Astemizole Suppliers USA
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Product | Description | |
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Astemizole Quick inquiry Where to buy Suppliers range | Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic. Group: Biochemicals. Alternative Names: 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; Astemisan; Hismanal; Histamen; Paralergin; R 42512; R 43512; Retolen; Waruzol. Grades: Highly Purified. CAS No. 68844-77-9. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Astemizole Quick inquiry Where to buy Suppliers range | Astemizole is a potent and orally active nonsedating-type histamine H1 receptor antagonist with IC50 value of 4 nM. It competitively binds to histamine H1 receptor sites in the uterus, gastrointestinal tract, bronchial muscle and blood vessels. It suppresses the formation of edema and pruritus caused by histamine. It has antipruritic and anticholinergic effects. It is also a potent blocker of ether-a-go-go-related gene (ERG) potassium channel blocker with IC50 value of 0.9 nM. It exhibits antimalarial activity in multidrug resistant strains in vitro with IC50 value of 227-734 nM. It has the potential for combination therapy with antivancer drugs in resistant leukemia. It is considerably less potent at muscarinic acetylcholine receptors with Ki value of 2.4 μM. It may be used as a potential antineoplastic agent for decreasing proliferation of various cancer cells. It may be used as a pharmacological chaperone to restore protein function for some mutated forms of hERG channels and correct folding defects. It was developed by Johnson & Johnson. Synonyms: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzim; Laridal; 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; Astemisan; Hismanal; Histamen; Paralergin; R 42512; Retolen; Waruzol. Grades: ≥99% by HPLC. CAS No. 68844-77-9. Molecular formula: C28H31FN4O. Mole weight: 458.57. | |
Astemizole-d3 Quick inquiry Where to buy Suppliers range | Labeled Astemizole. Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic. Group: Biochemicals. Alternative Names: 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxy-d3-phenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; Astemisan-d3; Hismanal-d3; Histamen-d3; Paralergin-d3; R 42512-d3; R 43512-d3; Retolen-d3; Waruzol-d3. Grades: Highly Purified. CAS No. 1189961-39-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
O-Desmethyl Astemizole Quick inquiry Where to buy Suppliers range | A metabolite of Astemizole. Group: Biochemicals. Alternative Names: 4- [2- [4- [ [1- [ (4-Fluorophenyl) methyl] -1H-benzimidazol-2-yl] amino] -1-piperidinyl] ethyl] phenol; Desmethylastemizole; O-Demethylastemizole; R 44271. Grades: Highly Purified. CAS No. 73736-50-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
O-Desmethylastemizole Quick inquiry Where to buy Suppliers range | A metabolite of Astemizole. Synonyms: 4-[2-[4-[[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]phenol; Desmethylastemizole. Grades: > 95%. CAS No. 73736-50-2. Molecular formula: C27H29FN4O. Mole weight: 444.56. |