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2-(Bromomethyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline is an intermediate used in the synthesis of 1,2,3,4-Tetrahydro-4-(1-hydroxycyclohexyl)-2-methyl-7-isoquinolinol (T293623), which is a useful synthetic compound. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C11H14BrNO, Molecular Weight: 256.14. US Biological Life Sciences.
CeMMEC1 is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (Kd = 1.8 μM; IC50 = 0.9 μM). It does not bind to either the first or second bromodomain of BRD4. CeMMEC1 can also inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells. Synonyms: CeMMEC1; 440662-09-9; N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide; N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-1-oxoisoquinoline-4-carboxamide; Oprea1_520920; SCHEMBL20942542; BCP19839; EX-A1815; EiM08-22966; AKOS005754739; AC-35499; MS-25094; HY-111445; CS-0040872; Z1863671528; N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-2-METHYL-1-OXO-1,2-DIHYDRO-4-ISOQUINOLINECARBOXAMIDE. Grades: ≥98%. CAS No. 440662-09-9. Molecular formula: C19H16N2O4. Mole weight: 336.3.
Minalrestat
Minalrestat is an aldose reductase inhibitor originated by Wyeth. In Aug 2002, Phase-III for Diabetic retinopathy was discontinued in USA and Europe. Uses: Diabetic retinopathy. Synonyms: Minalrestat, ARI-509; WAY-121509; WAY-ARI-509; WAYARI-509; ARI509; WAY121509; WAYARI-509; WAYARI509; Minalrestat [USAN:INN];2-[(4-bromo-2-fluorophenyl)methyl]-6-fluorospiro[isoquinoline-4,3'-pyrrolidine]-1,2',3,5'-tetrone. Grades: 98%. CAS No. 129688-50-2. Molecular formula: C19H11BrF2N2O4. Mole weight: 449.21.
2-Bromo-4-methyl-benzoic Acid
2-Bromo-4-methyl-benzoic Acid can be used to synthesize difluoropyrrolidines (an orexin receptor modulator) and isoquinolinones and azepinones. Group: Biochemicals. Grades: Highly Purified. CAS No. 7697-27-0. Pack Sizes: 1g, 5g. Molecular Formula: C8H7BrO2, Molecular Weight: 215.04. US Biological Life Sciences.
Worldwide
CeMMEC13
CeMMEC13 is an isoquinolinone and a potent inhibitor of TAF1 bromodomain with IC50 of 2.1 μM. It acts on the bromodomain of TAF1 but does not bind to bromodomains of BRD4, BRD9, or CREBBP. CeMMEC13 synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells. Synonyms: CeMMEC13; 1790895-25-8; 1-Methyl-2-oxo-1,2-dihydro-quinoline-4-carboxylic acid (2,3-dihydro-benzo[1,4]dioxin-6-yl)-amide; N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide; CHEMBL4871450; N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methyl-2-oxoquinoline-4-carboxamide; SCHEMBL20942221; BCP25037; EX-A1816; BDBM50572136; s8329; AKOS027600530; CeMMEC13, >=98% (HPLC); CCG-267868; AC-35506; BS-15617; HY-101088; CS-0020799; C73404; A924884; Z441586532; N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-1-methyl-2-oxo-4-quinolinecarboxamide. Grades: ≥98%. CAS No. 1790895-25-8. Molecular formula: C19H16N2O4. Mole weight: 336.3.
MethylBromoacetate
MethylBromoacetate is an organic building block that has been used as a reactant in the preparation of isoquinolinone indole acetic acid derivatives as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. Group: Polymerization reagents. CAS No. 96-32-2. Product ID: methyl 2-bromoacetate. Molecular formula: 152.97g/mol. Mole weight: C3H5BrO2. COC(=O)CBr. InChI=1S/C3H5BrO2/c1-6-3(5)2-4/h2H2, 1H3. YDCHPLOFQATIDS-UHFFFAOYSA-N.