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| Product | Description | |
|---|---|---|
| Calcein-AM | Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Calcein acetoxymethyl ester. CAS No. 148504-34-1. Pack Sizes: 1 mg. Product ID: HY-D0041. |  |
| Calcein-AM | Calcein-AM. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CalceinO,O'-diacetatetetrakis(acetoxymethyl)ester,Calceinacetoxymethylester,Diacetate,CAL-AM,NSC689290. Product Category: Fluorescein Fluorophores. Appearance: White to off-white solid. CAS No. 148504-34-1. Molecular formula: C46H46N2O23. Mole weight: 994.86. Purity: 95%+. IUPACName: Acetyloxymethyl2-[[2-(acetyloxymethoxy)-2-oxoethyl]-[[3',6'-diacetyloxy-7'-[[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]methyl]-3-oxospiro[2-benzofuran-1,9'-xanthene]-2'-yl]methyl]amino]acetate. Product ID: ACM148504341-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: Calcein AM. |  |
| Calcein-AM - CAS 148504-34-1 | A cell-permeable, non-fluorescent, and hydrophobic compound, which is rapidly hydrolyzed by intracellular esterases releasing the membrane-impermeable, hydrophilic, and intensely fluorescent calcein. Group: Fluorescence/luminescence spectroscopy. |  |
| CP 100356 | CP 100356 is a high affinity P-glycoprotein inhibitor.Ki value is 58 nM for mouse Pgp1a and 94nMfor Pgp1b isoforms. It can Inhibit calcein-AM uptake in MDR1-transfected MDCKII cells with IC50 value of 0.5 μM and prazosin transport in BCRP-transfected MDCKII cells with IC50 value of 1.5 μM. Preclinical development for Cancer in USA was discontinued. Uses: Cancer. Synonyms: CP 100356; CP100356; CP-100356; 4-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-6,7-dimethoxy-2-Quinazolinamine; 142715-48-8(hydrochloride). Grades: >98 %. CAS No. 142716-85-6. Molecular formula: C31H36N4O6. Mole weight: 560.64. |  |
| CP-100356 hydrochloride | CP-100356 hydrochloride is an orally active dual MDR1 (P-gp)/BCRP inhibitor, with an IC50s of 0.5 and 1.5 μM for inhibiting MDR1-mediated Calcein-AM transport and BCRP-mediated Prazosin transport, respectively. CP-100356 hydrochloride is also a weak inhibitor of OATP1B1 (IC50=?66 μM). CP-100356 hydrochloride is devoid of inhibition against MRP2 and major human P450 enzymes (IC50>15 μM)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 142715-48-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108347. | |
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