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7-Ethyl-10-hydroxycamptothecin. Group: Biochemicals. Grades: Highly Purified. CAS No. 86639-52-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C22H20N2O5. US Biological Life Sciences.
Worldwide
7-Ethyl-10-hydroxycamptothecin
7-Ethyl-10-hydroxycamptothecin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-10-Hydroxycamptothecin. Appearance: Powder. CAS No. 86639-52-3. Molecular formula: C22H20N2O5. Mole weight: 392.4. Purity: 0.98. IUPACName: (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione. Canonical SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O. Density: 1.51±0.1 g/ml. Product ID: ACM86639523. Alfa Chemistry ISO 9001:2015 Certified. Categories: 7-ethyl-10-hydroxy-camptothecin.
7-Ethyl-10-hydroxycamptothecin-[d5] is the labelled analogue of 7-Ethyl-10-hydroxycamptothecin, which is the active metabolite of irinotecan, a DNA topoisomerase inhibitor. Synonyms: 7-Ethyl-10-hydroxycamptothecin-d5 (SN 38-D5); 1H-Pyrano[3',?4':6,?7]?indolizino[1,?2-b]?quinoline-3,?14(4H,?12H)?-dione, 4-ethyl-11-(ethyl-d5)?-4,?9-dihydroxy-, (4S)?-; 10-Hydroxy-7-ethylcamptothecin-d5; SN 38 Lactone-d5; USP Irinotecan Related Compound B-d5. Grade: >95%. CAS No. 718612-51-2. Molecular formula: C22H15D5N2O5. Mole weight: 397.45.
SN-38. (7-Ethyl-10-hydroxycamptothecin)
A metabolite of Irinotecan, a DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 136572-09-3. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
SN-38
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC 50 s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. CAS No. 86639-52-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13704.
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