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| Product | Description | |
|---|---|---|
| Cabozantinib | Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET , with IC 50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT , RET , AXL , TIE2 , and FLT3 ( IC 50 =4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: XL184; BMS-907351. CAS No. 849217-68-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13016. |  |
| Cabozantinib | Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Grade: >98%. CAS No. 849217-68-1. Molecular formula: C28H24FN3O5. Mole weight: 501.51. |  |
| Cabozantinib-d4 L-Malate Salt | Cabozantinib-d4 L-Malate Salt. Group: Biochemicals. Alternative Names: N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N'- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide-d4 (2S)-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Cabozantinib Des-O-fluoroaniline | It is an impurity of Cabozantinib. Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic acid; Cabozantinib Impurity 03. CAS No. 849217-77-2. Molecular formula: C22H20N2O6. Mole weight: 408.40. | |
| Cabozantinib, Free Base, 99+% | Cabozantinib, also known as XL184, is an orally bioavailable novel tysosine kinase inhibitor of c-MET and VEGF receptor 2 (VEGFR2). It inhibited MET and VEGFR2 with IC50 values of 1.3 nM and 35 pM, respectively. It also inhibited MET-activating kinase domain mutations Y1248H, D1246N, or K1262R with IC50 values of 3.8, 11.8, and 14.6 nM, respectively. It strongly inhibited several kinases that are implicated in tumor pathobiology including KIT, RET, AXL, TIE2, and FLT3 with IC50 values of 4.6, 5.2, 7, 14.3, and 11.3 nM, respectively. In cellular assays, cabozantinib inhibited phosphorylation of MET, VEGFR2, KIT, FLT3, and AXL with IC50 values of 7.8, 1.9, 5.0, 7.5, and 42 [micro]M, respectively. Cabozantinib inhibited tumor angiogenesis, tumor growth and metastasis in cancers with dysregulated MET and VEGFR signaling. Yakes F.M., et al "Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth." Mol. Cancer Ther. 10: 229 Group: Biochemicals. Alternative Names: BMS-907351; XL-184; Cometriq; N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide (2S)-2-Hydroxybutanedioic Acid. Grades: Highly Purified. CAS No. 849217-68-1. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
| Cabozantinib impurity 59 | Cabozantinib impurity 59. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-ethoxy-3-oxopropanoic acid. CAS No. 1071-46-1. Molecular formula: C5H8O4. Mole weight: 132.11. Catalog: APB1071461. |  |
| Cabozantinib L-Malate Salt | Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis. Group: Biochemicals. Alternative Names: N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide (2S)-2-Hydroxybutanedioic Acid; Cabozantinib S-Malate; BMS-907351; XL-184; Cometriq. Grades: Highly Purified. CAS No. 849217-68-1. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
| Cabozantinib Malate | It mainly targets MET and VEGFR2 tyrosine kinases, which are related to the growth and spread of prostate cancer, and inhibits tumor metastasis and angiogenesis. CAS No. 1140909-48-3. Product ID: PAP-0093. Molecular formula: C32H30FN3O10. Product Keywords: Other Active Pharmaceutical Ingredients; Cabozantinib Malate; PAP-0093; ; C32H30FN3O10; 1140909-48-3. Appearance: Solid. Color: White to Off-White. EC Number: 691-711-0. Physical State: Solid. Solubility: DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly). Storage: Sealed in dry,Room Temperature. Applications: For the treatment of progressive and metastatic medullary thyroid cancer. Melting Point: 166-169°C. |  |
| Cabozantinib N-oxide | It is an impurity of Cabozantinib. Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: 4-(4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6,7-dimethoxyquinoline 1-oxide; 1,1-Cyclopropanedicarboxamide, N-(4-((6,7-dimethoxy-1-oxido-4-quinolinyl)oxy)phenyl)-N'-(4-fluorophenyl)-; Cabozantinib Impurity 04. CAS No. 1621681-63-7. Molecular formula: C28H24FN3O6. Mole weight: 517.51. | |
| Cabozantinib S-malate | Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: Cabozantinib malate; cabozantinib (S)-malate; Cabometyx; 1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (2S)-2-hydroxybutanedioic acid. Grade: >98%. CAS No. 1140909-48-3. Molecular formula: C28H24FN3O5.C4H6O5. Mole weight: 635.59. | |
| Cabozantinib S-malate | Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2 , c-Met , Kit , Axl and Flt3 with IC 50 s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: XL184 S-malate; BMS-907351 S-malate. CAS No. 1140909-48-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12044. | |
| Cabozantinib (Standard) | Cabozantinib (Standard) is the analytical standard of Cabozantinib. This product is intended for research and analytical applications. Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET , with IC 50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT , RET , AXL , TIE2 , and FLT3 ( IC 50 =4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 849217-68-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13016R. | |
| 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine | 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine is used in preparation of Cabozantinib Defluorination impurity. Synonyms: Cabozantinib Amine Analog; 4-[(6,7-Dimethoxy-4-quinolinyl)oxy]benzenamine; 6,7-Dimethoxy-4-(4-aminophenoxy)quinoline; [4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl]amine; 4-(4-Aminophenoxy)-6,7-dimethoxyquinoline; 4-[(6,7-Dimethoxy-4-quinolinyl)oxy]aniline. Grade: ≥95%. CAS No. 190728-25-7. Molecular formula: C17H16N2O3. Mole weight: 296.32. | |
| 4-Chloro-7,8-dimethoxyquinoline | 4-Chloro-7,8-dimethoxyquinoline is a highly potent compound extensively utilized in the research of ailments encompassing fungal infections, malaria and cancer. This arises from its unparalleled chemical architecture, which actively obstructs distinct enzymatic processes and pathways intricately linked to these afflictions. Synonyms: NSC382169; Quinoline, 4-chloro-7,8-dimethoxy-; Cabozantinib Impurity 54. Grade: ≥95%. CAS No. 99878-79-2. Molecular formula: C11H10ClNO2. Mole weight: 223.66. | |
| 5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione | 5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione is an impurity of Cabozantinib, which is a potent VEGFR2 inhibitor. Synonyms: 5-(Methoxymethylene) Meldrum's Acid; 1,3-Dioxane-4,6-dione, 5-(methoxymethylene)-2,2-dimethyl-; NSC662768; 2-(Methoxymethylene)malonic acid isopropylidene ester; 2,2-dimethyl-5-methoxymethylene-1,3-dioxan-4,6-dione; 2,2-dimethyl 4,6-dioxo-5-methoxymethylene-1,3-dioxane; Cabozantinib impurity 56; Lenvatinib Impurity 79. Grade: ≥95%. CAS No. 15568-85-1. Molecular formula: C8H10O5. Mole weight: 186.16. | |
| N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N'- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide | N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N'- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide. Group: Biochemicals. Alternative Names: XL184; Cabozantinib. Grades: Highly Purified. CAS No. 849217-68-1. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C28H24FN3O5. US Biological Life Sciences. | Worldwide |
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