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| Product | Description | |
|---|---|---|
| Atopaxar | Atopaxar (E5555) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. Atopaxar, an antiplatelet agent, interferes with platelet signaling. Atopaxar can be used for the research of atherothrombotic disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E5555; ER-172594-00. CAS No. 751475-53-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-18200. |  |
| Atopaxar | Atopaxar is a Protease-activated receptor-1 (PAR-1) inhibitor. It can inhibit the binding of a high-affinity thrombin receptor-activating peptide ([(3)H]haTRAP) to PAR-1 with IC50 value of 0.019μM. Atopaxar exhibits potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 values of 0.064 and 0.031μM. It may become a therapeutic option for atherothrombotic disease. In May 2012, Phase-II for Acute coronary syndromes in European Union was discontinued. Uses: Acute coronary syndromes. Synonyms: E5555; E-5555; E 5555; ER-172594-00; ER172594-00; ER 172594-00; Atopaxar;1-(3-(tert-butyl)-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethan-1-one;474550-69-1(hydrobromide). Grades: 98%. CAS No. 751475-53-3. Molecular formula: C29H38FN3O5. Mole weight: 527.64. |  |
| E 5555 hydrobromide | E 5555 hydrobromide is a potent and orally bioactive thrombin receptor (or protease-activated receptor 1, PAR1) antagonist (IC50 = 19 nM). It inhibits human platelet aggregation induced by thrombin and TRAP with IC50 values of 64 and 31nM, respectively. Synonyms: Atopaxar hydrobromide; ER 172594-06 HBr; E 5555 hydrobromide; E-5555 hydrobromide; E5555 hydrobromide. Grades: 99%. CAS No. 474550-69-1. Molecular formula: C29H38FN3O5.HBr. Mole weight: 608.54. | |
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