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Product | Description | |
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Alvimopan Quick inquiry Where to buy Suppliers range | Alvimopan. Group: Biochemicals. Alternative Names: N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine; ADL 8-2698; LY 246736. Grades: Highly Purified. CAS No. 156053-89-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C25H32N2O4. US Biological Life Sciences. | Worldwide |
Alvimopan Quick inquiry Where to buy Suppliers range | Alvimopan is a novel, oral, peripherally acting antagonist of the mu opioid receptor, which can help gastrointestinal recovery after surgery. Phase III IC50: Mu-type opioid receptor= 1.7 nM. Uses: A peripheral μ-opioid receptor antagonist. gastroprokinetic. Synonyms: 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid ADL 8-2698 ADL8-2698 alvimopan alvimopan anhydrous anhydrous alvimopan Entereg LY 246736 LY-246736 LY246736 trans-3,4-dimethyl-4-(3-hydroxyphenyl) pipe. Grades: ≥98%. CAS No. 156053-89-3. Molecular formula: C25H32N2O4. Mole weight: 424.53. | |
Alvimopan Acyl Glucuronide (mixture of isomers) Quick inquiry Where to buy Suppliers range | A metabolite of Alvimopan. Synonyms: Alvimopan Acyl-β-D-glucuronide. Grades: > 95%. CAS No. 1260616-95-2. Molecular formula: C31H40N2O10. Mole weight: 600.67. | |
Alvimopan dihydrate Quick inquiry Where to buy Suppliers range | Alvimopan dihydrate is a novel, orally available peripherally restricted opioid antagonist with low systemic absorption. It accelerates the gastrointestinal recovery period with most common side effects in chronic pain patients with OBD were abdominal pai. Synonyms: 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid;dihydrate ADL 8-2698 ADL8-2698 alvimopan alvimopan anhydrous anhydrous alvimopan Entereg LY 246736 LY-246736 LY246736 trans-3,4-dimethyl-4-(3-hydroxyph. CAS No. 170098-38-1. Molecular formula: C25H32N2O4.2H2O. Mole weight: 460.57. | |
Alvimopan Dihydrate Quick inquiry Where to buy Suppliers range | Alvimopan Dihydrate. Uses: For analytical and research use. Group: API Standards; Pharmaceutical Toxicology. Alternative Names: LY 246736 dihydrate, ADL 8-2698 dihydrate, Glycine, N-[2-[[4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-, dihydrate, [3R-[1(S*),3alpha,4alpha]]-,Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-, hydrate (1:2), Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-, dihydrate (9CI), Alvimopan dihydrate. CAS No. 170098-38-1. IUPAC Name: 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid;dihydrate. Molecular formula: C25H32N2O4.2H2O. Mole weight: 460.56. Catalog: APS170098381. SMILES: O. O. C[C@H]1CN (C[C@H] (Cc2ccccc2)C (=O)NCC (=O)O)CC[C@@]1 (C)c3cccc (O)c3. Format: Neat. Product Type: API. Shipping: Room Temperature. | |
Alvimopan Metabolite Quick inquiry Where to buy Suppliers range | A metabolite of Alvimopan. Synonyms: ADL 08-0011. Grades: > 95%. CAS No. 156130-41-5. Molecular formula: C23H29NO3. Mole weight: 367.49. | |
Alvimopan monohydrate Quick inquiry Where to buy Suppliers range | The monohydrate salt form of Alvimopan could be commonly used in postoperative recovery of gastrointestinal for acting as a mu-opioid receptor (PAM-OR) antagonist with IC50: 1.7 nM. Uses: The monohydrate salt form of alvimopan could be commonly used in postoperative recovery of gastrointestinal for acting as a mu-opioid receptor (pam-or) antagonist. Synonyms: UNII-28LAR2REDG; 28LAR2REDG; DTXSID30160641; 3078AH; 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid;hydrate. Grades: 98%. CAS No. 1383577-62-5. Molecular formula: C25H34N2O5. Mole weight: 442.55. | |
(2R,3R,4R)-Alvimopan Quick inquiry Where to buy Suppliers range | (2R,3R,4R)-Alvimopan is derived from (S)-4-Phenyl-2-oxazolidinone (P335820), which is an intermediate for the synthesis and development for cholesterol absorption inhibitor AZD4121. Group: Biochemicals. Grades: Highly Purified. CAS No. 342639-35-4. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C25H32N2O4, Molecular Weight: 424.53. US Biological Life Sciences. | Worldwide |
(2S,3S,4S)-Alvimopan Quick inquiry Where to buy Suppliers range | (2S,3S,4S)-Alvimopan is an isomer of Alvimopan (A575800), which is a peripheral µ-opioid receptor antagonist and gastroprokinetic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C25H32N2O4, Molecular Weight: 424.53. US Biological Life Sciences. | Worldwide |
JDTic dihydrochloride Quick inquiry Where to buy Suppliers range | JDTic dihydrochloride is a highly selective antagonist for the κ-opioid receptor with IC50 value of 0.02nM without affecting the μ- or δ-opioid receptors. It is a 4-phenylpiperidine derivative and distantly structurally related to analgesic drugs such as meperidine and ketobemidone and more closely to the mu opioid antagonist alvimopan. It is structurally distinct from other kappa antagonists such as norbinaltorphimine. It is more selective and potent for KOR activity than other KOR antagonists. It is shown to block the antinociceptive response of nicotine in the tail-flick test with a dose-dependent manner. It can also block the nicotine withdrawal signs in mice via effecting the expression of a CPA associated with nicotine withdrawal. It is also reported to decrease the number of somatic withdrawal signs in morphine-dependent rats. It may produce antidepressant and anxiolytic effects and may be used in the treatment of addiction to cocaine and morphine. Uses: Jdtic dihydrochloride is shown to block the antinociceptive response of nicotine in the tail-flick test with a dose-dependent manner. it can also block the nicotine withdrawal signs in mice via effecting the expression of a cpa associated with nicotine withdrawal. it is also reported to decrease the number of somatic withdrawal signs in morphine-dependent rats. it may produce antidepressant and anxiolytic effects and may be used in the treatment of addiction to cocaine and morphine. Synonyms: JDTic (2HCl);(3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide hydrochloride;(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4- . Grades: 95%. CAS No. 785835-79-2. Molecular formula: C28H41Cl2N3O3. Mole weight: 538.55. |