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2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a food-derived carcinogen that is found in high temperature-cooked fish and meat. In humans, PhIP is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts, which are directly correlated with increased risk of breast, colon, and prostate cancers. Synonyms: PhIP; 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine. Grades: ≥98%. CAS No. 105650-23-5. Molecular formula: C13H12N4. Mole weight: 224.3.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (2-Amino-1-Me-6-PhIP) N-b-D-glucuronide is an indispensable tool in the realm of biomedicine. This particular chemical derivative assumes a pivotal role in the comprehensive exploration of the intricate processes of metabolism and detoxification surrounding the highly potent mutagen, 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine - a prevalent entity present in thermally processed meats. Synonyms: 1-Deoxy-1-[(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]-b-D-glucopyranuronic acid PhIP-N-b-D-glucuronide. CAS No. 133084-70-5. Molecular formula: C19H20N4O6. Mole weight: 400.39.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N-β-D-Glucuronide Sodium Salt
Carcinogenic Sodium Salt, is a metabolite of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Synonyms: 1-Deoxy-1-[(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]-β-D-glucopyranuronic Acid Sodium Salt; PhIP-N-β-D-glucuronide Sodium Salt. Grades: 97%. Molecular formula: C19H19N4NaO6. Mole weight: 422.37.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N- β-D-Glucuronide Triacetate is an intermediate in the synthesis of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N- β-D-Glucuronide Sodium Salt which is a carcinogenic Sodium Salt, is a metabolite of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) (A617000). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C26H28N4O9, Molecular Weight: 540.52. US Biological Life Sciences.
The DNA adduct formed from N-Hydroxy-PHIP. Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV. Synonyms: 2'-Deoxy-8-[(1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl)amino]guanosine; dG-C8-PhIP. Grades: 96%. CAS No. 142784-25-6. Molecular formula: C23H23N9O4. Mole weight: 489.49.
The DNA adduct formed from N-Hydroxy-PHIP. Group: Biochemicals. Alternative Names: dG-C8-PHIP. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences.
1-(2-amino-5-phenylpyridin-3-yl)-1-methylthiourea N- β-D-Glucuronide Methyl Ester Triacetate is an intermediate in the synthesis of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N- β-D-Glucuronide Sodium Salt which is a carcinogenic Sodium Salt, is a metabolite of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) (A617000). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C26H30N4O9S, Molecular Weight: 574.6. US Biological Life Sciences.
1-Deoxy-1-thiocyanato-glucopyranuronic Acidmethyl Ester Triacetate is an intermediate in the synthesis of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine N- β-D-Glucuronide Sodium Salt which is a carcinogenic Sodium Salt, is a metabolite of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) (A617000). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 50mg. Molecular Formula: C14H17NO9S, Molecular Weight: 375.35. US Biological Life Sciences.
Worldwide
AVE 0991
AVE 0991 is an agonist of nonpeptide Ang-(1-7) receptor Mas that has potential as a cardiovascular drug. Synonyms: 1-ethyl-3-[3-[4-[(5-formyl-4-methoxy-2-phenylimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylurea5-formyl-4-methoxy-2-phenyl-1-((4-(2-ethyl-aminocarbonylsulfonamido-5-isobutyl-3-thienyl)phenyl)methyl)imidiazoleAVE 0991; AVE-0991; AVE0991. CAS No. 304462-19-9. Molecular formula: C29H32N4O5S2. Mole weight: 580.72.
Chlorophyllin sodium copper salt
Chlorophyllin sodium copper salt. Synonyms: Chlorophyllin, coppered trisodium salt. CAS No. 11006-34-1. Pack Sizes: 5, 25, 100 g in glass bottle. Product ID: CDC10-0144. Molecular formula: C34H31CuN4Na3O6. Category: Cosmetic Color Additives. Product Keywords: Cosmetic Ingredients; Cosmetic Color Additives; Chlorophyllin sodium copper salt; CDC10-0144; 11006-34-1; C34H31CuN4Na3O6; Chlorophyllin, coppered trisodium salt; 234-242-5; 11006-34-1. Grade: commercial grade. Purity: 0.99. Color: Dark Green to Black. EC Number: 234-242-5. Physical State: Powder. Solubility: H2O: 100 mg/mL, dark green. Quality Level: 200. Storage: 2-8°C. Application: Chlorophyllin sodium copper salt has been used to study the effect of chlorophyllin against radiation-induced hematopoietic syndrome. It has been used to study the effect of chlorophyllin on the excretion of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its metabolites into the breast-milk of lactating rats. Boiling Point: N/A. Melting Point: >300°C.
PhIP
PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat [1] [2]. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. CAS No. 105650-23-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118716.
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