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A protected histidine derivative for only the critical coupling step in Boc SPPS. After coupling the Boc- and Trt-groups are cleaved simultaneously by TFA. Uses: Peptide synthesis. Additional or Alternative Names: Boc-His(Trt)-OH, N-α-t.-Boc-N-im-trityl-L-histidine. Product Category: Amino Acids. CAS No. 32926-43-5. Mole weight: 497.58. Product ID: ACM32926435. Alfa Chemistry  ISO 9001:2015 Certified.
Boc-His(Trt)-OH
Boc-His(Trt)-OH is a histidine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 32926-43-5. Pack Sizes: 25 g; 100 g; 500 g. Product ID: HY-W010788.
Boc-His(Trt)-Aib-Gln(Trt)-Gly-Gly-OH
Boc-His(Trt)-Aib-Gln(Trt)-Gly-Gly-OH is a protected pentapeptide used in peptide synthesis. It includes histidine (His), α-aminoisobutyric acid (Aib), glutamine (Gln), and two glycine (Gly) residues. The Boc (tert-Butyloxycarbonyl) group protects the N-terminus of the histidine residue, while the Trt (Trityl) groups shield the side chains of histidine and glutamine, preventing premature reactions. The Aib residue adds conformational rigidity, and the two glycine residues at the C-terminus are free, indicated by -OH, allowing for further coupling or modifications. This peptide is designed to ensure controlled reactivity and stability throughout the synthesis process. Synonyms: HXQGG; N2-(2-((S)-2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoyl)-N5-trityl-L-glutaminylglycylglycine. Grade: ≥96%. Molecular formula: C62H66N8O9. Mole weight: 1067.26.
Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH
It is the PDC linker targeting moietie of peptide drug conjugates (PDCs). Synonyms: N2-(2-((S)-2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoyl)-N5-trityl-L-glutaminylglycine. Grade: 95%. CAS No. 3034670-38-4. Molecular formula: C60H63N7O8. Mole weight: 1010.19.
Boc-His(Trt)-Aib-Gln(Trt)-OH
Boc-His(Trt)-Aib-Gln(Trt)-OH is a protected tripeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the histidine (His) residue, preventing it from reacting during synthesis. The side chain imidazole group of histidine and the amide group of glutamine (Gln) are protected by Trt (Trityl) groups, shielding these functional groups from unwanted reactions until selective deprotection is performed. Aib (α-aminoisobutyric acid), known for inducing helical structures, is the middle residue. The -OH at the C-terminus of glutamine indicates a free carboxyl group, allowing for further coupling or modifications. This peptide is used to incorporate histidine, Aib, and glutamine into peptides, with specific protections to ensure controlled and efficient peptide synthesis. Synonyms: HXQ; N2-(2-((S)-2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoyl)-N5-trityl-L-glutamine. Grade: ≥95%. Molecular formula: C58H60N6O7. Mole weight: 953.15.
Boc-His(Trt)-Aib-Gly-OH is a protected tripeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the histidine (His) residue, preventing it from reacting during synthesis. The imidazole side chain of histidine is protected by a Trt (Trityl) group, which shields it from unwanted reactions until deprotection is performed. Aib (α-aminoisobutyric acid), known for its helical structure-inducing properties, is the middle residue. Gly (Glycine), the final amino acid, has a free carboxyl group at the C-terminus, indicated by -OH, allowing for further peptide coupling or modifications. This peptide is used to introduce histidine, Aib, and glycine into peptide sequences, with specific protections to ensure controlled and efficient peptide synthesis. Synonyms: HXG; (S)-(2-(2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoyl)glycine. Grade: ≥97%. Molecular formula: C36H41N5O6. Mole weight: 639.75.
Boc-His(Trt)-Aib-OH
Boc-His(Trt)-Aib-OH, a highly specialized peptide synthesis reagent employed within the biomedical industry, presents a powerful capability for the creation of peptide sequences inclusive of unconventional amino acids. Its steadfast utilization helps to promote the generation of distinct and optimal peptide architectures, critical for the progression of targeted drug development, including the likes of Alzheimer's disease, cancer and many other diseases. Synonyms: (S)-2-(2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoic acid. CAS No. 2061897-68-3. Molecular formula: C34H38N4O5. Mole weight: 582.7.
Boc-His(Trt)-Gln(Trt)-Gly-OH
Boc-His(Trt)-Gln(Trt)-Gly-OH is a protected tripeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the histidine (His) residue, preventing premature reactions during synthesis. The side chain imidazole group of histidine and the amide group of glutamine (Gln) are protected by Trt (Trityl) groups, shielding these functional groups until selective deprotection is required. Gly (Glycine), the final amino acid in the sequence, has a free carboxyl group at the C-terminus, indicated by -OH, which allows for further peptide coupling or modifications. This compound is used to introduce histidine, glutamine, and glycine into peptides, with controlled protection of functional groups to ensure efficient and precise peptide synthesis. Synonyms: HQG; N2-(Na-(tert-Butoxycarbonyl)-Nt-trityl-L-histidyl)-N5-trityl-L-glutaminylglycine. Grade: ≥96%. Molecular formula: C56H56N6O7. Mole weight: 925.10.