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| Product | Description | |
|---|---|---|
| Angiostatin | It is produced by the strain of Dihetrospora catenulata SANK 10481, D. chlamidospora SANK 12181, Verticillum viveostratosum SANK 13358. It has the function of inhibiting Angiotensin converting enzyme. Synonyms: ANGIO. CAS No. 86090-08-6. Molecular formula: C9H14N2O8. Mole weight: 278.21. |  |
| Angiostatin K1-3 human | recombinant, expressed in E. coli, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| Monoclonal Anti-Angiostatin antibody produced in mouse | clone 79735, purified immunoglobulin, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Thapsigargin | A widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca(2+)-ATPases in mammalian cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium releaser that blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. It induces apoptosis by disrupting intracellular free Ca2+ levels. Group: Biochemicals. Alternative Names: Octanoic Acid (3S, 3aR, 4S, 6S, 6aR, 7S, 8S, 9bS)-6-(Acetyloxy)-2, 3, 3a, 4, 5, 6, 6a, 7, 8, 9b- decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester; (-)-Thapsigargin; Octanoic Acid [3S-[3α,3a β,4α,6 β,6a β,7 β, 8α(Z), 9bα]]-6-(Acetyloxy)-2, 3, 3a, 4, 5, 6, 6a, 7, 8, 9b-decahydro-3, 3a-dihydroxy-3, 6, 9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4, 5-b]furan-7-yl Ester. Grades: Highly Purified. CAS No. 67526-95-8. Pack Sizes: 2.5mg. US Biological Life Sciences. |  Worldwide |
| Thapsigargin | Potent, cell-permeable, IP3-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. Induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemotherapeutic prodrug formulations. In cells, sarco/endoplasmic calcium ATPases (SERCAs) transport free calcium into the sarcoplasmic and endoplasmic reticula, lowering intracellular calcium levels to stop signaling through this cation. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM). Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells. In vivo, thapsigargin and related sesquiterpene lactones have anti-inflammatory and anti-cancer effects. Uses: Enzyme inhibitors. Synonyms: Octanoic acid. Grades: >99%. CAS No. 67526-95-8. Molecular formula: C34H50O12. Mole weight: 650.75. | |
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