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| Product | Description | |
|---|---|---|
| Apoptolidin | Apoptolidin is an apoptosis inducer produced by Nocardiopsis sp. Apoptolidin can induce apoptosis of metastatic cells, but has no effect on normal cells. Synonyms: (1R)-O-2,6-Dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-(1→4)-O-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→8)-3,5,7-trideoxy-1-C-[(2S,4S,5S,8E,10E,12R,13R,14E,16E,18E)-12-[(6-deoxy-4-O-methyl-α-L-glucopyranosyl)oxy]-5-hydroxy-4-methoxy-9,13,15,17,19-pentamethyl-20-oxooxacycloeicosa-8,10,14,16,18-pentaen-2-yl]-3,5-dimethyl-9-O-methyl-L-glycero-α-D-galacto-2-nonulopyranose; Apoptolidin A; FU 40A. Grade: ≥95%. CAS No. 194874-06-1. Molecular formula: C58H96O21. Mole weight: 1129.37. |  |
| Apoptolidin | Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene at an IC50 = 11 ng/ml. It is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action. Group: Biochemicals. Grades: Highly Purified. CAS No. 194874-06-1. Pack Sizes: 100ug. US Biological Life Sciences. |  Worldwide |
| Apoptolidin A Ready Made Solution | 1 mg/mL in DMSO. Group: Fluorescence/luminescence spectroscopy. |  |
| Isoapoptolidin | Isopoptolidin, originally isolated from a Nocardiopsis sp., is a ring expanded isomer of apoptolidin. In water an equilibrium mixture of apoptolidin / isoapoptolidin (~1.5:1) is formed within hours. In a rapid F0F1-ATPase assay isoapoptolidin exhibited a IC50 of 17 uM compared to 0.7 uM for apoptolidin. Group: Biochemicals. Grades: Highly Purified. CAS No. 476647-30-0. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Isoapoptolidin | It is a ring expanded isomer of apoptolidin originally isolated from Nocardiopsis sp. It demonstrates 10-fold reduced F1FO-ATP synthase inhibitory activity compared to apoptolidin (IC50s = 17 and 0.7 μM, respectively). Synonyms: (3E,5E,7E,9R,10R,11E,13E,17S,18S,20S,21R)-10-[(6-Deoxy-4-O-methyl-α-L-glucopyranosyl)oxy]-21-[O-2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-(1→4)-O-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→7)-2,4,6-trideoxy-1-C-hydroxy-2,4-dimethyl-8-O-methyl-L-glycero-β-D-galacto-octopyranosyl]-17,20-dihydroxy-18-methoxy-3,5,7,9,13-pentamethyloxacycloheneicosa-3,5,7,11,13-pentaen-2-one; Isoapoptolidin A. Grade: >90% by HPLC. CAS No. 476647-30-0. Molecular formula: C58H96O21. Mole weight: 1129.38. | |
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