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Exhibits an extraordinarily high mutagenic potency in the Ames test. Group: Biochemicals. Alternative Names: IsoIQ. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
1-[(3-Amino-4-quinolinyl)amino]-2-methyl-2-propanol is an intermediate in synthesizing Resiquimod-d5 (R144682), an isotope labelled Resiquimod (R144680) which is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 129655-59-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C13H17N3O, Molecular Weight: 231.29. US Biological Life Sciences.
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1-Amino-3-Hydroxybenzene
1-Amino-3-Hydroxybenzene is used in the preparation of inhibitors of mammalian carbonic anhydrase isoforms. Also used in the preparation of quinoline tethered fluorescent carbon dots for regulated anticancer discovery. Group: Biochemicals. Grades: Highly Purified. CAS No. 591-27-5. Pack Sizes: 10g, 50g. Molecular Formula: C6H7NO. US Biological Life Sciences.
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2-(2-Aminobenzoyl)pyridine-d4
2-(2-Aminobenzoyl)pyridine-d4 is the isotope labelled analog of 2-(2-Aminobenzoyl)pyridine, which is an intermediate used for the synthesis of various Quinoline derivatives. It can also be used in the synthesis of the antitumoral agent batracylin and related isoindolo[1,2-b]quinazolin-12(10H)-ones. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C12H6D4N2O, Molecular Weight: 202.25. US Biological Life Sciences.
Worldwide
2-Amino-1-methyl-3H-imidazo[4,5-f]quinoline
Heterocyclic Organic Compound. Alternative Names: 5-f)quinolin-2-amine,1-methyl-1h-imidazo(;5-f)quinoline,2-amino-1-methyl-1h-imidazo(;2-AMINO-1-METHYL-3H-IMIDAZO[4,5-F]QUINOLINE;2-AMINO-1-METHYLIMIDAZO[4,5-F]QUINOLINE;ISOIQ;1H-Imidazo[4,5-f]quinolin-2-amine,1-methyl-(9CI);(1-methylimidazo[4,5-f]quinoli. CAS No. 102408-25-3. Molecular formula: C11H10N4. Mole weight: 198.22. Catalog: ACM102408253.
2-Amino-1-methylimidazo[4,5-f]quinoline
2-Amino-1-methylimidazo[4,5-f]quinoline. Group: Biochemicals. Alternative Names: IsoIQ. Grades: Highly Purified. CAS No. 102408-25-3. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C11H10N4. US Biological Life Sciences.
2-Methyl-1-[(3-nitro-4-quinolinyl)amino]-2-propanol is an intermediate in synthesizing Resiquimod-d5 (R144682), an isotope labelled Resiquimod (R144680) which is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 129655-57-8. Pack Sizes: 250mg, 500mg. Molecular Formula: C13H15N3O3, Molecular Weight: 261.279999999999. US Biological Life Sciences.
Isotope labelled 3-(5-Amino-3-methyl-1H-pyrazol-1-yl)-Benzoic Acid is a reagent used in the synthesis of quinoline derivatives used as caspase-3 inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C11H8D4ClN3O2, Molecular Weight: 257.71. US Biological Life Sciences.
Intermediate in the preparation of Tyrosine Kinase Inhibitors. Group: Biochemicals. Alternative Names: 4-[(3-Chloro-4-fluorophenyl)amino]-6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-7-ethoxy-3-quinolinecarbonitrile. Grades: Highly Purified. CAS No. 915945-40-3. Pack Sizes: 25mg. US Biological Life Sciences.
Isotope labelled 8-Amino-6-methoxyquinoline exhibits oxidizing properties as well as potential anti-tuberculosis application with its antimycobacterial messages as well. Group: Biochemicals. Alternative Names: 6-Methoxy-8-quinolinamine-d5; 8-Amino-6-methoxy-quinoline-d5; 6-Methoxy-8-aminoquinoline-d5; 6-Methoxyquinolin-8-amine-d5; 6-Methoxyquinolin-8-ylamine-d5; 8-Amino-6-methoxyquinoline-d5; Amichin-d5; NSC 119507-d5; NSC 119508-d5; NSC 13573-d5; WR 15081-d5. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
Bosutinib Isomer
Bosutinib Isomer is an isomer of Bosutinib. Synonyms: 4-[(3,5-Dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile; Bosutinib isomer 4; PF-06651481; PF-06651481-00. Grades: > 95%. CAS No. 1391063-17-4. Molecular formula: C26H29Cl2N5O3. Mole weight: 530.46.
Bosutinib Isomer Methanoate
Bosutinib Isomer is the 3,5-dichloro-4-methoxy isomer of Bosutinib. It has been reported that this compound has been offered incorrectly as Bosutinib (B676095) C&E News 90 (21) 2012 34-35 and Levinson NM, Boxer SG (2012) Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain. PLoS ONE 7(4): e29828. doi:10. 1371/journal. pone. 0029828. Group: Biochemicals. Alternative Names: 4-[(3,5-Dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile Methanoate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
ML 193
ML 193 is a GPR55 antagonist with IC50 value of 221 nM. Synonyms: ML-193; ML 193; ML193; CID 1261822; CID-1261822; CID1261822; N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide. Grades: ≥98% by HPLC. CAS No. 713121-80-3. Molecular formula: C28H25N5O4S. Mole weight: 527.59.
Pazufloxacin isomer Impurity
Pazufloxacin isomer Impurity is an impurity of Pazufloxacin. Pazufloxacin is a fluoroquinolone antibiotic. Synonyms: (R)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3R)-. CAS No. 166665-94-7. Molecular formula: C16H15FN2O4. Mole weight: 318.30.
Sandramycin
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity. Synonyms: (-)-Sandramycin; 3-Hydroxy-N-[23-[(3-hydroxyquinoline-2-carbonyl)amino]-8, 11, 28, 31-tetramethyl-2, 6, 9, 12, 15, 22, 26, 29, 32, 35-decaoxo-7, 27-di(propan-2-yl)-5, 25-dioxa-1, 8, 11, 14, 21, 28, 31, 34-octazatricyclo[34.4.0.016, 21]tetracontan-3-yl]quinoline-2-carboxamide. Grades: ≥95%. CAS No. 100940-65-6. Molecular formula: C60H76N12O16. Mole weight: 1221.32.
Saquinavir
Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.36 μM. Group: Inhibitors. Alternative Names: n1-[ (1s, 2r) -3-[ (3s, 4as, 8as) -3-[[ (1, 1-dimethylethyl) amino]carbonyl]octahydro-2 (1h) -isoquinolinyl]-2-hydroxy-1- (phenylmethyl) propyl]-2-[ (2-quinolinylcarbonyl) amino]-butanediamide; SAGUINAVIR; SAQUINAVIR; 2-[[2-METHYL-3- (TRIFLUOROMETHYL) PHENYL]AMINO]PYRIDINE-3-CARBOXYLIC ACID; (2S)-N-[ (2S, 3R)-4-[ (3S, 4AS, 8AS)-3- (TERT-BUTYLCARBAMOYL)-3, 4, 4A, 5, 6, 7, 8, 8A-OCTAHYDRO-1H-ISOQUINOLIN-2-YL]-3-HYDROXY-1-PHENYL-BUTAN-2-YL]-2- (QUINOLINE-2-CARBONYLAMINO)BUTANEDIAMIDE; FLUNIXIN; FLUNIXINE; SAQUINAVIRMESYLATE (SUBJECTTOPATENTFREE). CAS No. 127779-20-8. Molecular formula: C38H50N6O5. Mole weight: 670.84. Appearance: Solid. Purity: 0.9973. Canonical SMILES: O=C (N[C@@H] (CC (N)=O)C (N[C@@H] (CC1=CC=CC=C1)[C@H] (O)CN2[C@H] (C (NC (C) (C)C)=O)C[C@@] (CCCC3) ([H])[C@@]3 ([H])C2)=O)C4=NC5=CC=CC=C5C=C4. Catalog: ACM127779208.
Sitafloxacin isomer III (RRS)
An isomer of Sitafloxacin. Sitafloxacin is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer. Synonyms: 7-((R)-7-amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 3-Quinolinecarboxylicacid,7-[(7R)-7-amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-; 7-[(7R)?-7-amino-5-azaspiro[2.4]?hept-5-yl]?-8-chloro-6-fluoro-1-[(1R,?2S)?-2-fluorocyclopropyl]?-1,?4-dihydro-4-oxo-3-Quinolinecarboxylic acid. CAS No. 127254-10-8. Molecular formula: C19H18ClF2N3O3. Mole weight: 409.818.
Tariquidar dihydrochloride is a potent P-glycoprotein (P-gp) inhibitor (IC50 = 5.1 nM). Tariquidar was found to reverse drug resistance in multiple MDR cell lines. Tariquidar binds to the p-glycoprotein transporter, and inhibits transmembrane transport of anticancer drugs, leading to increased concentrations and enhanced cytotoxic effects of anticancer drugs. Synonyms: N-[2-[[[4-[2- (3, 4-dihydro-6, 7-dimethoxy-2 (1H) -isoquinolinyl) ethyl]phenyl]amino]carbonyl]-4, 5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1992047-62-7. Molecular formula: C38H38N4O6.2HCl. Mole weight: 719.66.
WQ3810
WQ3810 is a newly developed fluoroquinolone withunique substituents at the N1 and C7 positions of the quinolone ringfor the treatment of antibiotic-resistant infections. Synonyms: 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-8-methyl-4-oxo-7-[3-(propan-2-ylamino)azetidin-1-yl]quinoline-3-carboxylic acid; 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-(isopropylamino)azetidin-1-yl)-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WQ-3810; WQ 3810; WQ3810. CAS No. 888032-58-4. Molecular formula: C22H22F3N5O3. Mole weight: 461.44.
2-Amino-3-methyl-3H-imidazo[4,5-H]quinoline
A closely related isomer to the heterocyclic food mutagen IQ. Useful for biological and structure-activity studies of IQ. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
2-Oxo-Zoniporide, HCl
2-Oxo-Zoniporide is an metabolite of Zoniporide, a potent and selective inhibitor of human sodium-hydrogen exchanger isoform1(NHE-1) and protects against cardiac ischemia-reperfusion injury. Group: Biochemicals. Alternative Names: N-(Aminoiminomethyl)-5-cyclopropyl-1-(1,2-dihydro-2-oxo-5-quinolinyl)-1H-pyrazole-4-carboxamide Hydrochloride. Grades: Highly Purified. CAS No. 372078-42-7. Pack Sizes: 1mg. Molecular Formula: C17H17ClN6O2, Molecular Weight: 372.81. US Biological Life Sciences.
Worldwide
Bederocin
Bederocinis a MetS(methionyl-tRNA synthetase) inhibitor with antibacterial activity against clinical isolates of Staphylococcus aureus, Streptococcus pyogenes, and other clinically important gram-positive bacteria. But Bederocinis has little activity against gram-negative bacteria. Uses: Antibacterials. Synonyms: REP8839; REP-8839; REP 8839; 4(1H)-Quinolinone, 2-((3-(((4-bromo-5-(1-fluoroethenyl)-3-methyl-2-thienyl)methyl) mino)propyl)amino)-. Grades: 98%. CAS No. 757942-43-1. Molecular formula: C20H21BrFN3OS. Mole weight: 450.37.
Cletoquine oxalate
Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment. Group: Inhibitors. Alternative Names: 2-[[4-[ (7-Chloro-4-quinolinyl) amino]pentyl]amino]ethanol Oxalate; (+/-)-Desethylhydroxychloroquine Oxalate. CAS No. 14142-64-4. Molecular formula: C18H24ClN3O5. Mole weight: 397.85. Appearance: Brown Solid. Purity: 0.96. IUPACName: 2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol;oxalic acid. Canonical SMILES: CC(CCCNCCO)NC1=C2C=CC(=CC2=NC=C1)Cl. C(=O)(C(=O)O)O. Catalog: ACM14142644.
dCBP-1
dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand. dCBP-1 is exceptionally potent at killing multiple myeloma cells and can abolish the enhancer that drives MYC oncogene expression. As an efficient degrader of this unique class of acetyltransferases, dCBP-1 is a useful tool alongside domain inhibitors for dissecting the mechanism by which these factors coordinate enhancer activity in normal and diseased cells. Group: Others. Alternative Names: dCBP-1; dCBP 1; dCBP1. CAS No. 2484739-25-3. Molecular formula: C51H63F2N11O10. Mole weight: 1028.13. Appearance: Solid powder. Purity: >98%. IUPACName: 5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1Hpyrazol-4-yl)-1(2H)-quinolinyl]-1-[1-[15-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-4-piperidinyl]-1,4,6,7-tetrahydro-N-methyl-. Canonical SMILES: O=C (N1CCC (N (C2CCN (C (CCOCCOCCOCCOCCNC3=CC4=C (C (N (C (CC5) C (NC5=O) =O) C4=O) =O) C=C3) =O) CC2) N=C6N7CCCC8=C7C=C (C (F) F) C (C9=CN (C) N=C9) =C8) =C6C1) NC. Catalog: ACM2484739253.
Ethyl 2- (2-isobutyl-6-quinolyloxy-8-p-toluenesulfonamido) acetate. Group: Biochemicals. Alternative Names: 2-[[8-[[ (4-Methylphenyl) sulfonyl]amino]-2- (2-methylpropyl) -6-quinolinyl]oxy]acetic acid ethyl ester. Grades: Highly Purified. CAS No. 316124-91-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C24H28N2O5S. US Biological Life Sciences.
Worldwide
Nadifloxacin isomer 4
An impurity of Nadifloxacin, which is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Synonyms: 8-amino-9-fluoro-5-methyl-1,7-dioxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic acid. Grades: > 95%. Molecular formula: C15H15FN2O4. Mole weight: 306.3.
Procaterol HCl
Procaterol hydrochloride is a long-acting, very potent and specific beta-2-adrenergic receptor agonist. It acts as a vasodialator for long term treatment of asthma. It was developed by Pfizer. Uses: Procaterol hydrochloride acts as a vasodialator for long term treatment of asthma. Synonyms: 5-(1-Hydroxy-2-isopropylamino)butyl-8-hydroxycarbostyril hydrochloride;8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1h)-quinolinonmono;(R*,S*)-(±)-8-Hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]quinolin-2(1H)-one monohydrochloride;CI-888;CI888. Grades: 95%. CAS No. 62929-91-3. Molecular formula: C16H23ClN2O3. Mole weight: 326.82.
Saquinavir-d9
Labeled Saquinavir. A selective HIV protease inhibitor. Antiviral. Group: Biochemicals. Alternative Names: (2S) -N1 [ (1S, 2R) -3- [ (3S, 4aS, 8aS) -3- [ [ (1, 1-Dimethylethyl) amino] carbonyl] octahydro-2- (1H) -isoquinolinyl] -2-hydroxy-1- (phenylmethyl) propyl] -2- [ (2-quinolinylcarbonyl) amino] butanediamide-d9; Fortovase-d9; Invirase-d9; Ro 31-8959-d9. Grades: Highly Purified. CAS No. 1356355-11-7. Pack Sizes: 1mg. US Biological Life Sciences.
An isomerous impurity of Indacaterol. Indacaterol is an ultra-long-acting β-adrenoceptor agonist used as an oral inhaled bronchodilator. It is indicated for the treatment of patients with chronic obstructive pulmonary disease (COPD). Synonyms: 5-[(1S)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-2(1H)-quinolinone. Grades: 95%. CAS No. 1235445-80-3. Molecular formula: C24H28N2O3. Mole weight: 392.499.
Vedroprevir
Vedroprevir is a selective hepatitis C virus (HCV) NS3 protease inhibitor. It is a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1(GT1) infection. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion. It retained wild-type activity against multiple classes of NS5B and NS5A inhibitor resistance mutations. It showed good oral bioavailability in all three species tested. It was developed by Gilead Sciences and was terminated in clinic phase 2 trials. Uses: Vedroprevir is a pharmaceutical drug that is used in the treatment of hepatitis c virus in patients with hcv genotype 1(gt1) infection. Synonyms: GS9451; GS-9451; GS 9451; Vedroprevir; (1R,2R)-N-[[(1alpha,3beta,5alpha)-Bicyclo[3.1.0]hex-3-yloxy]carbonyl]-3-methyl-L-valyl-(4R)-4-[[8-chloro-2-[2-[(1-methylethyl)amino]-4-thiazolyl]-7-[2-(4-morpholinyl)ethoxy]-4-quinolinyl]oxy]-L-prolyl-1-amino-2-ethyl-cyclopropanecarboxylic acid;GS9451;GS-9451;(1R,2R)-1-((2S,4R)-1-((2S)-2-(((((1R,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)carbonyl)amino)-3,3-dimethylbutanoyl)-4-((8-chloro-2-(2-(isopropylamino)thiazol-4-yl)-7-(2-morpholinoethoxy)quinolin-4-yl)oxy)pyrrolidine-2-carboxamido)-2-ethylcyclopropane-1-carboxylic acid. Grades: >98%. CAS No. 1098189-15-1. Molecular formula: C45H60ClN7O9S. Mole weight: 910.52.
Zoniporide hydrochloride
Zoniporide hydrochloride is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1), which is mostly expressed in the heart. Zoniporide inhibits NHE1-dependent Na+ uptake (IC50: 14 nM) and protects from cardiac ischemia-reperfusion injury (EC50 = 0.25 nM). Synonyms: N-(aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide monohydrochloride. Grades: 99%. CAS No. 241800-97-5. Molecular formula: C17H16N6O.HCl. Mole weight: 356.81.
Zoniporide Hydrochloride
Zoniporide is a potent and selective inhibitor of human sodium-hydrogen exchanger isoform1(NHE-1) and protects against cardiac ischemia-reperfusion injury. Group: Biochemicals. Alternative Names: N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide Hydrochloride;CP 597396 Hydrochloride; N-[5-Cyclopropyl-1-(quinolin-5-yl)-1H-pyrazole-4-carbonyl]guanidine Hydrochloride; [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine Hydrochloride. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
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