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| Product | Description | |
|---|---|---|
| Avanafil | A phosphodiesterase. Group: Biochemicals. Alternative Names: (S) -2- (2-Hydroxymethyl-1-pyrrolidinyl) -4- (3-chloro-4-methoxybenzylamino) -5-[ (2-pyrimidinylmethyl) carbamoyl]pyrimidine; 4-[[ (3-Chloro-4-methoxyphenyl) methyl]amino]-2-[ (2S) -2- (hydroxymethyl) -1-pyrrolidinyl]-N- (2-pyrimidinylmethyl) -5-pyrimidinecarboxamide; TA 1790. Grades: Highly Purified. CAS No. 330784-47-9. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Avanafil | Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC 50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: TA1790. CAS No. 330784-47-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-18252. |  |
| Avanafil Impurity 13 | Avanafil Impurity 13 is an impurity of Avanafil, a medication prescribed for treating erectile dysfunction. Synonyms: 1,4,5,6-tetrahydropyrimidin-2-ylmethanamine; Avanafil Related Compound 1. Grades: > 95%. CAS No. 759408-08-7. Molecular formula: C5H11N3. Mole weight: 113.16. |  |
| Avanafil Intermediates | Avanafil Intermediates. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1246834-64-9. Molecular formula: C7H11N3O2. Mole weight: 169.18. Catalog: APB1246834649. |  |
| Avanafil metabolite M4 | Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16, as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil. Grades: ≥98%. Molecular formula: C23H26ClN7O4. Mole weight: 499.95. | |
| Avanafil Related Compound 1 | Synonyms: 4-(3-chloro-4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylsulfinylpyriMidine; Ethyl 4-((3-chloro-4-Methoxybenzyl)aMino)-2-(Methylsulfinyl)pyriMidine-5-carboxylate. Grades: > 95%. CAS No. 330785-82-5. Molecular formula: C16H18ClN3O4S. Mole weight: 383.86. | |
| 3- (S) - hydroxypyrrolidinyl avanafil | 3- (S) - hydroxypyrrolidinyl avanafil is a metabolite of Avanafil (A794670), a phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 330785-58-5. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C23H26ClN7O4, Molecular Weight: 499.95. US Biological Life Sciences. | Worldwide |
| 2-?Pyrimidinemethanol | 2-?Pyrimidinemethanol is a reactant used in the synthesis of avanafil, which is used to treat erectile dysfunction. Also used in the synthesis of. Group: Biochemicals. Grades: Highly Purified. CAS No. 42839-09-8. Pack Sizes: 50mg, 100mg. Molecular Formula: C5H6N2O, Molecular Weight: 110.11. US Biological Life Sciences. | Worldwide |
| 3-Chloro-4-methoxybenzylamine | 3-Chloro-4-methoxybenzylamine is a reagent in the synthesis of avanafil (A794670) which is used for the treatment of erectile dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 115514-77-7. Pack Sizes: 250mg, 1g. Molecular Formula: C8H10ClNO. US Biological Life Sciences. | Worldwide |
| 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide | 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide. Group: Biochemicals. Alternative Names: (S) -2- (2-Hydroxymethyl-1-pyrrolidinyl) -4- (3-chloro-4-methoxybenzylamino) -5-[ (2-pyrimidinylmethyl) carbamoyl]pyrimidine; 4-[[ (3-Chloro-4-methoxyphenyl) methyl]amino]-2-[ (2S) -2- (hydroxymethyl) -1-pyrrolidinyl]-N- (2-pyrimidinylmethyl) -5-pyrimidinecarboxamide; TA 1790; Avanafil. Grades: Highly Purified. CAS No. 330784-47-9. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C23H26ClN7O3. US Biological Life Sciences. | Worldwide |
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