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| Product | Description | |
|---|---|---|
| Abcb1 | Abcb1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ABCB1;MDR1 HUMAN MEMBRANE PREPARATION;PGP;Ac-Pro-Gly-Pro-OH. Product Category: Heterocyclic Organic Compound. CAS No. 292171-04-1. Molecular formula: C14H21N3O5. Mole weight: 311.336. Product ID: ACM292171041. Alfa Chemistry ISO 9001:2015 Certified. Categories: ABCB11. |  |
| ABCB1 | ABCB1, a CXC receptor ligand from the extracellular matrix (ECM), is produced during airway inflammation. Its activity links ECM degradation to neutrophil recruitment in airway inflammation. It may be a biomarker and therapeutic target for neutrophil inflammatory diseases. Synonyms: Ac-PGP; Ac-Pro-Gly-Pro-OH; Acetyl Pro-Gly-Pro-OH; N-acetyl-L-prolyl-glycyl-L-proline; N-α-PGP. Grade: 95%. CAS No. 292171-04-1. Molecular formula: C14H21N3O5. Mole weight: 311.34. |  |
| Anti-ABCB11 antibody produced in rabbit | affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. |  |
| Anti-ABCB1 antibody produced in rabbit | affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-ABCB1 antibody produced in mouse | clone 1F11, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Avapritinib | Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC 50 s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V , respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2 [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BLU-285. CAS No. 1703793-34-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101561. |  |
| CCT129202 | CCT129202 is an inhibitor of Aurora kinase activity and displays a favorable antineoplastic effect in preclinical studies. CCT129202 significantly reversed ABCB1- and ABCG2-mediated MDR in vitro, in vivo and ex vivo by inhibiting the function of their transporters and enhanced the eradication of cancer stem-like cells by chemotherapeutic agents. CCT129202 may be a candidate as MDR reversal agent for antineoplastic combination therapy and merits further clinical investigation. Synonyms: CCT129202; CCT-129202; CCT 129202. CAS No. 942947-93-5. Molecular formula: C23H25ClN8OS. Mole weight: 497.02. | |
| Dofequidar fumarate | Dofequidar fumarate, a quinoline derivative, is a multidrug resistance (MDR)-reversing quinoline derivative by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1, or both. It has potential to treat advanced and recurrent breast cancer and non-small lun. Synonyms: MS-209; MS 209; MS209. CAS No. 153653-30-6. Molecular formula: C34H35N3O7. Mole weight: 597.66. | |
| FTY720 Hydrochloride (Gilenya, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol. HCl, Fingolimod) | Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Autophagy inducer. Apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 162359-56-0. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. |  Worldwide |
| Ganoderenic acid B | Ganoderenic acid B is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderenic acid B exhibits potent reversal effect on ABCB1-mediated multidrug resistance of HepG2/ADM cells to Doxorubicin [1]. Uses: Scientific research. Group: Natural products. CAS No. 100665-41-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N1514. | |
| Genz-123346 Free base | Genz-123346 is a glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function. Synonyms: Genz-123346; Genz123346; Genz 123346. CAS No. 491833-30-8. Molecular formula: C24H38N2O4. Mole weight: 418.57. | |
| IKK 16 hydrochloride | IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-?B pathway[1][2][3][4][5][6][7]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1186195-62-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13687A. | |
| MC70 | MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC 50 of 0.69 μM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1 [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1031367-64-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113805. | |
| ML230 | ML230 (CID44640177; SID 88095709) is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2 , and 36-fold selective for ABCG2 over ABCB1 with EC 50 s values of 0.13 μM and 4.65 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID44640177; SID 88095709. CAS No. 1776055-05-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111678. | |
| Olaparib | Olaparib is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy.PARP1 acts as a critical molecule in the repair of DNA single-strand breaks (SSBs) and plays an important role in maintaining DNA integrity. de Murcia, J., et al. "Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells." Proc. Natl. Acad. Sci. USA 94: 7303-7307 (1997).PARP inhibitors inhibit PARP1 during S-phase and...num drugs." Proc. Natl. Acad. Sci. USA 105: 17079-17084 (2008).Long-term treatment with olaparib caused the development of drug resistance, which was induced by up-regulation of Abcb1a/b genes encoding P-glycoprotein efflux pumps. The resistance to... Group: Biochemicals. Alternative Names: 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone; AZD-2281; KU 0059436; KU-59436; 1- (Cyclopropylcarbonyl) -4- [5- [ (3, 4-dihydro-4-oxo-1-phthalazinyl) methyl] -2-fluorobenzoyl] piperazine. Grades: Highly Purified. CAS No. 763113-22-0. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??FN?O?, Molecular Weight: 434.46. US Biological Life Sciences. | Worldwide |
| Zn(II) Mesoporphyrin IX | Zn(II) Mesoporphyrin IX (ZnMP) is a specific activator of ABCB10 , significantly increasing its ATPase activity and acting as a substrate for ABCB10 in heme synthesis. Zn(II) Mesoporphyrin IX may promote the transcription of hemoglobinization genes by facilitating the degradation of the Bach1 repressor. Zn(II) Mesoporphyrin IX aids in studying the potential roles of ABCB10 in heme synthesis, oxidative stress protection, hepatitis C, and other areas [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: ZnMP. CAS No. 14354-67-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W583212. | |
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