Bifunctional Enzyme Suppliers USA
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Product | Description | |
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Aranorosin Quick inquiry Where to buy Suppliers range | Antibiotic. Antibacterial. Antifungal. Anticancer compound. Inhibits anti-apoptotic functions regulated by Bcl-2. Circumvents arbekacin (ABK)-resistance in MRSA by inhibiting the bifunctional enzyme AAC(6')/APH(2''). Group: Biochemicals. Grades: Highly Purified. CAS No. 117184-53-9. Pack Sizes: 250ug, 1mg. Molecular Formula: C23H33NO6. US Biological Life Sciences. | Worldwide |
ATIC Dimerization Inhibitor (Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR Transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI) Quick inquiry Where to buy Suppliers range | A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691nM, Kd = 240nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~24h), compared to AICA-riboside. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
CAY10640 Quick inquiry Where to buy Suppliers range | Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the EPHX2 gene. sEH is a member of the epoxide hydrolase family. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM. Synonyms: sEHi; Soluble Epoxide Hydrolase Inhibitor; CAY 10640; CAY-10640. Grades: ≥98%. CAS No. 1208549-68-1. Molecular formula: C17H20F3N3O3. Mole weight: 371.4. | |
MJ33 lithium salt Quick inquiry Where to buy Suppliers range | MJ33 is a selective and reversible inhibitor of the acidic, calcium-independent (ai)PLA2 activity of Prdx6. Prdx6 is a bifunctional enzyme with both non-selenium glutathione peroxidase (Gpx) and PLA2 activities. Synonyms: 1-Hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol, Li. Grades: ≥95%. CAS No. 1007476-63-2. Molecular formula: C22H43F3LiO6P. Mole weight: 498.5. | |
Oltipraz Quick inquiry Where to buy Suppliers range | Oltipraz, a promising cancer chemopreventive agent, is a bifunctional inducer, modulating both phase I and II drug-metabolizing enzymes to enhance carcinogen detoxification. Uses: Anticarcinogenic agents. Synonyms: CD1400; CD 1400; CD-1400. Grades: >98%. CAS No. 64224-21-1. Molecular formula: C8H6N2S3. Mole weight: 226.33. | |
Phenyl a-D-glucopyranoside Quick inquiry Where to buy Suppliers range | Phenyl a-D-glucopyranoside, a glycoside compound employed in the management of both cancer and diabetes, displays bifunctional properties by repressing enzymes implicated in neoplastic cell growth while simultaneously optimizing glycemic control. Its versatility extends to its widespread utilization in exploring key areas of inquiry in the biomedical field, cementing its significance as an essential tool in advancing scientific progress. CAS No. 4630-62-0. Molecular formula: C12H16O6. Mole weight: 256.25. | |
Tretazicar Quick inquiry Where to buy Suppliers range | Tretazicar (CB1954) is a dinitrobenzamide prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide (EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr). Ntr converts CB1954 to 2- and 4-hydroxylamino derivatives, whereupon the non-enzymatic reaction of the 4-hydroxylamino derivative with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA. Ntr delivery has been achieved in vitro using retroviral and adenoviral vectors and confirmed by immunocytochemical demonstration of Ntr expression. The Ntr-expressing cells have been shown to be sensitized to CB1954 by up to 2000-fold. The Ntr-CB1954 system shows effective bystander killing in mixed populations of Ntr-expressing and non-expressing cells treated with CB1954. The efficacy of this enzyme-prodrug approach in model systems compared with other VDEPT approaches demonstrates the feasibility and future promise of this gene therapy strategy. Uses: Antineoplastic agents. Synonyms: CB1954; CB-1954; CB 1954; Tretazicar. Grades: 0.98. CAS No. 21919-05-1. Molecular formula: C9H8N4O5. Mole weight: 252.186. |