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| Product | Description | |
|---|---|---|
| acetyl-CoA carboxylase | A biotinyl-protein. Also catalyses transcarboxylation; the plant enzyme also carboxylates propanonyl-CoA and butanoyl-CoA. Group: Enzymes. Synonyms: acetyl coenzyme A carboxylase. Enzyme Commission Number: EC 6.4.1.2. CAS No. 9023-93-2. ACC. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5813; acetyl-CoA carboxylase; EC 6.4.1.2; 9023-93-2; acetyl coenzyme A carboxylase. Cat No: EXWM-5813. |  |
| Acetyl-CoA Carboxylase 1 from Human, Recombinant | Acetyl-CoA Carboxylase (ACC) regulates the metabolism of fatty acids. This enzyme catalzes the formation of Malonyl CoA through the irreversible carboxylation of acetyl CoA. There are two main isoforms of Acetyl-CoA carboxylase expressed in mammals, Acetyl-CoA carboxylase 1 (ACACA) and Acetyl-CoA carboxylase 2 (ACACB). ACACA has broad tissue distribution but is enriched in tissues critical for fatty acid sythesis such as adipose tissue. ACACB is enriched in tissues such as skeletal muscle and heart that are critical for fatty acid oxidation. The Acetyl-CoA Carboxylase enzymes are activated by Citrate, glutamate, and dicarboxylic acids and negatively regulated by long ...he study of enzyme kinetics, screening inhibitors, and selectivity profiling. Group: Enzymes. Synonyms: ACAC; ACACA; ACC1; ACC; ACCA; acetyl-CoA carboxylase alpha; acetyl coenzyme A carboxylase; acetyl-CoA carboxylase. Enzyme Commission Number: EC 6.4.1.2. CAS No. 9023-93-2. ACC. Mole weight: 292.5 kDa. Activity: > 20 units/μg protein. Storage: Store at -70°C. Avoid multiple freeze-thaw cycles. Form: Supplied as a solution in 50 mM Tris-HCl, pH 8.0, 275 mM NaCl, 10% glycerol, 1 mM EDTA and 2 mM DTT. Source: Sf9 cells. Species: Human. ACAC; ACACA; ACC1; ACC; ACCA; acetyl-CoA carboxylase alpha; acetyl coenzyme A carboxylase; acetyl-CoA carboxylase. Cat No: NATE-0942. | |
| Acetyl-CoA Carboxylase 1 human | recombinant, expressed in Sf9 cells. Group: Fluorescence/luminescence spectroscopy. |  |
| Acetyl-CoA Carboxylase 2 from Human, Recombinant | Acetyl-CoA Carboxylase (ACC) regulates the metabolism of fatty acids. This enzyme catalzes the formation of Malonyl CoA through the irreversible carboxylation of acetyl CoA. There are two main isoforms of Acetyl-CoA carboxylase expressed in mammals, Acetyl-CoA carboxylase 1 (ACACA) and Acetyl-CoA carboxylase 2 (ACACB). ACACA has broad tissue distribution but is enriched in tissues critical for fatty acid sythesis such as adipose tissue. ACACB is enriched in tissues such as skeletal muscle and heart that are critical for fatty acid oxidation. The Acetyl-CoA Carboxylase enzymes are activated by Citrate, glutamate, and dicarboxylic acids and negatively regulated by long ...ercise. the enzyme also may be used for acc regulation study in anti-obesity and anti-type 2 diabetes therapeutics. Group: Enzymes. Synonyms: ACACB; ACC2; acetyl-CoA carboxylase beta; acetyl coenzyme A carboxylase; acetyl-CoA carboxylase. Enzyme Commission Number: EC 6.4.1.2. CAS No. 9023-93-2. ACC. Mole weight: 277 kDa. Activity: > 25 units/μg protein. Storage: Store at -70°C. Avoid multiple freeze-thaw cycles. Form: Supplied as a solution in 50 mM Tris-HCl, pH 8.0, 275 mM NaCl, 10% glycerol, 1 mM EDTA and 2 mM DTT. Source: Sf9 cells. Species: Human. ACACB; ACC2; acetyl-CoA carboxylase beta; acetyl coenzyme A carboxylase; acetyl-CoA carboxylase. Cat No: NATE-0943. | |
| Acetyl-CoA Carboxylase-IN-1 | Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC 50 value of ?5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 179343-23-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152117. |  |
| [acetyl-CoA carboxylase] kinase | Phosphorylates and inactivates EC 6.4.1.2, acetyl-CoA carboxylase, which can be dephosphorylated and reactivated by EC 3.1.3.17, [phosphorylase] phosphatase. The enzyme is more active towards the dimeric form of acetyl-CoA carboxylase than the polymeric form. Phosphorylates serine residues. Group: Enzymes. Synonyms: acetyl coenzyme A carboxylase kinase (phosphorylating); acetyl-CoA carboxylase bound kinase; acetyl-CoA carboxylase kinase; acetyl-CoA carboxylase kinase (cAMP-independent); acetyl-CoA carboxylase kinase 2; acetyl-CoA carboxylase kinase-2; acetyl-CoA carboxylase kinase-3 (AMP-activated); acetyl-coenzyme A carboxylase kinase; ACK2; ACK3; AMPK; I-peptide kinase; STK5. Enzyme Commission Number: EC 2.7.11.27. CAS No. 77000-06-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3147; [acetyl-CoA carboxylase] kinase; EC 2.7.11.27; 77000-06-7; acetyl coenzyme A carboxylase kinase (phosphorylating); acetyl-CoA carboxylase bound kinase; acetyl-CoA carboxylase kinase; acetyl-CoA carboxylase kinase (cAMP-independent); acetyl-CoA carboxylase kinase 2; acetyl-CoA carboxylase kinase-2; acetyl-CoA carboxylase kinase-3 (AMP-activated); acetyl-coenzyme A carboxylase kinase; ACK2; ACK3; AMPK; I-peptide kinase; STK5. Cat No: EXWM-3147. | |
| [acetyl-CoA carboxylase]-phosphatase | Simultaneously dephosphorylates and activates EC 6.4.1.2 acetyl-CoA carboxylase. Acts similarly on EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase), EC 2.4.1.1 (phosphorylase), EC 2.4.1.11 [glycogen(starch) synthase], and dephosphorylates phosphoprotamine and 4-nitrophenyl phosphate. Not identical to EC 3.1.3.17 ([phosphorylase] phosphatase ) or EC 3.1.3.43 {[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase}. Group: Enzymes. Enzyme Commission Number: EC 3.1.3.44. CAS No. 77000-10-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3648; [acetyl-CoA carboxylase]-phosphatase; EC 3.1.3.44; 77000-10-3. Cat No: EXWM-3648. | |
| biotin-[acetyl-CoA-carboxylase] ligase | This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. This enzyme participates in biotin metabolism. This protein may use the morpheein model of allosteric regulation. Group: Enzymes. Synonyms: biotin-[acetyl-CoA carboxylase] synthetase; biotin-[acetyl coenzyme A carboxylase] synthetase; acetyl coenzyme A holocarboxylase synthetase; acetyl CoA holocarboxylase synthetase; biotin:apocarboxylase ligase; Biotin holoenzyme synthetase; HCS. Enzyme Commission Number: EC 6.3.4.15. CAS No. 37340-95-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5784; biotin-[acetyl-CoA-carboxylase] ligase; EC 6.3.4.15; 37340-95-7; biotin-[acetyl-CoA carboxylase] synthetase; biotin-[acetyl coenzyme A carboxylase] synthetase; acetyl coenzyme A holocarboxylase synthetase; acetyl CoA holocarboxylase synthetase; biotin:apocarboxylase ligase; Biotin holoenzyme synthetase; HCS. Cat No: EXWM-5784. | |
| 1-(5-Amino-2-hydroxyphenyl)ethanone | 1-(5-Amino-2-hydroxyphenyl)ethanone is used in the preparation of alkylated flavonoid compounds for use as therapeutic antioxidants. It is also used to synthesize spiro[chromanone-piperidine]s as acetyl-CoA carboxylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 50-80-6. Pack Sizes: 50mg, 100mg. Molecular Formula: C8H9NO2, Molecular Weight: 151.16. US Biological Life Sciences. |  Worldwide |
| 1-Bromo-2-methyl-4- (trifluoromethoxy) benzene | 1-Bromo-2-methyl-4- (trifluoromethoxy) benzene is used to prepare acetyl-CoA carboxylase inhibitors for metabolic syndrome treatment. Group: Biochemicals. Grades: Highly Purified. CAS No. 261951-96-6. Pack Sizes: 250mg, 1g. Molecular Formula: C8H6BrF3O, Molecular Weight: 255.03. US Biological Life Sciences. | Worldwide |
| 2'- (1, 1-Dimethylethyl) -2', 6'-dihydro-1- (1H-indazol-5-ylcarbonyl) spiro[piperidine-4, 5' (7'H) -pyrano[3, 2-c]pyrazol]-7'-one | 2'- (1, 1-Dimethylethyl) -2', 6'-dihydro-1- (1H-indazol-5-ylcarbonyl) spiro[piperidine-4, 5' (7'H) -pyrano[3, 2-c]pyrazol]-7'-one is a dual inhibitor of acetyl-CoA carboxylase 1 and 2 (ACC1 and ACC2). Group: Biochemicals. Grades: Highly Purified. CAS No. 1197815-64-7. Pack Sizes: 5mg, 50mg. Molecular Formula: C22H25N5O3, Molecular Weight: 407.47. US Biological Life Sciences. | Worldwide |
| 2,2'-[1,4-Phenylenebis(oxy)]bis-propanoic Acid Dimethyl Ester | 2,2'-[1,4-Phenylenebis(oxy)]bis-propanoic Acid Dimethyl Ester is an intermediate in the synthesis of (±)-Fluazifop (F407430). (±)-Fluazifop is a grass-selective herbicide which inhibits acetyl-CoA carboxylase in sensitive plant species. Group: Biochemicals. Grades: Highly Purified. CAS No. 85977-51-1. Pack Sizes: 5mg, 10mg. Molecular Formula: C14H18O6. US Biological Life Sciences. | Worldwide |
| 2-?(4-?Hydroxyphenoxy-?2,?3,?5,?6-?d4)?-propanoic Acid | 2-?(4-?Hydroxyphenoxy-?2,?3,?5,?6-?d4)?-propanoic Acid is an intermediate in synthesizing (±)-Fluazifop-d4 (F407432), a labeled analogue of (±)-Fluazifop (F407430), which is a grass-selective herbicide which inhibits acetyl-CoA carboxylase in sensitive plant species. Group: Biochemicals. Grades: Highly Purified. CAS No. 127893-32-7. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C9H6D4O4, Molecular Weight: 186.2. US Biological Life Sciences. | Worldwide |
| ACC2 Inhibitor (N-(1-(2-(4-Isopropoxyphenoxy)-2,5-bithiazol-5-yl)ethyl)acetamide) | Cell-permeable. A potent and selective inhibitor of ACC2 (Acetyl-CoA Carboxylase) (IC50 = 28nM for hACC2 vs 210nM for hACC1 in in vitro studies). Group: Biochemicals. Alternative Names: N-(1-(2-(4-Isopropoxyphenoxy)-2,5-bithiazol-5-yl)ethyl)acetamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Acetyl coenzyme A lithium salt | Acetyl coenzyme A trilithium salt is a lithium salt of an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. Acetyl coenzyme A is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl coenzyme A is a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-coA is a positive regulator of pyruvate carboxylase and is a precursor of the neurotransmitter acetylcholine. Applications: A cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. Group: Coenzymes. Synonyms: Acetyl-S-CoA Li3. CAS No. 32140-51-5. Purity: ≥95%. Mole weight: 881. Appearance: Powder. Form: Solid. Acetyl-S-CoA Li3; Acetyl coenzyme A lithium salt; 32140-51-5. Cat No: COEC-082. | |
| AMPK activator | AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. D942 is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels. AMPK activator stimulates glucose uptake in L6 myocytes and promotes phosphorylation of acetyl-CoA carboxylase, which shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 μM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Because of the favorable physiological outcomes of AMPK activation on metabolism, AMPK has been considered to be an important therapeutic target for controlling human diseases including metabolic syndrome and cancer. Synonyms: D942; AMPK activator; 5-[3-[4-[2- (4-Fluorophenyl) ethoxy]phenyl]propyl]furan-2-carboxylic Acid. Grades: ≥95%. CAS No. 849727-81-7. Molecular formula: C22H21FO4. Mole weight: 368.4. |  |
| Azo Coenzyme A Triammonium salt | Azo Coenzyme A Triammonium Salt, a fundamental biochemical reagent, holds momentous implications in exploring enzymatic reactions that involve coenzyme A and its various derivatives. This reagent remarkably aids in the synthesis of inhibitors for the acetyl-CoA carboxylase enzyme, which is crucial for fatty acid synthesis. The said reagent has also been scrutinized for its potential applications in treating metabolic disorders, hyperlipidemia and other related conditions, thereby signifying relatively consequential implications in the field of life sciences. Synonyms: (E)-4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl Coenzyme A (ammonium salt); 9H-Purin-6-amine, 9- [ (2ξ ) -5-O- [ [ [ [ (3R) -4- [ [3- [ [2- [ [4- [4- [ (E) -2- (4-butylphenyl) diazenyl] phenyl] -1-oxobutyl] thio] ethyl] amino] -3-oxopropyl] amino] -3-hydroxy-2, 2-dimethyl-4-oxobutoxy] hydroxyphosphinyl] oxy] hydroxyphosphinyl] -3-O-phosphono-β -D-threo-pentofuranosyl] -, ammonium salt; Coenzyme A, S-[4-[ (1E) -2- (4-Butylphenyl) diazenyl]benzenebutanoate], ammonium salt. Grades: >99%. CAS No. 2260670-58-2. Molecular formula: C41H67N12O17P3S. Mole weight: 1125.03. | |
| Berberine chloride hydrate | The plant-based alkaloid berberine has potential therapeutic applications for breast cancer, although a better understanding of the genes and cellular pathways regulated by this compound is needed to define the mechanism of its action in cancer treatment. In this review, the molecular targets of berberine in various cancers, particularly breast cancer, are discussed. Berberine was shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells. Some signaling pathways affected by berberine, including the MAP (mitogen-activated protein) kinase and Wnt/β-catenin pathways, are critical for reducing cellular migration and sensitivity to various growth factors. Treatment with BBR(Berberine) in rats on the atherogenic diet reduced plasma total cholesterol and nonHDL cholesterol levels by 29%-33% and 31%-41%, respectively, with no significant differences being observed among the three doses. Berberine induced both apoptotic and autophagic death of HepG2 cells, which was associated with a significant activation of AMPK and an increased expression of the inactive form of acetyl-CoA carboxylase (ACC). Berberine did not show major effects on viability of HEK-293 embryonic kidney and HCT116 colon carcinoma cells and was not toxic in concentrations up to 20 μM. Berberine inhibited β-catenin transcriptional activity and attenuated anchorage-independent growth. As a result of berberine treatment, cellular levels of active β-catenin were reduced concomitant with an increase in the expression of E-cadherin. Synonyms: Natural Yellow 18. Grades: >98%. CAS No. 141433-60-5. Molecular formula: C20H18ClNO4. Mole weight: 371.81. | |
| CP-640186 | CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase ( ACC ) inhibitor with IC 50 s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 591778-68-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15259. | |
| CP640186 HCl | CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431. Synonyms: CP640186; CP 640186. Grades: 0.98. CAS No. 591778-70-0. Molecular formula: C30H36ClN3O3. Mole weight: 522.09. | |
| CP-640186 hydrochloride | CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase ( ACC ) inhibitor with IC 50 s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 591778-70-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15259A. | |
| Doxorubicin hydrochloride | Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC 50 s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Hydroxydaunorubicin hydrochloride; ADR. CAS No. 25316-40-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15142. | |
| Doxorubicin hydrochloride | Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 25316-40-9. Molecular formula: C27H30ClNO11. Purity: 0.9958. Product ID: ACM25316409-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| ethylmalonyl-CoA decarboxylase | The enzyme, which exists in all vertebrates, decarboxylates ethylmalonyl-CoA, a potentially toxic compound that is formed in low amounts by the activity of EC 6.4.1.2 (acetyl-CoA carboxylase) and EC 6.4.1.3 (propanoyl-CoA carboxylase). It prefers the S isomer, and can decarboxylate (R)-methylmalonyl-CoA with lower efficiency. cf. EC 4.1.1.41 (methylmalonyl-CoA decarboxylase). Group: Enzymes. Enzyme Commission Number: EC 4.1.1.94. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4844; ethylmalonyl-CoA decarboxylase; EC 4.1.1.94. Cat No: EXWM-4844. | |
| Firsocostat | Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase ( ACC ) inhibitor; inhibits human ACC1 and ACC2 with IC 50 values of 2.1 and 6.1 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ND-630; GS-0976; NDI-010976. CAS No. 1434635-54-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16901. | |
| Fluazifop-P-butyl | Fluazifop-P-butyl, a graminicide from arylophenoxypropionate group, is a acetyl-CoA carboxylase (ACCase) inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 79241-46-6. Pack Sizes: 10 mM * 1 mL; 50 mg. Product ID: HY-B2007. | |
| [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase | The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79). Thr-172 within the catalytic subunit (α-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase. GTP can act instead of ATP. Group: Enzymes. Synonyms: AMPK; AMP-activated protein kinase; HMG-CoA reductase kinase; β-hydro. Enzyme Commission Number: EC 2.7.11.31. CAS No. 172522-01-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3152; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase; EC 2.7.11.31; 172522-01-9; AMPK; AMP-activated protein kinase; HMG-CoA reductase kinase; β-hydroxy-β-methylglutaryl-CoA reductase kinase; [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase; 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase; 3-hydroxy-3-methylglutaryl-CoA reductase kinase; hydroxymethylglutaryl coenzyme A reductase kinase; hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating); hydroxymethylglutaryl-CoA reductase kinase; reductase kinase; STK29. Cat No: EXWM-3152. | |
| L-Arginine,l-histidyl-L-methionyl-L-arginyl-L-seryl-L-alanyl-L-methionyl-L-serylglycyl-L-Leucyl-L-histidyl-L-Leucyl-L-valyl-l-lysyl-l-arginyl- | L-Arginine,l-histidyl-L-methionyl-L-arginyl-L-seryl-L-alanyl-L-methionyl-L-serylglycyl-L-Leucyl-L-histidyl-L-Leucyl-L-valyl-l-lysyl-l-arginyl-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (SER76,ARG86,87)-ACC-ALPHA (73-87) (DEPHOSPHORYLATED) (E COLI, RAT);(SER76,ARG86,87)-ACETYL-COA CARBOXYLASE 1 (73-87) (DEPHOSPHORYLATED) (E COLI, RAT);(SER77,ARG87,88)-ACC-ALPHA (74-88) (DEPHOSPHORYLATED) (BOVINE, OVINE);(SER77,ARG87,88)-ACETYL-COA CARBO. Product Category: Heterocyclic Organic Compound. CAS No. 125911-68-4. Molecular formula: C74H131N29O18S2. Mole weight: 1779.15. Purity: >95%. Product ID: ACM125911684. Alfa Chemistry ISO 9001:2015 Certified. | |
| Lipid Metabolism Compound Library | A unique collection of 496 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS). - Covers several important targets, key components in lipid metabolism pathway, such as Acetyl-CoA Carboxylase?Acyltransferase?cholesteryl ester transfer protein (CETP)?FAAH?Fatty Acid Synthase (FASN)?HMG-CoA Reductase (HMGCR), etc. - Detailed compound information with structure, target, and biological activity description. - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2510. Categories: Lipid Metabolism Compounds Libraries. |  |
| ND-630 | ND-630, also called as NDI 010976, is a highly selective, reversible inhibitor of acetyl-CoA carboxylase (ACC) and had IC50 values of 2 and 7 nM for ACC1 and 2, respectively, EC50 values in HepG2 serum free and 10% serum of 9 and 66 nM, respectively, and 2-fold C2C12 fatty acid oxidation (FAOxn) stimulation at 200 nM. Uses: Enzyme inhibitors. Synonyms: ND 630; ND630; NDI-010976; NDI 010976; NDI010976; GS-0976; GS0976; GS 0976; Firsocostat; Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-; 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid; (R)-2-(1-(2-(2-Methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid; 2-[1-{(2R)-2-(2-methoxyphenyl)-2-[(oxan-4-yl)oxy]ethyl}-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl]-2-methylpropanoic acid; GS-ACC; GS-Y. Grades: ≥95%. CAS No. 1434635-54-7. Molecular formula: C28H31N3O8S. Mole weight: 569.63. | |
| ND-630 S enantiomer | ND-630 S enantiomer is the S enantiomer of ND-630 which is an acetyl-CoA carboxylase (ACC) inhibitor, and improves metabolic syndrome endpoints, decreases liver steatosis, decreases expression of inflammatory markers and improves fibrosis. Synonyms: 2-[1-[(2S)-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid; ND-630 (S enantiomer); ND 630 (S enantiomer); ND630 (S enantiomer). Molecular formula: C28H31N3O8S. Mole weight: 569.63. | |
| ND-646 | ND-646 is an orally bioactive inhibitor of acetyl-CoA carboxylase (ACC) that inhibits both ACC1 and ACC2. It prevents ACC subunit dimerization to inhibit fatty acid synthesis in vitro and in vivo. Synonyms: ND 646; ND646; BCP29105; CS-7887; BCP 29105; CS 7887; BCP-29105; CS7887; Thieno[2,3-d]pyrimidine-3(2H)-acetamide, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-; 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetamide; (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanamide. Grades: ≥95%. CAS No. 1434639-57-2. Molecular formula: C28H32N4O7S. Mole weight: 568.64. | |
| Olumacostat glasaretil | OG (Olumacostat glasaretil) is a acetyl-coenzyme A carboxylase inhibitor. Acetyl-COA carboxylase is the key point for the first, rate-limiting step in de novo fatty acid synthesis. OG can inhibit in vitro human sebocyte lipid production, it can also reduce in vivo sebaceous gland size in hamster ears. Synonyms: Olumacostat glasaretil; DRM01B; DRM-01B; DRM 01B. 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyl 5-(tetradecyloxy)furan-2-carboxylate. Grades: 98%. CAS No. 1261491-89-7. Molecular formula: C26H43NO7. Mole weight: 481.63. | |
| PF 05175157 | PF-05175157 is a selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 and isoform ACC2 dominant. IC50 values are 27 nM and 33 nM, respectively. It was originated by Pfizer. ACC inihibitors can inhibit de novo lipogenesis and increase β-oxidation of long-chain fatty acids. In Feb 2015, Phase-II for Type-2 diabetes mellitus in USA was discontinued. Uses: Type 2 diabetes mellitus. Synonyms: PF-05175157; PF05175157; 1,4-Dihydro-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one. Grades: 98%. CAS No. 1301214-47-0. Molecular formula: C23H27N5O2. Mole weight: 405.50. | |
| PT 1 | PT 1 is an AMPK (AMP-activated protein kinase) activator that stimulates AMPK heterotrimer (α1β1γ1) activity (EC50=0.3 μM). PT1 dose-dependently increases phosphorylation of AMPK and its downstream substrate, acetyl-CoA carboxylase, without increasing the cellular AMP:ATP ratio in L6 myotubes. It stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Synonyms: PT 1; PT1; PT-1; 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid. Grades: ≥98% by HPLC. CAS No. 331002-70-1. Molecular formula: C23H16ClN3O6S. Mole weight: 497.91. | |
| pyruvate carboxylase | A biotinyl-protein containing manganese (animal tissues) or zinc (yeast). The animal enzyme requires acetyl-CoA. Group: Enzymes. Synonyms: pyruvic carboxylase. Enzyme Commission Number: EC 6.4.1.1. CAS No. 9014-19-1. PC. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5812; pyruvate carboxylase; EC 6.4.1.1; 9014-19-1; pyruvic carboxylase. Cat No: EXWM-5812. | |
| RSVA 405 | RSVA 405, an analog of resveratol, can significantly activate AMPK (EC50 = 1 μM) and inhibit acetyl-CoA carboxylase (ACC), one target of AMPK and a key regulator of fatty acid biogenesis, in nondifferentiated and proliferating 3T3-L1 adipocytes. It activates AMPK indirectly through a CaMKKβ-dependent mechanism. Synonyms: 2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid; RSVA405; RSVA 405; RSVA-405. Grades: ≥98% by HPLC. CAS No. 140405-36-3. Molecular formula: C17H20N4O2. Mole weight: 312.37. | |
| SAMS | SAMS peptide, a synthetic peptide substrate for AMPK based on the sequence around Ser79 on acetyl-CoA carboxylase, is more selective for the kinase than acetyl CoA carboxylase itself, and provides a convenient and sensitive assay for AMPK. Synonyms: (Ser76, Arg86.87)-ACC-α (73-87) (dephosphorylated) (E.coli, rat); (Ser76, Arg86.87)-Acetyl-CoA Carboxylase 1 (73-87) (dephosphorylated) (E.coli, rat); (Ser77, Arg87.88)-ACC-α (74-88) (dephosphorylated) (bovine, ovine); (Ser77, Arg87.88)-Acetyl-CoA Carboxyla; H-His-Met-Arg-Ser-Ala-Met-Ser-Gly-Leu-His-Leu-Val-Lys-Arg-Arg-OH; L-histidyl-L-methionyl-L-arginyl-L-seryl-L-alanyl-L-methionyl-L-seryl-glycyl-L-leucyl-L-histidyl-L-leucyl-L-valyl-L-lysyl-L-arginyl-L-arginine. Grades: >95%. CAS No. 125911-68-4. Molecular formula: C74H131N29O18S2. Mole weight: 1779.15. | |
| Spiromesifen | Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen reduces lipid biosynthesis via inhibition of acetyl-CoA carboxylase , and has no cross-resistance to any resistant mite or whitefly populations [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BSN 2060. CAS No. 283594-90-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-114591. | |
| Stevioside hydrate (BRN 0077427, CCRIS 6116) | Noncaloric natural sweetener, 300 times more potent than sucrose. Antidiabetic. Antihyperglycaemic and antihypoglycaemic. Potentiates insulin secretion. Enhances acetyl-CoA carboxylase (ACC) gene expression. Increases insulin sensitivity. Antihypertensive. Ca2+ influx inhibitor. Anticancer compound. Chemopreventive. Anti-inflammatory. IKKbeta, NF-kappaB and MAPK signaling inhibitor. Induces TNF-alpha, IL-1beta and nitric oxide release. Immunomodulator. Increasees phagocytic activity, haemagglutination antibody titre, delayed type hypersensitivity. Increased proliferation in LPS and Con A stimulated B and T cells. Peripheral me-opioid receptors activator. Important for regulation of glucose homeostasis. Anti-atherosclerotic. Group: Biochemicals. Alternative Names: BRN 0077427, CCRIS 6116. Grades: Highly Purified. CAS No. 57817-89-7 (anhy). Pack Sizes: 10mg, 50mg. Molecular Formula: C38H60O18. xH2O. US Biological Life Sciences. | Worldwide |
| TOFA | TOFA is a cell-permeable, potent, reversible, and competitive allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). It inhibits the fatty acid biosynthesis by blocking the synthesis of malonyl-CoA. Uses: Hypolipidemic agents. Synonyms: 5-tetradecoxyfuran-2-carboxylic acid; 5-(tetradecyloxy)-2-furancarboxylic acid; 5-(tetradecyloxy)-2-furoic acid; RMI 14514; RMI-14514. CAS No. 54857-86-2. Molecular formula: C19H32O4. Mole weight: 324.45. | |
| TOFA | TOFA (RMI14514;MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α ( ACCA ). Uses: Scientific research. Group: Signaling pathways. Alternative Names: RMI14514; MDL14514. CAS No. 54857-86-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101068. | |
| TOFA - CAS 54857-86-2 | A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Group: Fluorescence/luminescence spectroscopy. | |
| tyrosine 3-monooxygenase | The active centre contains mononuclear iron(II). The enzyme is activated by phosphorylation, catalysed by EC 2.7.11.27, [acetyl-CoA carboxylase] kinase. The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34 (6,7-dihydropteridine reductase), or slowly rearranges into the more stable compound 7,8-dihydrobiopterin. Group: Enzymes. Synonyms: L-tyrosine hydroxylase; tyrosine 3-hydroxylase; tyrosine hydroxylase. Enzyme Commission Number: EC 1.14.16.2. CAS No. 9036-22-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0954; tyrosine 3-monooxygenase; EC 1.14.16.2; 9036-22-0; L-tyrosine hydroxylase; tyrosine 3-hydroxylase; tyrosine hydroxylase. Cat No: EXWM-0954. | |
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