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ABH
ABH is an inhibitor of arginase types I and II. Synonyms: Amino-2-borono-6-hexanoic acid; (S)-2-amino-6-boronohexanoic acid. Grade: ≥90%. CAS No. 222638-65-5. Molecular formula: C6H14BNO4. Mole weight: 175.
ABH (hydrochloride) is an orally active arginase inhibitor ( K i = 8.5 nM). ABH hydrochloride promotes NO production and reduces the expression of inflammatory response-related molecules ( ICAM-1 , VCAM-1 , MCP-1 ). ABH hydrochloride improves erectile function, reduces lung damage, promotes wound healing, reduces arterial blood pressure, and improves vascular fibrosis [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. CAS No. 194656-75-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-112868B.
ABH hydrochloride
Fluorescence/Luminescence Spectroscopy. Uses: For analytical and research use. Group: Reagents. CAS No. 194656-75-2. Pack Sizes: 5MG, 25MG.
2'-Deoxy-6-thioguanosine-5'-monophosphate
2'-Deoxy-6-thioguanosine-5'-monophosphate is an innovative pharmaceutical entity, exquisitely designed for unveiling remarkable antiviral potency, assiduously directing its action towards impeding the pernicious propagation of RNA viruses. Deploying its inhibitory prowess upon viral enzyme activity, it efficaciously curtails the abhorrent virus's proclivity to proliferate, ensuing in a substantial amelioration of both the intensity and duration of the affliction. Synonyms: 2'-Deoxy-6-thio-5'-guanylic acid. CAS No. 15303-00-1. Molecular formula: C10H14N5O6PS. Mole weight: 363.29.
5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-D-lyxono-1,4-lactone, a vital intermediate for drug synthesis, has a plethora of biomedicinal applications. Analogues of glycerolipid-derived inhibitors of the alpha/beta-hydrolase domain-6 (ABHD6) enzyme can be prepared using it, which can pave the way for potential treatments of metabolic and neurological diseases. The compound's versatility also encompasses the development of novel synthetic paths for therapeutic agents, including anticancer drugs. Its multifarious nature is celebrated amongst the scientific community as a game-changer in drug discovery and development. Synonyms: (3aS,6R,6aS)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4(3aH)-one; (3aS,6R,6aS)-6-({[Dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4(3aH)-one; 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-D-ribonic acid γ-lactone; D-Lyxonic acid, 5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-, γ-lactone. CAS No. 849372-15-2. Molecular formula: C14H26O5Si. Mole weight: 302.44.
AA38-3
AA38-3 is a serine hydrolase (SH) inhibitor that can inhibit three SHs, ABHD6, ABHD11, and FAAH. Synonyms: 4-Nitrophenyl piperidine-1-carboxylate; 1-Piperidinecarboxylic acid, 4-nitrophenyl ester; 4-Nitrophenyl 1-piperidinecarboxylate. Grade: ≥95%. CAS No. 65815-76-1. Molecular formula: C12H14N2O4. Mole weight: 250.25.
ABD957
ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC50 of 0.21 ?M for ABHD17B. ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3007772-60-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142161.
Benzyldimethylchlorosilane
Benzyldimethylchlorosilane. Group: Self assembly and contact printing materials. Alternative Names: PhCH2Me2SiCl; benzyldimethylchlorosilane; SILANE,BENZYLCHLORODIMETHYL. CAS No. 1833-31-4. Pack Sizes: 10 g; 100 g. Product ID: benzyl-chloro-dimethylsilane. Molecular formula: 184.74. Mole weight: C9H13ClSi. C[Si](C)(CC1=CC=CC=C1)Cl. ABHNFDUSOVXXOA-UHFFFAOYSA-N. 97%.
DNA oxidative demethylase
Contains iron; activity is slightly stimulated by ascorbate. Catalyses oxidative demethylation of the DNA base lesions N1-methyladenine, N3-methylcytosine, N1-methylguanine, and N3-methylthymine. It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA. Group: Enzymes. Synonyms: alkylated DNA repair protein; α-ketoglutarate-dependent dioxygenase ABH1; alkB (gene name). Enzyme Commission Number: EC 1.14.11.33. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0651; DNA oxidative demethylase; EC 1.14.11.33; alkylated DNA repair protein; α-ketoglutarate-dependent dioxygenase ABH1; alkB (gene name). Cat No: EXWM-0651.
DO264
DO264 is a potent, selective, and in vivo active ABHD12 inhibitor. DO264 inhibits ABHD12 and increases lyso-PS content in human monocytic cells. Synonyms: DO-264; DO 264; 1-(1-(3-Chloro-4-(2-chloro-4-(trifluoromethoxy)phenoxy)pyridin-2-yl)piperidin-4-yl)-3-(pyridin-3-yl)thiourea. Grade: 99%. CAS No. 2301866-59-9. Molecular formula: C23H20Cl2F3N5O2S. Mole weight: 558.40.
Galactosyl-β-D-(1-4)-N-Acetyllactosamine
Galactosyl-β-D-(1-4)-N-Acetyllactosamine is a derivative of N-Acetyllactosamine, component of oligosaccharide portion of many N-and O-linked glycoproteins. It is a building unit for the antigenic determinants of a number of certain human blood group activities as well as of the ABH Type 2 determinants. Synonyms: 4-O-β-D-Galactopyranosyl-β-D-(1-4)-galactopyranosyl-N-acetyl-D-glucosamine; N-((2R,3R,4S,5R)-4-(((2S,3R,4R,5R,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-3,5,6-trihydroxy-1-oxohexan-2-yl)acetamide; Galactosyl-β-D-(1→4)-N-acetyllactosamine; O-β-D-Galactopyranosyl-(1→4)-O-β-D-galactopyranosyl-(1→4)-2-(acetylamino)-2-deoxy-D-glucose. CAS No. 38237-96-6. Molecular formula: C20H35NO16. Mole weight: 545.49.
Hydrocortisone Acetate EP impurity G
Hydrocortisone Acetate EP impurity G. Synonyms: UNII-ABH947V8F4; Hydrocortisone 11,21-diacetate; Cortisol, 11,21-diacetate; ABH947V8F4; [2-[(8S,9S,10R,11S,13S,14S,17R)-11-acetyloxy-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate; 2-((8S,9S,10R,11S,13S,14S,17R)-11-Acetoxy-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate; Hydrocortisone acetate impurity G [EP]; HYDROCORTISONE ACETATE IMPURITY G [EP IMPURITY]; 17-Hydroxy-3,20-dioxopregn-4-ene-11beta,21-diyl diacetate; 17-HYDROXY-3,20-DIOXOPREGN-4-ENE-11.BETA.,21-DIYL DIACETATE; Pregn-4-ene-3,20-dione, 11,21-bis(acetyloxy)-17-hydroxy-, (11beta)-; PREGN-4-ENE-3,20-DIONE, 11,21-BIS(ACETYLOXY)-17-HYDROXY-, (11.BETA.)-; 2-((8S,9S,10R,11S,13S,14S,17R)-11-Acetoxy-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethylacetate. Grade: > 95%. CAS No. 81968-66-3. Molecular formula: C25H34O7. Mole weight: 446.55.
KC01
KC01 is a covalent inhibitor of ABHD16A. ABHD16A is a phosphatidylserine (PS) lipase that generates lyso-PS in mammalian systems. KC01 can deplete lysoPSs from cells, including lymphoblasts derived from subjects with PHARC. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KC01; K C01; K-C01. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1646795-59-6. Molecular formula: C22H39NO3. Mole weight: 365.56. Purity: >98%. IUPACName: (Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide. Canonical SMILES: O=C(N)CCCC/C=C1C(OC\1CCCCCCCCCCCCC)=O. Product ID: ACM1646795596. Alfa Chemistry ISO 9001:2015 Certified. Categories: KC-17.
KC01
KC01 is an effective inhibitor of ABHD16A , with IC 50 s of 90 nM for hABHD16A and 520 nM for mABHD16A. KC01 significantly reduces lyso-PSs, and decreases lyso-PS and LPS-induced cytokine production in mouse macrophages [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1646795-59-6. Pack Sizes: 1 mg. Product ID: HY-120299.
KT109
KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC 50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGL&alpha. KT109 shows inhibitory activity against PLA2G7 (IC 50 =1 μM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402612-55-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18540.
Mica
Mica is a group of minerals that are widely used in various industries such as cosmetics, construction, and electronics. It is a naturally occurring mineral that belongs to the silicate family and is characterized by its unique properties such as high electrical and thermal insulation, and resistance to heat, chemicals, and weather. Mica minerals are mainly composed of potassium, aluminum, silicon, and oxygen, and they can be found in several forms such as sheets, flakes, and powders. In cosmetics, mica is used to add shimmer and glimmer effects to products such as eyeshadows, lipsticks, and nail polishes. Uses: Designed for use in research and industrial production. Additional or Alternative Names: abhrak;biotite;c1000;davenitep12;daze;fluorophlogopite;glist;hx610. Product Category: Heterocyclic Organic Compound. Appearance: shiny, reflective appearance with a layered or flaky texture. CAS No. 12001-26-2. Molecular formula: Al2K2O6Si. Mole weight: 256.24. Density: 2.77. ECNumber: 310-127-6. Product ID: ACM12001262. Alfa Chemistry ISO 9001:2015 Certified.
p-Azidobenzoylhydrazide
p-Azidobenzoylhydrazide. Group: Biochemicals. Alternative Names: ABH. Grades: Highly Purified. CAS No. 63296-32-2. Pack Sizes: 50mg, 100mg, 250mg. US Biological Life Sciences.
The enzyme catalyses the posttranslational modification of uridine residues at the wobble position 34 of the anticodon loop of tRNA. Group: Enzymes. Synonyms: ALKBH8; ABH8; Trm9; tRNA methyltransferase 9. Enzyme Commission Number: EC 2.1.1.229. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1832; tRNA (carboxymethyluridine34-5-O)-methyltransferase; EC 2.1.1.229; ALKBH8; ABH8; Trm9; tRNA methyltransferase 9. Cat No: EXWM-1832.
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