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(-)-1-[1-(4-Chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)-sulfonyl]piperazine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-[(4-CHLOROPHENYL)(PHENYL)METHYL]-4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE;(-)-1-[1-(4-CHLOROPHENYL)PHENYLMETHYL]-4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE. Product Category: Heterocyclic Organic Compound. CAS No. 163837-56-7. Molecular formula: C24H25ClN2O2S. Mole weight: 440.99. Product ID: ACM163837567. Alfa Chemistry ISO 9001:2015 Certified.
8-[(4-Chlorophenyl)azo]-5-[[4-[ethyl[(3-sulfophenyl)methyl]amino]phenyl]azo]naphthalene-2-sulfonic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: EINECS 289-079-2, CID3021093, 8-((4-Chlorophenyl)azo)-5-((4-(ethyl((3-sulfophenyl)methyl)amino)phenyl)azo)naphthalene-2-sulphonic acid, 85977-48-6. Product Category: Heterocyclic Organic Compound. CAS No. 85977-48-6. Molecular formula: C31H26ClN5O6S2. Mole weight: 664.151040 [g/mol]. Purity: 0.96. IUPACName: 8-[(4-chlorophenyl)diazenyl]-5-[[4-[ethyl-[(3-sulfophenyl)methyl]amino]phenyl]diazenyl]naphthalene-2-sulfonic acid. Canonical SMILES: CCN(CC1=CC(=CC=C1)S(=O)(=O)O)C2=CC=C(C=C2)N=NC3=C4C=CC(=CC4=C(C=C3)N=NC5=CC=C(C=C5)Cl)S(=O)(=O)O. Density: 1.44g/cm³. ECNumber: 289-079-2. Product ID: ACM85977486. Alfa Chemistry ISO 9001:2015 Certified.
ABBV-167
ABBV-167 is a phosphate prodrug of venetoclax, a Bcl-2 inhibitor. Synonyms: Benzamide, 4-(4-((2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)-2-((7-((phosphonooxy)methyl)-7H-pyrrolo(2,3-b)pyridin-5-yl)oxy)-; (5-{5-(4-{[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl}-1-piperazinyl)-2-[({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)carbamoyl]phenoxy}-7H-pyrrolo[2,3-b]pyridin-7-yl)methyl dihydrogen phosphate. CAS No. 1351456-78-4. Molecular formula: C46H53ClN7O11PS. Mole weight: 978.45.
ABT 263-[d8]
ABT 263-[d8] is a labelled ABT 263. ABT 263, also named Navitoclax, is an orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. Synonyms: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide-d8. CAS No. 1217620-38-6. Molecular formula: C47H47D8ClF3N5O6S3. Mole weight: 982.66.
ABT 263-d8
A novel inhibitor of antiapoptotic BCL-2 proteins; a new. Group: Biochemicals. Alternative Names: 4- [4- [ [2- (4-Chlorophenyl) -5, 5-dimethyl-1-cyclohexen-1-yl] methyl] -1-piperazinyl] -N- [ [4- [ [ (1R) -3- (4-morpholinyl) -1- [ (phenylthio) methyl] propyl] amino] -3- [ (trifluoromethyl) sulfonyl] phenyl] sulfonyl] benzamide-d8. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Avagacestat
BMS-708163 is a potent and orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP (IC50 = 0.30 nM) to Aβ40 than signaling through Notch (IC50s = 58 nM). Uses: Gamma secretase inhibitors and modulators. Synonyms: Avagacestat; BMS 708163; (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide. Grade: >98%. CAS No. 1146699-66-2. Molecular formula: C20H17ClF4N4O4S. Mole weight: 520.89.
BCL2-IN-1
BCL2-IN-1, a potent Bcl-2 inhibitor, binds Bcl-2 with a Ki of <0.01 nM. Synonyms: 4-(4-{[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl}-1-piperazinyl)-N-[(4-{[(trans-4-methoxycyclohexyl)methyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide; Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(trans-4-methoxycyclohexyl)methyl]amino]-3-nitrophenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-. Grade: 98%. CAS No. 1257044-75-9. Molecular formula: C47H54ClN7O7S. Mole weight: 896.49.
BM-1244
BM-1244 is a potent Bcl-xL and Bcl-2 inhibitor with Kis of 134 and 450 nM, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (Extracted from patent WO2019033119A1). Synonyms: 4-Piperidinecarboxylic acid, 1-[(3R)-3-[[4-[[[4-[4-[3-[2-(4-chlorophenyl)-5-methyl-1-(1-methylethyl)-4-(methylsulfonyl)-1H-pyrrol-3-yl]-5-fluorophenyl]-1-piperazinyl]phenyl]amino]sulfonyl]-2-[(trifluoromethyl)sulfonyl]phenyl]amino]-4-(phenylthio)butyl]-; 1-[(3R)-3-[(4-{[4-(4-{3-[2-(4-Chlorophenyl)-1-isopropyl-5-methyl-4-(methylsulfonyl)-1H-pyrrol-3-yl]-5-fluorophenyl}-1-piperazinyl)phenyl]sulfamoyl}-2-[(trifluoromethyl)sulfonyl]phenyl)amino]-4-(phenylsulfanyl)butyl]-4-piperidinecarboxylic acid. Grade: ≥98%. CAS No. 1619923-32-8. Molecular formula: C54H59ClF4N6O8S4. Mole weight: 1159.79.
BM 957
BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with Kis of 1.2, <1 nM and IC50s of 5.4, 6.0 nM, respectively. Synonyms: BM-957; (R)-5-(4-Chlorophenyl)-1-ethyl-4-(3-(4-(4-((4-((4-(4-hydroxypiperidin-1-yl)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonamido)phenyl)piperazin-1-yl)phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid; 1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-1-ethyl-4-[3-[4-[4-[[[4-[[(1R)-3-(4-hydroxy-1-piperidinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]-2-methyl-. Grade: ≥95%. CAS No. 1391107-54-2. Molecular formula: C52H56ClF3N6O7S3. Mole weight: 1065.68.
CBR-470-1
CBR-470-1, a non-covalent Nrf2 activator, is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). It protects SH-SY5Y neuronal cells from MPP+ induced cytotoxicity by activating the Keap1-Nrf2 cascade. Synonyms: 3-Thiophenamine, 4-[(4-chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-, 1,1-dioxide, (3R,4S)-rel-; (3S,4R)-4-[(4-Chlorophenyl)sulfonyl]-N-isobutyltetrahydro-3-thiophenamine 1,1-dioxide; (3S,4R)-4-[(4-chlorophenyl)sulfonyl]-3-[(2-methylpropyl)amino]thiolane-1,1-dione. Grade: ≥98%. CAS No. 2416095-06-0. Molecular formula: C14H20ClNO4S2. Mole weight: 365.90.
CCR1 antagonist 7
CCR1 antagonist 7 is a chemokine receptor 1 (CCR1) antagonist with an IC50 of 4 nM. Synonyms: 1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-5-methyl-N-[(1S)-1-[2-[(methylamino)sulfonyl]-4-pyridinyl]butyl]-; 1-(4-Chlorophenyl)-5-methyl-N-{(1S)-1-[2-(methylsulfamoyl)-4-pyridinyl]butyl}-1H-pyrazole-4-carboxamide. Grade: 98%. CAS No. 2446154-74-9. Molecular formula: C21H24ClN5O3S. Mole weight: 461.96.
Desmorpholinyl Navitoclax-NH-Me
Desmorpholinyl Navitoclax-NH-Me is an inhibitor of Bcl-xL. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739. Synonyms: Desmorpholinyl ABT-263-NH-Me; Benzamide, 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(methylamino)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-; 4-(4-{[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl}-1-piperazinyl)-N-[(4-{[(2R)-4-(methylamino)-1-(phenylsulfanyl)-2-butanyl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide. Grade: ≥98%. CAS No. 2365172-82-1. Molecular formula: C44H51ClF3N5O5S3. Mole weight: 918.55.
Glyparamide
Glyparamide is a chlorophenyl-containing sulfonylurea with hypoglycemic activity and rarely causes hepatic injury. Synonyms: Glyparamide; 5581-42-0; Glyparamide [USAN]; P-1306; 1-(4-chlorophenyl)sulfonyl-3-[4-(dimethylamino)phenyl]urea; 1-((p-chlorophenyl)sulfonyl)-3-(p-(dimethylamino)phenyl)urea; 4-Chloro-N-((4-(dimethylamino)phenyl)carbamoyl)benzenesulfonamide; Benzenesulfonamide, 4-chloro-N-(di-methylamino)phenyl)amino)carbonyl)-; 1-[([[(4-CHLOROPHENYL)SULFONYL]AMINO]CARBONYL)AMINO]-4-(DIMETHYLAMINO)BENZENE. Grade: >98%. CAS No. 5581-42-0. Molecular formula: C15H16ClN3O3S. Mole weight: 353.82.
Ibipinabant
Ibipinabant is a potent and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and peripheral cannabinoid (CB2), respectively. Uses: Cannabinoid receptor cb1 antagonists. Synonyms: BMS-646256; BMS646256; BMS 646256; SLV-319; SLV 319; SLV319; JD-5001; JD 5001; JD5001; Ibipinabant.3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4S-phenyl-1H-pyrazole-1-carboximidamide. Grade: ≥98%. CAS No. 464213-10-3. Molecular formula: C23H20Cl2N4O2S. Mole weight: 487.40.
KN-93
KN-93. Group: Biochemicals. Alternative Names: N- [2- [ [ [3- (4-Chlorophenyl) -2-propen-1-yl] methylamino] methyl] phenyl] -N- (2-hydroxyethyl) -4-methoxy Benzene sulfonamide. Grades: Highly Purified. CAS No. 139298-40-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C26H29ClN2O4S. US Biological Life Sciences.
Worldwide
Navitoclax (ABT 263)
A novel inhibitor of antiapoptotic BCL-2 proteins; a new. Group: Biochemicals. Alternative Names: 4- [4- [ [2- (4-Chlorophenyl) -5, 5-dimethyl-1-cyclohexen-1-yl] methyl] -1-piperazinyl] -N- [ [4- [ [ (1R) -3- (4-morpholinyl) -1- [ (phenylthio) methyl] propyl] amino] -3- [ (trifluoromethyl) sulfonyl] phenyl] sulfonyl] benzamide; Navitoclax. Grades: Highly Purified. CAS No. 923564-51-6. Pack Sizes: 5mg, 10mg, 50mg, 100mg. Molecular Formula: C??H??ClF?N?O?S?, Molecular Weight: 974.61. US Biological Life Sciences.
(R)-(+)-SLV 319 is a less active enantiomer of SLV 319, which is a central cannabinoid (CB1) receptor antagonist. SLV 319 has the potential to treat neuroinflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction, and gastrointestinal disorders. Synonyms: (R)-SLV 319; (R)-SLV319; (R)-SLV-319; (4R)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide. Grade: 99%. CAS No. 656827-86-0. Molecular formula: C23H20Cl2N4O2S. Mole weight: 487.4.