Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| 5'-Methylthioadenosine | 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis [1]. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine. CAS No. 2457-80-9. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-16938. |  |
| 5'-Methylthioadenosine-d3 | 5'-Methylthioadenosine-d3 is the deuterium labeled 5'-Methylthioadenosine[1]. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2][3][4]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: 5'-(Methylthio)-5'-deoxyadenosine-d3; 5'-Deoxy-5'-(methylthio)adenosine-d3; 5'-S-Methyl-5'-thioadenosine-d3. CAS No. 174838-38-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-16938S1. | |
| 2-Methylthioadenosine 5-monophosphate | 2-Methylthioadenosine 5-monophosphate. Group: Biochemicals. Grades: Highly Purified. CAS No. 22140-20-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C11H16N5O7PS. US Biological Life Sciences. |  Worldwide |
| 5?-Deoxy-5?-methylthioadenosine - CAS 2457-80-9 | A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Group: Fluorescence/luminescence spectroscopy. |  |
| 2-MeS-ADP trisodium | 2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Methylthioadenosine diphosphate trisodium; 2-Methylthio-ADP trisodium. CAS No. 475193-31-8. Pack Sizes: 1 mg (10 mM * 185 ?L in Water); 5 mg (10 mM * 927 ?L in Water); 10 mg (10 mM * 1854 ?L in Water). Product ID: HY-108648. | |
| 2-Methylthioadenosine | 2-Methylthioadenosine. Group: Biochemicals. Grades: Highly Purified. CAS No. 4105-39-9. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C11H15N5O4S. US Biological Life Sciences. | Worldwide |
| 2-Methylthioadenosine | 2-Methylthioadenosine is an adenosine precursor to 2-MeS-ATP, 2-MeS-ADP and 2-MeS-AMP. Synonyms: 2-(Methylthio)adenosine; NSC 36900; (2R,3R,4S,5R)-2-(6-amino-2-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; Adenosine, 2-(methylthio)-; 2-MeS-adenosine. Grades: ≥95%. CAS No. 4105-39-9. Molecular formula: C11H15N5O4S. Mole weight: 313.33. |  |
| 2-Methylthioadenosine | 2-Methylthioadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis , etc [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4105-39-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-131795. | |
| 2-Methylthioadenosine diphosphate trisodium salt | 2-Methylthioadenosine diphosphate trisodium salt is a potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13), which induces platelet aggregation and shape change and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1. Synonyms: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt; 2-MeS-ADP; 2 MeS ADP; 2MeSADP; 2-Methylthio-ADP; 2 Methylthio ADP. Grades: ≥98% by HPLC. CAS No. 475193-31-8. Molecular formula: C11H14N5Na3O10P2S. Mole weight: 539.24. | |
| 2-Methylthioadenosine triphosphate tetrasodium salt | 2-Methylthioadenosine triphosphate tetrasodium salt. Group: Biochemicals. Grades: Purified. CAS No. 100020-57-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 5'-Chloro-5'-deoxyadenosine | 5'-Chloro-5'-deoxyadenosine (CAS# 892-48-8) is an intermediate in the synthesis of 5'-Deoxy-5'-(methylthio)adenosine (D242600), a substrate to study the specificity and kinetics of 5'-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Synonyms: 5'-Chloroadenosine; 5'-deoxy-5'-chloroadenosine. Grades: 96 %. CAS No. 892-48-8. Molecular formula: C10H12ClN5O3. Mole weight: 285.69. | |
| 5'-Deoxy-5'-(methylthio)adenosine | 5?-Deoxy-5?-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5?-methyl thioadenosine phosphoryl ase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5?-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN). Group: Biochemicals. Alternative Names: 5'-S-Methyl-5'-thioadenosine; 5'-(Methylthio)-5'-deoxyadenosine; 5'-(Methylthio)adenosine; 5'-Deoxy (methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine; 5'-S-Methylthioadenosine; NSC 335422; Vitamin L2; 1-(6-Amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio- β-D-ribofuranose. Grades: Highly Purified. CAS No. 2457-80-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 8-Methylthioadenosine | 8-Methylthioadenosine, an extensively researched biochemical compound, is widely employed in biomedical studies due to its involvement in diverse physiological processes. With its potential therapeutic implications in cancer, liver diseases, and immunological disorders, this nucleoside serves as a valuable asset for exploring innovative treatment strategies within the realm of biomedicine. Synonyms: 8-Methylthio-adenosine; 8-methylsulphanyladenosine; 8-MeS-adenosine; Adenosine, 8-(methylthio)-; (2R,3R,4S,5R)-2-(6-amino-8-(methylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol. Grades: ≥95%. CAS No. 29836-01-9. Molecular formula: C11H15N5O4S. Mole weight: 313.33. | |
| adenosylhomocysteine nucleosidase | Also acts on S-methyl-5'-thioadenosineto give adenine and S-methyl-5-thioribose (cf. EC 3.2.2.16, methylthioadenosine nucleosidase). Group: Enzymes. Synonyms: S-adenosylhomocysteine hydrolase (ambiguous); S-adenosylhomocysteine nucleosidase; 5'-methyladenosine nucleosidase; S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase; AdoHcy/MTA nucleosidase. Enzyme Commission Number: EC 3.2.2.9. CAS No. 9055-10-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3991; adenosylhomocysteine nucleosidase; EC 3.2.2.9; 9055-10-1; S-adenosylhomocysteine hydrolase (ambiguous); S-adenosylhomocysteine nucleosidase; 5'-methyladenosine nucleosidase; S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase; AdoHcy/MTA nucleosidase. Cat No: EXWM-3991. |  |
| methylthioadenosine nucleosidase | Does not act on S-adenosylhomocysteine. cf. EC 3.2.2.9 adenosylhomocysteine nucleosidase. Group: Enzymes. Synonyms: 5'-methylthioadenosine nucleosidase; MTA nucleosidase; MeSAdo nucleosidase; methylthioadenosine methylthioribohydrolase. Enzyme Commission Number: EC 3.2.2.16. CAS No. 50812-28-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3970; methylthioadenosine nucleosidase; EC 3.2.2.16; 50812-28-7; 5'-methylthioadenosine nucleosidase; MTA nucleosidase; MeSAdo nucleosidase; methylthioadenosine methylthioribohydrolase. Cat No: EXWM-3970. | |
| MT-DADMe-ImmA | MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MTDIA; Methylthio-DADMe-Immucillin A. CAS No. 653592-04-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101496. | |
| MTDIA | MTDIA is a human 5'-methylthioadenosine phosphorylase (MTAP) inhibitor, which is solely responsible for 5'-methylthioadenosine (MTA) metabolism to permit S-adenosylmethionine salvage. It is used as an anticancer candidate. Synonyms: Methylthio-DADMe-Immucillin A; MT-DADMe-ImmA; (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-3-hydroxy-4-((methylthio)methyl)pyrrolidin-1-ium. Grades: 98%. CAS No. 653592-04-2. Molecular formula: C13H19N5OS. Mole weight: 294.35. | |
| MTDIA hydrochloride | MTDIA is a methylthioadenosine phosphorylase (MTAP) inhibitor. MTAP is responsible for 5'-methylthioadenosine (MTA) metabolism to permit S-adenosylmethionine salvage. Transition-state (TS) analogues of MTAP are in development as anticancer drug candidates and MTDIA is one of these TS analogues. Uses: Anticancer drug candidate. Synonyms: (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-3-hydroxy-4-((methylthio)methyl)pyrrolidin-1-ium chloride; MTDIA; MTDIA HCl; Methylthio-DADMe-Immucillin A; MT-DADMe-ImmA; MT-DADMe-ImmA HCl. Grades: 98%. CAS No. 1399840-35-7. Molecular formula: C13H20ClN5OS. Mole weight: 329.85. | |
| S-methyl-5'-thioadenosine deaminase | The enzyme from Thermotoga maritima also functions as S-adenosylhomocysteine deaminase (EC 3.5.4.28) and has some activity against adenosine. Adenosine 5'-phosphate and S-adenosyl-L-methionine (SAM) are not substrates. Group: Enzymes. Synonyms: MTA deaminase; 5-methylthioadenosine deaminase. Enzyme Commission Number: EC 3.5.4.31. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4559; S-methyl-5'-thioadenosine deaminase; EC 3.5.4.31; MTA deaminase; 5-methylthioadenosine deaminase. Cat No: EXWM-4559. | |
| S-methyl-5'-thioadenosine phosphorylase | Also acts on 5'-deoxyadenosine and other analogues having 5'-deoxy groups. Group: Enzymes. Synonyms: 5'-deoxy-5'-methylthioadenosine phosphorylase; MTA phosphorylase; MeSAdo phosphorylase; MeSAdo/Ado phosphorylase; methylthioadenosine phosphorylase; methylthioadenosine nucleoside phosphorylase; 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase; S-methyl-5-thioadenosine phosphorylase; S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-α-D-ribosyl-transferase. Enzyme Commission Number: EC 2.4.2.28. CAS No. 61970-06-7. MTAP. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2655; S-methyl-5'-thioadenosine phosphorylase; EC 2.4.2.28; 61970-06-7; 5'-deoxy-5'-methylthioadenosine phosphorylase; MTA phosphorylase; MeSAdo phosphorylase; MeSAdo/Ado phosphorylase; methylthioadenosine phosphorylase; methylthioadenosine nucleoside phosphorylase; 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase; S-methyl-5-thioadenosine phosphorylase; S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-α-D-ribosyl-transferase. Cat No: EXWM-2655. | |
| S-methyl-5'-thioadenosine phosphorylase from Human, Recombinant | MTAP expression is crucial for the catabolism of methylthioadenosine, which is a by-product of polyamine biosynthesis in the methionine salvage pathway. Protein expression is decreased by homozygous deletion and promoter hypermethylation. N-terminal gst-tagged 57 kda protein containing amino acids 2-end. Applications: S-methyl-5?-thioadenosine phosphorylase human (mtap) is an enzyme used in cancer research that is deficient in many types of cancer. decreased mtap expression may be used as a potential indicator of disease progression of gastrointestinal stromal tumors. mtap may be a used to develop potential therapeutic strategies for hepat ocellular carcinoma ...CAS No. 61970-06-7. MTAP. Mole weight: 57 kDa. Storage: -70°C. Form: Supplied as a solution in 25 mM Tris-HCl, pH 8.0,100 mM NaCl, 0.05% Tween-20, 10% glycerol,and 3 mM DTT. Source: E. coli. Species: Human. S-methyl-5'-thioadenosine phosphorylase; EC 2.4.2.28; 5'-deoxy-5'-methylthioadenosine phosphorylase; MTA phosphorylase; MeSAdo phosphorylase; MeSAdo/Ado phosphorylase; methylthioadenosine phosphorylase; methylthioadenosine nucleoside phosphorylase; 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase; S-methyl-5-thioadenosine phosphorylase; S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-α-D-ribosyl-transferase; MTAP. Cat No: NATE-0462. | |
| S-methyl-5'-thioinosine phosphorylase | No activity with S-methyl-5'-thioadenosine. The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine. Group: Enzymes. Synonyms: MTIP; MTI phosphorylase; methylthioinosine phosphorylase. Enzyme Commission Number: EC 2.4.2.44. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2673; S-methyl-5'-thioinosine phosphorylase; EC 2.4.2.44; MTIP; MTI phosphorylase; methylthioinosine phosphorylase. Cat No: EXWM-2673. | |
| tRNA (cytidine34-2'-O)-methyltransferase | The enzyme from Escherichia coli catalyses the 2'-O-methylation of cytidine or 5-carboxymethylaminomethyluridine at the wobble position at nucleotide 34 in tRNALeuCmAA and tRNALeucmnm5UmAA. The enzyme is selective for the two tRNALeu isoacceptors and only methylates these when they present the correct anticodon loop sequence and modification pattern. Specifically, YibK requires a pyrimidine nucleoside at position 34, it has a clear preference for an adenosine at position 35, and it fails to methylate without prior addition of the N6-(isopentenyl)-2-methylthioadenosine modification at position 37. Group: Enzymes. Synonyms: yibK (gene name); methyltransferase yibK; TrmL; tRNA methyltransferase L; tRNA (cytidine34/5-carboxymethylaminomethyluridine34-2'-O)-methyltransferase. Enzyme Commission Number: EC 2.1.1.207. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1808; tRNA (cytidine34-2'-O)-methyltransferase; EC 2.1.1.207; yibK (gene name); methyltransferase yibK; TrmL; tRNA methyltransferase L; tRNA (cytidine34/5-carboxymethylaminomethyluridine34-2'-O)-methyltransferase. Cat No: EXWM-1808. | |
| 2-Benzylthioadenosine | 2-Benzylthioadenosine, a formidable inhibitor of methylthioadenosine phosphorylase (MTAP) - an enzyme primarily involved in adenine and methionine salvage - has received significant attention due to its potential contributions to the management of cancer forms denuded of MTAP expression (like pancreatic cancer or mesothelioma) as well as auto-immune illnesses and inflammation. Synonyms: (2R,3R,4S,5R)-2-(6-amino-2-(benzylthio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; 2-(Benzylsulfanyl)adenosine; Adenosine, 2-[(phenylmethyl)thio]-. Grades: ≥95%. CAS No. 43157-48-8. Molecular formula: C17H19N5O4S. Mole weight: 389.43. | |
| 2-MeS-5'-AMP | 2-MeS-5'-AMP is a potent antagonist of adenylate cyclase-coupled platelet ADP P2Y purinoceptor. Synonyms: 2- Methylthioadenosine- 5'- O- monophosphate, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 22140-20-1. Molecular formula: C11H16N5O7PS (free acid). Mole weight: 393.3 (free acid). | |
| 2-MeS-ATP | 2-MeS-ATP is an agonist of P2Y purinoceptors that inhibits soluble guanylate cyclase. Uses: Purinergic agonists. Synonyms: 2- Methylthioadenosine- 5'- O- triphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 43170-89-4. Molecular formula: C11H18N5O13P3S (free acid). Mole weight: 553.3 (free acid). | |
| Deoxyadenosine | Deoxyadenosine is a substrate of bacterial methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase and a product inhibitor produced by radical SAM enzymes. Uses: Mta/sah nucleosidase. Synonyms: 5'-deoxyadenosine; 5'-dAdo; 5'-deoxyadenosine; 5'dAdo; 5'-dAdo.(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-methyltetrahydrofuran-3,4-diol. Grades: ≥95%. CAS No. 4754-39-6. Molecular formula: C10H13N5O3. Mole weight: 251.245. | |
| L-Alanosine | L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine is the inhibitor for methylthioadenosine phosphorylase (MTAP)[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC-153353; SDX-102. CAS No. 5854-93-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-16933. | |
| Vopimetostat | TNG-462 is an orally active and selective PRMT5 inhibitor with anti-tumor activity against methylthioadenosine phosphorylase (MTAP) deficiency and/or methylthioadenosine (MTA) accumulation cancers[1][2].. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TNG-462. CAS No. 2760483-96-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156680. | |
Our database is helping our users find suppliers everyday.
