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| Product | Description | |
|---|---|---|
| 4-(3-Pyridinyl)-2-pyrimidine amine | 4-(3-Pyridinyl)-2-pyrimidine amine. Group: Biochemicals. Alternative Names: 4-(3-Pyridinyl)-2-aminopyrimidine; 4-(Pyridin-3-yl)pyrimidin-2-amine. Grades: Highly Purified. CAS No. 66521-66-2. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences. |  Worldwide |
| 4-(3-Pyridinyl)-2-pyrimidine amine 99+% (HPLC) | 4-(3-Pyridinyl)-2-pyrimidine amine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-chloromethyl Benzamide | N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-chloromethyl Benzamide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide, 2-Methyl-5-[[4-(chloromethyl)benzoyl]amino]-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine,Benzamide, 4-(chloromethyl)-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, 4-(Chloromethyl)-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide, N-[5-[[4-(Chloromethyl)benzoyl]amino]-2-methylphenyl]-4-(3-pyridyl)-2-pyrimidineamine. CAS No. 404844-11-7. IUPAC Name: 4-(chloromethyl)-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide. Molecular formula: C24H20ClN5O. Mole weight: 429.90. Catalog: APS404844117. SMILES: Cc1ccc(NC(=O)c2ccc(CCl)cc2)cc1Nc3nccc(n3)c4cccnc4. Format: Neat. |  |
| N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine | A selective inhibitor of protein kinase C. Synonyms: N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine; 4-Methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline; 4-Methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine. Grade: 98%. CAS No. 152460-10-1. Molecular formula: C16H15N5. Mole weight: 277.32. |  |
| 1-Methyl-1,4-bis[[4-[[[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]amino]carbonyl]phenyl]methyl]-piperazinium | 1-Methyl-1,4-bis[[4-[[[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]amino]carbonyl]phenyl]methyl]-piperazinium. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Des(methylpiperazinyl) Imatinib Dimer Piperazinium Chloride,Piperazinium, 1-methyl-1,4-bis[[4-[[[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]amino]carbonyl]phenyl]methyl]-. CAS No. 1821122-73-9. IUPAC Name: 4-[[4-methyl-4-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]piperazin-4-ium-1-yl]methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide. Molecular formula: C53H51N12O2. Mole weight: 888.05. Catalog: APS1821122739. SMILES: Cc1ccc(NC(=O)c2ccc(CN3CC[N+](C)(Cc4ccc(cc4)C(=O)Nc5ccc(C)c(Nc6nccc(n6)c7cccnc7)c5)CC3)cc2)cc1Nc8nccc(n8)c9cccnc9. Format: Neat. | |
| 4-(3-Pyridinyl)-2-pyrimidinamine | Intermediate in the preparation of Nilotinib. Group: Biochemicals. Alternative Names: 2-Amino-4-(3-pyridinyl)pyrimidine; 4-(3-Pyridyl)-2-pyrimidinamine; 4-(Pyridin-3-yl)pyrimidin-2-amine. Grades: Highly Purified. CAS No. 66521-66-2. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 4-methyl-3 [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] benzoic acid | 4-methyl-3 [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] benzoic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 641569-94-0. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C17H14N4O2. US Biological Life Sciences. | Worldwide |
| 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is an intermediate of Nilotinib, which is a Bcr-Abl inhibitor used to treat chronic myelogenous leukemia (CML). Synonyms: 4-Methyl-3-((4-(3-pyridyl)pyrimidin-2-yl)amino)benzoic acid; Nilotinib Hydrochloride Monohydrate Impurity D; Nilotinib Impurity D. Grade: ≥98%. CAS No. 641569-94-0. Molecular formula: C17H14N4O2. Mole weight: 306.32. | |
| 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: methyl 4-methyl-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]benzoate. Appearance: White to pale yellow to light brown solid. CAS No. 917392-54-2. Molecular formula: C18H16N4O2. Mole weight: 320.35. Purity: 0.98. Product ID: ACM917392542. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 4-Methyl-3- ( (4- (3-pyridinyl) -2-pyrimidinyl) amino) -N- (5- (4-methyl-1H-imidazol-1-yl) -3- (trifluoromethyl) phenyl) benzamide | 4-Methyl-3- ( (4- (3-pyridinyl) -2-pyrimidinyl) amino) -N- (5- (4-methyl-1H-imidazol-1-yl) -3- (trifluoromethyl) phenyl) benzamide. Group: Biochemicals. Alternative Names: Nilotinib. Grades: Highly Purified. CAS No. 641571-10-0. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C28H22F3N7O. US Biological Life Sciences. | Worldwide |
| Flumatinib | Flumatinib is a multi-kinase inhibitor of c-Abl, PDGFRβ and c-Kit with IC50 values of 1.2 nM, 307.6 nM and 2662 nM respectively. It can predominantly inhibit the autophosphorylation of Bcr-Abl in K562 cell in vitro. It can inhibit the phosphorylation of c-Kit in Mo7e cell and the phosphorylation of PDGFR in Swiss3T3 cell in higher concentration. It has no or little effect on other tyrosine kinase including EGFR, KDR, c-Src andHER2. It can reduce the expression of C-MYC, HIF-1 α and VEGF in U266 cell line in a time- and dose-dependent manners. It effectively overcame the drug resistance of certain KIT mutants with activation loop mutations. It was developed by Jiangsu Hansoh Pharmaceutical Co., Ltd. and is currently in Phase III clinical trials in China for the treatment of chronic myelogenous leukemia (CML). Uses: Flumatinib is used for the treatment of chronic myelogenous leukemia (cml). Synonyms: 4-[(4-methylpiperazin-1-yl)methyl]-N-(6-methyl-5-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}pyridin-3-yl)-3-(trifluoromethyl)benzamide; HH-GV678; HHGV678; HH GV678; 4-[(4-Methyl-1-piperazinyl)methyl]-N-(6-methyl-5-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}-3-pyridinyl)-3-(trifluoromethyl)benzamide. Grade: >98%. CAS No. 895519-90-1. Molecular formula: C29H29F3N8O. Mole weight: 562.59. | |
| Imatinib | Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with an IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. Imatinib is an oral chemotherapy agent used to treat cancers. Specifically, it is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+), certain types of gastrointestinal stromal tumors (GIST), hypereosinophilic syndrome (HES), chronic eosinophilic leukemia (CEL), systemic mastocytosis, and myelodysplastic syndrome. Synonyms: CGP057148B; STI571; Gleevec; Glivec; N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide; 4-[(4-Methyl-1-piperazinyl)methyl]-N-(4-methyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}phenyl)benzamide. Grade: >98%. CAS No. 152459-95-5. Molecular formula: C29H31N7O. Mole weight: 493.60. | |
| Imatinib-[d3] | Imatinib-[d3] is the labelled analogue of Imatinib. Imatinib can be used for the treatment of chronic myelogenous leukemia and acute lymphocytic leukemia. Synonyms: Imatinib D3; Genfatinib-d3; 4-[[4-(methyl-d3)-1-piperazinyl]methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide. Grade: 95% by HPLC; 99% atom D. CAS No. 1134803-18-1. Molecular formula: C29H28D3N7O. Mole weight: 496.62. | |
| Imatinib-[d8] | Imatinib-[d8] is the labelled analogue of Imatinib, a treatment of chronic myeloid leukemia. Synonyms: Imatinib D8; 4-[(4-Methyl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide; Genfatinib-d8. Grade: 95% by HPLC; 95% atom D. CAS No. 1092942-82-9. Molecular formula: C29H23D8N7O. Mole weight: 501.65. | |
| Imatinib, Methanesulfonate Salt (STI-571, CGP-57148B) | A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). Imatinib inhibits bcr-abl tyrosine kinase activity, upon which some types of tumor cells depend for growth. Imatinib acts by binding to the ATP binding site of bcr-abl and competitively inhibiting its tyrosine kinase activity. Imatinib is selective for bcr-abl, but it also targets several other kinases (c-kit and PDGF-R). (1). Group: Biochemicals. Alternative Names: 4- [ (4-Methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] phenyl] benzamide Methanesulfonate; CGP 57148B; Imatinib Mesilate; Imatinib Methanesulfonate; Imatinib Mesylate; STI 571; Bcr-abl Inhibitor IV; Abl Inhibitor V, PDGFR Tyrosine Kinase Inhibitor XXIV, c-Kit Inhibitor IV. Grades: Highly Purified. CAS No. 220127-57-1. Pack Sizes: 25mg, 1g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| Imatinib (Piperazine)-4-oxide | Imatinib (Piperazine)-4-oxide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Benzamide, 4-[(4-methyl-4-oxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, Imatinib (piperidine)-N-oxide, CGP 71422, 4-[(4-Methyl-4-oxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide. CAS No. 571186-91-9. IUPAC Name: 4-[(4-methyl-4-oxidopiperazin-4-ium-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide. Molecular formula: C29H31N7O2. Mole weight: 509.60. Catalog: APS571186919. SMILES: Cc1ccc(NC(=O)c2ccc(CN3CC[N+](C)([O-])CC3)cc2)cc1Nc4nccc(n4)c5cccnc5. Format: Neat. | |
| Imatinib (Piperidine)-1-oxide | Imatinib (Piperidine)-1-oxide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Benzamide, 4-[(4-methyl-1-oxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, 4-[(4-Methyl-1-oxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide. CAS No. 938082-57-6. IUPAC Name: 4-[(4-methyl-1-oxidopiperazin-1-ium-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide. Molecular formula: C29H31N7O2. Mole weight: 509.60. Catalog: APS938082576. SMILES: CN1CC[N+]([O-])(Cc2ccc(cc2)C(=O)Nc3ccc(C)c(Nc4nccc(n4)c5cccnc5)c3)CC1. Format: Neat. | |
| Imatinib (Piperidine)-4-oxide | Imatinib (Piperidine)-4-oxide is an impurity of Imatinib (Gleevec). Imatinib impurity D. Group: Biochemicals. Alternative Names: 4- [ (4-Methyl-4-oxido-1-piperazinyl) methyl] -N- [4-methyl-3- [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] phenyl] benzamide; CGP 71422. Grades: Highly Purified. CAS No. 571186-91-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Imatinib (Piperidine)-N,N-dioxide | Imatinib (Piperidine)-N,N-dioxide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Imatinib N1,N4-Dioxide, Benzamide, 4-[(4-methyl-1,4-dioxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-, Imatinib (Piperidine)-N,N-dioxide,4-[(4-methyl-1,4-dioxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide. CAS No. 571186-93-1. IUPAC Name: 4-[(4-methyl-1,4-dioxidopiperazine-1,4-diium-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide. Molecular formula: C29H31N7O3. Mole weight: 525.60. Catalog: APS571186931. SMILES: Cc1ccc(NC(=O)c2ccc(C[N+]3([O-])CC[N+](C)([O-])CC3)cc2)cc1Nc4nccc(n4)c5cccnc5. Format: Neat. | |
| Imatinib (piperidine)-N-oxide | Imatinib (piperidine)-N-oxide. Group: Biochemicals. Alternative Names: 4- [ (4-Methyl-4-oxido-1-piperazinyl) methyl] -N- [4-methyl-3- [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] phenyl] benzamide; CGP 71422. Grades: Highly Purified. CAS No. 571186-91-9. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C29H31N7O2. US Biological Life Sciences. | Worldwide |
| Mocetinostat | Mocetinostat. Group: Biochemicals. Alternative Names: N- (2-Aminophenyl) -4- [ [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] methyl] benzamide; MG 0103; MGCD 0103. Grades: Highly Purified. CAS No. 726169-73-9. Pack Sizes: 10mg. Molecular Formula: C23H20N6O, Molecular Weight: 396.44. US Biological Life Sciences. | Worldwide |
| N-[4-[[4- (Chloromethyl) benzoyl]amino]-2-methylphenyl]-4- (3-pyridyl) -2-pyrimidineamine | Intermediate in the preparation of Imatinib impurities. Group: Biochemicals. Alternative Names: 4- (Chloromethyl) -N- [3-methyl-4- [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] phenyl] benzamide. Grades: Highly Purified. CAS No. 796738-74-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| N-(4-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine. | Intermediate in the preparation of Imatinib impurities. Group: Biochemicals. Alternative Names: 3-Methyl-4-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline; 2-Methyl-N1-[4-(3-pyridinyl)-2-pyrimidinyl]-1,4-benzenediamine. Grades: Highly Purified. CAS No. 112696-91-0. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| N-Boc-N-Desmethyl Imatinib | Imatinib derivative. Group: Biochemicals. Alternative Names: 4- [ [4- [ [ [4-Methyl-3- [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] phenyl] amino] carbonyl] phenyl] methyl] -1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 1076199-23-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-Desmethyl imatinib | N-Desmethyl imatinib. Group: Biochemicals. Alternative Names: N- [4-Methyl-3- [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] phenyl] -4- (1-piperazinylmethyl) -benzamide; N-Desmethyl gleevec; CGP-74588. Grades: Highly Purified. CAS No. 404844-02-6. Pack Sizes: 1mg, 2mg, 5mg. Molecular Formula: C28H29N7O. US Biological Life Sciences. | Worldwide |
| N-Desmethyl Imatinib-[d4] | N-Desmethyl Imatinib-[d4] is the labelled analogue of N-Desmethyl Imatinib, which is a metabolite of Imatinib. Synonyms: Desmethyl imatinib D4; N-Desmethyl Imatinib-d4; N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide-d4; N-Desmethyl Gleevec-d4; Norimatinib-d4; Imatinib EP Impurity C-d4. Grade: 95% by HPLC; 98% atom D. Molecular formula: C28H25D4N7O. Mole weight: 483.60. | |
| Nilotinib-d3 | Labeled analog of Nilotinib (AMN1O7), which might be useful in treatment of chronic myelogenous leukemia. Group: Biochemicals. Alternative Names: 4-Methyl-N- [3- (4- (methyl-d3) -1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl] -3- [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] benzamide; AMN 107-d3; Tasigna-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Nilotinib-[d6] | Nilotinib-[d6] is the Labelled analog of Nilotinib, which may be used to treat chronic myelogenous leukemia. Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM. Synonyms: Nilotinib D6; 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide-d6. Grade: 95% by HPLC; 95% atom D. CAS No. 1268356-17-7. Molecular formula: C28H16D6F3N7O. Mole weight: 535.55. | |
| Nilotinib, Free Base (AMN107) | Nilotinib, a novel, selective BCR-ABL inhibitor, fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib. Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC50 < 30nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants. Group: Biochemicals. Alternative Names: 4-Methyl-N- [3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl] -3- [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] benzamide; AMN107; Tasigna. Grades: Highly Purified. CAS No. 641571-10-0. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Nilotinib N-Oxide | A metabolite of Nilotinib. Group: Biochemicals. Alternative Names: 4-Methyl-N- [3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl] -3- [ [4- (3-pyridinyl-N-oxide) -2-pyrimidinyl] amino] benzamide. Grades: Highly Purified. CAS No. 1246817-85-5. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
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