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AR-A014418 is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β), a serine/threonine protein kinase involved in multiple diseases including Alzheimer's disease and type 2 diabetes. Synonyms: SN 4521; SN4521; SN-4521; AR-A 014418; AR-A014418; AR-A-014418; AR-AO-14418; GSK-3beta Inhibitor VIII; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea. Grades: ≥ 98%. CAS No. 487021-52-3. Molecular formula: C12H12N4O4S. Mole weight: 308.312.
CaCCinh-A01. Group: Biochemicals. Grades: Purified. CAS No. 407587-33-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
CaCCinh-A01
CaCCinh-A01 has been found to be a calcium-activated chloride channel (CaCC) inhibitor, wich IC50 ~ 10 μM. Synonyms: CaCCinh-A01; CaCC(inh)-A01, TMEM16 Blocker I. 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid. Grades: ≥99% by HPLC. CAS No. 407587-33-1. Molecular formula: C18H21NO4S. Mole weight: 347.43.
An aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC50=10uM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC50=2.1uM). Group: Biochemicals. Alternative Names: ANO Blocker I, Anoctamin Blocker I, TMEM16 Blocker I, 6-tert-butyl-2- (furan-2-carboxamido) -4, 5, 6, 7-tetrahydrobenzo [b]thiophene-3-carboxylic acid, CaCC Blocker I. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??NO?S, Molecular Weight: 347.43. US Biological Life Sciences.
Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104nm). Inhibition is competitive with respect to ATP (Ki = 38nm). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 =um) and over 26 other kinases. Inhibits b-amyloid-mediated neurodegeneration in hippocampal slices. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences.
Worldwide
T16Ainh - A01
T16Ainh - A01. Group: Biochemicals. Grades: Purified. CAS No. 552309-42-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
T16Ainh-A01 is a selective inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). T16Ainh-A01 inhibits EGF-induced increases in CaCC currents, and blocks proliferation of pancreatic cancer and squamous carcinoma cells in culture. Synonyms: 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide. Grades: ≥98% by HPLC. CAS No. 552309-42-9. Molecular formula: C19H20N4O3S2. Mole weight: 416.52.
An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50=1.1uM). Fully blocks CaCC current in salivary gland cells at 10uM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact at 10uM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
It is an impurity of paricalcitol, an analogue of vitamin D2. Paricalcitol is a medication used for the treatment of secondary hyperparathyroidism. Synonyms: (3S,6R)-2,3-Dimethyl-6-[(1R,3aalpha)-4beta-hydroxy-7abeta-methylhydrindane-1beta-yl]-4-heptene-2-ol; Paricalcitol Impurity A01. CAS No. 95716-67-9. Molecular formula: C19H34O2. Mole weight: 294.47.
2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide. Group: Biochemicals. Alternative Names: T16Ainh-A01. Grades: Highly Purified. CAS No. 552309-42-9. Pack Sizes: 10mg. Molecular Formula: C19H20N4O3S2, Molecular Weight: 416.52. US Biological Life Sciences.
Worldwide
4-Epitetracycline hydrochloride
4-Epitetracycline hydrochloride is an epimer of Tetracycline (HY-A0107). Tetracycline can undergo epimerization in solution to 4-Epitetracycline hydrochloride, which shows a much lower antibiotic activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 23313-80-6. Pack Sizes: 5 mg. Product ID: HY-136443.
Adenosine 5'-monophosphate monohydrate
Adenosine 5'-monophosphate monohydrate is an adenosine A 1 receptor agonist. Adenosine 5'-monophosphate monohydrate has significant antiviral activity against HSV-1 and HSV-2 [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 5'-AMP monohydrate. CAS No. 18422-05-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-A0181A.
Adenosine monophosphate
Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: AMP. CAS No. 61-19-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-A0181.
Adinazolam
Adinazolam (U 41123) is a benzodiazepine agonist. Adinazolam, a triazolobenzodiazepine, has dual anxiolytic and antidepressant activities [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: U 41123. CAS No. 37115-32-5. Pack Sizes: 1 mg. Product ID: HY-A0198.
Alizapride hydrochloride
Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders [1] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 59338-87-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-A0125A.
AR-AO 14418-[d3]
AR-AO 14418-[d3] is a labelled analogue of AR-AO 14418, a Glycogen Synthase Kinase 3β (GSK-3β) inhibitor. Synonyms: AR-AO 14418-d3; AR-A014418-d3. CAS No. 1216908-63-2. Molecular formula: C12H9D3N4O4S. Mole weight: 311.33.
Buclizine dihydrochloride
Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat and shows anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 129-74-8. Pack Sizes: 100 mg. Product ID: HY-A0128A.
Carboprost tromethamine
Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandin F 2&alpha. Carboprost tromethamine can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 58551-69-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-A0195.
Cefetamet
Cefetamet is a cephalosporin antibiotic. Cefetamet has the potential for the research of both upper and lower community-acquired respiratory tract infections [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 15-8074; Deacetoxycefotaxime. CAS No. 65052-63-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0111.
Cephapirin
Cephapirin (Cefapirin) is an ephalosporin antibiotic with broad-spectrum antimicrobial activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cefapirin. CAS No. 21593-23-7. Pack Sizes: 5 mg. Product ID: HY-A0153.
Cephapirin sodium
Cephapirin sodium (Cefapirin sodium) is an ephalosporin antibiotic with broad-spectrum antimicrobial activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cefapirin sodium. CAS No. 24356-60-3. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg. Product ID: HY-A0153A.
Ceruletide
Ceruletide is a decapeptide and a potent cholecystokinin receptor agonist. Ceruletide is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Caerulein; Cerulein; FI-6934. CAS No. 17650-98-5. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg. Product ID: HY-A0190.
Chlophedianol hydrochloride
Chlophedianol (Clofedanol) hydrochloride is an orally active and potent antitussive agent. Chlophedianol hydrochloride can be used for the research of acute cough due to upper respiratory tract infections (URIs) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Clofedanol hydrochloride; Calmotusin hydrochloride; NSC 113595 hydrochloride. CAS No. 511-13-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-A0161A.
Chlorphenesin
Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 104-29-0. Pack Sizes: 10 mM * 1 mL; 25 mg. Product ID: HY-A0133.
Chlorphenesin carbamate
Chlorphenesin carbamate is a centrally acting skeletal muscle relaxant, as well as a derivate of Chlorphenesin (HY-A0133). Chlorphenesin carbamate can be used for the research of pain and discomfort related to skeletal muscle trauma and inflammation [1]. Chlorphenesin carbamate is a selective blocker of polysynaptic pathways at the spinal and supra-spinal levels [2]. Antinociceptive effect [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Maolate; U 19646. CAS No. 886-74-8. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107944.
Cilastatin
Cilastatin (MK0791) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC 50 of 0.1 μM. Cilastatin inhibits the bacterial metallob-lactamase enzyme CphA with an IC 50 of 178 μM. Cilastatin is an antibacterial adjunct [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK0791. CAS No. 82009-34-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-A0166.
Cilastatin sodium
Cilastatin sodium (MK0791 sodium) is a reversible, competitive renal dehydropeptidase I inhibitor with an IC 50 of 0.1 μM. Cilastatin sodium inhibits the bacterial metallob-lactamase enzyme CphA with an IC 50 of 178 μM. Cilastatin sodium is an antibacterial adjunct [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK0791 sodium. CAS No. 81129-83-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-A0166A.
Dapiprazole hydrochloride
Dapiprazole hydrochloride is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole hydrochloride suppresses the opioid withdrawal symptoms. Dapiprazole hydrochloride is also used as eye drops for reversing mydriasis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 72822-13-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0142A.
Desacetylcephapirin sodium
Desacetylcephapirin sodium (Deacetylcephapirin sodium) is an active metabolite of Cephapirin (HY-A0153A). Desacetylcephapirin sodium has antimicrobial against S. aureus and coagulase-negative staphylococci mastitis pathogen [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Deacetylcephapirin sodium. CAS No. 104557-24-6. Pack Sizes: 2.5 mg. Product ID: HY-131989.
Dexbrompheniramine
Dexbrompheniramine is an orally active H1 receptor antagonist. Dexbrompheniramine is an antihistamine that reduces the effects of natural chemical histamine. Dexbrompheniramine can be used for the research of hay fever and urticaria [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Brompheniramine; (S)-Brompheniramine. CAS No. 132-21-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-A0191.
Diflorasone
Diflorasone act as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. Diflorasone is used for the research of skin diseases such as eczema or psoriasis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2557-49-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0158.
Dihomo-γ-linolenic acid
Dihomo-γ-linolenic acid (DGLA) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: DGLA; all-cis-8,11,14-Eicosatrienoic acid. CAS No. 1783-84-2. Pack Sizes: 5 mg (326.28 mM * 50 μL in Ethanol). Product ID: HY-A0143.
D-Thyroxine
D-Thyroxine (D-T4) is an orally active thyroid hormone that inhibits the secretion of TSH. D-Thyroxine can inhibit goiter, promote metamorphosis of tadpoles and influence cholesterol metabolism. D-Thyroxine can be used for the study of hypercholesterolemia [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: D-T4. CAS No. 51-49-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-A0152.
Enflurane
Enflurane, a volatile anaesthetic, is a potent inhibitor of high conductance Ca 2+ -activated K+ channels of Chara australis. Enflurane is an internal standard in monitoring halogenated volatile anaesthetics by headspace gas chromatography-mass spectrometry [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 13838-16-9. Pack Sizes: 100 mg. Product ID: HY-A0135.
Epoprostenol sodium
Epoprostenol sodium (Prostaglandin I2) sodium salt, the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH). Epoprostenol sodium is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Prostaglandin I2 sodium salt; Prostacyclin sodium salt; Flolan. CAS No. 61849-14-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0126A.
Etilefrine
Etilefrine (3-[2-(ethylamino)-1-hydroxyethyl]phenol) is an α adrenergic agonist [2]. Etilefrine also is an AMPK activator [1]. Etilefrine can be used for the research of postural hypotension [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 709-55-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-A0144.
Etilefrine hydrochloride
Etilefrine hydrochloride is an orally active α adrenergic agonist. Etilefrine hydrochloride is also an AMPK activator. Etilefrine hydrochloride can be used for the research of postural hypotension [1] [2] [3] [4]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 943-17-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-A0144A.
Etofibrate
Etofibrate is the ethandiol-1,2 diester of the nicotinic and clofibric acids. Etofibrate has been shown to be a potent hypolipidemic agent in animal and human. Uses: Scientific research. Group: Signaling pathways. CAS No. 31637-97-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-A0127.
Felypressin
Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin is widely used in dental procedures [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: PLV-2. CAS No. 56-59-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-A0182.
Felypressin acetate
Felypressin acetate (PLV-2 acetate) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin acetate is widely used in dental procedures [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: PLV-2 acetate. CAS No. 914453-97-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0182A.
Glisoxepide
Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 25046-79-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-A0176.
Glucosylquestiomycin
It is produced by the strain of Micridispora sp. TP-A0184. It has anti-gram positive bacteria, negative bacteria and yeast activity, but lower than Questiomycin. Synonyms: D-(+)-glucosylquestiomycin; N-β-D-Glucopyranosylquestiomycin A. CAS No. 218150-62-0. Molecular formula: C18H18N2O7. Mole weight: 374.35.
Grepafloxacin hydrochloride
Grepafloxacin (OPC-17116) hydrochloride is an oral actively fluoroquinolone antibiotic with potent activity against community-acquired respiratory pathogens including Streptococcus pneumonia. Grepafloxacin hydrochloride has high tissue penetration and a promising pharmacodynamic profile [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OPC-17116 hydrochloride; dl-Grepafloxacin hydrochloride. CAS No. 161967-81-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0147A.
Halofantrine hydrochloride
Halofantrine hydrochloride (SKF-102886) is a blocker of delayed rectifier potassium current via the inhibition of human-ether-a-go-go-related gene (HERG) channel and a potent antimalarial compound [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKF-102886; WR-171669 hydrochloride. CAS No. 36167-63-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-A0148A.
Histamine phosphate
Histamine (phosphate) is a strong histamine receptor activator and vasodilator neuroagent, capable of activating nitric oxide synthase. Uses: Scientific research. Group: Natural products. Alternative Names: Histamine diphosphate. CAS No. 51-74-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-A0129.
HPMC
HPMC (Hypromellose) is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Hypromellose; (Hydroxypropyl)methyl cellulose; Celacol HPM 5000. CAS No. 9004-65-3. Pack Sizes: 500 mg; 1 g. Product ID: HY-A0104.
Isoflurane
Isoflurane is a volatile general anaesthetic used for induction and maintenance of general anesthesia. Isoflurane binds to and enhances GABAA receptor. Isoflurane inhibits electron transfer in respiratory complex I [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 26675-46-7. Pack Sizes: 100 mg; 500 mg. Product ID: HY-A0134.
Levamisole
Levamisole ((-)-Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC 50 =300 μM) and α3β4 (EC 50 =100 μM) subtype of nAChRs. Orally active [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (-)-Tetramisole. CAS No. 14769-73-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-A0106.
Methyl aminolevulinate hydrochloride
Methyl aminolevulinate hydrochloride is an agent used as a sensitizer in photodynamic therapy (PDT). Methyl aminolevulinate is a proagent that can be metabolized to Protoporphyrin IX [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 79416-27-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-A0169A.
N-Acetyl-D-glucosamine
N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: N-Acetyl-2-amino-2-deoxy-D-glucose. CAS No. 7512-17-6. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-A0132.
N-Acetyl-D-glucosamine-13C
N-Acetyl-D-glucosamine- 13 C is the 13 C labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: N-Acetyl-2-amino-2-deoxy-D-glucose- 13 C. CAS No. 253679-94-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-A0132S1.
Naloxegol oxalate
Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a μ-opioid-receptor antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NKTR-118 oxalate; AZ-13337019 oxalate. CAS No. 1354744-91-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-A0118A.
Phenprocoumon
Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K. Uses: Scientific research. Group: Signaling pathways. CAS No. 435-97-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-A0145.
Phosphatidylserine
Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Phospholipids, phosphatidylserines; Serine glycerophosphatides. CAS No. 1446756-47-3. Pack Sizes: 5 mg (50 mg/mL * 100 μL in Chloroform); 10 mg (50 mg/mL * 200 μL in Chloroform); 25 mg (50 mg/mL * 500 μL in Chloroform). Product ID: HY-A0183.
Plicamycin
Plicamycin (Mithramycin A) is a selective specificity protein 1 ( Sp1 ) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mithramycin A. CAS No. 18378-89-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0122.
Progabide
Progabide is a gamma-aminobutyric acid receptor ( GABA ) agonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SL 76002. CAS No. 62666-20-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0173.
Quinupristin
Quinupristin is a streptogramin antibiotic. Quinupristin blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 120138-50-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-A0162.
Regadenoson
Regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of agents to the human CNS [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CVT-3146. CAS No. 313348-27-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0168.
Sancycline
Sancycline (6-Demethyl-6-deoxytetracycline) acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bonomycin; 6-Demethyl-6-deoxytetracycline. CAS No. 808-26-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17466.
Sapropterin dihydrochloride
Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin also drives autoimmunity. Sapropterin can be used in study of phenylketonuria (PKU) [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride. CAS No. 69056-38-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-A0124A.
Sodium tetradecyl sulfate
Sodium tetradecyl sulfate (Tergitol 4) is a novel scleroembolic agent and an apoptosis inducer. Sodium tetradecyl sulfate can be used for research on varicose veins and vascular malformation diseases [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tergitol 4. CAS No. 139-88-8. Pack Sizes: 100 mL. Product ID: HY-A0199.
Tetracycline
Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections [1]. Uses: Scientific research. Group: Natural products. Alternative Names: MK-801 maleate. CAS No. 60-54-8. Pack Sizes: 200 mg; 1 g; 5 g; 10 g. Product ID: HY-A0107.
Thioproperazine
Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RP 7843; SKF 5883; Thioperazine. CAS No. 316-81-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-A0151.
An N-aroylaminothiazole that strongly activates TMEM16A (ANO1) calcium-activated chloride channel (CaCC) at 0 Ca2+ concentration (Ca2+ independent), with the capability of producing large and sustained CaCC Cl-1 currents (EC50=3uM) in TMEM16A-expressing Fisher Rat Thyroid (FRT) Cells without elevation of cytoplasmic Ca2+ level, and in human A253 cells. Shown to increase CaCC conductance in human salivary and airway submucosal gland epithelial cells, IL-4 treated bronchial cells, and stimulated submucosal gland secretion in human bronchi and smooth muscle contraction in mouse intestine. Activation effect can be abolished by the addition of a TMEM16A inhibitor T16A-A01 at 10uM in TMEM16A-transfected cells and in cultures of human salivary gland and IL-4-treated bronchial epithelia, but not in intestine. Does not affect CFTR Cl- conductance or ENaC Na+ conductance. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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