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An NS3 serine protease inhibitor of hepatitis C virus, for the treatment of HCV infection. Synonyms: EBP 520; EBP-520; EBP520; SCH-503034; SCH503034; SCH 503034 trade name: Victrelis. Grades: 0.98. CAS No. 394730-60-0. Molecular formula: C27H45N5O5. Mole weight: 519.687.
Boceprevir
Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a K i of 14 nM in both enzyme assay and an EC 90 of 350 nM in cell-based replicon assay [1] [2] [3] [4] [5]. Boceprevir inhibits SARS-CoV-2 3CL pro activity [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EBP 520; SCH 503034. CAS No. 394730-60-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10237.
Boceprevir
Inhibits HCV NS3 serine proteases in cells and HCV replicon system in vivo. Has therapeutic potential in combination with IFN therapy. Investigated in clinical studies, in combination with current standard of care treatments for HCV. Group: Biochemicals. Alternative Names: (1R, 2S, 5S) -N-[3-Amino-1- (cyclobutylmethyl) -2, 3-dioxopropyl]-3-[ (2S) -2-[[[ (1, 1-dimethylethyl) amino]carbonyl]amino]-3, 3-dimethyl-1-oxobutyl]-6, 6-dimethyl-3-azabicyclo[3. 1. 0]hexane-2-carboxamide; EBP 520; Sch 503034. Grades: Highly Purified. CAS No. 394730-60-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C??H??N?O?, Molecular Weight: 519.68. US Biological Life Sciences.
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Boceprevir-d9
A labeled NS3 serine protease inhibitor of hepatitis C virus. Group: Biochemicals. Alternative Names: (1R, 2S, 5S) -N-[3-Amino-1- (cyclobutylmethyl) -2, 3-dioxopropyl]-3-[ (2S) -2-[[[ (1, 1-dimethylethyl) amino]carbonyl]amino]-3, 3-dimethyl-1-oxobutyl]-6, 6-dimethyl-3-azabicyclo[3. 1. 0]hexane-2-carboxamide; EBP 520; Sch 503034. Grades: Highly Purified. CAS No. 1256751-11-7. Pack Sizes: 500ug. US Biological Life Sciences.
(1R,2S,5S)-Methyl 6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Boceprevir intermediates. CAS No. 565456-77-1. Molecular formula: C9H15NO2.HCl. Mole weight: 205.68. Purity: 0.98. IUPACName: methyl (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate;hydrochloride. Canonical SMILES: CC1([C@@H]2[C@H]1[C@H](NC2)C(=O)OC)C.Cl. Product ID: ACM565456771. Alfa Chemistry ISO 9001:2015 Certified. Categories: METHYL (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXANE-2-CARBOXYLATE HYDROCHLORIDE.
Used in the preparation of Boceprevir and its analogs. Group: Biochemicals. Alternative Names: (3R,7aS)-1,7a-Dihydro-3-phenyl-3H,5H-pyrrolo[1,2-c]oxazol-5-one; (3R,7aS)-3-Phenyl-1,7a-dihydro-5H-pyrrolo[1,2-c][1,3]oxazol-5-one. Grades: Highly Purified. CAS No. 134107-65-6. Pack Sizes: 100mg. US Biological Life Sciences.
Used in the preparation of Boceprevir and its analogs. Group: Biochemicals. Alternative Names: (+)-(3R,7aS)-Tetrahydro-3-phenyl-3H,5H-pyrrolo[1,2-c]oxazol-5-one. Grades: Highly Purified. CAS No. 103201-79-2. Pack Sizes: 250mg. US Biological Life Sciences.
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Boc-(S)-2-amino-3-hydroxy-3-methylbutanoic acid
Boc-(S)-2-amino-3-hydroxy-3-methylbutanoic acid is used as a reagent in the synthesis of metabolites of PPI-2458, which is a selective, irreversible inhibitor of methionine aminopeptidase-2 (MetAP2). N-Boc-3-hydroxy-L-valine is also used in the preparation of Boceprevir, an NS3 serine protease inhibitor of hepatitis C virus for the treatment of HCV infection. Synonyms: Boc-L-Ser(3,3-dimethyl)-OH; (S)-Boc-β,β-dimethyl-serine; N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-threonine; N-[(1,1-Dimethylethoxy)carbonyl]-3-hydroxy-L-valine; (S)-2-(tert-Butoxycarbonylamino)-3-hydroxy-3-methylbutanoic Acid; n-boc-(s)-2-amino-3-hydroxy-3-methylbutanoic acid; (S)-2-N-Boc-amino-3-hydroxy-3-methylbutyric acid; (S)-N-Boc-2-Amino-3-hydroxy-3-methylbutanoic acid; L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-3-hydroxy-; L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-; N-(tert-butoxycarbonyl)-3-hydroxy-L-valine; (2S)-2-(N-tert-Butoxycarbonyl)amino-3-hydroxy-3-methylbutanoic acid; N-boc-3-hydroxy-L-valine. Grades: ≥ 98% (Assay). CAS No. 102507-13-1. Molecular formula: C10H19NO5. Mole weight: 233.26.
Chlorcyclizine hydrochloride
Chlorcyclizine is a phenylpiperazine that acts as a histamine H1 receptor antagonist (Ki = 9 nM). It is believed to be effective against hepatitis C virus (HCV; EC50 = 44 nM in vitro), targeting viral entry into host cells. Chlorcyclizine showed a synergistic effect with other hepatitis C drugs such as ribavirin, interferon, telaprevir, boceprevir, sofosbuvir, daclatasvir, and cyclosporin A. Synonyms: NSC 169496; Chlorcyclizine HCl; 1-[(4-chlorophenyl)phenylmethyl]-4-methyl-piperazine monohydrochloride. Grades: ≥98%. CAS No. 14362-31-3. Molecular formula: C18H21ClN2·HCl. Mole weight: 337.3.
D-Phenylglycinamide
D-Phenylglycinamide is used in the synthesis of Boceprevir, an inhibitor of Hepatitis C. Group: Biochemicals. Alternative Names: (αR)-α-Aminobenzeneacetamide; (R)-α-Aminobenzeneacetamide; ( α R) - α -Aminon Benzene acetamide; (R)-2-Amino-2-phenylethanamide; D-2-Phenylglycinamide. Grades: Highly Purified. CAS No. 6485-67-2. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C?H??N?O, Molecular Weight: 150.18. US Biological Life Sciences.
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