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| Product | Description | |
|---|---|---|
| BACE-1 Inhibitor | BACE-1 Inhibitor is a potent, selective and cell-permeable inhibitor of human β-secretase (BACE-1) binding to the active site of BACE-1. It inhibits secretion of amyloid-β (Aβ) precursor protein (APP; IC50 = 29 nM) in HEK293T cells and also suppresses formation of the Aβ peptides Aβ38, Aβ40, and Aβ42 in primary chick neurons (IC50s = 3.7, 4.7, and 4.8 nM, respectively). Synonyms: BACE-1 Inhibitor; BACE 1 Inhibitor; BACE1 Inhibitor; Beta-Secretase Inhibitor IV; β-Secretase Inhibitor IV; N1-[(1S,2R)-3-(Cyclopropylamino)-2-hydroxy-1-(phenylmethyl)propyl]-5-[methyl(methylsulfonyl)amino]-N3-[(1R)-1-phenylethyl]-1,3-benzenedicarboxamide; Axon 1125. Grade: 98%. CAS No. 797035-11-1. Molecular formula: C31H38N4O5S. Mole weight: 578.72. |  |
| BACE-1 inhibitor 1 | BACE-1 inhibitor 1 is a potent BACE-1 inhibitor with an IC50 of 56 nM. Synonyms: N-{3-[(3R)-5-Amino-3-(difluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-bromo-2-pyridinecarboxamide; 2-Pyridinecarboxamide, N-[3-[(3R)-5-amino-3-(difluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-bromo-. Grade: 98%. CAS No. 1262858-14-9. Molecular formula: C17H14BrF3N4O2. Mole weight: 443.22. | |
| BACE-1 inhibitor 2 | BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC50 of 1.5 nM in BACE-1 enzymatic assay. Synonyms: N-(3-((4aS,6S,8aS)-2-amino-3,3-difluoro-6-methyl-4,4a,5,6-tetrahydro-3H-pyrano[3,4-b]pyridin-8a(8H)-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide. Molecular formula: C21H21F4N5O3. Mole weight: 467.42. | |
| 3-(Boc-aminomethyl)benzoic Acid | 3-(Boc-aminomethyl)benzoic Acid is used to synthesize aminodi hydroquinazolines as inhibitors of BACE-1 ( β-site APP cleaving enzyme). It is also used to prepare spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 117445-22-4. Pack Sizes: 500mg, 1g. Molecular Formula: C13H17NO4, Molecular Weight: 251.28. US Biological Life Sciences. |  Worldwide |
| β-Secretase Inhibitor IV | β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC 50 s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 797035-11-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-10133. |  |
| Boc-(3-aminomethyl) benzoic acid | Boc-(3-aminomethyl) benzoic acid (CAS# 117445-22-4) is used to synthesize aminodihydroquinazolines as inhibitors of BACE-1 (β-site APP cleaving enzyme). It is also used to prepare spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. Synonyms: Boc-3-Amb-OH. Grade: ≥ 98 % (HPLC). CAS No. 117445-22-4. Molecular formula: C13H17NO4. Mole weight: 251.27. | |
| Elenbecestat | Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant BACE-1 inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E2609. CAS No. 1388651-30-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109055. | |
| Glabrolide | Glabrolide is a triterpenoid β-secretase 1 (BACE-1) inhibitor derived from Glycyrrhiza uralensis Fisch. Synonyms: 3β,22β-Dihydroxy-11-oxoolean-12-en-30-oic acid γ-lactone; Olean-12-en-29-oic acid, 3,22-dihydroxy-11-oxo-, gamma-lactone, (3beta,20beta,22beta)-. Grade: ≥95%. CAS No. 10401-33-9. Molecular formula: C30H44O4. Mole weight: 468.67. | |
| NB-360 free base | NB-360 is a potent and brain penetrable BACE-1 inhibitor. NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. NB-360 stopped accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared. Uses: Designed for use in research and industrial production. Additional or Alternative Names: NB-360; NB 360; NB360. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1262857-73-7. Molecular formula: C21H19F4N5O2. Mole weight: 449.41. Purity: >98%. IUPACName: N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide. Canonical SMILES: CC1=C(C(NC2=CC=C(F)C([C@]3(C)CO[C@@](C)(C(F)(F)F)C(N)=N3)=C2)=O)N=CC(C#N)=C1. Product ID: ACM1262857737. Alfa Chemistry ISO 9001:2015 Certified. |  |
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