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| Product | Description | |
|---|---|---|
| Anisomycin | Anisomycin. Group: Biochemicals. Grades: Highly Purified. CAS No. 22862-76-6. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C14H19NO4. US Biological Life Sciences. |  Worldwide |
| Anisomycin | It is produced by the strain of Streptomyces griseolus. It inhibits protein synthesis. it has anti-fungal, anti-fine bacteria, anti-tumor and antigenic insect action. Synonyms: Flagecidin; NSC-76712; AI3-50846; NSC76712; AI350846; NSC 76712; AI3 50846. Grades: ≥98%. CAS No. 22862-76-6. Molecular formula: C14H19NO4. Mole weight: 265.30. |  |
| Anisomycin (Flagecidin, Antibiotic SA 3097C1, Antibiotic PA 106, Anhydroscopin A, NSC) | Anisomycin is a phenyl methyl enepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin acts as an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. More recently, anisomycin has been demonstrated to induce apoptosis, to be a selective signalling agonist, to activate mitogen-activated protein (MAP) kinases and to be immunomodulatory via its action on T cells. Group: Biochemicals. Alternative Names: ((2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate. Grades: Highly Purified. CAS No. 22862-76-6. Pack Sizes: 25mg, 100mg, 250mg. US Biological Life Sciences. | Worldwide |
| 25S rRNA (adenine2142-N1)-methyltransferase | In the yeast Saccharomyces cerevisiae this methylation is important for resistance towards hydrogen peroxide and the antibiotic anisomycin. Group: Enzymes. Synonyms: BMT2 (gene name); 25S rRNA m1A2142 methyltransferase. Enzyme Commission Number: EC 2.1.1.286. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1893; 25S rRNA (adenine2142-N1)-methyltransferase; EC 2.1.1.286; BMT2 (gene name); 25S rRNA m1A2142 methyltransferase. Cat No: EXWM-1893. |  |
| p38 MAP Kinase Inhibitor XIX, Skepinone-L ((2-(2,4-Difluorophenylamino)-7-[2R-,3-dihydroxypropoxy]-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one)) | A cell-permeable phenylamino-dibenzosuberone-diol with a rigid molecular structure specifically designed to target hydrophobic region I in p38alpha & p38beta, but not in other kinases with bulky entrance-blocking gatekeeper residues. Shown to selectively inhibit p38alpha (IC50 = 5nM; [ATP] = 100uM) and p38beta (97% inhibition at 1uM), while exhibiting little affinity toward 400 other kinase constructs, including p38delta, p38upsilon, Erk1/2/3/4/5/8, JNK1/2/3, and MEK1/2/3/4/6. Shown to prevent cellular HSP27 Ser82 phosphorylation upon p38 activation by Anisomycin in HeLa (IC50 = 25nM) or by TNF-alpha in THP-1 cultures. Unlike the ATP-binding site-targeting BIRB 796 and SB 203580, Skepinone-L does not inhibit JNK-mediated c-Jun or ERK-dependent CREB phosphorylation in THP-1 cultures. Oral administration to D-Gal-sensitized mice is reported to greatly reduce plasma TNF-alpha production upon LPS challenge (by 77%; 3mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Preussin | Preussin is extracted from Aspergillus ochraceus. It has the effect of anti-filamentous fungi and yeast, its antifungal spectrum is wider than anisomycin, and the activity is stronger than anisomycin. Synonyms: 3-Pyrrolidinol, 1-methyl-5-nonyl-2-(phenylemthyl)-. CAS No. 119463-16-0. Molecular formula: C21H35NO. Mole weight: 317.51. | |
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