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| Product | Description | |
|---|---|---|
| 6-Diazo-5-oxo-L-norleucine | 6-Diazo-5-oxo-L-norleucine. Group: Biochemicals. Alternative Names: L-Nle(6-Diazo-5-oxo)-OH; 6-Diazo-5-oxo-L-2-aminohexanoic acid. Grades: Highly Purified. CAS No. 157-03-9. Pack Sizes: 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences. |  Worldwide |
| 6-Diazo-5-oxo-L-norleucine 99+% | 6-Diazo-5-oxo-L-norleucine 99+%. Group: Biochemicals. Grades: Reagent Grade. CAS No. 157-03-9. Pack Sizes: 25mg, 100mg, 500mg. US Biological Life Sciences. | Worldwide |
| 6-Diazo-5-oxo-L-nor-leucine | It is produced by the strain of Streptomyces ambofaciens. It has anti-tumor activity and is not suitable for clinical use due to excessive toxicity. Its N-acetyl (Duazomycin) also has anti-tumor effect. Uses: Antibiotics, antineoplastic. Synonyms: 6-Diazo-5-oxonorleucine; 6-diazo-5-oxo-L-norleucine; L-DON; (S)-2-Amino-6-diazo-5-oxocaproic acid; L-6-Diazo-5-oxonorleucine; DON; NSC 7365; L-DON; 2-Amino-6-diazo-5-oxohexanolic acid. Grades: ≥ 99% (Assay by titration). CAS No. 157-03-9. Molecular formula: C6H9N3O3. Mole weight: 171.15. |  |
| Duazomycin A | Duazomycin A is produced by the strain of Streptomyces ambofaciens. It has the activity of anti-gram-positive bacteria, yeast and yeast-like fungi, and has strong inhibitory effect on sarcoma 180 and adenocarcinoma 755. Synonyms: Duazomycine; Duazomycinum; N-Acetyl-6-diazo-5-oxo-L-norleucine. CAS No. 2508-89-6. Molecular formula: C8H11N3O4. Mole weight: 213.19. | |
| JHU-083 | JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b + cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1998725-11-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122218. |  |
| JHU-292 | JHU-292 is the prodrug of 6-diazo-5-oxo-L-norleucine (DON), a glutaminase antagonist with therapeutic effect on hematological malignancies. Compared to DON, JH-292 exhibits excellent stability in human plasma and reduced gastrointestinal side effects. It would be metabolized to DON in tumor cells with the tumor cell/plasma DON ratio enhanced 15-fold. Uses: The treatment of hematological malignancies. Synonyms: JHU-292; JHU292. | |
| JHU395 | JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2079938-92-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128775. | |
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