Cabozantinib Suppliers USA
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Product | Description | |
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Cabozantinib Quick inquiry Where to buy Suppliers range | Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Grades: >98%. CAS No. 849217-68-1. Molecular formula: C28H24FN3O5. Mole weight: 501.51. | |
Cabozantinib-d4 L-Malate Salt Quick inquiry Where to buy Suppliers range | Cabozantinib-d4 L-Malate Salt. Group: Biochemicals. Alternative Names: N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N'- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide-d4 (2S)-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Cabozantinib Des-O-fluoroaniline Quick inquiry Where to buy Suppliers range | It is an impurity of Cabozantinib. Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic acid; Cabozantinib Impurity 03. CAS No. 849217-77-2. Molecular formula: C22H20N2O6. Mole weight: 408.40. | |
Cabozantinib, Free Base, 99+% Quick inquiry Where to buy Suppliers range | Cabozantinib, also known as XL184, is an orally bioavailable novel tysosine kinase inhibitor of c-MET and VEGF receptor 2 (VEGFR2). It inhibited MET and VEGFR2 with IC50 values of 1.3 nM and 35 pM, respectively. It also inhibited MET-activating kinase domain mutations Y1248H, D1246N, or K1262R with IC50 values of 3.8, 11.8, and 14.6 nM, respectively. It strongly inhibited several kinases that are implicated in tumor pathobiology including KIT, RET, AXL, TIE2, and FLT3 with IC50 values of 4.6, 5.2, 7, 14.3, and 11.3 nM, respectively. In cellular assays, cabozantinib inhibited phosphorylation of MET, VEGFR2, KIT, FLT3, and AXL with IC50 values of 7.8, 1.9, 5.0, 7.5, and 42 [micro]M, respectively. Cabozantinib inhibited tumor angiogenesis, tumor growth and metastasis in cancers with dysregulated MET and VEGFR signaling. Yakes F.M., et al "Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth." Mol. Cancer Ther. 10: 229 Group: Biochemicals. Alternative Names: BMS-907351; XL-184; Cometriq; N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide (2S)-2-Hydroxybutanedioic Acid. Grades: Highly Purified. CAS No. 849217-68-1. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
Cabozantinib L-Malate Salt Quick inquiry Where to buy Suppliers range | Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis. Group: Biochemicals. Alternative Names: N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide (2S)-2-Hydroxybutanedioic Acid; Cabozantinib S-Malate; BMS-907351; XL-184; Cometriq. Grades: Highly Purified. CAS No. 849217-68-1. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
Cabozantinib Malate Quick inquiry Where to buy Suppliers range | It mainly targets MET and VEGFR2 tyrosine kinases, which are related to the growth and spread of prostate cancer, and inhibits tumor metastasis and angiogenesis. Uses: Used for research and manufacturing. Group: Other Active Pharmaceutical Ingredients. CAS No. 1140909-48-3. Product ID: PAP-0093. Appearance: Solid. | |
Cabozantinib N-oxide Quick inquiry Where to buy Suppliers range | It is an impurity of Cabozantinib. Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: 4-(4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6,7-dimethoxyquinoline 1-oxide; 1,1-Cyclopropanedicarboxamide, N-(4-((6,7-dimethoxy-1-oxido-4-quinolinyl)oxy)phenyl)-N'-(4-fluorophenyl)-; Cabozantinib Impurity 04. CAS No. 1621681-63-7. Molecular formula: C28H24FN3O6. Mole weight: 517.51. | |
Cabozantinib S-malate Quick inquiry Where to buy Suppliers range | Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: Cabozantinib malate; cabozantinib (S)-malate; Cabometyx; 1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (2S)-2-hydroxybutanedioic acid. Grades: >98%. CAS No. 1140909-48-3. Molecular formula: C28H24FN3O5.C4H6O5. Mole weight: 635.59. | |
N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N'- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide Quick inquiry Where to buy Suppliers range | N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N'- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide. Group: Biochemicals. Alternative Names: XL184; Cabozantinib. Grades: Highly Purified. CAS No. 849217-68-1. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C28H24FN3O5. US Biological Life Sciences. | Worldwide |
N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-N-phenylcyclopropane-1,1-dicarboxamide Quick inquiry Where to buy Suppliers range | It is an impurity of Cabozantinib. Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: 1,1-Cyclopropanedicarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl-; Cabozantinib Impurity 02. CAS No. 849221-94-9. Molecular formula: C28H25N3O5. Mole weight: 483.52. | |
N-(4-fluorophenyl)-N-(4-((6-hydroxy-7-methoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide Quick inquiry Where to buy Suppliers range | It is an impurity of Cabozantinib. Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: 1,1-Cyclopropanedicarboxamide, N-(4-fluorophenyl)-N'-[4-[(7-hydroxy-6-methoxy-4-quinolinyl)oxy]phenyl]-; Cabozantinib Impurity 06. CAS No. 1628530-42-6. Molecular formula: C27H22FN3O5. Mole weight: 487.48. | |
N-(4-fluorophenyl)-N-(4-((7-hydroxy-6-methoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide Quick inquiry Where to buy Suppliers range | It is an impurity of Cabozantinib. Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: 1,1-Cyclopropanedicarboxamide, N-(4-fluorophenyl)-N'-(4-((6-hydroxy-7-methoxy-4-quinolinyl)oxy)phenyl)-; Dimethyl cabozantinib; Cabozantinib Impurity 05. Grades: 99% by HPLC. CAS No. 1628530-47-1. Molecular formula: C27H22FN3O5. Mole weight: 487.48. | |
N,N'-bis(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)cyclopropane-1,1-dicarboxamide Quick inquiry Where to buy Suppliers range | It is an impurity of Cabozantinib. Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: 1,1-Cyclopropanedicarboxamide, N,N'-bis(4-((6,7-dimethoxy-4-quinolinyl)oxy)phenyl)-; Cabozantinib Impurity 01. CAS No. 2439164-91-5. Molecular formula: C39H34N4O8. Mole weight: 686.72. | |
N,N'-bis(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Quick inquiry Where to buy Suppliers range | It is an impurity of Cabozantinib. Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: Cabozantinib Impurity EXA; 1,1-Cyclopropanedicarboxamide, N,N'-bis(4-fluorophenyl)-; Cabozantinib Impurity 06. CAS No. 1431468-36-8. Molecular formula: C17H14F2N2O2. Mole weight: 316.30. |