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| Product | Description | |
|---|---|---|
| Aminopterin | Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a K i of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Aminofolic acid; APGA. CAS No. 54-62-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14518. |  |
| Aminopterin | Aminopterin. Group: Biochemicals. Alternative Names: N-[4-[[ (2, 4-Diamino-6-pteridinyl) methyl]amino]benzoyl]-L-glutamic acid; 4-Aminofolic acid, 4-aminopteroyl-L-glutamic acid, 4-amino-PGA; NSC 739. Grades: Highly Purified. CAS No. 54-62-6. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C19H20N8O5. US Biological Life Sciences. |  Worldwide |
| Aminopterin (4-Aminofolic Acid, 4-Aminopteroyl-L-glutamic Acid, 4-Amino-PGA) | A folic acid antag. Group: Biochemicals. Alternative Names: 4-Aminofolic Acid, 4-Aminopteroyl-L-glutamic Acid, 4-Amino-PGA. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Aminopterin 7-Carboxamide | Aminopterin 7-Carboxamide. Group: Biochemicals. Alternative Names: N-[4-[[ (2, 4-Diamino-7-carboxamide-6-pteridinyl) methyl]amino]benzoyl]-L-glutamic Acid. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Aminopterin 7-Carboxamide Dimethyl Ester | Aminopterin 7-Carboxamide Dimethyl Ester. Group: Biochemicals. Alternative Names: N-[4-[[ (2, 4-Diamino-7-carboxamide-6-pteridinyl) methyl]amino]benzoyl]-L-glutamic Acid Dimethyl Ester. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Aminopterin hydrate | 100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C19H20N8O5. CAS No. 54-62-6. Prepack ID 38080224-100mg. Molecular Weight 440.41. See USA prepack pricing. |  |
| Aminopterin hydrate | 25mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C19H20N8O5. CAS No. 54-62-6. Prepack ID 38080224-25mg. Molecular Weight 440.41. See USA prepack pricing. | |
| 7-Hydroxy Aminopterin | The 7-hydroxy metabolite of Aminopterin as substrate for folylpolyglutamate synthetase (FPGS). Group: Biochemicals. Alternative Names: N-[4-[[ (2, 4-Diamino-7, 8-dihydro-7-oxo-6-pteridinyl) methyl]amino]benzoyl]-L-glutamic Acid; N-[p-[[ (2, 4-Diamino-7-hydroxy-6-pteridinyl) methyl]amino]benzoyl]-L-glutamic Acid; N-[4-[[ (2, 4-Diamino-1, 7-dihydro-7-oxo-6-pteridinyl) methyl]amino]benzoyl]- L-Glutamic Acid. Grades: Highly Purified. CAS No. 97772-99-1. Pack Sizes: 1mg, 2mg. US Biological Life Sciences. | Worldwide |
| 7-Hydroxy Aminopterin 1-Carboxylic Acid Ethyl Ester | 7-Hydroxy Aminopterin 1-Carboxylic Acid Ethyl Ester. Group: Biochemicals. Alternative Names: 7-Hydroxy-1-carboxy-aminopterin ; N- [p- [ [1- (7-Hydroxy-2, 4-diamino-6-pteridinyl) -1-carboxymethyl] amino] benzoyl] -glutamic Acid Ethyl Ester. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C22H24N8O8, Molecular Weight: 528.47. US Biological Life Sciences. | Worldwide |
| Edatrexate | Edatrexate is a polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. Uses: Antineoplastic agents. Synonyms: 10-ethyl-deaza-aminopterin; 10-EDAM; 10 EDAM; 10EDAM; CGP-30694; CGP30694; CGP30694; D 03942; D-03942; D03942. CAS No. 80576-83-6. Molecular formula: C22H25N7O5. Mole weight: 467.49. |  |
| Pralatrexate | Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Uses: Aminopterin/ analogs & derivatives; folic acid antagonists. Synonyms: Pralatrexate;Folotyn; 10-Propargyl-10-deazaaminopterin; HSDB 7786; pralatrexato; pralatrexatum; PDX; CHEBI:71223; NSC-754230; UNII-A8Q8I19Q20; Pralatrexate(Folotyn); DTXSID3048578; A8Q8I19Q20; (2S)-2-(4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzamido)pentanedioic acid; N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid; L-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-; DTXCID3028504; 146464-95-1 (racemic); NSC754230; NSC 754230; (2S)-2-((4-((1RS)-1-((2,4-Diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acid; NCGC00242596-01; (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid. Grades: >98%. CAS No. 146464-95-1. Molecular formula: C23H23N7O5. Mole weight: 477.47. | |
| Talotrexin ammonium | Talotrexin ammonium is the ammonium salt of an antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance. Synonyms: PT-523; PT 523; PT523; NSC 712783; NSC712783; NSC-712783; N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine. CAS No. 648420-92-2. Molecular formula: C28H34N10O6. Mole weight: 590.60. | |
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