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| Product | Description | |
|---|---|---|
| CEP-11981 | CEP-11981 is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death. VEGFR and Tie2 are frequently overexpressed by a variety of tumor cell types and play crucial roles in the regulation of angiogenesis and the maintenance of tumor blood vessels. Tie2 (tyrosine kinase with immunoglobulin-like and EGF-like domains) is activated by angiopoietin-1 (Ang-1). Synonyms: CEP-11981; CEP 11981; CEP11981. CAS No. 856691-93-5. Molecular formula: C28H27N7O. Mole weight: 477.57. |  |
| Evinacumab | Evinacumab (REGN1500) is a human anti- ANGPTL3 ( angiopoietin-like protein 3 ) monoclonal antibody (IgG4 class antibody). Evinacumab reduces plasma lipids in dyslipidemic mice by blocking ANGPTL3. Evinacumab can be used in studies of homozygous familial hypercholesterolaemia (HoFH), refractory hypercholesterolaemia (both familial and non-familial) and severe hypertriglyceridaemia [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: REGN1500. CAS No. 1446419-85-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99194. |  |
| Faricimab | Faricimab, an overall good safety and tolerability profile, is a bispecific antibody targeting Angiopoietin-2 ( Ang-2 ) and vascular endothelial growth factor-A ( VEGF-A ). Faricimab prevents retinal vascular leakage, cell death and inflammation in retinal ischemia/reperfusion (I/R) injury and sCNV mouse models. Faricimab demonstrates statistically superior visual acuity gains versus Ranibizumab (HY-P9951). Faricimab can be used for retinal diseases, such as age-related macular degeneration (w-AMD), diabetic macular edema (DME) and macular edema following retinal vein occlusion (RVO) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: RG7716. CAS No. 1607793-29-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99116. | |
| Nesvacumab | Nesvacumab is a human monoclonal antibody targeting Angiopoietin 2. Nesvacumab has the potential for the treatment of various cancers. CAS No. 1296818-77-3. | |
| Q-Peptide | This sequence belongs to the integrin motif of the Ang1 and Ang2 fibrinogen-like (fbg-lk) domain and has been found conserved in mice, rats, humans, and other species. Synonyms: Angiopoietin-1 (312-318) (bovine); L-Serine, L-glutaminyl-L-histidyl-L-arginyl-L-α-glutamyl-L-α-aspartylglycyl-; H-Gln-His-Arg-Glu-Asp-Gly-Ser-OH. Grades: ≥95%. CAS No. 1361235-89-3. Molecular formula: C31H49N13O14. Mole weight: 827.81. | |
| Tie2 Inhibitor 7 | Tie2 Inhibitor 7 is a selective inhibitor of Tie2 kinase activity with Ki value of 1.3 μM. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with IC50 value of 0.3 μM. Synonyms: (S) -5- (4- ( ( (2- ( (1-Cyclohexylethyl) amino) -2-oxoethyl) ( (p-tolyloxy) carbonyl) amino) methyl) phenyl) nicotinic acid; 5-[4-[[[2-[[ (1S) -1-Cyclohexylethyl]amino]-2-oxoethyl]- (4-methylphenoxy) carbonylamino]methyl]phenyl]pyridine-3-carboxylic acid. Grades: ≥95%. CAS No. 1020412-97-8. Molecular formula: C31H35N3O5. Mole weight: 529.6. | |
| Trebananib | Trebananib (2xCon4C; AMG 386) is an Fc fusion peptibody that prevents Tie2 receptor activation through binding of both angiopoietin 1 (Ang1) and Ang2. Trebananib has anti-angiogenesis activity [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: 2xCon4C; AMG 386. CAS No. 894356-79-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99546. | |
| Vanucizumab | Vanucizumab is a first-in-class, bispecific IgG1-like monoclonal antibody that simultaneously blocks VEGF-A and angiopoietin-2 (Ang-2) from interacting with their receptors. Vanucizumab has antiangiogenic and anticancer effects [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human VEGFA Recombinant Antibody; RO5520985. CAS No. 1448221-05-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99330. | |
| Vasculotide | Vasculotide, an angiopoietin-1 mimetic, is a Tie-2 activator and induces Tie-2 phosphorylation. Vasculotide has anti-inflammatiory effect and anti-permeability. Vasculotide ameliorates endotoxin-induced endothelial barrier dysfunction. Vasculotide promotes angiogenesis in a mouse model of diabetic ulcer. Vasculotide protects mice from vascular leakage and reduces mortality in murine abdominal sepsis. Vasculotide decreases microvascular leakage and improves microcirculatory perfusion in a rat model of hemorrhagic shock [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 1359657-45-6. Pack Sizes: 1 mg. Product ID: HY-P10580. | |
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