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| Product | Description | |
|---|---|---|
| Alvimopan | Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC 50 of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor ( K i =0.47 nM) over κ- and δ-opioid receptors ( K i s=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ADL 8-2698; LY 246736. CAS No. 156053-89-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13243. |  |
| Alvimopan | Alvimopan. Group: Biochemicals. Alternative Names: N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine; ADL 8-2698; LY 246736. Grades: Highly Purified. CAS No. 156053-89-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C25H32N2O4. US Biological Life Sciences. |  Worldwide |
| Alvimopan | Alvimopan is a novel, oral, peripherally acting antagonist of the mu opioid receptor, which can help gastrointestinal recovery after surgery. Phase III IC50: Mu-type opioid receptor= 1.7 nM. Uses: A peripheral μ-opioid receptor antagonist. gastroprokinetic. Synonyms: 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid ADL 8-2698 ADL8-2698 alvimopan alvimopan anhydrous anhydrous alvimopan Entereg LY 246736 LY-246736 LY246736 trans-3,4-dimethyl-4-(3-hydroxyphenyl) pipe. Grades: ≥98%. CAS No. 156053-89-3. Molecular formula: C25H32N2O4. Mole weight: 424.53. |  |
| Alvimopan Acyl Glucuronide (mixture of isomers) | A metabolite of Alvimopan. Synonyms: Alvimopan Acyl-β-D-glucuronide. Grades: > 95%. CAS No. 1260616-95-2. Molecular formula: C31H40N2O10. Mole weight: 600.67. | |
| Alvimopan dihydrate | Alvimopan dihydrate is a novel, orally available peripherally restricted opioid antagonist with low systemic absorption. It accelerates the gastrointestinal recovery period with most common side effects in chronic pain patients with OBD were abdominal pai. Synonyms: 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid;dihydrate ADL 8-2698 ADL8-2698 alvimopan alvimopan anhydrous anhydrous alvimopan Entereg LY 246736 LY-246736 LY246736 trans-3,4-dimethyl-4-(3-hydroxyph. CAS No. 170098-38-1. Molecular formula: C25H32N2O4.2H2O. Mole weight: 460.57. | |
| Alvimopan Impurity 4 | Alvimopan Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 156130-41-5. Molecular Formula: C23H29NO3. Mole Weight: 367.49. Catalog: APB156130415. |  |
| Alvimopan impurity A | Alvimopan impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-((3R,4R)-3,4-dimethylpiperidin-4-yl)phenol. Molecular Formula: C13H19NO. Mole Weight: 205.3. Catalog: APB02527. | |
| Alvimopan impurity B | Alvimopan impurity B. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-((3S,4S)-3,4-dimethylpiperidin-4-yl)phenol. Molecular Formula: C13H19NO. Mole Weight: 205.3. Catalog: APB02528. | |
| Alvimopan impurity C | Alvimopan impurity C. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-methyl 2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoate hydrochloride. Molecular Formula: C24H32ClNO3. Mole Weight: 417.97. Catalog: APB02526. | |
| Alvimopan impurity D | Alvimopan impurity D. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-methyl 2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoate. Molecular Formula: C24H31NO3. Mole Weight: 381.51. Catalog: APB02525. | |
| Alvimopan impurity E | Alvimopan impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-methyl 2-benzyl-3-((3S,4S)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoate hydrochloride. Molecular Formula: C24H32ClNO3. Mole Weight: 417.97. Catalog: APB02523. | |
| Alvimopan impurity F | Alvimopan impurity F. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-methyl 2-benzyl-3-((3S,4S)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoate. Molecular Formula: C24H31NO3. Mole Weight: 381.51. Catalog: APB02524. | |
| Alvimopan impurity G | Alvimopan impurity G. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic acid. Molecular Formula: C25H32N2O4. Mole Weight: 424.53. Catalog: APB02522. | |
| Alvimopan impurity H | Alvimopan impurity H. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((R)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic acid. Molecular Formula: C25H32N2O4. Mole Weight: 424.53. Catalog: APB02521. | |
| Alvimopan impurity I | Alvimopan impurity I. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((R)-2-benzyl-3-((3S,4S)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic acid. Molecular Formula: C25H32N2O4. Mole Weight: 424.53. Catalog: APB02520. | |
| Alvimopan impurity J | Alvimopan impurity J. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((S)-2-benzyl-3-((3S,4S)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic acid. Molecular Formula: C25H32N2O4. Mole Weight: 424.53. Catalog: APB02519. | |
| Alvimopan Metabolite | A metabolite of Alvimopan. Synonyms: ADL 08-0011. Grades: > 95%. CAS No. 156130-41-5. Molecular formula: C23H29NO3. Mole weight: 367.49. | |
| Alvimopan monohydrate | The monohydrate salt form of Alvimopan could be commonly used in postoperative recovery of gastrointestinal for acting as a mu-opioid receptor (PAM-OR) antagonist with IC50: 1.7 nM. Uses: The monohydrate salt form of alvimopan could be commonly used in postoperative recovery of gastrointestinal for acting as a mu-opioid receptor (pam-or) antagonist. Synonyms: UNII-28LAR2REDG; 28LAR2REDG; DTXSID30160641; 3078AH; 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid;hydrate. Grades: 98%. CAS No. 1383577-62-5. Molecular formula: C25H34N2O5. Mole weight: 442.55. | |
| (2R,3R,4R)-Alvimopan | (2R,3R,4R)-Alvimopan is derived from (S)-4-Phenyl-2-oxazolidinone (P335820), which is an intermediate for the synthesis and development for cholesterol absorption inhibitor AZD4121. Group: Biochemicals. Grades: Highly Purified. CAS No. 342639-35-4. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C25H32N2O4, Molecular Weight: 424.53. US Biological Life Sciences. | Worldwide |
| (2S,3S,4S)-Alvimopan | (2S,3S,4S)-Alvimopan is an isomer of Alvimopan (A575800), which is a peripheral µ-opioid receptor antagonist and gastroprokinetic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C25H32N2O4, Molecular Weight: 424.53. US Biological Life Sciences. | Worldwide |
| JDTic dihydrochloride | JDTic dihydrochloride is a highly selective antagonist for the κ-opioid receptor with IC50 value of 0.02nM without affecting the μ- or δ-opioid receptors. It is a 4-phenylpiperidine derivative and distantly structurally related to analgesic drugs such as meperidine and ketobemidone and more closely to the mu opioid antagonist alvimopan. It is structurally distinct from other kappa antagonists such as norbinaltorphimine. It is more selective and potent for KOR activity than other KOR antagonists. It is shown to block the antinociceptive response of nicotine in the tail-flick test with a dose-dependent manner. It can also block the nicotine withdrawal signs in mice vi... it can also block the nicotine withdrawal signs in mice via effecting the expression of a cpa associated with nicotine withdrawal. it is also reported to decrease the number of somatic withdrawal signs in morphine-dependent rats. it may produce antidepressant and anxiolytic effects and may be used in the treatment of addiction to cocaine and morphine. Synonyms: JDTic (2HCl);(3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide hydrochloride;(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4- . Grades: 95%. CAS No. 785835-79-2. Molecular formula: C28H41Cl2N3O3. Mole weight: 538.55. | |
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