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| Product | Description | |
|---|---|---|
| BIRT 377 | BIRT 377. Group: Biochemicals. Grades: Purified. CAS No. 213211-10-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| BIRT 377 | BIRT 377 is a negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM), which is involved in some important immunological events. BIRT 377 reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1, and inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo. Synonyms: BIRT-377; BIRT 377; BIRT377; (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione; (R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-1,5-dimethylimidazolidine-2,4-dione. Grades: ≥98% by HPLC. CAS No. 213211-10-0. Molecular formula: C18H15BrCl2N2O2. Mole weight: 442.13. |  |
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