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(-)-1-[1-(4-Chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)-sulfonyl]piperazine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-[(4-CHLOROPHENYL)(PHENYL)METHYL]-4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE;(-)-1-[1-(4-CHLOROPHENYL)PHENYLMETHYL]-4-[(4-METHYLPHENYL)SULFONYL]PIPERAZINE. Product Category: Heterocyclic Organic Compound. CAS No. 163837-56-7. Molecular formula: C24H25ClN2O2S. Mole weight: 440.99. Product ID: ACM163837567. Alfa Chemistry ISO 9001:2015 Certified.
8-[(4-Chlorophenyl)azo]-5-[[4-[ethyl[(3-sulfophenyl)methyl]amino]phenyl]azo]naphthalene-2-sulfonic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: EINECS 289-079-2, CID3021093, 8-((4-Chlorophenyl)azo)-5-((4-(ethyl((3-sulfophenyl)methyl)amino)phenyl)azo)naphthalene-2-sulphonic acid, 85977-48-6. Product Category: Heterocyclic Organic Compound. CAS No. 85977-48-6. Molecular formula: C31H26ClN5O6S2. Mole weight: 664.151040 [g/mol]. Purity: 0.96. IUPACName: 8-[(4-chlorophenyl)diazenyl]-5-[[4-[ethyl-[(3-sulfophenyl)methyl]amino]phenyl]diazenyl]naphthalene-2-sulfonic acid. Canonical SMILES: CCN(CC1=CC(=CC=C1)S(=O)(=O)O)C2=CC=C(C=C2)N=NC3=C4C=CC(=CC4=C(C=C3)N=NC5=CC=C(C=C5)Cl)S(=O)(=O)O. Density: 1.44g/cm³. ECNumber: 289-079-2. Product ID: ACM85977486. Alfa Chemistry ISO 9001:2015 Certified.
ABT 263-d8
A novel inhibitor of antiapoptotic BCL-2 proteins; a new. Group: Biochemicals. Alternative Names: 4- [4- [ [2- (4-Chlorophenyl) -5, 5-dimethyl-1-cyclohexen-1-yl] methyl] -1-piperazinyl] -N- [ [4- [ [ (1R) -3- (4-morpholinyl) -1- [ (phenylthio) methyl] propyl] amino] -3- [ (trifluoromethyl) sulfonyl] phenyl] sulfonyl] benzamide-d8. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Avagacestat
BMS-708163 is a potent and orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP (IC50 = 0.30 nM) to Aβ40 than signaling through Notch (IC50s = 58 nM). Uses: Gamma secretase inhibitors and modulators. Synonyms: Avagacestat; BMS 708163; (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide. Grades: >98%. CAS No. 1146699-66-2. Molecular formula: C20H17ClF4N4O4S. Mole weight: 520.89.
Glyparamide
Glyparamide is a chlorophenyl-containing sulfonylurea with hypoglycemic activity and rarely causes hepatic injury. Synonyms: Glyparamide; 5581-42-0; Glyparamide [USAN]; P-1306; 1-(4-chlorophenyl)sulfonyl-3-[4-(dimethylamino)phenyl]urea; 1-((p-chlorophenyl)sulfonyl)-3-(p-(dimethylamino)phenyl)urea; 4-Chloro-N- ( (4- (dimethylamino) phenyl) carbamoyl) benzenesulfonamide; Benzenesulfonamide, 4-chloro-N-(di-methylamino)phenyl)amino)carbonyl)-; 1-[ ([[ (4-CHLOROPHENYL) SULFONYL]AMINO]CARBONYL) AMINO]-4- (DIMETHYLAMINO) BENZENE. Grades: >98%. CAS No. 5581-42-0. Molecular formula: C15H16ClN3O3S. Mole weight: 353.82.
Ibipinabant
Ibipinabant is a potent and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and peripheral cannabinoid (CB2), respectively. Uses: Cannabinoid receptor cb1 antagonists. Synonyms: BMS-646256; BMS646256; BMS 646256; SLV-319; SLV 319; SLV319; JD-5001; JD 5001; JD5001; Ibipinabant.3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4S-phenyl-1H-pyrazole-1-carboximidamide. Grades: ≥98%. CAS No. 464213-10-3. Molecular formula: C23H20Cl2N4O2S. Mole weight: 487.40.
JD-5037
Jd-5037 is a peripherally-restricted cannabinoid inverse agonist at CB1 receptors that can be used as an anti-obesity drug, with a 700-fold higher affinity compared to CB2 receptors. Synonyms: JD 5037; JD5037; (S) -2- ( ( (E) - ( (S) -3- (4-chlorophenyl) -4-phenyl-4, 5-dihydro-1H-pyrazol-1-yl) ( (4-chlorophenyl) sulfonamido) methylene) amino) -3-methylbutanamide. Grades: >98%. CAS No. 1392116-14-1. Molecular formula: C27H27Cl2N5O3S. Mole weight: 572.5.
KN-93
KN-93. Group: Biochemicals. Alternative Names: N- [2- [ [ [3- (4-Chlorophenyl) -2-propen-1-yl] methylamino] methyl] phenyl] -N- (2-hydroxyethyl) -4-methoxy Benzene sulfonamide. Grades: Highly Purified. CAS No. 139298-40-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C26H29ClN2O4S. US Biological Life Sciences.
Worldwide
KP496
KP496, a novel dual antagonist of cysLT receptor and TP, is currently in clinical development as a dry powder inhaler. KP496 inhibited epithelial hypertrophy and increased mucus production in asthmatic animals. Synonyms: KP496; KP 496; KP-496; 2- [4- [ (4-chlorophenyl) sulfonylamino] butyl- [ [3- [ (4-propan-2-yl-1, 3-thiazol-2-yl) methoxy] phenyl] methyl] sulfamoyl] benzoic acid. CAS No. 217799-03-6. Molecular formula: C31H34ClN3O7S3. Mole weight: 692.27.
Lisaftoclax
Lisaftoclax is a dual Bcl-2 and Bcl-xl inhibitor with antineoplastic activity. Synonyms: 14-chloro-N-[4-({[(2S)-1,4-dioxan-2-yl]methyl}amino)-3-nitrobenzene-1-sulfonyl]-71H-6-oxa-7(5)-pyrrolo[2,3-b]pyridina-4(1,4)-piperazina-2(6,7)-spiro[3.5]nonana-1(1),5(1,3)-dibenzenaheptaphan-26-ene-54-carboxamide; Bcl-2/Bcl-xl inhibitor 1; (S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3-nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1-yl)benzamide; 4-(4-{[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl}-1-piperazinyl)-N-[(4-{[(2S)-1,4-dioxan-2-ylmethyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide. CAS No. 2180923-05-9. Molecular formula: C45H48ClN7O8S. Mole weight: 882.42.
LP99
LP99 is the first selective BRD7/9 bromodomain inhibitor. The effect of LP99 on IL-6 expression demonstrates for the first time that a small-molecule BRD7/9 inhibitor may have a similar function and utility to IL-6 neutralizing antibodies, such as tocilizumab, in the treatment of rheumatoid arthritis. Synonyms: N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxoquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamideN-((2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl)-2-methylpropane-1-sulfonamideN-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamideGTPL8572; GTPL 8572; GTPL-8572; LP99; LP-99; LP 99. Grades: >98%. CAS No. 1808951-93-0. Molecular formula: C26H30ClN3O4S. Mole weight: 516.05.
LY 181984
LY 181984 is an antitumor sulfonylurea. Uses: Antitumor. Synonyms: LY 181984; LY-181984; LY181984; MPCU. N-(((4-chlorophenyl)amino)carbonyl)-4-methyl-Benzenesulfonamide;1-(4-chlorophenyl)-3-(4-methylphenyl)sulfonylurea. Grades: ≥98%. CAS No. 3955-50-8. Molecular formula: C14H13ClN2O3S. Mole weight: 324.78.
Navitoclax
Navitoclax is an orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. Uses: Antineoplastic agents. Synonyms: ABT-263; ABT 263; ABT263; 4-[4-[[2- (4-chlorophenyl) -5, 5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[ (2R) -4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3- (trifluoromethylsulfonyl) phenyl]sulfonylbenzamide. Grades: 98%. CAS No. 923564-51-6. Molecular formula: C47H55ClF3N5O6S3. Mole weight: 974.611.
Navitoclax (ABT 263)
A novel inhibitor of antiapoptotic BCL-2 proteins; a new. Group: Biochemicals. Alternative Names: 4- [4- [ [2- (4-Chlorophenyl) -5, 5-dimethyl-1-cyclohexen-1-yl] methyl] -1-piperazinyl] -N- [ [4- [ [ (1R) -3- (4-morpholinyl) -1- [ (phenylthio) methyl] propyl] amino] -3- [ (trifluoromethyl) sulfonyl] phenyl] sulfonyl] benzamide; Navitoclax. Grades: Highly Purified. CAS No. 923564-51-6. Pack Sizes: 5mg, 10mg, 50mg, 100mg. Molecular Formula: C??H??ClF?N?O?S?, Molecular Weight: 974.61. US Biological Life Sciences.
Worldwide
Posaconazole Impurity 16
Posaconazole Impurity 16 is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme. Synonyms: ((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-chlorobenzenesulfonate; D-erythro-Pentitol, 1,4-anhydro-2-[[[(4-chlorophenyl)sulfonyl]oxy]methyl]-2,3,5-trideoxy-4-C-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)-; 1,4-Anhydro-2-({[(4-chlorophenyl)sulfonyl]oxy}methyl)-2,3,5-trideoxy-4-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)-D-erythro-pentitol; Posaconazole Intermediate (R-trans isomer). Grades: ≥95%. CAS No. 2243786-07-2. Molecular formula: C20H18ClF2N3O4S. Mole weight: 469.89.
(R)-(+)-SLV 319 is a less active enantiomer of SLV 319, which is a central cannabinoid (CB1) receptor antagonist. SLV 319 has the potential to treat neuroinflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction, and gastrointestinal disorders. Synonyms: (R)-SLV 319; (R)-SLV319; (R)-SLV-319; (4R)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide. Grades: 99%. CAS No. 656827-86-0. Molecular formula: C23H20Cl2N4O2S. Mole weight: 487.4.
Slv319
Slv319 is a potent antagonist of CB1 recceptor (Ki = 7.8 nM) used for the treatment of neuroinflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction and gastrointestinal disorders, as well as inhibits CP 55,940-induced hypotension and WIN 55,212-2-induced hypothermia in vivo. Synonyms: Slv319; Slv 319; Slv-319; 3-(4-Chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide; CHEMBL158784. Grades: 98%. CAS No. 362519-49-1. Molecular formula: C23H20Cl2N4O2S. Mole weight: 487.399.
Terutroban
Terutroban is a potent, orally active antagonist of the thromboxane/prostaglandin A2(TP) receptor (IC50 = 16.4 nM). In guinea pigs it also inhibits U 46619 induced increase pressure in the bronchi. Synonyms: Terutroban; S 18886; S-18886; S18886; 3-[(6R)-6-[(4-chlorophenyl)sulfonylamino]-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]propanoic acid3-((6-amino-(4-chlorobenzenesulfonyl)-2-methyl-5,6,7,8-tetrahydronapht)-1-yl)propionic acid3-((6R)-6-(((4-chlorophenyl)sulfonyl)amino)-2-methyl-5,6,7,8 te. CAS No. 165538-40-9. Molecular formula: C20H22ClNO4S. Mole weight: 407.91.
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