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| Product | Description | |
|---|---|---|
| A350619 Hydrochloride | A350619 Hydrochloride is an activator of guanylyl cyclase (sGC). It activates basal sGC and synergistically activates sGC in the presence of NO. Acting as an sGC stimulator, it may be more effective than PDE5 inhibitors in the treatment of ED. Group: Biochemicals. Grades: Highly Purified. CAS No. 1217201-17-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C21H26Cl2N2OS, Molecular Weight: 425.41. US Biological Life Sciences. |  Worldwide |
| A3 hydrochloride | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| A3 hydrochloride | ?98% (HPLC), solid. Uses: For analytical and research use. Group: Fluorescence/luminescence spectroscopy. CAS No. 78957-85-4. Pack Sizes: 10MG, 50MG. Mole weight: 321.22. Catalog: AP78957854. Assay: ?98% (HPLC). | |
| A 350619 hydrochloride | A 350619 hydrochloride is an activator of soluble guanylyl cyclase (sGC) that stimulates basal sGC and synergistically activates sGC in the presence of NO. It is effective for the use of ED treatment. Uses: The treatment of ed. Synonyms: A-350619 hydrochloride; A350619 hydrochloride; A 350619 hydrochloride; 3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1217201-17-6. Molecular formula: C21H25ClN2OS.HCl. Mole weight: 425.41. |  |
| A 357300 hydrochloride | A 357300 hydrochloride is a potent and reversible inhibitor of methionine aminopeptidase-2 (MetAP-2). In murine models, it significantly inhibits CHP-134-derived neuroblastoma s.c. xenograft growth rate with a treatment-to-control (T/C) ratio at day 24 of 0.19 (P < 0.001) without toxicity. Uses: Novel treatment of neuroblastoma. Synonyms: A-357300; A 357300; A357300; N'-(3-amino-2-hydroxy-5-(isopropylthio)pentanoyl)-3-chlorobenzohydrazide hydrochloride. Grades: 99%. CAS No. 369358-07-6. Molecular formula: C15H22ClN3O3S.HCl. Mole weight: 396.33. | |
| a-3 Hydrochloride | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively. Uses: Designed for use in research and industrial production. Additional or Alternative Names: A3, Hydrochloride, A3 hydrochloride, IN1547, N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide hydrochloride, N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide, HCl, A-3HYDROCHLORIDE, A1980_SIGMA, SCHEMBL3503907, CHEMBL1255867, CTK7E9088, OR0890T, MolPort-001-756-823, CCG-222331, LP01027, NCGC00094317-01, 3B3-053691, N-(2-Aminoethyl)-5-chloronaphthalene-1-sulphonamide hydrochloride, N-(2-AMINOETHYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE, HYDROCHLORIDE, 78957-85-4. Product Category: Inhibitors. CAS No. 78957-85-4. Molecular formula: C12H14Cl2N2O2S. Mole weight: 321.22. Purity: 0.96. IUPACName: N-(2-aminoethyl)-5-chloronaphthalene-1-sulfonamide;hydrochloride. Product ID: ACM78957854. Alfa Chemistry ISO 9001:2015 Certified. |  |
| B-Raf inhibitor 1 dihydrochloride | B-Raf inhibitor 1 is an inhibitor of B-Raf kinase with IC50 values of 0.31μM and 0.72μM for cell proliferation, respectively in A375 and HCT116. B-Raf is important in signal transduction and some mutant B-Raf occurs in cancer cells. The most common mutation of these is V600E, which makes B-Raf kinase constitutively active. B-Raf inhibitor 1 belongs to the type IIA inhibitors and binds to the DFG-out ATP-binding site of B-Raf. The selectivity of B-Raf inhibitor 1 is less than of other type inhibitors. Besides mutant B-Raf, it can also inhibit wild type B-Raf and other tyrosine kinase. In cells with wild type B-Raf, B-Raf inhibitor 1 can activate the RAF-MEK-ERK signaling pathway via Raf dimerization. The preclinical toxicity test shows B-Raf inhibitor 1 can induce hyperplasia in a mouse model. Synonyms: 1,5-Isoquinolinediamine, N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, hydrochloride (1:2). Grades: >98%. CAS No. 1191385-19-9. Molecular formula: C26H21Cl3N8. Mole weight: 551.86. | |
| L,L-Dityrosine Dihydrochloride | L,L-Dityrosine Dihydrochloride. Group: Biochemicals. Alternative Names: (a3S,a3'S)-a3,a3'-Diamino-6,6'-dihydroxy-[1,1'-biphenyl]-3,3'-dipropanoic acid hydrochloride; [S-(R*,R*)]- a,a'-Diamino-6,6'-dihydroxy-[1,1'-biphenyl]-3,3'-dipropanoic acid hydrochloride; 3,3'-Bityrosine hydrochloride. Grades: Highly Purified. CAS No. 221308-01-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C18H20N2O6·2HCl. US Biological Life Sciences. | Worldwide |
| PSB 10 hydrochloride | PSB 10 is a potent and highly selective antagonist for the human adenosine A3 receptor that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively). It produces thermal hyperalgesia in mice in vivo. Synonyms: PSB 10 hydrochloride; PSB10 hydrochloride; PSB-10 hydrochloride; 8-Ethyl-1,4,7,8-tetrahydro-4-methyl-2-(2,3,5-trichlorophenyl)-5H-imidazo[2,1-i]purin-5-one monohydrochloride. Grades: ≥98% by HPLC. CAS No. 591771-91-4. Molecular formula: C16H14Cl3N5O.HCl. Mole weight: 435.14. | |
| PSB 11 hydrochloride | PSB 11 hydrochloride, an anti-inflammatory imidazopurinone, has displayed potent and highly selective antagonist characteristics towards human Adenosine A3-R, with low affinity for the rat A3 receptor (Ki values are 2.3 and > 10000 nM respectively). It displays > 1000-fold selectivity over human A1 and A2A receptors (Ki values are 4.1 and 3.3 μM respectively) and > 180-fold selectivity over rat A1, rat A2A and mouse A2B receptors. Synonyms: 5H-Imidazo[2,1-i]purin-5-one, 8-ethyl-3,4,7,8-tetrahydro-4-methyl-2-phenyl-, hydrochloride (1:1), (8R)-; PSB11 hydrochloride; PSB-11 hydrochloride; (8R)-8-Ethyl-3,4,7,8-tetrahydro-4-methyl-2-phenyl-5H-imidazo[2,1-i]purin-5-one hydrochloride (1:1); 5H-Imidazo[2,1-i]purin-5-one, 8-ethyl-1,4,7,8-tetrahydro-4-methyl-2-phenyl-, monohydrochloride, (8R)-; (R)-8-ethyl-4-methyl-2-phenyl-7,8-dihydro-3H-imidazo[2,1-i]purin-5(4H)-one Hydrochloride. Grades: ≥98% by HPLC. CAS No. 453591-58-7. Molecular formula: C16H17N5O.HCl. Mole weight: 331.80. | |
| Ulixertinib hydrochloride | Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC 50 of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BVD-523 hydrochloride; VRT752271 hydrochloride. CAS No. 1956366-10-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15816A. |  |
| Adenosine A2A Receptor Agonist I, Hydrochloride (CGS 21680) | A xanthin derivative that acts as a potent agonist of adenosine A2A receptors (Ki = 27nM). Exhibits reduced affinity for A2B receptors (Ki = 67nM), but offers greater selectivity over A1R (Ki = 290nM) and A3R (88.8uM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington's disease. Group: Biochemicals. Alternative Names: CGS-21680; 3- (4- (2- ( (6-amino-9- ( (2R, 3R, 4S, 5S) -5- (ethylcarbamoyl) -3, 4-di hydroxytetra hydrofuran-2-yl) -9H-purin-2-yl) amino) ethyl) phenyl) propanoic acid). Grades: Highly Purified. CAS No. 124182-57-6. Pack Sizes: 5mg. Molecular Formula: C23H29N7O6 HCl, Molecular Weight: 536. US Biological Life Sciences. | Worldwide |
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