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| Product | Description | |
|---|---|---|
| Bafilomycin | Bafilomycins are a family of macrolide antibiotics isolated from Streptomycetes sp. They exhibits antitumor, antiparasitic, immunosuppressant and antifungal activity. CAS No. 151499-39-7. |  |
| Bafilomycin a1 | Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 88899-55-2. Molecular formula: C35H58O9. Mole weight: 622.83. Purity: >98 %. Product ID: ACM88899552. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Bafilomycin A1 | Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H + -ATPase ( V-ATPase ) with IC 50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: BafA1. CAS No. 88899-55-2. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-100558. |  |
| Bafilomycin A1 | Bafilomycin A1 Inhibitor. Uses: Scientific use. Product Category: T6740. CAS No. 88899-55-2. |  |
| Bafilomycin A1 (NSC381866) | Bafilomycin A1 is a member of a potent family of macrocyclic lactones with a broad spectrum of biological activity including activity against bacteria, yeast, fungi, nematodes, insects and antitumor cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase. Related to: Bafilomycin B1, Bafilomycin C1, Concanamycin A.Source:Streptomyces griseus. Group: Biochemicals. Alternative Names: 21-O-De(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin Oxacyclohexadecane, hygrolidin deriv.; (-)-Bafilomycin A1; NSC 381866; [7R-[3Z, 5E, 7R*, 8S*, 9S*, 11E, 13E, 15S*, 16R*[1S*, 2R*, 3S*(2R*, 4R*, 5S*, 6R*)]]]-8-Hydroxy-16-[2-hydroxy-1-methyl-3-[tetrahydro-2, 4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3, 15-dimethoxy-5, 7, 9, 11-tetramethyl-oxacyclohexadeca-3, 5, 11, 13-tetraen-2-one. Grades: Highly Purified. CAS No. 88899-55-2. Pack Sizes: 100ug, 1mg. Molecular Formula: C35H58O9, Molecular Weight: 622.8. US Biological Life Sciences. |  Worldwide |
| Bafilomycin b1 | Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K+-dependent ATPase of E. coli. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 88899-56-3. Molecular formula: C44H65NO13. Mole weight: 815.99. Purity: 0.9822. Product ID: ACM88899563. Alfa Chemistry ISO 9001:2015 Certified. Categories: Bafilomycin-A1. | |
| Bafilomycin B1 | Bafilomycin B1 is produced by the strain of Streptomyces griseus ssp. sulphurus TU 1022 and Str. griseus TU 2437. A member of a potent family of macrocyclic lactones; broadly active against bacteria, fungi, insects, nematodes and protozoans; a potential agent for treating osteoporosis. It can inhibit the growth of gram-positive bacteria, negative bacteria, fungi, yeast and protozoa, and has the effects of insect killing, nematode killing and immunosuppression. Synonyms: Setamycin. Grades: >95% by HPLC. CAS No. 88899-56-3. Molecular formula: C44H65NO13. Mole weight: 815.98. | |
| Bafilomycin B1 (Setamycin) | Bafilomycin B1 shares the same mode of action and activity as its more accessible A1 analogue Bafilomycin B1 is broadly active against bacteria, fungi, insects, nematodes and protozoans. Bafilomycin B1 has attracted interest as a potential antiosteoporotic agent in treating bone lytic diseases. Group: Biochemicals. Alternative Names: Setamycin. Grades: Highly Purified. CAS No. 88899-56-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Bafilomycin B1 (Setamycin, BRN4640118) | Macrolide antibiotic. Specific vacuolar-type H+-ATPase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 88899-56-3. Pack Sizes: 100ug, 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Bafilomycin b2 | Bafilomycin b2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BAFILOMYCIN B2. Product Category: Heterocyclic Organic Compound. CAS No. 88907-48-6. Molecular formula: C45H67NO13. Mole weight: 830.01. Purity: 0.96. IUPACName: [(2R,4R,5R,6R)-2-[(2S,3R,4S)-3-hydroxy-4-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-2-methoxy-5-methyl-6-propan-2-yloxan-4-yl] (E)-4-[(2-hydroxy-5-oxocycl. Canonical SMILES: CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)NC3=C(CCC3=O)O)OC)O)OC)C. Product ID: ACM88907486. Alfa Chemistry ISO 9001:2015 Certified. Categories: Bafilomycin (BAF). | |
| Bafilomycin c1 | Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC). Uses: Designed for use in research and industrial production. Additional or Alternative Names: BAFILOMYCIN C1;2-Demethyl-2-methoxy-24-methylhygrolidin;Antibiotic L-681110A1;L-681110A1. Product Category: Inhibitors. Appearance: Light tan solid. CAS No. 88979-61-7. Molecular formula: C39H60O12. Mole weight: 720.8865. Purity: 0.96. IUPACName: 4-[2-hydroxy-2-[3-hydroxy-4-(10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl)pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl]oxy-4-oxobut-2-enoic acid. Canonical SMILES: CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)O)O)O)OC)C. Density: 1.18 g/cm³. Product ID: ACM88979617. Alfa Chemistry ISO 9001:2015 Certified. Categories: Bafilomycin-A1. | |
| Bafilomycin C1 | Bafilomycin C1 is a macrolide compound found in Streptomyces and an inhibitor of V-ATPase protein. It has a wide range of activities against bacteria, fungi, insects, and nematodes. It is a potential drug for the treatment of osteoporosis. Synonyms: L-681,110A1. Grades: >95% by HPLC. CAS No. 88979-61-7. Molecular formula: C39H60O12. Mole weight: 720.88. | |
| Bafilomycin C1 (Antibiotic L-681,110A1) | Bafilomycin C1 shares the same mode of action and activity as its more accessible A1 analogue Bafilomycin C1 is broadly active against bacteria, fungi, insects, nematodes and cestodes. Bafilomycin C1 has attracted interest as a potential antiosteoporotic agent in treating bone lytic diseases.The presence of the fumarate group has provided an ideal ligand for affinity chromatography of V-ATPase. Group: Biochemicals. Alternative Names: Antibiotic L-681,110A1. Grades: Highly Purified. CAS No. 88979-61-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Bafilomycin C1 (L-681,110A1, 2-Demethyl-2-methoxy-24-methyl-hygrolidin) | Antibiotic. Specific vacuolar-type H+-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Antibacterial, antifungal, insecticidal and antihelmintic. Potential anti-osteoporotic agent in treating bone lytic diseases. Neuroprotection inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 88979-61-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Bafilomycin D | Bafilomycin D is a macrolide antibiotic produced by Streptomyces. Bafilomycin D is an inhibitor that is more selective than Balifomycin A. Synonyms: Tubaymycin, 3D5. Grades: >99% by HPLC. CAS No. 98813-13-9. Molecular formula: C35H56O8. Mole weight: 604.81. | |
| Bafilomycin D | Bafilomycin D is a specific inhibitor of vacuolar-type ATPase ( V-ATPase ). Bafilomycin D has antimicrobial, insecticidal, herbicidal and cytotoxic activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 98813-13-9. Pack Sizes: 1 mg. Product ID: HY-108970. | |
| Bafilomycin D (Tubaymycin, Antibiotic 3D5) | Bafilomycin D shares the same mode of action as bafilomycin A1 which has been the analog of choice in cell biology studies of the role of ATPase. Bafilomycin D contains the ring opened side chain and is a much more stable analog of bafilomycin A1. In-house data demonstrate that bafilomycin D is also a much more selective inhibitor of mammalian cells than bafilomycin A which exhibits a broad profile against tumor cells, fungi and nematodes. Limited availability has restricted a more in depth investigation of this metabolite. Group: Biochemicals. Alternative Names: Tubaymycin, Antibiotic 3D5. Grades: Highly Purified. CAS No. 98813-13-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Concanamycin A (Folimycin, Antibiotic TAN 1323B) | Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp. It has has been shown to act as a potent and specific vacuolar-APTase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins. Group: Biochemicals. Alternative Names: Folimycin, Antibiotic TAN 1323B. Grades: Highly Purified. CAS No. 80890-47-7. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Concanamycin A (Olimycin, Antibiotic TAN 1323B, Antibiotic X4357B) (High Purity) | Antibiotic. More potent and specific H+-ATPase inhibitor than bafilomycin A1. Inhibits acidification of organelles such as lysosomes and the Golgi apparatus. Blocks cell surface expression of viral glycoproteins without affecting their synthesis. Cytotoxic in a number of cell lines in a cell viability assay. Induces nitric oxide (NO) production. Autophagy inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 80890-47-7. Pack Sizes: 25ug, 100ug, 1mg. US Biological Life Sciences. | Worldwide |
| Leucanicidin | It is produced by the strain of Streptomyces. It is a potent nematocide and insecticide belonging to the bafilomycin class. It also has anti-fungal properties. Synonyms: (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[(6-deoxy-2-O-methyl-α-L-mannopyranosyl)oxy]tetrahydro-2-hydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one; 21-O-De(3-carboxy-1-oxo-2-propenyl)-2-demethyl-21-O-(6-deoxy-2-O-methyl-α-L-mannopyranosyl)-2-methoxy-24-methylhygrolidin. Grades: >95% by HPLC. CAS No. 91021-66-8. Molecular formula: C42H70O13. Mole weight: 783.00. | |
| TRPML Agonist (ML-SA1, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1) | A membrane permeable dihydroquinolinyloxo-isoindolinedione compound that acts as a potent and selective agonist of lysosomal mucolipin transient receptor potential (TRP) channel 1,2,3 (TRPML) in all mammalian cells. Does not appear to affect six other related TRP channels. Shown to rapidly activate whole-endolysosome TRPML-like current and induce lysosomal Ca2+ release (~10uM). Its activating action on whole-endolysosome is comparable to that of PI(3,5)P2 (1uM) with which it shows a synergistic effect. ML-SA1-induced Ca2+ responses are reportedly abolished by glycyl-L-phenylalanine 2-naphthylamide, induces osmotic lysis of lysosomes, and Bafilomycin A1, a V-ATPase inhibitor. Also reduces lactosylceramide and cholesterol accumulation and corrects trafficking defects in Niemann-Pick (NP) disease cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 332382-54-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
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