Activated Peptidase Suppliers USA
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Product | Description | |
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1,3-Bis-(Z-Leu-Leu)-diaminoacetone Quick inquiry Where to buy Suppliers range | 1,3-Bis-(Z-Leu-Leu)-diaminoacetone, a cysteine protease inhibitor, can specifically and efficiently inhibit the processing of p-Prl signal peptide (IC50 ca. 50 nM) without affecting the activity of signal peptidase and lysosomal cathepsin, proteasome, and other proteases. Synonyms: (Z-LL)2 Ketone; Z-Leu-Leu-NH-CH2-CO-CH2-NH-Leu-Leu-Z; 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide; 1,3-di-(N-carboxybenzoyl-leucyl-leucyl)aminoacetone; Dibenzyl [(4S,7S,15S,18S)-7,15-diisobutyl-2,20-dimethyl-5,8,11,14,17-pentaoxo-6,9,13,16-tetraazahenicosane-4,18-diyl]biscarbamate. Grades: ≥95%. CAS No. 313664-40-3. Molecular formula: C43H64N6O9. Mole weight: 809.00. | |
1-Bromo-3-methyl-2-butene (90%) Quick inquiry Where to buy Suppliers range | 1-Bromo-3-methyl-2-butene is used to prepare xanthine dipeptidyl peptidase inhibitors for treatment of type 2 diabetes. It can also be used to synthesize natural and non-natural prenylated chalcones with antitumor, antioxidant activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 870-63-3. Pack Sizes: 1g, 5g. Molecular Formula: C5H9Br, Molecular Weight: 149.03. US Biological Life Sciences. | Worldwide |
6-Aminohexanoic acid (EACA) Quick inquiry Where to buy Suppliers range | 6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in electrophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxypeptidase, plasmin, and plasminogen activator. Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B. Group: Biochemicals. Alternative Names: 6-Amino-n-hexanoic Acid; 6-Aminocaproic Acid; 6-Aminohexanoic Acid; A 14719; ACS; Acepramin; Acepramine; Acikaprin; Afibrin; Amicar; Amikar; Aminokapron; CL 10304; CY 116; Caplamin; Capramol; Caprocid; Caprolisin; EACA; EACS; Epsamon; Epsicapron; Epsikapron; Epsilcapramin; Epsilon S; Hemocaprol; Hemopar; Hepin; Ipsilon; NSC 212532; NSC 26154; NSC 400230; Respramin; ε-Amino-n-caproic Acid; ε-Amino-n-hexanoic Acid; ε-Aminocaproic Acid; ε-Aminohexanoic Acid; ε-Leucine; ε-Norleucine; ω-Aminocaproic Acid; ω-Aminohexanoic Acid. Grades: Highly Purified. CAS No. 60-32-2. Pack Sizes: 500g, 1Kg. Molecular Formula: C6H13NO2, Molecular Weight: 131.17. US Biological Life Sciences. | Worldwide |
Antagonist G Quick inquiry Where to buy Suppliers range | Antagonist G is a substance P analog, which is a broad spectrum neuropeptide growth factor antagonist and antiproliferative agent. It was developed for the treatment of small cell lung cancer. It could inhibit neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro. It also inhibits growth of SCLC xenografts in mice in vivo. It blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. It activates JNK and stimulates apoptosis. It is an anticancer agent and is resistant to degradation by peptidases. Synonyms: [Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11). Grades: 98%. CAS No. 115150-59-9. Molecular formula: C49H66N12O6S. Mole weight: 951.20. | |
ASP-4000 Quick inquiry Where to buy Suppliers range | ASP-4000 is a dipeptidyl peptidase 4 (DPP) inhibitor with antihyperglycemic activity. Uses: Hyperlipidaemia; hyperlipoproteinaemia type iia;primary biliary cirrhosis. Synonyms: ASP4000; ASP-4000 free base; 2-Pyrrolidinecarbonitrile, 1-(((1R,3S,4S,6R)-6-hydroxy-2-azabicyclo(2.2.1)hept-3-yl)carbonyl)-, (2S)-. Grades: 98%. CAS No. 851510-67-3. Molecular formula: C12H17N3O2. Mole weight: 235.28. | |
ASP-4000 hydrochoride Quick inquiry Where to buy Suppliers range | ASP-4000 is a dipeptidyl peptidase 4 (DPP) inhibitor. It has antihyperglycemic activity. Uses: Antihyperglycemic agent. Synonyms: ASP-4000 hydrochoride; ASP 4000 hydrochoride; ASP4000 hydrochoride; UNII-7393JFE67B;(2S)-1-(((1R,3S,4S,6R)-6-Hydroxy-2-azabicyclo(2.2.1)hept-3-yl)carbonyl)-2-pyrrolidinecarbonitrile hydrochloride. Grades: 98%. CAS No. 851389-35-0. Molecular formula: C12H18ClN3O2. Mole weight: 271.74. | |
Boc-3,4-dichloro-D-phenylalanine Quick inquiry Where to buy Suppliers range | Boc-3,4-dichloro-D-phenylalanine is used to prepare fluorinated β-aminoacyl 1,2,4-triazolo[4,3-a]piperazine amides as dipeptidyl peptidase IV inhibitors and antidiabetic agents. It is also used in the synthesis of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3-(2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide as a potent and orally active dual neurokinin NK1/NK2 receptor antagonist. Synonyms: Boc-D-Phe(3,4-DiCl)-OH; Boc-D-Phe(3,4-Cl2)-OH; (R)-Boc-2-amino-3-(3,4-dichlorophenyl)propionic acid; Boc-D-Phe(3,4-Cl2)-OH; (R)-2-((tert-Butoxycarbonyl)amino)-3-(3,4-dichlorophenyl)propanoic acid; D-Phenylalanine, 3,4-dichloro-N-[(1,1-dimethylethoxy)carbonyl]-; Boc-D-3,4-Dichlorophenylalanine; AK162594; N-BOC-3,4-DICHLORO-D-PHENYLALANINE. Grades: ≥ 98% (HPLC). CAS No. 114873-13-1. Molecular formula: C14H17Cl2NO4. Mole weight: 334.20. | |
Cilastatin Ammonium Salt Quick inquiry Where to buy Suppliers range | Cilastatin Ammonium Salt is the ammonium salt of Cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Synonyms: (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid Ammonium Salt; MK-791 Ammonium Salt. Grades: > 95%. CAS No. 877674-82-3. Molecular formula: C16H29N3O5S. Mole weight: 375.48. | |
Cilastatin sodium Quick inquiry Where to buy Suppliers range | Cilastatin sodium is the sodium salt of cilastatin, which is a dipeptidase inhibitor of renal enzyme dehydropeptidase-I and leukotriene D4 peptidase. It inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. It reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. It can be combined intravenously with imipenem in order to protect it from dehydropeptidase. It suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy. It usually confers antibiotic resistance to certain bacteria because itself does not have antibiotic activity. It has nephroprotective effects. Synonyms: L 642957; MK 791; L642957; MK791; L-642957; MK-791; [R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic Acid Monosodium Salt; (2Z) ?-7- [ [ (2R) ?-2-Amino-2-carboxyethyl] ?thio] ?-2- [ [ [ (1S) ?-2, ?2-dimethylcyclopropyl] ?carbonyl] ?amino] ?-2-heptenoic Acid Sodium Salt; sodium S-((Z)-6-carboxy-6-((S)-2,2-dimethylcyclopropane-1-carboxamido)hex-5-en-1-yl)-L-cysteinate. Grades: ≥99% by HPLC. CAS No. 81129-83-1. Molecular formula: C16H25N2NaO5S. Mole weight: 380.43. | |
Clasto-Lactacystin beta-lactone (Omuralide) Quick inquiry Where to buy Suppliers range | In vitro lactacystin does not react with the proteasome. It rather undergoes a spontaneous conversion (lactonization) to the active metabolite clasto-lactacystin beta-lactone. Potent and selective irreversible and cell permeable proteasome inhibitor. Inhibits the chymotrypsin-like, trypsin-like and caspase-like peptidase activity of the proteasome. The active metabolite of lactacystin with higher potency since it does not require hydrolysis in order to become cell permeable. Calpain and cathepsin inhibitor. Apoptosis inducer. Anticancer compound. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Induces neuritogenesis. Autophagy inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 154226-60-5. Pack Sizes: 100ug. Molecular Formula: C10H15NO4, Molecular Weight: 213.2. US Biological Life Sciences. | Worldwide |
D-Alanine 7-amido-4-methylcoumarin free base Quick inquiry Where to buy Suppliers range | D-Alanine 7-amido-4-methylcoumarin free base is a biochemical compound utilized extensively in biomedical research, presenting a commendable versatility as a fluorogenic substrate facilitating the scrutiny of an array of enzymatic activities encompassing amino peptidases and peptidases. Synonyms: D-Alanine-AMC-free base. Molecular formula: C13H14N2O3. Mole weight: 246.26. | |
Evogliptin Quick inquiry Where to buy Suppliers range | This active molecular is a selective dipeptidyl peptidase 4 (DPP4) inhibitor under the development of Dong-A. Evogliptin improves insulin resistance and delays the onset of diabetes. Evogliptin monotherapy improved HbA1c, fasting plasma glucose level, OGTT results and β-cell function. In Sep 1st 2016, preclinical trials in Type-2 diabetes mellitus (Combination therapy) in Russia was on-going. In Sep 12th 2016, Phase-I clinical trials in non-alcoholic steatohepatitis (Combination therapy) in USA was on-going. Uses: Type-2 diabetes mellitus. Synonyms: (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one;CHEMBL1779710; UNII-09118300L7; DA-1229; DA 1229; DA1229; 1222102-29-5; Evogliptin [INN];1246960-27-9 (HCl). Grades: 98%. CAS No. 1222102-29-5. Molecular formula: C19H26F3N3O3. Mole weight: 401.43. | |
Fmoc-Dha-OH Quick inquiry Where to buy Suppliers range | Fmoc-Dha-OH, a pivotal intermediate, is used for synthesizing a plethora of biologically active compounds encompassing antimicrobial peptides, dipeptidyl peptidase IV inhibitors, and enzyme inhibitors. Researchers have employed it to fabricate Fmoc-Dha-OH-derived peptidomimetics manifested by the impeding activity against a myriad of cancer cell lines. The said compound holds sheer potential for the design and development of novel pharmaceutical agents targeting numerous diseases. Synonyms: Fmoc-dehydro-Ala-OH; N-(9H-Fluorene-9-ylmethoxycarbonyl)-2,3-didehydro-L-alanine; 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)acrylic acid. CAS No. 261522-33-2. Molecular formula: C18H15NO4. Mole weight: 309.3. | |
H-Ala-Ala-Ala-OME acetate Quick inquiry Where to buy Suppliers range | H-Ala-Ala-Ala-OME is a substrate for a simultaneous determination of the esterase and the peptidase activities of pancreatic elastase. Synonyms: AAA-OMe. CAS No. 84794-58-1. Molecular formula: C12H23N3O6. Mole weight: 305.33. | |
H-Gly-Pro-pNA.HCl Quick inquiry Where to buy Suppliers range | H-Gly-Pro-pNA.HCl has been used as a substrate in dipeptidyl peptidase-IV (DPP-IV) enzyme assay. It has also been used to determine DPP-IV inhibitory activity. Uses: API. CAS No. 103213-34-9. Product ID: 10-101-345. | |
K 579 Quick inquiry Where to buy Suppliers range | K 579, a cyanopyrrolidine compound, is a potent and slow-binding dipeptidyl peptidase IV (DPP IV) inhibitor. It has been shown to reduce blood DPP IV activity and attenuate glucose excursion following glucose loading in Zucker fatty rats. It reduces plasma glucose concentration by augmenting GLP-1 and insulins response after glucose intake in rats in vivo. It is used as a long-acting hypoglycemic agent. Synonyms: K 579; K579; K-579; (2S)-1-[[[4-Methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-2-pyrrolidinecarbonitrile; (S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile; DPP IV Inhibitor IV. Grades: ≥99% by HPLC. CAS No. 440100-64-1. Molecular formula: C17H24N6O. Mole weight: 328.41. | |
Leucyl-phenylalanine Quick inquiry Where to buy Suppliers range | Leucyl-phenylalanine is a competitive inhibitor of both the peptidase and the esterase activities of carboxy peptidase Y. Synonyms: L-leucyl-L-Phenylalanine. CAS No. 3063-5-6. Molecular formula: C15H22N2O3. Mole weight: 278.35. | |
Linagliptin N-Acetyl Impurity Quick inquiry Where to buy Suppliers range | An impurity of Linagliptin. Linagliptin is a dipeptidyl peptidase-4 inhibitor with a hpyerglycemic activity. It was approved for the treatment of diabetes mellitus type 2. Synonyms: (R)-N-(1-(7-(But-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)acetamide. Grades: 95%. CAS No. 1803079-49-3. Molecular formula: C27H30N8O3. Mole weight: 514.58. | |
Linagliptin N-Boc Impurity Quick inquiry Where to buy Suppliers range | An impurity of Linagliptin. Linagliptin is a dipeptidyl peptidase-4 inhibitor with a hpyerglycemic activity. It was approved for the treatment of diabetes mellitus type 2. Synonyms: Linagliptin Related Compound B, N-[(3R)-1-[7-(2-butyn-1-yl)-2,3,6,7-tetrahydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-2,6-dioxo-1H-purin-8-yl]-3-piperidinyl]-carbamic Acid 1,1-Dimethylethyl Ester. Grades: 95%. CAS No. 668273-75-4. Molecular formula: C30H36N8O4. Mole weight: 572.67. | |
L-Phenylalanine 7-amido-4-methylcoumarin trifluoroacetate salt Quick inquiry Where to buy Suppliers range | L-Phenylalanine 7-Amido-4-methylcoumarin, Trifluoroacetate Salt is a fluorogenic substrate for phenylalanine peptidase yielding a blue fluorescent solution from cleavage. L-Phenylalanine 7-Amido-4-methylcoumarin, Trifluoroacetate Salt can be used as reactant/reagent for activation of lymphocyte progranzyme by dipeptidyl peptidase I. Synonyms: (S)-2-Amino-N-(4-Methyl-2-Oxo-2H-Chromen-7-Yl)-3-Phenylpropanamide 2,2,2-Trifluoroacetate; L-Phenylalanine-AMC TFA salt. Grades: ≥ 98% (HPLC). CAS No. 108321-84-2. Molecular formula: C21H19F3N2O5. Mole weight: 436.38. | |
L-Pyroglutamic Acid b-Naphthylamide ((S)-N-(2-Naphthyl)-5-oxopyrrolidine-2-carboxamide. ) Quick inquiry Where to buy Suppliers range | A substrate for pyroglutamate aminopeptidase. Used for colorimetric determination of pyrrolidonyl peptidase activity in bacteria. Group: Biochemicals. Alternative Names: (S)-N-(2-Naphthyl)-5-oxopyrrolidine-2-carboxamide. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
N-acetylmuramoyl-L-alanine amidase L2 Quick inquiry Where to buy Suppliers range | N-Acetylmuramoyl-l-alanine amidases are peptidoglycan hydrolases with the specificity to cleave the amide bond between the lactyl group of the muramic acid and the α-amino group of l-alanine, and are able to cause dissolution of the peptidoglycan structure and thus do not exhibit peptidase activity. Synonyms: NAMAA L2. | |
N-Cyano-N'-methyl-ethanimidamide Quick inquiry Where to buy Suppliers range | N-Cyano-N'-methyl-ethanimidamide has exhibited significant inhibitory activity against the dipeptidyl peptidase IV (DPP-4), which represents a pharmacological target for mitigating type 2 diabetes. In addition to this, the product has demonstrated antiviral potential against a diverse range of viral strains, among which the human immunodeficiency virus (HIV) is notable. The product's diverse clinical applications thus mandate in-depth investigation and analysis. Synonyms: 1-Cyanoimino-N-methylethanamine. CAS No. 56563-12-3. Molecular formula: C4H7N3. Mole weight: 97.12. | |
N-Ethylmaleimide Quick inquiry Where to buy Suppliers range | N-Ethylmaleimide (NEM) is a derivative of maleic acid and is used as a reagent for alkylation and covalent modification of nucleophilic thiol residues on proteins. It acts as an irreversible inhibitor of all cysteine peptidases that alkylates the active site thiol group of the enzymes. Uses: Used in cancer research; a sulfhydryl reagent that is widely used in experimental biochemical studies. Synonyms: NEM; 1-Ethyl-1H-pyrrole-2,5-dione; ethylmaleimide. Grades: >98.0%(HPLC)(N). CAS No. 128-53-0. Molecular formula: C6H7NO2. Mole weight: 125.13. | |
NSC-687852, UCHL5 inhibitor (b-AP15, 3, 5-bis[ (4-nitrophenyl) methylidene]-1-prop-2-enoylpiperidin-4-one, (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-1-prop-2-enoyl-piperidin-4-one) Quick inquiry Where to buy Suppliers range | Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1009817-63-3. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
NVP DPP 728 dihydrochloride Quick inquiry Where to buy Suppliers range | NVP DPP 728, a cyanopyrrolidine, is a potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor with excellent oral bioavailability and potent antihyperglycemic activity (Ki = 11 nM, IC50=14 nM). NVP DPP 728 exhibits > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Synonyms: NVP DPP 728 dihydrochloride; NVPDPP728 dihydrochloride; NVP-DPP-728 dihydrochloride; 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile dihydrochloride. Grades: ≥97% by HPLC. CAS No. 207556-62-5. Molecular formula: C15H18N6O.2HCl. Mole weight: 371.27. | |
P32/98 hemifumarate Quick inquiry Where to buy Suppliers range | P32/98 is a competitive dipeptidyl peptidase IV (DPP IV) inhibitor exhibiting anti-diabetic activity. Study shows that long-term treatment with P32/98 improves glucose tolerance, insulinemia, beta-cell glucose responsiveness, and peripheral insulin sensitivity. Synonyms: (2S,3S)-2-amino-3-methyl-1-(3-thiazolidinyl)-1-Pentanone (2E)-2-butenedioate (2:1). Grades: ≥98%. CAS No. 251572-86-8. Molecular formula: C9H18N2OS·1/2C4H4O4. Mole weight: 260.4. | |
Retagliptin Quick inquiry Where to buy Suppliers range | Retagliptin is a selective, competitive and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor. It may be used to treat type 2 diabetes. Synonyms: SP-2086; UNII-328C4R3P9L. Grades: 98%. CAS No. 1174122-54-3. Molecular formula: C19H18F6N4O3. Mole weight: 464.4. | |
Saxagliptin Quick inquiry Where to buy Suppliers range | Saxagliptin is a drug which was developed for the treatment of respiratory disorders such as asthma and Chronic Obstructive Pulmonary Disease (COPD). It is orally active and acts as a selective Phosphodiesterase-4 inhibitor. Uses: Dipeptidyl-peptidase iv inhibitors. Synonyms: BMS-477118; BMS 477118; BMS477118; Onglyza. Grades: 0.98. CAS No. 361442-04-8. Molecular formula: C18H25N3O2. Mole weight: 315.417. | |
Seco Rapamycin (sodium salt) Quick inquiry Where to buy Suppliers range | Seco-rapamycin is the first in vivo open-ring metabolite of rapamycin which is a natural macrolide immunosuppressant. Seco-rapamycin inhibits the ChT-L (D) and PGPH (E) peptidases, and activate the T-L (F) peptidase and poorly activates mTOR. IC50: ChT-L. Uses: A decomposition product of rapamycin (r124000). Synonyms: sodium;(2S)-1-[2-[(2R,3R,6S)-2-hydroxy-6-[(2S,9S,11R,13R,14R,17R,21R)-14-hydroxy-22-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxodocosa-3,5,7,15,19-pentaenyl]-3-methyloxan-2-yl]-2-oxoacetyl]piperidine-2-c. Grades: > 95%. CAS No. 148554-65-8. Molecular formula: C51H78NNaO13. Mole weight: 936.15. | |
(S)-N-Boc-adamantylglycine Quick inquiry Where to buy Suppliers range | (S)-N-Boc-adamantylglycine is used to prepare saxagliptin as a highly potent and long-acting and orally active dipeptidyl peptidase IV inhibitor for treatment of type 2 diabetes. Synonyms: (S)-Boc-1-adamantyl-glycine; (αS)?-α-[[(1,?1-Dimethylethoxy)?carbonyl]?amino]?-tricyclo[3.3.1.13,?7]?decane-1-acetic Acid. Grades: 95%. CAS No. 361441-97-6. Molecular formula: C17H27NO4. Mole weight: 309.40. | |
Suc-Leu-Tyr-AMC Quick inquiry Where to buy Suppliers range | Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease), and used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; emission max: 460 nm). Suc-Leu-Tyr-AMC can also be cleaved by the Ti protease from E. coli. Uses: Peptide Inhibitors. CAS No. 94367-20-1. Product ID: R0810. | |
Sulphostin Quick inquiry Where to buy Suppliers range | Sulphostin is a dipeptidyl peptidase IV inhibitor produced by Streptomyces sp. MK 251-43F3. Thiofostine has a strong inhibitory effect on DPP-N activity with IC50 of 6.0 ng/mL, which is 100 times stronger than the known DDP-JV inhibitor Diprotin A. CAS No. 307345-51-3. Molecular formula: C5H13N4O5PS. Mole weight: 272.22. | |
Talabostat Quick inquiry Where to buy Suppliers range | Talabostat, also called as PT100 or Val-boroPro, is a potent, nonselective and orally available dipeptidyl peptidase IV(DPP-IV) inhibitor (Ki= 0.18 nM) with antineoplastic and hematopoiesis- stimulating activities. Synonyms: [(2R)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid; L-valinyl-L-boroproline; PT 100; PT-100; PT100 cpd; talabostat; valinyl-boroproline. CAS No. 149682-77-9. Molecular formula: C9H19BN2O3. Mole weight: 214.07. | |
Talabostat mesylate Quick inquiry Where to buy Suppliers range | Talabostat mesylate is the orally bioavailable mesylate salt of an amino boronic dipeptide with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell- dependent activity. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. Dipeptidyl peptidases are involved in the activation of polypeptide hormones and chemokines. Uses: For research used only. Synonyms: (R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-ylboronic acid methanesulfonic acid (1:1); PT-100; PT100; PT 100; D05989; D-05989; D 05989; Val-boro-pro; Talabostat. Grades: 98%. CAS No. 150080-09-4. Molecular formula: C10H23BN2O6S. Mole weight: 310.17. | |
tert-Butoxycarbonyl-ε-aminocaproic Acid Quick inquiry Where to buy Suppliers range | Protected ε-Aminocaproic Acid. Used in the preparatiom of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxy peptidase, plasmin, and plasminogen activator. Group: Biochemicals. Alternative Names: 6-[N- (tert-Butoxycarbonyl) amino]caproic Acid; BOC-ε-aminocaproic Acid; Boc-6-aminohexanoic Acid; N-(tert-Butoxycarbonyl)-6-aminocaproic Acid; N-(tert-Butoxycarbonyl)-6-aminohexanoic Acid; N-(tert-Butoxycarbonyl)-ε-aminocaproic Acid; N-(tert-Butoxycarbonyl)-ε-aminohexanoic Acid; N-(tert-Butyloxycarbonyl)-ε-aminocaproic Acid. Grades: Highly Purified. CAS No. 6404-29-1. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C11H21NO4, Form: White. US Biological Life Sciences. | Worldwide |
trans-L-4-Hydroxyproline β-naphthylamide Quick inquiry Where to buy Suppliers range | . Uses: Used for colorimetric determination of peptidase activity in bacteria. Synonyms: L-Hyp-βNA. Grades: ≥ 99% (HPLC, TLC). CAS No. 3326-64-5. Molecular formula: C15H16N2O2. Mole weight: 256.08. | |
Trelagliptin Quick inquiry Where to buy Suppliers range | Trelagliptin is a highly selective, long-acting dipeptidyl peptidase IV (DPP-4) inhibitor. This inhibitor provides sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes. Group: Biochemicals. Grades: Highly Purified. CAS No. 865759-25-7. Pack Sizes: 5mg, 10mg. Molecular Formula: C18H20FN5O2, Molecular Weight: 357.38. US Biological Life Sciences. | Worldwide |
Vialinin A Quick inquiry Where to buy Suppliers range | Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 = 1.5, 5.9 and 22.3 μM, respectively), displaying no significant inhibitory effects on UCH-L3, USP2, and USP8 activity. Vialinin A has been shown to reduce the release of TNF-α (IC50 = 0.09 nM) from RBL-2H3 mast cells. Synonyms: 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester; Ganbajunin C. Grades: ≥98% by HPLC. CAS No. 858134-23-3. Molecular formula: C34H26O8. Mole weight: 562.57. | |
Y-29794 Tosylate Quick inquiry Where to buy Suppliers range | Y-29794 is an orally active, potent and specific non-peptide inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β-peptide. Synonyms: (2-((8-(Dimethylamino)octyl)thio)-6-isopropylpyridin-3-yl)(thiophen-2-yl)methanone 4-methylbenzenesulfonate; Y29794 tosylate; Y 29794 tosylate; Methanone, [2-[[8-(dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienyl-, 4-methylbenzenesulfonate (1:1); Methanone, [2-[[8-(dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienyl-, mono(4-methylbenzenesulfonate); 2-[(8-Dimethylaminooctyl)thio]-3-(2-thenoyl)-6-isopropylpyridine p-toluenesulfonate. Grades: ≥95%. CAS No. 143984-17-2. Molecular formula: C30H42N2O4S3. Mole weight: 590.86. | |
ZJ 43 Quick inquiry Where to buy Suppliers range | ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki = 0.8 and 23 nM, respectively). It inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) and decreases the deleterious effects of excessive extracellular glutamate. ZJ 43 has been shown to reduce neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduce locomotor activity in the PCP-model of schizophrenia. Synonyms: ZJ 43; ZJ43; ZJ-43; N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid; (2S) -2- [ [ (1S) -1-carboxy-3-methylbutyl] carbamoylamino] pentanedioic acid. CAS No. 723331-20-2. Molecular formula: C12H20N2O7. Mole weight: 304.3. |