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| Product | Description | |
|---|---|---|
| Bromodomain Ligand 2 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| BET Bromodomain Ligand | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Bromodomain Non-Acetylated Ligand 1 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Bromodomain Non-Acetylated Ligand 2 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| 3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-α-phenyl-benzenemethanol | 3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-α-phenyl-benzenemethanol is bromodomain ligand acting as a selective inhibitor of the first bromodomain of BRD4. Potential applications involved decreased lifespan of lung adenocarcinoma cell lines and reduction of cell proliferation in leukemia cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1429129-68-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C18H17NO3, Molecular Weight: 295.33. US Biological Life Sciences. |  Worldwide |
| AT6 | AT6 is a PROTAC AT1 analogue, which is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 with highly selectivity to bromodomain (Brd4). Uses: Scientific research. Group: Signaling pathways. CAS No. 2098836-50-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-112375. |  |
| AU-24118 | AU-24118 is a selective and orally bioavailable PROTAC degrader of mSWI-SNF ATPases (SMARCA2 and SMARCA4) and PBRM1. AU-24118 integrates a bait moiety binding to the bromodomains of SMARCA2 and SMARCA4, along with a ligand moiety for CRBN ligase. AU-24118 demonstrates tumor regression in prostate cancer model. AU-24118 can be studied to combat prostate cancer. (Pink: PBRM1/SMARCA2,4 ligand (HY-171774); Blue: CRBN ligand (HY-171775))[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3084244-26-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163410. | |
| CPI-268456 | CPI-268456 is a ligand of bromodomain-containing protein 4 (BRD4). It binds to BRD4 and inhibits LPS-induced IL-6 secretion in THP-1 cells. Synonyms: 2-[(4S)-8-chloro-6-(4-chlorophenyl)-1-methyl-4H-[1,2]oxazolo[5,4-d][2]benzazepin-4-yl]acetamide. Grade: ≥98%. CAS No. 1380087-86-4. Molecular formula: C20H15Cl2N3O2. Mole weight: 400.3. |  |
| FHD-609 | FHD-609 is a PROTAC degrader and inhibitor of BRD9 ( Bromodomain-containing protein 9 ). FHD-609 targets to ncBAF , can be used for research of wide range of cancers that contain a mutation in a BAF complex subunit. FHD-609 in combination with Telomelysin or INO5401, may play a role in adrenocortical carcinoma (ACC) treatment. (Blue: BRD9 ligand-6 (HY-49393), Black: linker (HY-168309); Pink: (S)-Deoxy-thalidomide-Br (HY-168308) ) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2676211-64-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153367. | |
| GNE-987 | GNE-987, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, is used in PROTAC-Antibody Conjugate (PAC). GNE-987 shows picomolar activity of cell BRD4 degradation (DC50 = 0.03 nM for EOL-1 AML cell line), and binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50s = 4.7 and 4.4 nM, respectively). It combines a potent BET binder/inhibitor, a VHL binding fragment and a 10 methylene spacer moiety. Synonyms: 7-(3,5-Difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxamide; N-[11-({7-(3,5-Difluoropyridin-2-yl)-2-methyl-10-[(methylsulfonyl)methyl]-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carbonyl}amino)undecanoyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide. Grade: ≥98%. CAS No. 2417371-71-0. Molecular formula: C56H67F2N9O8S2. Mole weight: 1096.31. | |
| GNE-987 | GNE-987 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. GNE-987 exhibits picomolar cell BRD4 degradation activity (DC50=0.03 nM for EOL-1 AML cell line). GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50=4.7 and 4.4 nM, respectively). GNE-987 incorporates a potent BET binder/inhibitor, a VHL-binding fragment, and a ten methylene spacer moiety. GNE-987 can be used in PROTAC-Antibody Conjugate (PAC)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2417371-71-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-129937A. | |
| JET-209 | JET-209 is a potent PROTAC CBP/p300 degrader, with DC50 values of 0.05 nM and 0.2 nM for CBP and p300. JET-209 contains Lenalidomide (HY-A0003) (the cereblon ligand), a linker and GNE-207 (HY-120028) (bromodomain Inhibitor). JET-209 is used for cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3033714-58-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-154984. | |
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