. Molecular formula: C26H29NO2. Mole weight: 387.52. Reference: J. Med. Chem., 28, 1491, 1985; J. Biol. Chem, 269, 4458, 1994; Cancer Res., 52, 4969, 1992. |  |
| (Z)-4-Hydroxytamoxifen | (Z)-4-Hydroxytamoxifen is a metabolite of Tamoxifen and acts as an estrogen receptor antagonist. It exhibits more than 100-fold affinity over Tamoxifen. (Z)-4-Hydroxytamoxifen also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing. Synonyms: Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-; 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol; Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-; Phenol, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-, (Z)-; (Z)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-en-1-yl]phenol; 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; 4-Hydroxy-(Z)-tamoxifen; 4-Hydroxytamoxifen; Hydroxytamoxifen; ICI 79280; trans-4-Hydroxytamoxifen; trans-Hydroxytamoxifen. Grades: ≥98% by HPLC. CAS No. 68047-06-3. Molecular formula: C26H29NO2. Mole weight: 387.51. | |
| (Z)-4-Hydroxytamoxifen | (Z)-4-Hydroxy Tamoxifen is a metabolite of Tamoxifen. (Z)-4-Hydroxy Tamoxifen is a hydroxylated analogue of Tamoxifen. (Z)-4-Hydroxy Tamoxifen is a metabolite of Tamoxifen with anti-estrogenic properties. Estrogen receptor modulator. Activates intein-linked inactive Cas9 to reduce off target effects of CRISPR-mediated gene editing. Group: Biochemicals. Alternative Names: 4-[ (1Z) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; 4-Hydroxy-(Z)-tamoxifen; 4-Hydroxytamoxifen; Hydroxytamoxifen; ICI 79280. Grades: Highly Purified. CAS No. 68047-06-3. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C26H29NO2, Molecular Weight: 387.51. US Biological Life Sciences. | Worldwide |
| 4-Hydroxy Tamoxifen | One of the impurities of Tamoxifen, which is an estrogen response modifier as well as protein kinase C inhibitor. Synonyms: (E/Z)-4-Hydroxy Tamoxifen; 4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (E/Z)-4-Hydroxytamoxifen; 4-Hydroxytamoxifen; 4-Hydroxy-(E/Z)-tamoxifen; Afimoxifene; TamoGel. Grades: > 95%. CAS No. 58047-06-3. Molecular formula: C26H29NO2. Mole weight: 387.53. | |
| 4-Hydroxy Tamoxifen (contains up to 10% E isomer) | A metabolite of Tamoxifen. Group: Biochemicals. Alternative Names: 4- [ (1Z) -1- [ [4- [2- (Dimethylamino) ethoxy] phenyl] phenylmethylene] propyl] phenol; 4'-Hydroxytamoxifen. Grades: Highly Purified. CAS No. 82413-23-8. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 4-Hydroxy Tamoxifen-d6 (contains up to 10% E isomer) | A labeled metabolite of Tamoxifen. Group: Biochemicals. Alternative Names: 4- [ (1Z) -1- [ [4- [2- (Dimethylamino-d6) ethoxy] phenyl] phenylmethylene] propyl] phenol; 4'-Hydroxytamoxifen-d6. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Afimoxifene | Afimoxifene (4-hydroxytamoxifen) is a selective estrogen receptor modulator which is the active metabolite of tamoxifen. Afimoxifene is a transdermal gel formulation and is being developed by Ascend Therapeutics, Inc. under the trademark TamoGel. Afimoxifene has completed a phase II clinical trial for the treatment of cyclical mastalgia. Uses: Estrogen antagonists. Synonyms: (E/Z)-4-Hydroxytamoxifen; 4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; TamoGel; Phenol, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-. Grades: ≥95%. CAS No. 68392-35-8. Molecular formula: C26H29NO2. Mole weight: 387.51. | |
| (E/Z)-4-Hydroxy tamoxifen | (E/Z)-4-Hydroxy tamoxifen. Group: Biochemicals. Alternative Names: 4-[1-[4-[2- (Dimethylamino) ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (E/Z)-4-Hydroxytamoxifen; 4-Hydroxytamoxifen. Grades: Highly Purified. CAS No. 68392-35-8. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C26H29NO2. US Biological Life Sciences. | Worldwide |
| N-Desmethyl Droloxifene (contains up to 5% Z isomer) | A metabolite of Droloxifene. Group: Biochemicals. Alternative Names: 3-[ (1E) -1-[4-[2- (Methylamino) ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol; N-Desmethyldroloxifene; K 106; N-Desmethyl-3-Hydroxytamoxifen. Grades: Highly Purified. CAS No. 83647-33-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-Desmethyl Droloxifene-d5 | A labeled metabolite of Droloxifene. Group: Biochemicals. Alternative Names: 3-[ (1E) -1-[4-[2- (Methylamino) ethoxy]phenyl]-2-phenyl-1-buten-1-yl-d5]-phenol; N-Desmethyldroloxifene-d5; K 106-d5;N-Desmethyl-3-hydroxytamoxifen-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-Methyl-L-prolinol | N-Methyl-L-prolinol (CAS# 34381-71-0) is a reagent used in the synthesis of novel 4-hydroxytamoxifen analogs used as estrogen-related receptor γ (ERRγ) inverse agonists. Synonyms: (S)-(-)-1-Methyl-2-pyrrolidinemethanol; (S)-(1-methylpyrrolidin-2-yl)methanol. CAS No. 34381-71-0. Molecular formula: C6H13NO. Mole weight: 115.17. | |
| Tamoxifen | Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells. Group: Biochemicals. Alternative Names: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; ICI 47699; Mammaton; Novaldex; Tamoxifen; Z-Tamoxifen. Grades: Highly Purified. CAS No. 10540-29-1. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| (Z)-4-Hydroxy Tamoxifen-d5 | A labeled metabolite of Tamoxifen. A hydroxylated analogue of Tamoxifen with anti-estrogenic properties. Group: Biochemicals. Alternative Names: 4-[ (1Z) -1-[4-[2- (Dimethylamino) ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen. Grades: Highly Purified. CAS No. 164365-20-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Acolbifene | Acolbifene, also known as EM-652, or SCH-57068, is a selective estrogen receptor modulator (SERM). Acolbifene is currently being studied in the prevention of breast cancer in women at high risk of breast cancer. EM-652 is the compound having the highest affinity for the estrogen receptor, including estradiol. It has higher affinity for the ER than ICI 182780, hydroxytamoxifen, raloxifene, droloxifene and hydroxytoremifene. EM-652 was also the most potent inhibitor of the percentage of cycling cancer cells. Synonyms: EM-652; SCH 57068; (2S)-3-(4-Hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol; (S)-3-(4-Hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol; (S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2H-chromen-7-ol. Grades: ≥98%. CAS No. 182167-02-8. Molecular formula: C29H31NO4. Mole weight: 457.57. | |
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