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(±)5-HETE lactone Quick inquiry Where to buy Suppliers range | (±) 5-HETE Lactone is a unique marker for 5-lipoxygenase activation. (±) 5-HETE Lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. It inhibits 5-LO (5-lipoxygenase) (IC50=27 μM) from rat basophilic leukemia cells. The lactone form is several times more potent. Synonyms: 6-pentadeca-1,3,6,9-tetraenyloxan-2-one; 6-[(1E,3Z,6Z,9Z)-pentadeca-1,3,6,9-tetraenyl]oxan-2-one. Grades: ≥98%. CAS No. 73279-37-5. Molecular formula: C20H30O2. Mole weight: 302.5. |