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1,2,3,4,5,6,7,8-Octahydro-2,4-dioxo-[1]benzothieno[2,3-d]pyrimidine-5-carboxylic Acid is used in the synthesis of imidazo[1,2-a]thienopyrimidin-2-one derivatives as blood platelet aggregation inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1417635-86-9. Pack Sizes: 10mg, 100mg. Molecular Formula: C11H10N2O4S, Molecular Weight: 266.27. US Biological Life Sciences.
2-Oxa-7-azaspiro[3.5]nonane is an intermediate used to prepare benzothienoazepine derivatives as potent respiratory syncytial virus RNA polymerase inhibitors. It is also used to prepare 1,7-Diazacarbazole derivatives as inhibitors of checkpoint kinase 1. Group: Biochemicals. Grades: Highly Purified. CAS No. 241820-91-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C7H13NO, Molecular Weight: 127.18. US Biological Life Sciences.
A37 is an aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor (IC50 = 4.6 μM; Ki = 300 nM). It competitively binds to the aldehyde binding pocket of ALDH1A1, resulting in the disruption of spheroid formation and a decrease of cell viability in ovarian cancer cells in vitro. Synonyms: Ethyl 2-[[3, 4-dihydro-4-oxo-3-[3- (1-pyrrolidinyl) propyl][1]benzothieno[3, 2-d]pyrimidin-2-yl]thio]acetate; CM037; CM-037; CM 037; A37; A-37; A 37. Grades: ≥97% by HPLC. CAS No. 896795-60-1. Molecular formula: C21H25N3O3S2. Mole weight: 431.57.
C8-BTBT
C8-BTBT is a conducting polymer with benzothieno[3,2-b]- benzothiophene (BTBT) as the base material for the development of air-stable semiconductors. It can form a spin coated thin film that can be used as a p-type semiconductor with charge mobility of 43 cm2 V-1s-1. It exhibits highly ordered self-assembled monolayer (SAM) on graphene and hexagonal boron nitride (hBN) with sheet resistance: <1,000 ohm/sq. Uses: C8-btbt is a conjugating polymer that can be used in a variety of organic electronics based applications which includes organic photovoltaic cells (opv), organic light emitting diodes (oleds) and organic thin film transistors (otfts). Group: Organic field effect transistor (ofet) materials. Alternative Names: 2,7-Dioctyl[1]benzothieno[3,2-b][1]benzothiophene. CAS No. 583050-70-8. Pack Sizes: 100, 250 mg in glass insert. Product ID: 2,7-dioctyl-[1]benzothiolo[3,2-b][1]benzothiole. Molecular formula: 464.77. Mole weight: C30H40S2. CCCCCCCCC1=CC2=C (C=C1)C3=C (C (C=CC (CCCCCCCC)=C4)=C4S3)S2. 1S / C30H40S2 / c1-3-5-7-9-11-13-15-23-17-19-25-27 (21-23) 31-30-26-20-18-24 (22-28 (26) 32-29 (25) 30) 16-14-12-10-8-6-4-2 / h17-22H, 3-16H2, 1-2H3, YWIGIVGUASXDPK-UHFFFAOYSA-N. YWIGIVGUASXDPK-UHFFFAOYSA-N.
Copper(I) iodide 99+%
Copper (I) Iodide used in the preparation of alkynyl imines and the synthesis of pyrroles and pyrrole heterocycles. It is also used in the synthesis of BTBT derivatives ([1]Benzothieno[3,2-b]benzothiophene) for use as semiconductors in transistors. Group: Biochemicals. Alternative Names: Copper Monoiodide; Copper(1+) Iodide; Copper(I) Iodide; Cuprous Iodide; Cuprous Iodide (CuI). Grades: Reagent Grade. CAS No. 7681-65-4. Pack Sizes: 100g, 250g, 1Kg. Molecular Formula: CuI, Molecular Weight: 190.45. US Biological Life Sciences.
Worldwide
CRT0066854
CRT0066854 is a selective and ATP-competitive inhibitor of the atypical PKC isoenzymes (IC50 values 639 nM and 132 nM for full-length PKCζ, PKCΙ, respectively). CRT0066854 decreases colony formation in HeLa cells, inhibits LLGL2 phosphorylation and polarized epithelial morphogenesis, and impedes directed migration of NRK cells. Synonyms: CRT0066854; CRT 0066854; CRT-0066854; (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine. Grades: 99%. CAS No. 1438881-19-6. Molecular formula: C24H25N5S. Mole weight: 415.55.
CRT 0066854 hydrochloride
The hydrochloride salt form of CRT 0066854, which has been found to be a PKC inhibitor. Synonyms: CRT 0066854 hydrochloride; CRT0066854 hydrochloride; CRT-0066854 hydrochloride; (2S)-3-Phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C24H25N5S.2HCl. Mole weight: 488.48.
Eggmanone
Eggmanone is a potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 = 72 nM) displaying >40-fold selectivity over PDE3, PDE10, and PDE11. Eggmanone acts via blocking hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Synonyms: 5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one. Grades: ≥98% by HPLC. CAS No. 505068-32-6. Molecular formula: C20H20N2O2S3. Mole weight: 416.58.
Necrostatin-5
Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase, an enzyme responsible for necroptosis. Synonyms: Nec-5; 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile; 3-p-methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide. Grades: ≥98%. CAS No. 337349-54-9. Molecular formula: C19H17N3O2S2. Mole weight: 383.5.
SB 205384
SB 205384 is a GABAA receptor modulator. SB 205384 potentiates α6, α3 and α5-subunit-containing receptors (EC50 = 280, 695 and 730 nM, respectively). It exhibits little effect on receptors which contains α1 or α2 subunits. Synonyms: SB 205384; SB-205384; SB205384. 4-Amino-5,6,7,8-tetrahydro-7-hydroxy-2-methyl-[1H]benzothieno[2,3-b]pyridine-3-carboxylic acid 2-butynyl ester. Grades: ≥98% by HPLC. CAS No. 160296-13-9. Molecular formula: C17H18N2O3S. Mole weight: 330.4.
Syntelin
Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor. Synonyms: [(5-{[(4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)thio]methyl}-4-phenyl-4H-1,2,4-triazol-3-yl)thio]acetic acid. Grades: 98%. CAS No. 438481-33-5. Molecular formula: C21H20N6O2S3. Mole weight: 484.61.
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