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| Product | Description | |
|---|---|---|
| Astemizole | Astemizole is a potent and orally active nonsedating-type histamine H1 receptor antagonist with IC50 value of 4 nM. It competitively binds to histamine H1 receptor sites in the uterus, gastrointestinal tract, bronchial muscle and blood vessels. It suppresses the formation of edema and pruritus caused by histamine. It has antipruritic and anticholinergic effects. It is also a potent blocker of ether-a-go-go-related gene (ERG) potassium channel blocker with IC50 value of 0.9 nM. It exhibits antimalarial activity in multidrug resistant strains in vitro with IC50 value of 227-734 nM. It has the potential for combination therapy with antivancer drugs in resistant leukemia. It is considerably less potent at muscarinic acetylcholine receptors with Ki value of 2.4 μM. It may be used as a potential antineoplastic agent for decreasing proliferation of various cancer cells. It may be used as a pharmacological chaperone to restore protein function for some mutated forms of hERG channels and correct folding defects. It was developed by Johnson & Johnson. Synonyms: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzim; Laridal; 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; Astemisan; Hismanal; Histamen; Paralergin; R 42512; Retolen; Waruzol. Grades: ≥99% by HPLC. CAS No. 68844-77-9. Molecular formula: C28H31FN4O. Mole weight: 458.57. |  |
| Astemizole | Astemizole (R 43512), a second-generation antihistamine agent to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC 50 of 4 nM. Astemizole also shows potent hERG K + channel blocking activity with an IC 50 of 0.9 nM. Astemizole has antipruritic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 43512. CAS No. 68844-77-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12532. |  |
| Astemizole | Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic. Group: Biochemicals. Alternative Names: 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; Astemisan; Hismanal; Histamen; Paralergin; R 42512; R 43512; Retolen; Waruzol. Grades: Highly Purified. CAS No. 68844-77-9. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| Astemizole-d3 | Heterocyclic Organic Compound. Alternative Names: 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxy-d3-phenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; Astemisan-d3; Hismanal-d3; Histamen-d3; Paralergin-d3; R 42512-d3; R 43512-d3; Retolen-d3; Waruzol-d3. CAS No. 1189961-39-4. Molecular formula: C28H28D3FN4O. Mole weight: 461.59. Appearance: White Solid. Purity: 0.96. IUPACName: 1-[ (4-fluorophenyl) methyl]-N-[1-[2-[4- (trideuteriomethoxy) phenyl]ethyl]piperidin-4-yl]benzimidazol-2-amine. Catalog: ACM1189961394. |  |
| Astemizole-d3 | Labeled Astemizole. Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic. Group: Biochemicals. Alternative Names: 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxy-d3-phenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine; Astemisan-d3; Hismanal-d3; Histamen-d3; Paralergin-d3; R 42512-d3; R 43512-d3; Retolen-d3; Waruzol-d3. Grades: Highly Purified. CAS No. 1189961-39-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| O-Desmethylastemizole | A metabolite of Astemizole. Synonyms: 4-[2-[4-[[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]phenol; Desmethylastemizole. Grades: > 95%. CAS No. 73736-50-2. Molecular formula: C27H29FN4O. Mole weight: 444.56. | |
| O-Desmethyl Astemizole | A metabolite of Astemizole. Group: Biochemicals. Alternative Names: 4- [2- [4- [ [1- [ (4-Fluorophenyl) methyl] -1H-benzimidazol-2-yl] amino] -1-piperidinyl] ethyl] phenol; Desmethylastemizole; O-Demethylastemizole; R 44271. Grades: Highly Purified. CAS No. 73736-50-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Tecastemizole | Tecastemizole (Norastemizole), a major metabolite of Astemizole, is a potent and selective H1 receptor antagonist. Tecastemizole shows anti-inflammatory activities [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Norastemizole. CAS No. 75970-99-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105014. | |
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