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| Product | Description | |
|---|---|---|
| 7-Ethyl-10-hydroxycamptothecin | 7-Ethyl-10-hydroxycamptothecin. Group: Biochemicals. Grades: Highly Purified. CAS No. 86639-52-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C22H20N2O5. US Biological Life Sciences. |  Worldwide |
| 7-Ethyl-10-hydroxycamptothecin | 7-Ethyl-10-hydroxycamptothecin is a natural compound widely employed in the biomedical sector, showcasing remarkable potency in studying sundry malignancies such as colon, lung and ovarian cancers by impeding the functionality of topoisomerase I. Synonyms: CHEMBL93068; AC1LCGB7; 4-Ethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; DTXSID30348003. Grades: >98%. CAS No. 130194-92-2. Molecular formula: C20H16N2O5. Mole weight: 364.357. |  |
| 7-Ethyl-10-hydroxycamptothecin | 7-Ethyl-10-hydroxycamptothecin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-10-Hydroxycamptothecin. Appearance: Powder. CAS No. 86639-52-3. Molecular formula: C22H20N2O5. Mole weight: 392.4. Purity: 0.98. IUPACName: (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione. Canonical SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O. Density: 1.51±0.1 g/ml. Product ID: ACM86639523. Alfa Chemistry ISO 9001:2015 Certified. Categories: 7-ethyl-10-hydroxy-camptothecin. |  |
| 7-Ethyl-10-hydroxycamptothecin | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| 7-Ethyl-10-hydroxycamptothecine | topoisomerase I inhibitor, inhibits DNA and RNA synthesis. CAS No. 86639-52-3. Product ID: 1-01625. Molecular formula: C22H20N2O5. Mole weight: 392.41. Purity: 0.99. |  |
| SN-38. (7-Ethyl-10-hydroxycamptothecin) | A metabolite of Irinotecan, a DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Irinotecan, Hydrochloride Salt, Trihydrate ([1,4-Bipiperidine]-1-carboxylic Acid (S)-4, 11-diethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3, 4, 6, 7]indolizino[1, 2-b]quinolin-9-yl Ester, HCl Trihydrate) | Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 136572-09-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| SN-38 | SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC 50 s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. CAS No. 86639-52-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13704. |  |
| Tenifatecan | Tenifatecan, also known as SN2310, is an injectable emulsion composed of 7-ethyl-10-hydroxycamptothecin (SN-38) conjugate with vitamin E through a succinate linker. SN-38 is the active metabolite of irinotecan. SN-38 binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and apoptosis. SN-38 has been reported to exhibit up to 1,000-fold more cytotoxic activity against various cancer cells in vitro than irinotecan. SN2310 Injectable Emulsion is being developed with the objective of demonstrating improved anti-tumor activity as a result of increased exposure to SN-38 based on a longer half-life. Synonyms: SN 2300; SN2300; SN-2300; BEL2310; BEL 2310; BEL-2310. CAS No. 850728-17-5. Molecular formula: C53H68N2O8. Mole weight: 861.12. | |
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