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| Product | Description | |
|---|---|---|
| Apelin-13 | Apelin-13, an endogenous neuropeptide, is the ligand for the G-protein-coupled receptor APJ, an alternative coreceptor with CD4 for HIV-1 infection. Apelin-13 is generated from apelin-36, which is a putative receptor protein related to the angiotensin receptor (AT1). Apelin-13 exerted an acidification-rate-promoting activity in the CHO cells expressing the APJ receptor with EC50 value of 0.37 nM. Apelin-13 is a 13 amino acid polypeptide encoded by the apelin gene which yields a pre-proprotein that is processed to generate bioactive peptides. Apelin-13 is also involved in the learning and memory process. Synonyms: Apelin-13 (human, bovine, mouse, rat); H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH; L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine. Grades: ≥95%. CAS No. 217082-58-1. Molecular formula: C69H111N23O16S. Mole weight: 1550.85. |  |
| Apelin-13 trifluoroacetate salt | ?95%. Group: Fluorescence/luminescence spectroscopy. |  |
| Apelin-13 trifluoroacetate salt | Apelin-13 trifluoroacetate salt is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM. Synonyms: Apelin-13 triTFA. Molecular formula: C75H114F9N23O22S. Mole weight: 1892.89. | |
| (Ala13)-Apelin-13 acetate salt (human, bovine, mouse, rat) | (Ala13)-Apelin-13 acetate salt (human, bovine, mouse, rat) is an antioxidant with the ability to scavenge active oxygen species such as superoxide and hydroxyl radicals, and may have therapeutic effects on diseases (such as arthritis and cancer) damaged by hydroxyl radicals. Synonyms: H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH acetate salt; L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-alanine acetate salt. Molecular formula: C63H107N23O16S.C2H4O2. Mole weight: 1534.81. | |
| (Ala13)-Apelin-13 (human, bovine, mouse, rat) | (Ala13)-Apelin-13 (human, bovine, mouse, rat) is an antioxidant with the ability to scavenge active oxygen species such as superoxide and hydroxyl radicals, and may have therapeutic effects on diseases (such as arthritis and cancer) damaged by hydroxyl radicals. Synonyms: (Ala13)-Apelin 13, human; H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH; L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-alanine; L-Glutaminyl-N5-(diaminomethylene)-L-ornithyl-L-prolyl-N5-(diaminomethylene)-L-ornithyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-alanine; Apelin 13 F13A. Grades: ≥95%. CAS No. 568565-11-7. Molecular formula: C63H107N23O16S. Mole weight: 1474.73. | |
| [Ala13]-Apelin-13 trifluoroacetate salt | ?96% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| (Glp1)-Apelin-13 trifluoroacetate salt | The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36 , apelin-17, and apelin-13, respectively. Synonyms: (pGlu1)Apelin-13; Pyr-Apelin-13; (Pyr1)Apelin-13; 5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine trifluoroacetate salt. Grades: ≥95%. Molecular formula: C69H108N22O16S·xCF3COOH. Mole weight: 1533.80. | |
| [Pyr1]-Apelin-13 | [Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist. Uses: Scientific research. Group: Peptides. Alternative Names: [pGlu1]-Apelin-13. CAS No. 217082-60-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1033. |  |
| [Pyr1]-Apelin-13 | [Pyr1]-Apelin-13 is the highly potent pyroglutamylated form of apelin-13, which is an endogenous ligand of the G protein-coupled APJ receptor with EC50 value of 0.37 nM. It is the major apelin form in human plasma and heart, which the N-terminal glutamine residue is cyclized to pyroglutamic acid. It exhibits higher APJ agonist potency than Apelin-13. It has antipyretic and vasoconstrictor effects in vitro and in vivo. It is widely used for studying APJ-mediated cellular and physiological functions both in cultures and in animals in vivo. It is reactive toward human, rat, bovine and murine species. Synonyms: [Pyr1]-Apelin-13; [Pyr1]-Apelin13; [Pyr1]-Apelin 13; 5-Oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine; Pyroglutamated apelin-13; [pGlu1]-apelin-13. Grades: 98%. CAS No. 217082-60-5. Molecular formula: C69H108N22O16S. Mole weight: 1533.81. | |
| [Pyr1]-Apelin-13 trifluoroacetate salt | ?96% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Apelin-12 acetate | Apelin-12 induces calcium mobilization in APJ-Gαq16 cells expressing human APJ and inhibits HIV-1 and HIV-2 infection in NP-2/CD4/APJ cells. Apelin-12 inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons. Synonyms: Preproapelin (66-77) (human, bovine, mouse, rat) acetate; (Des-Gln1)-Apelin-13 (human, bovine, mouse, rat) acetate; Apelin Precursor (66-77) (human, bovine, mouse, rat) acetate. Molecular formula: C66H107N21O16S. Mole weight: 1482.77. | |
| MM 54 | MM 54 is an apelin receptor antagonist with IC50 value of 93 nM. It can antagonize the inhibitory effect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Synonyms: MM-54; MM54; H-Cys(1)-Arg-Pro-Arg-Leu-Cys(1)-Lys-His-Cys(2)-Arg-Pro-Arg-Leu-Cys(2)-OH; L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-cysteinyl-L-lysyl-L-histidyl-L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-cysteine (1->6),(9->14)-bis(disulfide). Grades: ≥95%. CAS No. 1313027-43-8. Molecular formula: C70H121N29O15S4. Mole weight: 1737.15. | |
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