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| Product | Description | |
|---|---|---|
| Aphidicolin | Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola , inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 38966-21-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N6733. |  |
| Aphidicolin | Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 38966-21-1. Molecular formula: C20H34O4. Mole weight: 338.48. Purity: ≥99.0%. Canonical SMILES: C[C@@]12[C@]34[C@](CC[C@@]1([H])[C@@](C)([C@H](O)CC2)CO)([H])C[C@]([C@](CO)(O)CC4)([H])C3. Product ID: ACM38966211. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Aphidicolin-17-monoacetate | Aphidicolin-17-monoacetate is an antibiotic produced by Phoma betae PS-13, which inhibits DNA polymerase and interferes with root growth. Molecular formula: C22H36O5. Mole weight: 380.52. |  |
| Aphidicolin-3,18-orthoacetate | Aphidicolin-3,18-orthoacetate is an antibiotic produced by Phoma betae. It is a kind of phytotoxin, which can inhibit the growth of the roots of rice and mango. Molecular formula: C22H36O5. Mole weight: 380.52. | |
| (+)-Aphidicolin | Antibiotic. Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at early S phase. Prolongs the half life of DNA methyltransferase. Specific DNA polymerase alpha and delta inhibitor in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer. Group: Biochemicals. Alternative Names: [3R-(3α, 4α, 4aα, 6a β,8 β,9 β,11a β,11b β ) ]-Tetradecahydro-3, 9-dihydroxy-4, 11b-dimethyl-8, 11a-methano-11aH-cyclohepta [a]naphthalene-4, 9-dimethanol; Aphidicolin; ICI 69653; NSC 234714; (3α, 4α, 5α, 17α)-3, 17-Dihydroxy-4-methyl-9, 15-cyclo-C, 18-dinor-14, 15-secoandrostane-4, 17-dimethanol; (3R, 4R, 4aR, 6aS, 8R, 9R, 11aS, 11bS) -Tetradecahydro-3, 9-dihydroxy-4, 11b-dimethyl-8, 11a-methano-11aH-cyclohepta [a]naphthalene-4, 9-dimethanol. Grades: Highly Purified. CAS No. 38966-21-1. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C20H34O4, Molecular Weight: 338.48. US Biological Life Sciences. |  Worldwide |
| aphidicolan-16β-ol synthase | This is a bifunctional enzyme which also has EC 5.5.1.14 syn-copalyl diphosphate synthase activity. Aphidicolan-16β-ol is a precursor of aphidicolin, a specific inhibitor of DNA polymerase α (EC 2.7.7.7). Group: Enzymes. Synonyms: PbACS. Enzyme Commission Number: EC 4.2.3.42. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5201; aphidicolan-16β-ol synthase; EC 4.2.3.42; PbACS. Cat No: EXWM-5201. |  |
| BLM Helicase Inhibitor, ML216 (ML-216, 1- (4-Fluoro-3- (trifluoromethyl) phenyl) -3- (5- (pyridin-4-yl) -1, 3, 4-thiadiazol-2-yl) urea) | A cell-permeable pyridinyl-thiadiazolylurea compound that selectively blocks Bloom's syndrome protein (BLM) helicase activity of both full-length as well as truncated BLM636-1298 forms (IC50 = 2.98 and 0.97uM, respectively). Competes with and reversibly blocks DNA binding to BLM. However, the inhibition appears to be non-competitive with respect to ATP. Exhibits anti-proliferative activity in cells expressing BLM, but not in those lacking BLM. Induces sister chromatid exchanges (SCEs) and enhances the sensitivity of BLM containing PSNF5 cells to aphidicolin without affecting PSNG13 cells that are devoid of BLM. Displays favorable microsomal (T1/2 > 1.2h) and plasma stability (~100% at 5h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?F?N?OS. US Biological Life Sciences. | Worldwide |
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