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| Product | Description | |
|---|---|---|
| 8-Br-cGMP | 8-Br-cGMP is a stimulator of cGMP dependent protein kinases I α, I β & type II and cGMP-gated ion channels (cGMP agonist). Compared to cGMP, it has a superior stability. Synonyms: 8- Bromoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 51116-01-9. Molecular formula: C10H10BrN5O7P · Na. Mole weight: 446.1. |  |
| 8-Br-cGMP-AM | 8-Br-cGMP-AM is a precursor of 8-Br-cGMP, the PKG activator. The polar active analogue is released after the metabolism of 8-Br-cGMP-AM by esterases. Synonyms: 8- Bromoguanosine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grades: ≥ 97% by HPLC for mixture of isomers. CAS No. 272445-71-3. Molecular formula: C13H15BrN5O9P. Mole weight: 496.2. | |
| 4-N3-PET-8-Br-cGMP | 4-N3-PET-8-Br-cGMP is an analogue used for photoaffinity labelling of cGMP-responsive receptors, and an isozyme-selective activator of cGMP-dependent protein kinase I α and &beta. Synonyms: β- (4- Azidophenyl)- 1, N2- etheno- 8- bromoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 97% by HPLC. Molecular formula: C18H13BrN8O7P · Na. Mole weight: 587.2. | |
| BCMCM-caged 8-Br-cGMP | BCMCM-caged 8-Br-cGMP is a caged precursor of 8-bromo cGMP with improved solubility in water or buffers. 8-Br-cGMP and a fluorescent coumarin analogue are released by irradiation. Synonyms: [6,7-Bis(carboxymethoxy)coumarin-4-yl)methyl-8-bromoguanosine-3',5'-cyclic monophosphate. Grades: ≥ 98% by HPLC. CAS No. 370091-68-2. Molecular formula: C24H21BrN5O15P. Mole weight: 730.33. | |
| DMACM-caged 8-Br-cGMP | DMACM-caged 8-Br-cGMP is a fluorescent precursor of 8-bromo cyclic cGMP. 8-Br-cGMP and a fluorescent coumarin analogue are released by irradiation. It is much more lipophilic and membrane-permeant. Synonyms: (7- Dimethylaminocoumarin- 4- yl)methyl- 8- bromoguanosine- 3', 5'- monophosphate. Grades: ≥ 98% by HPLC. Molecular formula: C22H22BrN6O9P. Mole weight: 634.3. | |
| 8-Br-2'-O-Me-cGMP | 8-Br-2'-O-Me-cGMP is an analogue of cGMP that does not activate both protein kinase G and Epac. It is often used as an inactive control versus 8-Br-cGMP. Synonyms: 8- Bromo- 2'- O- methylguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C11H12BrN5O7P · Na. Mole weight: 460.1. | |
| Cyclic GMP | Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. cGMP may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of cyclic GMP (cGMP), 8-Br-cGMP, has antiplatelet activity, and cyclic GMP can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 7665-99-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113469. |  |
| Cyclic GMP sodium | Cyclic GMP (cGAMP) sodium is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP sodium can activate the stimulator of interferon genes (STING), activating the signaling cascade that leads to the production of type I interferons and other immune mediators. Cyclic-GMP-AMP, a conjugate of cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses. Cyclic GMP sodium may also activate PDE to degrade cAMP, inhibit myocardial calcium current I Ca , and regulate myocardial contractility. The derivative of Cyclic GMP sodium, 8-Br-cGMP, has antiplatelet activity, and Cyclic GMP sodium can be used in the study of antiviral immunity and cardiovascular diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 40732-48-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113469A. | |
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