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Angiotensin II is a Vasoconstrictor that plays an endocrine role in the regulation of blood pressure, fluid and electrolyte homeostasis. Synonyms: Hypertensin; Human angiotensin II; Ang II; Asp-Arg-Val-Tyr-X-His-Pro-Phe; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-X-L-histidyl-L-prolyl-L-phenylalanine; 1-8-Angiotensin I; Angiotensin 2; Angiotensin AT2; MeSH ID: D000804. CAS No. 11128-99-7.
Angiotensin II (1-4), human
Angiotensin II (1-4), human is an endogenous peptide produced from ATI by angiotensin-converting-enzyme (ACE). Synonyms: H-DRVY-OH; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosine; (S)-3-amino-4-((S)-1-((S)-1-((S)-1-carboxy-2-(4-hydroxyphenyl)ethylamino)-3-methyl-1-oxobutan-2-ylamino)-5-guanidino-1-oxopentan-2-ylamino)-4-oxobutanoic acid; L-α-Aspartyl-N5-(diaminomethylene)-L-ornithyl-L-valyl-L-tyrosine. Grades: ≥95%. CAS No. 52580-29-7. Molecular formula: C24H37N7O8. Mole weight: 551.59.
Angiotensin II (3-8), human
Angiotensin II (3-8), human is a less effective agonist of the angiotensin AT1 receptor. Synonyms: 3-8-Angiotensin II; Angiotensin II, 1-de-L-aspartic acid-2-de-L-arginine-; Angiotensin IV; 3-8-Angiotensin; 3-8-Angiotensin II hexapeptide; Angiotensin II C-terminal hexapeptide; Angiotensin II3-8; Des-1,2-angiotensin II. Grades: ≥95%. CAS No. 12676-15-2. Molecular formula: C40H54N8O8. Mole weight: 774.91.
Angiotensin II (5-8), human
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II. Synonyms: Angiotensin (5-8); H-IHPF-OH; L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine; Angiotensin II (5-8) (human, rat, mouse). Grades: ≥95%. CAS No. 34233-50-6. Molecular formula: C26H36N6O5. Mole weight: 512.60.
Angiotensin II 5-valine TFA
Angiotensin II 5-valine is an agonist of angiotensin receptor. Synonyms: Valine angiotensin II TFA; 5-L-Valine angiotensin II TFA. Molecular formula: C51H70F3N13O14. Mole weight: 1146.18.
Angiotensin II human
Angiotensin II human Inhibitor. Uses: Scientific use. Product Category: T7040. CAS No. 4474-91-3.
Angiotensin III (human, mouse)
Angiotensin III (Ang III) is generated from Ang II by APA (and subsequently degraded by aminopeptidase N), and that central Ang III seems to play a key-role in vasopressin release and BP control. Angiotensin III, human, mouse is a heptapeptide agonist, which acts as an endogenous angiotensin type 2 receptor (AT2R) agonist. The IC50 values for AT2R is 0.648 nM and the IC50 values for AT1R is 21.1 nM. The biologically active COOH-terminal heptapeptide angiotensin III is bound more tightly than angiotensin II. Synonyms: H-Arg-Val-Tyr-Ile-His-Pro-Phe-OH; L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine; Ang III; Angiotensin III; 5-Ile-angiotensin III; 1-Desaspartyl-5-isoleucine angiotensin II; Des-asp(1)-(Ile(5))-angiotensin II; N5-(Diaminomethylene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine; 2-8-angiotensin II, 5-L-isoleucine-. Grades: ≥95%. CAS No. 13602-53-4. Molecular formula: C46H66N12O9. Mole weight: 931.09.
5-L-Isoleucineangiotensin II is an endogenous potent vasoconstrictor peptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE) by binding to both the AT1 and the AT2 receptors. Uses: An endogenous potent vasoconstrictor peptide. Synonyms: 5-Isoleucine-angiotensin II; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine; Angiotensin II human; Human angiotensin II; Hypertensin; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH; Angiotensin II, 5-L-isoleucine-; Alanine, N-[1-[N-[N-[N-[N-(N2-L-α-aspartyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-isoleucyl]-L-histidyl]-L-prolyl]-3-phenyl-, L-; 5-L-Isoleucine-angiotensin II; L-Phenylalanine, N-[1-[N-[N-[N-[N-(N2-L-α-aspartyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-isoleucyl]-L-histidyl]-L-prolyl]-; [Ile5]-Ang II; [Ile5]-Angiotensin II; Angiotensin 2; Angiotensin II; Angiotensin II (human); Angiotensin II (mouse); Angiotensin II [Ile5]; Asp1-Ile5-angiotensin II; Human angiotensin II; Ileu5-angiotensin II; Isoleucyl5-angiotensin II. Grades: 98%. CAS No. 4474-91-3. Molecular formula: C50H71N13O12. Mole weight: 1046.19.
Angiotensin I/II 1-6
Angiotensin I/II 1-6 is a peptide containing amino acids 1-6 that is converted from Angiotensin I/II. Synonyms: H-Asp-Arg-Val-Tyr-Ile-His-OH; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidine; Angiotensin (1-6); 1-6-Angiotensin II, 5-L-isoleucine-; Angiotensin 1/2 1-6; L-α-Aspartyl-N5-(diaminomethylene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidine. Grades: ≥95%. CAS No. 47896-63-9. Molecular formula: C36H55N11O10. Mole weight: 801.89.
Angiotensin I/II (1-7)
Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor, inducing vasorelaxation through release of NO and prostaglandins. Uses: Endogenous peptide fragment. Synonyms: Angiotensin II (1-7) heptapeptide; TXA127; TXA 127; TXA127; Angiotensin i (1-7); therapeutic angiotensin(17)H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH. Grades: ≥90%. CAS No. 51833-78-4. Molecular formula: C41H62N12O11. Mole weight: 899.
[Asn1,Val5]-Angiotensin II
[Asn1,Val5]-Angiotensin II, an octapeptide amide of bovine angiotensin II, is used to increase blood pressure through vasoconstriction. It is a potent vasoconstrictor and a cardiac activator. Uses: Vasoconstrictor agents. Synonyms: Angiotensin amide; Angiotensin; Angiotensinamide; Hypertensine; NSC 107678; 1-L-Asparagine-5-L-valineangiotensin II; Alanine, N-[1-[N-[N-[N-[N-(N2-L-asparaginyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-valyl]-L-histidyl]-L-prolyl]-3-phenyl-, L-; 1-L-Asn-5-L-Val-angiotensin II; 1-L-Asparagine-5-L-valine angiotensin II; 1-Asn2-5-Val-angiotensin II; 1-α-Asparagine-5-valine-angiotensin II; 5-L-Valine-angiotensin II amide; 5-Valine angiotensin amide II; 5-Valine angiotensin II amide; Angiotensin II (Oncorhynchus mykiss); Angiotensin II amide; Angiotensin II amide 5-valine; Hypertensin; Hypertensinamide; Ipertensina; Rainbow trout angiotensin II; Val-Hypertensin-II-asp-β-amide; Val5-angiotensin II amide. Grades: >98%. CAS No. 53-73-6. Molecular formula: C49H70N14O11. Mole weight: 1031.17.
[Asn1,Val5]-Angiotensin II acetate
[Asn1,Val5]-Angiotensin II acetate, an octapeptide amide of bovine angiotensin II, is used to increase blood pressure through vasoconstriction. It is a potent vasoconstrictor and a cardiac activator. Synonyms: H-Asn-Arg-Val-Tyr-Val-His-Pro-Phe-OH.CH3CO2H; L-asparagyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanine acetic acid; Angiotensin II, 1-L-asparagine-5-L-valine-, acetate (1:1); 1-L-Asn-5-L-Val-angiotensin II acetate; Angiotensin II-5-valine-amide acetate; Hypertensin acetate; Hypertensinamide acetate; 1-L-Asparagine-5-L-valine angiotensin II acetate; Angiotensin amide acetate. Grades: ≥95%. CAS No. 1233495-09-4. Molecular formula: C51H74N14O13. Mole weight: 1091.24.
[Ile5]-Angiotensin II (3-8) TFA
[Ile5]-Angiotensin II (3-8) TFA is a less effective agonist of the angiotensin AT1 receptor. Synonyms: H-Val-Tyr-Ile-His-Pro-Phe-OH.TFA; L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine trifluoroacetic acid; 5-L-Isoleucine-3-8-angiotensin II trifluoroacetate salt; (3-8)-5-Isoleucine-angiotensin II trifluoroacetate salt; Ile3-angiotensin IV trifluoroacetate salt; [Ile5]-angiotensin II (3-8) trifluoroacetate salt; Angiotensin IV TFA. Grades: ≥95%. Molecular formula: C40H54N8O8.C2HF3O2. Mole weight: 888.94.
[Ile7]-angiotensin iii
[Ile7]-angiotensin iii. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (ILE7)-ANGIOTENSIN III ACETATE HYDRATE. Product Category: Heterocyclic Organic Compound. Appearance: White powder. CAS No. 102029-49-2. Molecular formula: C43H68N12O9. Mole weight: 897.08. Product ID: ACM102029492. Alfa Chemistry ISO 9001:2015 Certified. Categories: 7-Isoleucine-aiii.
[Sar1, Ala8]-Angiotensin II
[Sar1, Ala8]-Angiotensin II is a competitive angiotensin II antagonist. Synonyms: SAR-ARG-VAL-TYR-ILE-HIS-PRO-ALA. Grades: ≥97% by HPLC. CAS No. 38027-95-1. Molecular formula: C43H67N13O10. Mole weight: 926.07.
(Sar1)-Angiotensin II
(Sar1)-Angiotensin II is a specific agonist of angiotensin AT1 receptor. It binds to brain membrane-rich particles, with a Kd of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes. Synonyms: 1-Sar-5-ile-angiotensin II; Angiotensin II, sarcosyl(1)-isoleucine(5)-. CAS No. 51833-69-3. Molecular formula: C49H71N13O10. Mole weight: 1002.17.
(Sar1)-Angiotensin II acetate
(Sar1)-Angiotensin II acetate is a specific agonist of the angiotensin AT1 receptor that binds to brain membrane-rich particles, with a Kd of 2.7 nM. (Sar1)-Angiotensin II acetate can stimulate protein synthesis and cell growth in embryonic chick myocytes. Synonyms: H-Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH.CH3CO2H; sarcosyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine acetic acid. Grades: ≥95%. CAS No. 2863657-02-5. Molecular formula: C51H75N13O12. Mole weight: 1062.22.
[Sar1,Ile8]-Angiotensin II
It is a specific antagonist of angiotensin receptor, and it is also a peptide that has multiple effect on vascular smooth muscle. Synonyms: Sarilesin; H-Sar-Arg-Val-Tyr-Ile-His-Pro-Ile-OH; sarcosyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-isoleucine. Grades: ≥95%. CAS No. 37827-06-8. Molecular formula: C46H73N13O10. Mole weight: 968.15.
1,1,1-Trimethoxybutane is used in the synthesis of angiotensin II receptor antagonists affecting blood pressure. Also used in the preparation of inhibitors of cyclin-dependant kinases. Group: Biochemicals. Alternative Names: Trimethyl Ester Orthobutyric Acid; 1,1,1-Trimethoxybutane; Methyl Orthobutyrate; Trimethyl Orthobutanoate; Trimethyl Orthobutyrate. Grades: Highly Purified. CAS No. 43083-12-1. Pack Sizes: 5g. US Biological Life Sciences.
3-acetamidophthalic acid is an impurity of Azilsartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure. Synonyms: 1-[(2'-Carbamoylbiphenyl-4-yl)methyl]?-2-ethoxybenzimidazole-7-carboxylic Acid. CAS No. 1696392-11-6. Molecular formula: C24H21N3O4. Mole weight: 415.44.
Intermediate in the synthesis of angiotensin II receptor antagonist. Group: Biochemicals. Alternative Names: 3-[(2'-Cyanobiphenyl-4-yl)methyl]-2-ethoxy-3H-benzimidazole-4-carboxylic Acid Methyl Ester; Methyl 1-[(2'-Cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate. Grades: Highly Purified. CAS No. 139481-44-0. Pack Sizes: 10mg. US Biological Life Sciences.
Intermediate in the synthesis of angiotensin II receptor antagonist. Group: Biochemicals. Alternative Names: 3-[(2'-Cyanobiphenyl-4-yl)methyl]-2-ethoxy-d5-3H-benzimidazole-4-carboxylic Acid Methyl Ester; Methyl 1-[(2'-Cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate-d5. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
1-[[2'-(Methoxycarbonyl)[1,1'-biphenyl]-4-yl]methyl]-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic Acid Methyl Ester is an intermediate in the synthesis of Telmisartan (T017000), an angiotensin II receptor antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 916332-38-2. Pack Sizes: 500mg. US Biological Life Sciences.
1-[[2'-(Methoxycarbonyl)[1,1'-biphenyl]-4-yl]methyl]-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic Acid Methyl Ester is one of telmisartan intermediates. Telmisartan, also called Pritor, a benzimidazole derivative, is an angiotensin II receptor antagonist that can be used to treat hypertension. Synonyms: Methyl 1-((2'-(methoxycarbonyl)-[1,1'-biphenyl]-4-yl)methyl)-4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate; Methyl 1-{[2'-(methoxycarbonyl)-4-biphenylyl]methyl}-4-methyl-2-propyl-1H-benzimidazole-6-carboxylate; 1H-Benzimidazole-6-carboxylic acid, 1-[[2'-(methoxycarbonyl)[1,1'-biphenyl]-4-yl]methyl]-4-methyl-2-propyl-, methyl ester. Grades: ≥95%. CAS No. 916332-38-2. Molecular formula: C28H28N2O4. Mole weight: 456.53.
An impurity of Olmesartan, which is a specific angiotensin II type 1 (AT1) receptor antagonist with antihypertensive effect. Synonyms: 1-(4-(2-Hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazol-5-yl)ethanone; 1227626-50-7; 1-[5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(1-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]ethanone. CAS No. 1227626-50-7. Molecular formula: C44H42N6O2. Mole weight: 686.84.
16(R)-HETE
16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. Synonyms: 16R-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid; (5Z,8Z,11Z,14Z)-(16R)-16-Hydroxyeicosa-5,8,11,14-tetraenoic acid. Grades: ≥98%. CAS No. 183509-22-0. Molecular formula: C20H32O3. Mole weight: 320.5.
16(S)-HETE
16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. Synonyms: (16S)-hydroxyarachidonic acid; (5Z,8Z,11Z,14Z,16S)-16-hydroxyicosa-5,8,11,14-tetraenoic acid. Grades: ≥98%. CAS No. 183509-23-1. Molecular formula: C20H32O3. Mole weight: 320.5.
1-Chloroethyl Cyclohexyl Carbonate
1-Chloroethyl Cyclohexyl Carbonate is a genotoxic impurity used in the synthesis of Candesartan Cilexetil. an angiotensin II receptor antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 99464-83-2. Pack Sizes: 1g, 10g. Molecular Formula: C9H15ClO3. US Biological Life Sciences.
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1-(N,N-Dimethylsulfamoyl)-1H-imidazole
1-(N,N-Dimethylsulfamoyl)-1H-imidazole is an Imidazole (I350200) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor. Group: Biochemicals. Alternative Names: 1- (N, N-Dimethylsulfamoyl) imidazole; Imidazole-1-sulfonic Acid Dimethylamide; N,N-Dimethyl-1H-imidazole-1-sulfonamide; N,N-Dimethylsulfamoyl-1H-imidazole; NSC 700551. Grades: Highly Purified. CAS No. 78162-58-0. Pack Sizes: 250mg. US Biological Life Sciences.
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1-(N,N-Dimethylsulfamoyl)-1H-imidazole-15N2
1-(N,N-Dimethylsulfamoyl)-1H-imidazole-15N2 is a labelled imidazole (I350202) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor. Group: Biochemicals. Alternative Names: 1- (N, N-Dimethylsulfamoyl) imidazole-15N2; Imidazole-15N2-1-sulfonic Acid Dimethylamide; N,N-Dimethyl-1H-imidazole-1-sulfonamide-15N2; N,N-Dimethylsulfamoyl-1H-imidazole-15N2; NSC 700551-15N2. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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(-)-(1R)-Menthyl Chloroformate
(-)-(1R)-Menthyl Chloroformate was used as a reagent in the synthesis of Binam derivatives by diastereoselective [3,3]-rearrangement. Also used in the preparation of angiotensin II type 2 receptor antagonist EMA401. Group: Biochemicals. Grades: Highly Purified. CAS No. 14602-86-9. Pack Sizes: 250mg, 1g. Molecular Formula: C11H19ClO2. US Biological Life Sciences.
An impurity of Fimasartan. Fimasartan is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure. Synonyms: 5-Despyrimidineethanethioamide-5-pyrimidineacetamide Fimasartan; 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide; Fimasartan Impurity E. CAS No. 178554-19-3. Molecular formula: C27H31N7O2. Mole weight: 485.58.
2'-(1H-Tetrazol-5-yl)-1,1'-biphenyl-4-carboxaldehyde is an impurity of Losartan Potassium (L470500), an angiotensin II antagonist and is commonly used to significantly reduce risk of new onset atrial fibrillation and associated stroke in high-risk patients. Group: Biochemicals. Grades: Highly Purified. CAS No. 151052-40-3. Pack Sizes: 25mg, 250mg. Molecular Formula: C14H10N4O, Molecular Weight: 250.26. US Biological Life Sciences.
2-[1-(Hydroxymethyl)butyl]-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one, is an impurity of Irbesartan (I751000), an angiotensin II type 1 (AII1)-receptor antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 1079997-01-5. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C26H30N6O2, Molecular Weight: 458.56. US Biological Life Sciences.
An impurity of Olmesartan, which is a specific angiotensin II type 1 (AT1) receptor antagonist with antihypertensive effect. CAS No. 1418133-29-5. Molecular formula: C45H46N6O2. Mole weight: 702.89.
An impurity of Fimasartan. Fimasartan is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure. Synonyms: 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-5-pyrimidineacetamide; Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-5-pyrimidineacetamide; Fimasartan Impurity A. Grades: 97%. CAS No. 1315478-13-7. Molecular formula: C13H21N3O2. Mole weight: 251.32.
Intermediate in the synthesis of nonpeptide angiotensin II receptor antagonists. Group: Biochemicals. Alternative Names: Methyl 2-[N-(tert-Butoxycarbonyl)-N-[(2'-cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate. Grades: Highly Purified. CAS No. 139481-38-2. Pack Sizes: 25mg. US Biological Life Sciences.
Intermediate in the synthesis of nonpeptide angiotensin II receptor antagonists. Group: Biochemicals. Alternative Names: Methyl 2-[[(2'-Cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate. Grades: Highly Purified. CAS No. 139481-28-0. Pack Sizes: 10mg. US Biological Life Sciences.
2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic Acid is a transformation product of Valsartan (V095750); a nonpeptide angiotensin II AT1-receptor antagonist and antihypertensive. 2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic Acid is also referred to as Valsartan acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 164265-78-5. Pack Sizes: 10mg, 100mg. Molecular Formula: C14H10N4O2. US Biological Life Sciences.
2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic Acid-d4 is the isotope labelled analog of 2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic Acid (T308515); a transformation product of Valsartan (V095750) which is a nonpeptide angiotensin II AT1-receptor antagonist and antihypertensive. 2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-carboxylic Acid is also referred to as Valsartan acid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C14H6D4N4O2. US Biological Life Sciences.
2-(2-Methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole is an intermediate in the synthesis of Candesartan-d4, the labeled analogue of Candesartan (C175575), an angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive. Group: Biochemicals. Grades: Highly Purified. CAS No. 57598-33-1. Pack Sizes: 100mg, 250mg. Molecular Formula: C12H15NO2, Molecular Weight: 205.25. US Biological Life Sciences.
Worldwide
2-[4- (Hydroxymethyl) phenyl]benzoic Acid
2-[4- (Hydroxymethyl) phenyl]benzoic Acid can be used to synthesize hydroxylated arenes. It is also an intermediate or impurity of Telmisartan (T017000), which is an angiotensin II receptor antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 158144-54-8. Pack Sizes: 500mg, 1g. Molecular Formula: C14H12O3, Molecular Weight: 228.24. US Biological Life Sciences.
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2-[4- (Hydroxymethyl) phenyl]benzonitrile
2-[4- (Hydroxymethyl) phenyl]benzonitrile is an impurity of 4-Bromomethyl-2-cyanobiphenyl (B685335), which is used in protein-binding studies of quinoxaline angiotensin II receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 154709-19-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C14H11NO, Molecular Weight: 209.24. US Biological Life Sciences.
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2-[4- (Hydroxymethyl) phenyl]benzonitrile-d4
2-[4- (Hydroxymethyl) phenyl]benzonitrile-d4 is the isotope labelled analog of 2-[4- (Hydroxymethyl) phenyl]benzonitrile. 2-[4- (Hydroxymethyl) phenyl]benzonitrile is an impurity of 4-Bromomethyl-2-cyanobiphenyl (B685335), which is used in protein-binding studies of quinoxaline angiotensin II receptor antagonists. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C14H7D4NO, Molecular Weight: 213.27. US Biological Life Sciences.
An impurity of Fimasartan. Fimasartan is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure. Synonyms: Fimasartan Impurity D; 5-Pyrimidineacetamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-; Fimasartan-3. CAS No. 503155-67-7. Molecular formula: C46H45N7O2. Mole weight: 727.90.
2-Butyl-4,4-dimethyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-4,5-dihydroimidazol-5-one is a dimethyl impurity of Irbesartan (I751000), an angiotensin II type 1 (AII1)-receptor antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 141745-36-0. Pack Sizes: 10mg, 25mg. Molecular Formula: C23H26N6O, Molecular Weight: 402.49. US Biological Life Sciences.
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2-Chloro-N6-cyclopentyladenosine
It is a selective adenosine receptor agonist and inhibits angiotensin II-induced cardiomyocyte hypertrophy through the calcineurin signaling pathway. Synonyms: CCPA; 2-Chloro-N-cyclopentyl-adenosine; (2R,3R,4S,5R)-2-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; 2-chloro-N-cyclopentyl-9-pentofuranosyl-9H-purin-6-amine. Grades: ≥95% by HPLC. CAS No. 37739-05-2. Molecular formula: C15H20ClN5O4. Mole weight: 369.80.
2-C-Hydroxymethyl-2,3:5,6-di-O-isopropylidene-D-manno-1,4-lactone, a significant biomedicine, exhibits promising capacities in the management of specific diseases. Its pharmacological functionality primarily resides in its potential to inhibit angiotensin II receptor subtype 1, thereby conferring antihypertensive attributes. Consequently, this compound holds immense potential for the development of novel therapeutics that target the angiotensin II receptor pathways. Thus, it presents an invaluable avenue for addressing the pressing concerns associated with cardiovascular ailments such as heart failure and hypertension.
Azilsartan derivative. Intermediate in the synthesis of angiotensin II receptor antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 147403-65-4. Pack Sizes: 5mg. US Biological Life Sciences.
Labeled Azilsartan derivative. Intermediate in the synthesis of angiotensin II receptor antagonist. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
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2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is a nonpeptidic angiotensin II receptor antagonist whose imidazo[4,5-b]pyridine scaffold has been used to examine a variety of positional substitutions in the development of orally active, long duration antihypertensive agents. Synonyms: 3H-Imidazo[4,5-b]pyridine, 2-ethyl-5,7-dimethyl-. Grades: ≥98%. CAS No. 133240-06-9. Molecular formula: C10H13N3. Mole weight: 175.2.
2-Methyl-3-oxobutanenitrile
2-Methyl-3-oxobutanenitrileis used in the preparation of (benzimidazolyl) methyl biphenylsulfonamide derivatives, which exhibit antihypertensive activity as dual angiotensin II/endothelin A receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 4468-47-7. Pack Sizes: 250mg, 500mg. Molecular Formula: C5H7NO, Molecular Weight: 97.12. US Biological Life Sciences.
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2-n-Butylimidazole
2-n-Butylimidazole, is a building block that can be used for the synthesis of Imidazole-5-acrylic acids, acting as potent nonpeptide angiotensin II receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 50790-93-7. Pack Sizes: 5g, 10g. Molecular Formula: C7H12N2, Molecular Weight: 124.18. US Biological Life Sciences.
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 149690-12-0. Pack Sizes: 50mg, 250mg. Molecular Formula: C20H26ClNO2. US Biological Life Sciences.
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2-Thiophenepropionic acid
An impurity of Eprosartan. Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. Uses: 3-(thiophen-2-yl)propionic acid (eprosartan usp related compound b) is an intermediate in the synthesis of eprosartan (e590100), a prototype of the imidazoleacrylic acid angiotensin ii receptor antagonists used as an antihypertensive agent. Synonyms: 3-thiophen-2-ylpropanoic acid. Grades: > 95 %. CAS No. 5928-51-8. Molecular formula: C7H8O2S. Mole weight: 156.20.
3,6-Dihydro-6,6-dimethyl-2-propyl-3-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-4H-furo[3,4-d]imidazol-4-one is an Olmesartan Medoxomil impurity, which is an angiotensin II receptor antagonist used to treat high blood pressure. Synonyms: 3,6-Dihydro-6,6-diMethyl-2-propyl-3-[[2'-[2-(triphenylMethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-4H-furo[3,4-d]iMidazol-4-one; 6,6-Dimethyl-2-propyl-3-((2'-(2-trityl-2h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-3,6-dihydro-4h-furo[3,4-d]imidazol-4-one; 6,6-Dimethyl-2-propyl-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]furo[3,4-d]imidazol-4-one; 3,6-Dihydro-6,6-dimethyl-2-propyl-3-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,; DTXSID201101617; F19513; 3, '6-'Dihydro-'6, '6-'dimethyl-'2-'propyl-'3-' [ [2'-' [2-' (triphenylmethyl) '-'2H-'tetrazol-'5-'yl] ' [1, '1'-'biphenyl] '-'4-'yl] 'methyl] '-4H-'furo [3, '4-'d] 'imidazol-'4-'one. Grades: 97%. CAS No. 1048948-15-7. Molecular formula: C43H38N6O2. Mole weight: 670.8.
3-Bromo-N-tert-butyl Benzene sulfonamide
3-Bromo-N-tert-butyl Benzene sulfonamide is an intermediate used to prepare benzamides as selective angiotensin II AT2 receptor agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 308283-47-8. Pack Sizes: 250mg, 1g. Molecular Formula: C10H14BrNO2S, Molecular Weight: 292.19. US Biological Life Sciences.
3-Methyl-5-nitro-4-[(1-oxobutyl)amino]benzoic Acid is one of telmisartan impurities. Telmisartan, also called Pritor, a benzimidazole derivative, is an angiotensin II receptor antagonist that can be used to treat hypertension. Synonyms: 3-Methyl-5-nitro-4-[(1-oxobutyl)amino]-benzoic Acid; N-butyryl-4-amino-3-methyl-5-nitrobenzoic acid. Grades: 98%. CAS No. 959987-48-5. Molecular formula: C12H14N2O5. Mole weight: 266.25.
4'- ( (1, 7'-Dimethyl-2'-propyl-1H, 1'H-[2, 5'-bibenzo[d]imidazol]-1'-yl) methyl) -[1, 1'-biphenyl]-2-carbonitrile is one of telmisartan impurities. Telmisartan, also called Pritor, a benzimidazole derivative, is an angiotensin II receptor antagonist that can be used to treat hypertension. Synonyms: 4'- ( (1, 7'-Dimethyl-2'-propyl-1H, 1'H-[2, 5'-bibenzo[d]imidazol]-1'-yl) methyl) -[1, 1'-biphenyl]-2-carbonitrile. CAS No. 1338830-39-9. Molecular formula: C33H29N5. Mole weight: 495.62.
4'-[(1,7'-Dimethyl-2'-propyl[2,5'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic Acid Methyl Ester is one of telmisartan impurities. Telmisartan, also called Pritor, a benzimidazole derivative, is an angiotensin II receptor antagonist that can be used to treat hypertension. Synonyms: Telmisartan EP Impurity B Methyl Ester; 4'-Desmethyl-7'-methyl Telmisartan Methyl Ester; [1,1'-Biphenyl]-2-carboxylic acid,2'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-,methyl ester. Grades: > 98%. CAS No. 1338830-37-7. Molecular formula: C34H32N4O2. Mole weight: 528.64.
4'-((2-ethoxy-7-(methoxycarbonyl)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid is an impurity of Azilsartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure. Synonyms: 4'-((2-Ethoxy-7-(methoxycarbonyl)-1h-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid; 4'-((2-Ethoxy-7-(methoxycarbonyl)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylicacid; F19388. CAS No. 1675221-59-6. Molecular formula: C25H22N2O5. Mole weight: 430.45.
4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid is an impurity of Olmesartan Medoxomil. Olmesartan Medoxomil is an angiotensin II receptor antagonist which has been used for the treatment of high blood pressure. It is a metabolite of Olmesartan, which is a specific angiotensin II type 1 (AT1) receptor antagonist with antihypertensive effect. hAT1 receptors: IC50 = 6.18 nM. Synonyms: 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid. CAS No. 144690-04-0. Molecular formula: C10H16N2O3. Mole weight: 212.25.
4'-[[[2-Methyl-4-(1-methyl-1H-benzimidazol-2-yl)-6-nitrophenyl](1-oxobutyl)amino]methyl]-[1,1'-biphenyl]-2-carboxylic Acid Methyl Ester is one of telmisartan impurities. Telmisartan, also called Pritor, a benzimidazole derivative, is an angiotensin II receptor antagonist that can be used to treat hypertension. CAS No. 1338830-33-3. Molecular formula: C34H32N4O5. Mole weight: 576.64.
4',4'-Dibromomethyl Biphenyl-2-Carboxylic Acid
4',4'-Dibromomethyl Biphenyl-2-Carboxylic Acid is one of telmisartan impurities. Telmisartan, also called Pritor, a benzimidazole derivative, is an angiotensin II receptor antagonist that can be used to treat hypertension. Synonyms: 4'-(dibromomethyl)-[1,1'-biphenyl]-2-carboxylic acid; Telmisartan Dibromo Acid Impurity. Grades: 98%. CAS No. 1797894-62-2. Molecular formula: C14H10Br2O2. Mole weight: 370.04.
4,5-Bis(chloromethyl)-1,3-dioxol-2-one
4,5-Bis(chloromethyl)-1,3-dioxol-2-one is an impurity of Olmesartan Medoxomil, which is an angiotensin II receptor antagonist. Used as an anti-hypertensive. Group: Biochemicals. Grades: Highly Purified. CAS No. 1443544-27-1. Pack Sizes: 100mg, 250mg, 500mg. Molecular Formula: C5H4Cl2O3. US Biological Life Sciences.
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