Angiopoietin Suppliers USA
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Product | Description | |
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CEP-11981 Quick inquiry Where to buy Suppliers range | CEP-11981 is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death. VEGFR and Tie2 are frequently overexpressed by a variety of tumor cell types and play crucial roles in the regulation of angiogenesis and the maintenance of tumor blood vessels. Tie2 (tyrosine kinase with immunoglobulin-like and EGF-like domains) is activated by angiopoietin-1 (Ang-1). Synonyms: CEP-11981; CEP 11981; CEP11981. CAS No. 856691-93-5. Molecular formula: C28H27N7O. Mole weight: 477.57. | |
Nesvacumab Quick inquiry Where to buy Suppliers range | Nesvacumab is a human monoclonal antibody targeting Angiopoietin 2. Nesvacumab has the potential for the treatment of various cancers. CAS No. 1296818-77-3. | |
Q-Peptide Quick inquiry Where to buy Suppliers range | This sequence belongs to the integrin motif of the Ang1 and Ang2 fibrinogen-like (fbg-lk) domain and has been found conserved in mice, rats, humans, and other species. Synonyms: Angiopoietin-1 (312-318) (bovine); L-Serine, L-glutaminyl-L-histidyl-L-arginyl-L-α-glutamyl-L-α-aspartylglycyl-; H-Gln-His-Arg-Glu-Asp-Gly-Ser-OH. Grades: ≥95%. CAS No. 1361235-89-3. Molecular formula: C31H49N13O14. Mole weight: 827.81. | |
Tie2 Inhibitor 7 Quick inquiry Where to buy Suppliers range | Tie2 Inhibitor 7 is a selective inhibitor of Tie2 kinase activity with Ki value of 1.3 μM. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with IC50 value of 0.3 μM. Synonyms: (S) -5- (4- ( ( (2- ( (1-Cyclohexylethyl) amino) -2-oxoethyl) ( (p-tolyloxy) carbonyl) amino) methyl) phenyl) nicotinic acid; 5-[4-[[[2-[[ (1S) -1-Cyclohexylethyl]amino]-2-oxoethyl]- (4-methylphenoxy) carbonylamino]methyl]phenyl]pyridine-3-carboxylic acid. Grades: ≥95%. CAS No. 1020412-97-8. Molecular formula: C31H35N3O5. Mole weight: 529.6. |