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Product | Description | |
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GPR119 Agonist, AS1269574 (G-Protein Coupled Receptor 119 Agonist, 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist) Quick inquiry Where to buy Suppliers range | A pyrimidine compound that acts as an effective GPR119 agonist (EC50=2.5uM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward B-adrenergic or GLP-1 receptors. Shown to enhance 16.8mM glucose-induced insulin secretion from murine MIN-6 B-cells (mU/20 min=0.44 and 0.22, respectively, with or without 10uM AS1269574) in vitro and improve glucose tolerance in normal mice (100mg/kg; p.o.) without any significant hypoglycemic effect in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 330981-72-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Leukadherin-1 (aMb2 Agonist II, CD11b Agonist II, LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic Acid) Quick inquiry Where to buy Suppliers range | A furanyl thiazolidinone compound that binds CD11b aA/aI domain in a reversible manner and stabilizes aA in a high-affinity binding conformation toward known CD11b/CD18 (aMB2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 in enhancing Mac-1-mediated cell adhesion (EC50=4 vs. >50uM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
RXFP1 Agonist (2-Isopropoxy-N- (2- (3- (trifluoro methyl sulfonyl) phenylcarbamoyl) phenyl) benzamide, LGR7 Agonist, Relaxin/Insulin-like Family Peptide Receptor 1 Agonist, Leucine-Rich Repeat-Containing GPCR 7 Agonist) Quick inquiry Where to buy Suppliers range | A cell-permeable 2-acetamido-N-phenylbenzamide that selectively activates human, but not mouse, LGR7/RXFP1-mediated cAMP induction (EC50 = 200nM in THP1) via allosteric interaction with the ECL3 region without competing against ECL2-mediated relaxin binding or affecting AVPR1B- or LGR8/RXFP2-mediated cAMP induction. Although shown to be ~150-fold and 500-fold less potent than relaxin (RLX), respectively, in VEGF mRNA induction and cellular impedance assays, pharmacokinetic studies reveal superior in vivo stability to RLX and in vivo bioavailability in mice via oral (Cmax/Tmax = 604nM/plasma/1h and 1026ng/g heart/1.5h; 30mg/kg) or intraperitoneal (Cmax/Tmax = 9.29uM/plasma/1h and 28.6uMol/kg heart/1h; 30mg/kg) administration with good aqueous solubility (7uM in PBS). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
TGR5 Receptor Agonist, Cpd23g ( (4-cyclopropyl-3, 4-dihydroquinoxalin-1 (2H) -yl) (4- (2, 5-dimethylphenoxy) pyridin-3-yl) methanone, Bile Acid Receptor GPBAR-1 Agonist, Bile Acid Receptor Agonist, G Protein-coupled Bile Acid Receptor 1 Agonist) Quick inquiry Where to buy Suppliers range | A cell-permeable, orally available, phenoxypyrimidine carboxamide derivative that acts as a highly potent and selective agonist of Protein coupled receptor TGR5 (EC50 = 720 pM and 6.2nM for human and mouse TGR5, respectively). Does not exhibit any significant affinity towards other related targets such as GPR40, GPR119, and GPR120. Shown to increase glucagon-like peptide-1 (GLP-1) secretion in a dose-dependent manner and significantly reduce blood glucose levels in db/db mice following a single oral dose (50mg/kg). Exhibits desirable pharmacokinetic properties in rodent models (t½ = 1.5h, Cmax = 56ng/ml; and AUC = 147ng.h/ml following an oral dose of 5mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
GPR40 Agonist II (FFA1 Agonist II, Free Fatty Acid Receptor 1 Agonist II, 3- (4- ( (2, 6-Dichloropyridin-4-yl) ethynyl) phenyl) propanoic Acid) Quick inquiry Where to buy Suppliers range | A cell-permeable alkynedihydrocinnamic acid that acts as a potent GPR40/FFA1 agonist (EC50=40.7nM in inducing Ca2+ mobilization in hFFA1-expressing 1321N1 cells) with >100-fold selectivity over GPR43/FFA2, GPR41/FFA3, and a panel of 56 other receptors, ion channels, and transporters. Reported to enhance 12mM glucose-induced insulin secretion from rat INS-1E B-cells (by 34% at 10uM) and exhibit good aqueous solubility (199uM in PBS at pH 7.4), as well as chemical and metabolic stability. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
BzATP Triethylammonium Salt (2 (3) -O- (4-Benzoylbenzoyl) adenosine-5-triphosphate tri(triethylammonium) Salt, P2X7 Purinergic Receptor Agonist, BZATP, 2 ,3 -O-(4-benzoylbenzoyl)ATP, P2X Purinergic Receptor Agonist, BZATP) Quick inquiry Where to buy Suppliers range | A prototypic P2X7 purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC50 = 15uM vs 50uM). Serves as a photo-affinity analog of ATP. Its agonistic activity is significantly reduced in the presence of serum albumin. Can serve as a substrate analog for submitochondrial particle ATPase activity (Km = 940uM). Induces a dose-dependent decrease in wild-type murine neural progenitor cell viability and an increase in caspase-3 activity. These effects are not observed in P2X7-/- mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 112898-15-4. Pack Sizes: 1mg. Molecular Formula: C??H??N?O??P? 3C?H??N. US Biological Life Sciences. | Worldwide |
Glucagon-Like Peptide 1 Receptor Agonist II (4- (3- (benzyloxy) phenyl) -2- (ethylsulfinyl) -6- (trifluoromethyl) pyrimidine, Glucagon-Like Peptide 1 Receptor Agonist II, Compound B) Quick inquiry Where to buy Suppliers range | A pyrimidine small molecule that acts as a GLP-1 allosteric agonist that induces cAMP signaling in HEK293 cells expressing the GLP-1 receptor with EC50 = 0.66uM and 99% efficacy (similar data with rat GLP-1 receptor), does not compete with radiolabelled GLP-1 in receptor binding assays, and is not active in cells expressing the GLP-2, GIP, PTH, or glucagon receptors. In rodent islets, insulin secretion increases in a dose-dependent and glucose-dependent manner, either alone or in an additive fashion when combined with the endogenous GLP-1 peptide. In vivo, this molecule exhibits insulinotropic effects when dosed at 10mg/kg in SD rats undergoing an IVGTT and a hyperglycemic clamp. It is also shown to increase insulin secretion in perifusion assays involving normal and diabetic human islets ex vivo, at concentrations between 1 and 10uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
GPR81 Agonist, 3Cl-5OH-BA (3-Chloro-5-hydroxybenzoic Acid, Hydroxycarboxylic Acid Receptor 1 Agonist) Quick inquiry Where to buy Suppliers range | A hydroxybenzoic acid compound that acts as a GPR81/HCA1-selective agonist (EC50 ~7, 16, 17, 22, and 67uM toward rat, human, monkey, mouse, and dog species, respectively) with little activity towards the homologous GPR109A/HCA2/HM74A GPCR. Orally active in mice and exhibits NEFAc cholesterol-lowering efficacy in overnight fasted C57B16/J mice (ED50 ~100mg/kg, p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 53984-36-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
GTS-21 Dihydrochloride (DMBX-A, (E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine, DMBX-A, alpha7 nAChR Agonist, GTS-21, Alpha 7 Nicotinic Acetylcholine Receptor Agonist, GTS-21) Quick inquiry Where to buy Suppliers range | A partial agonist selective for alpha7 nAChRs (EC50 = 10uM). Used in neuroimmunology studies, cardiovascular disease research, and Alzheimer's disease studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 156223-05-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PNU-120596 (a7 nAChR Agonist, 1-(5-chloro-2,4-dimethoxy-phenyl)-3-(5-methyl-isoxazol-3-yl)-urea, α7 Neuronal Nicotinic Acetylcholine Receptor Agonist) Quick inquiry Where to buy Suppliers range | A urea derivative that acts as a potent, selective, and reversible positive allosteric modulator for the a7 subtype of neural nicotinic acetylcholine receptors (EC50 = 216nM), with no significant effect on a4B2, a3B4 and a9a10 receptors. Specifically increase a-7 nAChR-mediated channel currents and channel mean open time in cultured neurons (~1mM). However, it does neither affect ion selectivity nor unitary conductance. Shown to cross the blood-brain barrier. Causes conformational changes in the ligand binding domain of a7 nicotinic receptors that partially overlap with those caused by acetylcholine. Causes changes in cysteine accessibility at the inner beta sheet, transition zone, and agonist binding site. Also reported to potentiate agonist-evoked GABAergic postsynaptic inward currents in somatodendritic membrane of hippocampal interneurons. Group: Biochemicals. Grades: Highly Purified. CAS No. 501925-31-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PNU 282987 (PNU-282987, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide Hydrochloride, alpha7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987) Quick inquiry Where to buy Suppliers range | A potent agonist highly selective for alpha7 nAChRs (Ki = 26nM). Used in investigating the roles of alpha7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia. Group: Biochemicals. Grades: Highly Purified. CAS No. 123464-89-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Pramipexole Dihydrochloride (Pramipexole, Dopamine D2-like Receptor Agonist, Pramipexole, Dopamine D3 Receptor Agonist, Pramipexole, (S) -N-propyl -4, 5, 6, 7-tetra hydrobenzothiazole-2, 6-diamine Dihydrochloride) Quick inquiry Where to buy Suppliers range | Non-ergot Dopamine receptor agonist with selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9nM for D3, D2S, D2L and D4 receptors respectively). Exhibits very low affinity for serotoninergic 5-HT2A and 5-HT2B receptors, as well as D1-type receptors. Shows good solubility in aqueous media (100mM water and 100mM DMSO). Immediate-release (IR) pramipexole dihydrochloride is indicated for the treatment of signs and symptoms of idiopathic Parkinsons disease (PD). It is administered alone (without levodopa) or in combination with levodopa, during the entire progress of the disease, up to an advanced stage. Currently, it is also indicated for the treatment of moderate-to-severe primary restless legs syndrome (RLS). Group: Biochemicals. Grades: Highly Purified. CAS No. 104632-25-9. Pack Sizes: 10mg. Molecular Formula: C??H??N?S 2HCl. US Biological Life Sciences. | Worldwide |
Rosiglitazone maleate (BRL 49653, HSDB 7555, TDZ 01, Rosiglitazone XR, Avandia, PPAR Agonist X, PPARg Agonist IX) Quick inquiry Where to buy Suppliers range | Same activities as rosaglitazone but different formulation. Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and vascular function. Enhances proliferation of endogenous neural progenitor cells (NPCs). Anti-inflammatory compound. Has controversial therapeutic effects on the cardiovascular system. Promotes adipocyte differentiation of mesenchymal stem cells (MSCs). Group: Biochemicals. Grades: Highly Purified. CAS No. 155141-29-0. Pack Sizes: 25mg, 100mg, 1g. Molecular Formula: C18H19N3O3S. C4H4O4. US Biological Life Sciences. | Worldwide |
S 24795 (alpha 7 Nicotinic Acetylcholine Receptor Agonist, S 24795, 2-(2-(4-bromophenyl)-2-oxoethyl)-1-methylpyridin-1-ium Iodide, alpha 7 nAChR Agonist, S 24795, S-24795, S24795) Quick inquiry Where to buy Suppliers range | A potent partial agonist selective for alpha7 nAChRs (EC50 = 34uM). Widely used in investigating the roles of alpha7 nAChRs in aging, learning and memory, and cognition. Enhances memory in mouse models for Alzheimer's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 304679-75-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
TRPML Agonist (ML-SA1, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1) Quick inquiry Where to buy Suppliers range | A membrane permeable dihydroquinolinyloxo-isoindolinedione compound that acts as a potent and selective agonist of lysosomal mucolipin transient receptor potential (TRP) channel 1,2,3 (TRPML) in all mammalian cells. Does not appear to affect six other related TRP channels. Shown to rapidly activate whole-endolysosome TRPML-like current and induce lysosomal Ca2+ release (~10uM). Its activating action on whole-endolysosome is comparable to that of PI(3,5)P2 (1uM) with which it shows a synergistic effect. ML-SA1-induced Ca2+ responses are reportedly abolished by glycyl-L-phenylalanine 2-naphthylamide, induces osmotic lysis of lysosomes, and Bafilomycin A1, a V-ATPase inhibitor. Also reduces lactosylceramide and cholesterol accumulation and corrects trafficking defects in Niemann-Pick (NP) disease cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 332382-54-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
4-Quinolone-3-carboxamide furan CB2 agonist Quick inquiry Where to buy Suppliers range | 4-Quinolone-3-carboxamide furan CB2 agonist is an agonists of the peripheral cannabinoid (CB) receptor CB2 may have antinociceptive and anti-inflammatory effects, as well as prevent osteoporosis. Synonyms: 4Q3C CB2 Agonist; N-(1-adamantyl)-6-(furan-2-yl)-8-methoxy-4-oxo-1-pentylquinoline-3-carboxamide. Grades: ≥98%. CAS No. 1314230-75-5. Molecular formula: C30H36N2O4. Mole weight: 488.6. | |
5-Iodo-A-85380 Dihydrochloride Hydrate (3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine Dihydrochloride Hydrate, a4b2 and a6b2 Nicotinic Acetylcholine Receptors (nAChR) Agonist, 5-Iodo-A-85380) Quick inquiry Where to buy Suppliers range | A very potent agonist highly selective for alpha4beta2 and alpha6beta2 nicotinic acetylcholine receptors (nAChR) (Ki= 12 and 10 pM for human and rat alpha4beta2 nAChRs, respectively). An important nAChR ligand for the treatment of pain, smoking addition and other mental disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 213550-82-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
755-Ractopamine (ß-agonist)-Meat Quick inquiry Where to buy Suppliers range | 755-Ractopamine (ß-agonist)-Meat. Uses: For analytical and research use. Group: Food & Beverage Proficiency Testing. Catalog: APS005067. Format: 100g beef material. | |
7-alpha, 25-dihydroxycholesterol (EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC) Quick inquiry Where to buy Suppliers range | A highly potent and specific oxysterol EBI2 (GPR183) agonist with a kd of 450pM in a saturation binding analysis, and activates EBI2 (EC50=140pM compared with 2.1nM for its enantiomer 7b,25-OHC) in a GTP-gamma assay. Dose-dependenty suppresses forskolin-induced cAMP accumulation in EBI2-expressing SK-N-MC/CRE-beta galactosidase cell line with an IC50 of 2nM, but not in control cells. Stimulates migration of LPS-activated spleen B cells and T cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells from EBI2-deficient mice. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
A2AR-agonist-1 Quick inquiry Where to buy Suppliers range | A2AR-agonist-1 is a potent A2AR (Ki = 4.39) and ENT1(Ki = 3.47 ) agonist. Uses: A potent a2ar and ent1 agonist. Synonyms: N-(2-(1H-indol-3-yl)ethyl)-Adenosine. Grades: ≥98%. CAS No. 41552-95-8. Molecular formula: C20H22N6O4. Mole weight: 410.43. | |
Adenosine A1 Receptor Agonist I, CPA ( (2R, 3R, 4S, 5R) -2- (6- (cyclopentylamino) -9H-purin-9-yl) -5- (hydroxymethyl) tetrahydrofuran-3, 4-diol, N6-Cyclopentyl-adenosine) Quick inquiry Where to buy Suppliers range | A potent and selective agonist of adenosine A1 receptor (A1R) (Ki = 2.3nM, 790nM, 18.6uM, 43nM for human A1, A2A, A2B, and A3, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 41552-82-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Adenosine A1 Receptor Agonist II, CCPA ( (2R, 3R, 4S, 5R) -2- (2-chloro-6- (cyclopentylamino) -9H-purin-9-yl) -5- (hydroxymethyl) tetrahydrofuran-3, 4-diol, 2-Chloro-N6-cyclopentyladenosine) Quick inquiry Where to buy Suppliers range | An adenosine analog that acts as a selective, high affinity agonist for Adenosine A1 receptor (A1R) (Ki = 800 pM; 2.3uM, 18.8uM, and 42nM for human A1, A2A, A2B, A3 respectively). Shown to be centrally active following systemic administration and exhibits anti-convulsive effects. Also reported to inhibit adenylate cyclase activity in rat fat cell membrane (IC50 = 33nM). Diminishes respiratory rhythm, reduces heart rate, and enhances the activity of KATP channels. Reduces norepinephrine release by about 50% in untreated and pertussis toxin treated hearts.CAS Number:37739-05-2. Group: Biochemicals. Grades: Highly Purified. CAS No. 37739-05-2. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. | Worldwide |
Adenosine A2A Receptor Agonist I, Hydrochloride (CGS 21680) Quick inquiry Where to buy Suppliers range | A xanthin derivative that acts as a potent agonist of adenosine A2A receptors (Ki = 27nM). Exhibits reduced affinity for A2B receptors (Ki = 67nM), but offers greater selectivity over A1R (Ki = 290nM) and A3R (88.8uM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington's disease. Group: Biochemicals. Alternative Names: CGS-21680; 3- (4- (2- ( (6-amino-9- ( (2R, 3R, 4S, 5S) -5- (ethylcarbamoyl) -3, 4-di hydroxytetra hydrofuran-2-yl) -9H-purin-2-yl) amino) ethyl) phenyl) propanoic acid). Grades: Highly Purified. CAS No. 124182-57-6. Pack Sizes: 5mg. Molecular Formula: C23H29N7O6 HCl, Molecular Weight: 536. US Biological Life Sciences. | Worldwide |
Adenosine Receptor Agonist, NECA ( (2S, 3S, 4R, 5R) -5- (6-amino-9H-purin-9-yl) -N-ethyl-3, 4-di hydroxytetra hydrofuran-2-carboxamide ) Quick inquiry Where to buy Suppliers range | A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (Ki = 14nM, 20nM, 2.4uM and 6.2nM for A1, A2A, A2B, A3, respectively). Increases intracellular cAMP production (EC50 = 3.1uM in A2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 35920-39-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Agmatine sulfate endogenous agonist at Quick inquiry Where to buy Suppliers range | Agmatine sulfate endogenous agonist at. Group: Heterocyclic Organic Compound. Alternative Names: AGMATINE SULFATE ENDOGENOUS AGONIST AT;1-(4-aminobutyl)guanidine;2-(4-aminobutyl)guanidine;(4-Aminobutyl) guanidine;N1-(4-Aminobutyl)guanidine;2-(4-azanylbutyl)guanidine;4-Guanidino-1-butanamine;N-(4-Aminobutyl)guanidine. CAS No. 306-60-5. Molecular formula: C5H14N4. Mole weight: 130.19146. Boiling Point: 235?. Flash Point: 96?. Density: 1.20. | |
AhR Agonist V, VAF347 Quick inquiry Where to buy Suppliers range | A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation. Group: Biochemicals. Alternative Names: ((4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine). Grades: Highly Purified. CAS No. 574759-62-9. Pack Sizes: 10mg. Molecular Formula: C??H??ClF?N?, Molecular Weight: 349.7. US Biological Life Sciences. | Worldwide |
alpha,beta-methylene ATP (ab-MeATP, ab-methylene ATP, P2X Purinergic Receptor Agonist, a,b-methylene ATP, a,b-Methyleneadenosine 5?-triphosphate Lithium Salt) Quick inquiry Where to buy Suppliers range | A metabolically stable and selective P2X purinergic receptor agonist (pEC50 = 5.81) that is shown to be more potent than ATP. Elicits contractions in ileum through the release of endogenous acetylcholine, which can be blocked by tetrodotoxin (~1mM). Shown to depolarize cells of the longitudinal muscle strips (~ 200nM to 4uM) that reaches a peak within 2-3 min after application and then decays to a steady level. CAS No:104809-20-3. Group: Biochemicals. Grades: Highly Purified. CAS No. 104809-20-3. Pack Sizes: 5mg. Molecular Formula: C??H??N?O??P?; xLi+. US Biological Life Sciences. | Worldwide |
AMPA Agonist, CMPA (AMPA Activator, N,N-(2,2-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide) Quick inquiry Where to buy Suppliers range | A bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC50 = 45nM and 63nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10uM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 376.5. US Biological Life Sciences. | Worldwide |
AMPK Signaling Agonist, F17 (4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~0.1uM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-a1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25uM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C. Group: Biochemicals. Grades: Highly Purified. CAS No. 280112-24-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
ATPA (2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic Acid, (RS)-2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic Acid, Kainate Receptor Agonist, ATPA, (R,S)-ATPA) Quick inquiry Where to buy Suppliers range | A potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.33, 0.80, and 0.38uM for GluK1, GluK1/K2, and GluK1/K5, respectively) over GluK2-containing subtypes (EC50 = 106 and ?uM for GluK2/K5 and GluK2 respectively). Weakly interacts with AMPA receptors (EC50 = 7.6, 7.9 and 22uM for GluA4, GluA3, and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in synaptic transmission and plasticity. Group: Biochemicals. Grades: Highly Purified. CAS No. 140158-50-5. Pack Sizes: 1mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
Bethanechol Chloride (Carbamyl-beta-methylcholine chloride, Muscarinic Acetylcholine Receptors (mAChR) Agonist, Bethanechol Chloride) Quick inquiry Where to buy Suppliers range | An agonist selective for Muscarinic Acetylcholine Receptors (mAChRs, EC50 = 7, 14.5, 35 and 32uM for M4, M3, M1 and M5 respectively) with no effect on nicotinic receptors. It is not a substrate for acetylcholinesterase therefore has longer duration of action than acetylcholine. Clinically used to treat certain bladder related conditions. Group: Biochemicals. Grades: Highly Purified. CAS No. 590-63-6. Pack Sizes: 5g. Molecular Formula: C?H??ClN?O?. US Biological Life Sciences. | Worldwide |
C3a Receptor Agonist Quick inquiry Where to buy Suppliers range | Complement 3a (C3a) Receptor Agonist is a G protein-coupled receptor protein involved in the complement system complement pathway. C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. It stimulates differentiation of neural progenitor cells in vitro. Synonyms: C3A Receptor Agonist; 944997-60-8; C3a receptor agonist 1; 2-cyclohexyl-2-phenyl-N-[1-(3-pyridin-3-ylpropanoyl)piperidin-4-yl]acetamide; CHEMBL390036; CHEMBL535625; 2-cyclohexyl-2-phenyl-N-(1-(3-(pyridin-3-yl)propanoyl)piperidin-4-yl)acetamide; 2-Cyclohexyl-2-phenyl-N-{1-[3-(pyridin-3-yl)propanoyl]piperidin-4-yl}acetamide; Complement 3a Receptor Agonist; SCHEMBL14335900; GTPL11252; DTXSID90659061; BDBM50423085; AKOS028114559; compound 7 [PMID: 17459702]; MS-27755; HY-128132; CS-0095343; C3A Receptor Agonist, >=98% (HPLC), solid; F87576. Grades: ≥98%. CAS No. 944997-60-8. Molecular formula: C27H35N3O2. Mole weight: 433.6. | |
Ca2+ Channel Agonist 1 Quick inquiry Where to buy Suppliers range | A Ca2+ Channel Agonist that selectively acting on N-type Ca2+ channel and also be found to restrain the cdk activity at some extent. IC50: 14.23 uM (EC50, Ca2+ channel) 3.34 uM (EC50, cdk2). Uses: A ca2+ channel agonist that selectively acting on n-type ca2+ channel and also be found to restrain the cdk activity at some extent. Synonyms: Ca2+ channel agonist 1; SCHEMBL17628623; CS-5169; CS 5169; CS5169. Grades: 98%. CAS No. 1402821-24-2. Molecular formula: C19H26N6O. Mole weight: 354.46. | |
CB2 Agonist, JWH 015 ((2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone, JWH-015, JWH 015) Quick inquiry Where to buy Suppliers range | A potent and highly selective agonist for cannabinoid subtye 2 (CB2) receptor. Affinity for CB2 (Ki = 13.8nM) is more than 28-fold higher than that for CB1 (Ki = 383nM) receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 155471-08-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
CB2 Inverse Agonist, SR 144528 (5- (4- chloro- 3- methylphenyl)- 1- [(4- methylphenyl)methyl]- N- [(1S, 2S, 4R)- 1, 3, 3- trimethylbicyclo[2. 2. 1]hept- 2- yl]- 1H- pyrazole-3) Quick inquiry Where to buy Suppliers range | A selective inverse agonist for peripheral cannabinoid (CB2) receptors (Ki = 0.6nM and 400nM for CB2 and CB1 receptors, respectively). Has been used in studies related to control of pain initiation, suppression of inflammation, and immune activation. Group: Biochemicals. Grades: Highly Purified. CAS No. 192703-06-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
diABZI STING agonist-1 Quick inquiry Where to buy Suppliers range | diABZI STING agonist-1 is a selective agonist of stimulator of interferon genes (STING) receptor, with EC50s of 130, 186 nM for human and mouse, respectively. Synonyms: 1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-; (E)-1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzo[d]imidazole-5-carboxamide; STING agonist compound 3; 1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide. Grades: >98%. CAS No. 2138299-33-7. Molecular formula: C42H51N13O7. Mole weight: 849.94. | |
diABZI STING agonist-1-trihydrochloride Quick inquiry Where to buy Suppliers range | Cas No. 2138299-34-8. | |
DPDPE (Delta Opioid Receptor Agonist, DPDPE) Quick inquiry Where to buy Suppliers range | A potent agonist selective for delta opioid receptor (EC50 = 5.2nM). Exhibits anti-convulsant effects in vivo in rats, also used in nociceptive studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 88373-73-3. Pack Sizes: 1mg. Molecular Formula: C??H??N?O?S?, Peptide Sequence: Tyr-D-Pen-Gly-Phe-D-Pen (2-5 disulfide bond). US Biological Life Sciences. | Worldwide |
DREADD agonist 21 Quick inquiry Where to buy Suppliers range | DREADD agonist 21 has been found to be an agonist of hM3Dq with high selectivity. Synonyms: DREADD agonist 21; DREADD-agonist-21; DREADD agonist-21; 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine. Grades: ≥98% by HPLC. CAS No. 56296-18-5. Molecular formula: C17H18N4. Mole weight: 278.35. | |
DREADD agonist 21 dihydrochloride Quick inquiry Where to buy Suppliers range | DREADD agonist 21 (Compound 21) hydrochloride is a water soluble salt of DREADD agonist 21 (Compound 21). And it is a potent and selective agonist at muscarinic based DREADDs such as the excitatory hM3Dq, hM1Dq and inhibitory hM4Di DREADDs. Synonyms: 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride; 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 11-Piperazinyldibenzo[b, e][1, 4]diazepine dihydrochloride; Compound 21 dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C17H18N4·2HCl. Mole weight: 351.27. | |
DREADD Agonist 21 dihydrochloride Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 56296-18-5 (free base). Pack Sizes: 5MG, 25MG. Mole weight: 351.27. Catalog: ALP56296185. Assay: ≥98% (HPLC). | |
Dynorphin A (1-17) (Kappa Opioid Receptor Agonist) Quick inquiry Where to buy Suppliers range | An endogenous agonist for kappa opioid receptors. Involved in several neurological disorders, including neuropathic pain, stress, depression, and Alzheimer's and Parkinson's diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 80448-90-4. Pack Sizes: 500ug, 1mg, 5mg, 10mg. Molecular Formula: C99H155N31O23, Molecular Weight: 2147.5. US Biological Life Sciences. | Worldwide |
(±)-Epibatidine Dihydrochloride (2-(6-chloropyridin-3-yl)-7-azabicyclo[2. 2. 1]heptane, Nicotinic Acetylcholine Receptors (nAChR) Agonist, Epibatidine) Quick inquiry Where to buy Suppliers range | A potent partial agonist selective for alpha7 nAChRs (EC50 = 34uM). Widely used in investigating the roles of alpha7 nAChRs in aging, learning and memory, and cognition. Enhances memory in mouse models for Alzheimer's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 501684-93-1. Pack Sizes: 5mg. Molecular Formula: C??H??ClN? 2HCl xH2O. US Biological Life Sciences. | Worldwide |
G-1 (GPR30 Agonist, AC1MJFYZ, MLS001242405) Quick inquiry Where to buy Suppliers range | G-1 (GPR30 Agonist, AC1MJFYZ, MLS001242405). Group: Biochemicals. Alternative Names: 1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone. Grades: Highly Purified. CAS No. 881639-98-1. Pack Sizes: 10mg, 25mg. Molecular Formula: C21 H18 BrNO 3 , Molecular Weight: 412.3. US Biological Life Sciences. | Worldwide |
GB 31660.6-2019 α2-Agonists Mixture 169 100 μg/mL in Methanol Quick inquiry Where to buy Suppliers range | GB 31660.6-2019 α2-Agonists Mixture 169 100 μg/mL in Methanol. Uses: For analytical and research use. Group: Pharma & Vet Compounds & Metabolites; Pharma & Vet Compounds & Metabolites; Standards for Food Regulatory Methods. Catalog: APS008359. Format: Mixture. Shipping: Room Temperature. | |
GB/T 22286-2008 11 β-Agonists 100 μg/mL in Methanol Quick inquiry Where to buy Suppliers range | GB/T 22286-2008 11 β-Agonists 100 μg/mL in Methanol. Uses: For analytical and research use. Group: Standards for Food Regulatory Methods. Catalog: APS008374. Format: Mixture. Shipping: Room Temperature. | |
GLP-1R agonist DMB Quick inquiry Where to buy Suppliers range | GLP-1R agonist DMB is a glucagon-like peptide-1 (GLP-1) receptor agonist used potentially for the treatment of type 2 diabetes. Uses: Potential treatment of type 2 diabetes. Synonyms: N-(tert-Butyl)-6,7-dichloro-3-(methylsulfonyl)quinoxalin-2-amine. Grades: 99%. CAS No. 281209-71-0. Molecular formula: C13H15Cl2N3O2S. Mole weight: 348.25. | |
Glucagon-Like Peptide 1 Receptor Agonist Quick inquiry Where to buy Suppliers range | A nonpeptidic quinoxaline compound that acts as a GLP-1R agonist and an allosteric modulator of GLP-1 binding. Shown to induce GLP-1R-mediated cAMP production in BHK plasma membrane preparations (EC50=101nM) and potentiate glucose-dependent insulin release in pancreatic islets derived from wild-type, but not GLP-1R -/-, mice. Unlike GLP-1, its biological activity is not inhibited by orthosteric antagonists such as Exendin. Group: Biochemicals. Alternative Names: 6,7-dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-, 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline (DMB); Compound 2; GLP-1R Agonist. Grades: Highly Purified. CAS No. 281209-71-0. Pack Sizes: 5mg. Molecular Formula: C??H??Cl?N?O?S, Molecular Weight: 348.3. US Biological Life Sciences. | Worldwide |
Glucocorticoid receptor agonist Quick inquiry Where to buy Suppliers range | Glucocorticoid receptor agonist is an effective Glucocorticoid receptor agonist and probably has steroid-like anti-inflammatory properties. Uses: Glucocorticoid receptor agonist is an effective glucocorticoid receptor agonist and probably has steroid-like anti-inflammatory properties. Synonyms: 4-fluoro-2-[(4R)-5, 5, 5-trifluoro-4-hydroxy-2-methyl-4-(1H-pyrrolo[2, 3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol; Glucocorticoidreceptoragonist; CHEMBL1253898; 1245526-82-2; C20H20F4N2O2; 3695AH. Grades: 95%. CAS No. 1245526-82-2. Molecular formula: C20H20F4N2O2. Mole weight: 396.38. | |
GPR109b Agonist (1-(iso-Propyl)-1H-benzotriazole-5-carboxylic Acid) Quick inquiry Where to buy Suppliers range | A cell-permeable Niacin triazolo derivative that acts as a potent and selective agonist toward the human orphan G-protein-coupled receptor GPR109b/HM74, but not GPR109a/HM74A or b-adrenergic receptor. Effectively inhibits cAMP elevation induced by forskolin (5uM) and isoproterenol (1uM), respectively, in GPR109b-expressing CHO cells (EC50=400nM) and freshly isolated human adipocytes (EC50 about 1uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 306935-41-1. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
GPR43 (FFA2) Agonist ((S)-2-(4-chlorophenyl)-3,3-dimethyl-N-(5-phenylthiazol-2-yl)butanamide) Quick inquiry Where to buy Suppliers range | A phenylacetamide compound that acts as an allosteric agonist of FFA2 (GPR43), demonstrating a left-shifted acetate dose response (IC50=0.7uM) and 111% efficacy relative to acetate in hFFA2 forskolin-induced cAMP assays. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Herkinorin (mu Opioid Receptor Agonist, Herkinorin) Quick inquiry Where to buy Suppliers range | A potent agonist selective for u opioid receptor (Ki = 45nM) over kappa opioid receptors (Ki = 184nM). Widely used for pain research. Group: Biochemicals. Grades: Highly Purified. CAS No. 862073-77-6. Pack Sizes: 1mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
Interferon receptor agonist Quick inquiry Where to buy Suppliers range | Interferon receptor agonist. Group: Pheromone Ingredients. CAS No. 2215120-36-6. Molecular formula: C12H22N4O2. Mole weight: 254.33. | |
Loperamide Hydrochloride (mu-Opioid Receptor Agonist, Loperamide Hydrochloride, Imodium) Quick inquiry Where to buy Suppliers range | A very potent and highly selective peripheral resctricted u-opioid receptor agonist (Ki = 2nM). Often used as an antidiarrheal, antipruritic, and antihyperalgesic agent. In addition, shown to improve defective post-receptor insulin signaling in skeletal muscle cells and enhance insulin sensitivity in rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 34552-83-5. Pack Sizes: 1g. Molecular Formula: C??H??ClN?O?·HCl. US Biological Life Sciences. | Worldwide |
LY 344864 Hydrochloride (5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864) Quick inquiry Where to buy Suppliers range | A selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935. Group: Biochemicals. Grades: Highly Purified. CAS No. 186544-26-3. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O·HCl. US Biological Life Sciences. | Worldwide |
Muscimol (GABAA Receptor Agonist, Muscimol) Quick inquiry Where to buy Suppliers range | A constituent and psychoactive ingredient of the mushroom Amanita muscariathat acts as a potent agonist of GABAA receptors (EC50 = 28uM and 33uM in neonatal and adult rats, respectively), with preferential efficacy and selectivity to high-affinity receptor subtypes. Shown to be permeate the blood-brain barrier. Impairs associate and memory functions. Group: Biochemicals. Grades: Highly Purified. CAS No. 2763-96-4. Pack Sizes: 1mg. Molecular Formula: C?H?N?O?. US Biological Life Sciences. | Worldwide |
nAChR agonist CMPI hydrochloride Quick inquiry Where to buy Suppliers range | nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity. CAS No. 2250025-94-4. Molecular formula: C18H20Cl2N4O. Mole weight: 379.28. | |
Orexin 2 Receptor Agonist Quick inquiry Where to buy Suppliers range | N- [2- [3- [ [5- [3- (dimethylcarbamoyl) phenyl] -2-methoxyphenyl] sulfonylamino] anilino] ethyl] -3-methylbenzamide is an orexin 2 receptor agonist that is potentially for the treatment of narcolepsy. Synonyms: MDK-5220; MDK 5220; MDK5220. Orexin2 receptor agonist; CHEMBL3623075; N- [2- [3- [ [5- [3- (dimethylcarbamoyl) phenyl] -2-methoxyphenyl] sulfonylamino] anilino] ethyl] -3-methylbenzamide; GTPL9305; SCHEMBL18138813. Grades: ≥98%. CAS No. 1796565-52-0. Molecular formula: C32H34N4O5S. Mole weight: 586.707. | |
Orphan GPCR SP9155 Agonist P518 (human) Quick inquiry Where to buy Suppliers range | It is a hypothalamic neuropeptide of the RFamide family of peptides with orexigenic activity and is an endogenous ligand of the orphan G protein-coupled receptor GPR103. Synonyms: P518 (human); Orphan G-Protein Coupled Receptor SP9155 Agonist Peptide P518 (human); 26Rfa, Hypothalamic Peptide, human; H-Thr-Ser-Gly-Pro-Leu-Gly-Asn-Leu-Ala-Glu-Glu-Leu-Asn-Gly-Tyr-Ser-Arg-Lys-Lys-Gly-Gly-Phe-Ser-Phe-Arg-Phe-NH2; L-threonyl-L-seryl-glycyl-L-prolyl-L-leucyl-glycyl-L-asparagyl-L-leucyl-L-alanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-leucyl-L-asparagyl-glycyl-L-tyrosyl-L-seryl-L-arginyl-L-lysyl-L-lysyl-glycyl-glycyl-L-phenylalanyl-L-seryl-L-phenylalanyl-L-arginyl-L-phenylalaninamide. Grades: ≥95%. CAS No. 600171-68-4. Molecular formula: C127H195N37O37. Mole weight: 2832.13. | |
PAR-4 Agonist Peptide, amide Quick inquiry Where to buy Suppliers range | PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. Uses: Peptide Inhibitors. CAS No. 352017-71-1. Product ID: R1810. | |
PAR-4 Agonist Peptide, amide TFA Quick inquiry Where to buy Suppliers range | PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. Uses: Peptide Inhibitors. CAS No. 1228078-65-6. Product ID: R1811. | |
(±)-PD 128907 Hydrochloride (Dopamine D3 Receptor Agonist, PD 128,907, PD 128907, PD128907) Quick inquiry Where to buy Suppliers range | Selective dopamine D3 receptor agonist (Ki = 2.3nM) with an 18-fold selectivity over long dopamine receptors (D2L) and exhibited only weak affinity for D4.2 receptors (Ki = 169nM). Commonly used to reproduce cocaine's discriminative stimulus effects and also in peripheral systemic studies of hypertension. Group: Biochemicals. Grades: Highly Purified. CAS No. 112960-16-4. Pack Sizes: 5mg. Molecular Formula: C??H??NO? HCl. US Biological Life Sciences. | Worldwide |
PD 168077 Maleate (D4 Dopamine Receptor Agonist, PD 168077 Maleate, PD168077, PD-168077) Quick inquiry Where to buy Suppliers range | A selective D4 dopamine receptor agonist (Ki = 8.7nM, EC50 = 8.3nM). Suitable for central and peripheral delivery. Used in studies of penile erection, learning and memory. Exibits some binding affinity towards human D2 and D3 Receptors (Ki = 2.8uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 630117-19-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PHA-543,613 (N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, Alpha 7 Nicotinic Acetylcholine Receptor (alpha7 nAChR) Agonist, PHA-543613) Quick inquiry Where to buy Suppliers range | A potent agonist highly selective for alpha7 nicotinic acetylcholine receptor (alpha7 nAChR). Bioavaible admitted orally. Widely used in studies of the functional roles of alpha7 nAChR in learning and memory, sensory gating, and cognitive functions as well as Schizophrenia and Alzheimer's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 478149-53-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
PPAR agonist 1 Quick inquiry Where to buy Suppliers range | An agonist of PPAR α and PPAR &gamma. Synonyms: Benzenepropanoic acid, α -methoxy-4-[[3-[4-[ (methylsulfonyl) oxy]phenyl]propyl]amino]-, (αS)-. CAS No. 539813-69-9. Molecular formula: C20H25NO6S. Mole weight: 407.48. | |
PPAR Agonist IX, GQ-16 ((Z)-5-(5-Bromo-2-methoxybenzylidene)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione) Quick inquiry Where to buy Suppliers range | A cell-permeable thiazolidinedione that acts as a PPARg-selective agonist (Ki=160nM) and blocks Cdk-5-mediated Ser273 phosphorylation by stabilizing PPARg b-sheet structure, exhibiting no detectable activity towards PPARa, PPARd, or RXRa. Although a weaker PPAPg agonist than Thiazolidinediones (TZDs) family rosiglitazone (Max. fold of transactivation induction =8.57 and 24.8 with 10uM respective compound in U-937 reporter assays), GQ-16 can be safely administered at a higher dosage (20mg/kg/day; oral gavage) in mice to achieve similar in vivo efficacy as rosiglitazone (4mg/kg/day; o.g.) without adverse side effects commonly seen with TZDs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
PPAR-beta/delta Inverse Agonist (Methyl 3- (N- (4- (hexylamino) -2-methoxyphenyl) sulfamoyl) thiophene-2-carboxylate, ST247) Quick inquiry Where to buy Suppliers range | A cell-permeable, diaryl sulfonamide inverse agonist that demonstrates selectivity for the ligand-binding domain of the PPAR beta/delta receptor (IC50=93nM). Enhances the interaction of the PPARb/d ligand-binding domain with the co-repressor, SMRT-ID2 (EC50=10nM). Down-regulates the peroxisome proliferator response elements (PPREs)-driven target gene, ANGPTL4. Inhibits PPARb/d- specific agonist-induced transcriptional activity in human myofibroblasts and mouse thioglycollate-elicited peritoneal macrophages. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
(-)-Quinpirole Hydrochloride (Dopamine D2 Receptor Agonist, Quinpirole, Quinpirole, LY-171,555, LY 171555) Quick inquiry Where to buy Suppliers range | A potent, selective dopamine D2 receptor agonist with a Ki value of 4.8nM. Some D3(Ki = 24nM) and D4 (Ki = 30nM) receptor agonistic action has also been reported. In rat striatum studies in vitro, application of quinpriole inhibited single pulse dopamine overflow in a concentration-dependent manner (IC50 = 32.5nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 85798-08-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
REV-ERB Agonist II, SR9009 Quick inquiry Where to buy Suppliers range | A pyrrolidinecarbamate compound that acts as a specific REV-ERB-alpha/beta agonist. Exhibits a direct and reversible binding (Kd = 800nM REV-ERB-alpha) and shows excellent selectivity over a panel of 46 other nuclear receptors. Potently increases REV-ERB-dependent repressor activity (IC50 = 670 and 800nM in Gal4-REV-ERB-alpha and beta transfected HEK 293 cells) and reduces BMAL1 mRNA in HepG2 cells (IC50 = 710nM). Shown to cross the blood-brain barrier and exhibit desirable pharmacokinetic properties. A 7-day administration of SR9009 (100mg/kg, i.p., b.i.d.) causes a significant weight and fat loss in C57BL6 mice with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian pattern. 217739, CAS # 1379686-30-2, acts as a specific REV-ERB-α/ β agonist that exhibits a direct and reversible binding (Kd = 800nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 1379686-30-2. Pack Sizes: 25mg. Molecular Formula: C??H??ClN?O?S. US Biological Life Sciences. | Worldwide |
ROR-alpha/gamma Agonist Quick inquiry Where to buy Suppliers range | A cell-permeable diaryl amide derived from T1317 (a known LXR agonist and retinoic acid receptor (ROR) inverse agonist) that acts as a highly selective agonist of RORalpha/gamma and does not exhibit affinity for FXR, LXRa and LXRb. Shown to stabilize p53 in cancer cells and increase the expression of p21 and PUMA. Induces apoptosis in hepatocellular carcinoma (HepG2) cells in a RORa and p53-dependent process. Also reported to increase the expression of Sox4 and REV-ERBa in HepG2 cells. Exhibits suitable pharmacokinetic properties with sustained plasma levels even after 8 hours following a single i.p. injection. Exposure to SR1078 Induces expression of glucose-6-phosphatase and fibroblast growth factor 21 in murine models (10mg/kg/i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |