Calpain Suppliers USA
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Product | Description | |
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Calpain inhibitor i Quick inquiry Where to buy Suppliers range | powder. Group: Heterocyclic Organic Compound. Alternative Names: acetylleucyl-leucyl-norleucinal;N-AC-LEU-LEU-NORLEUCINAL;N-ACETYL-LEU-LEU-NLE-CHO;N-ACETYL-L-LEUCYL-L-LEUCYL-L-NORLEUCINAL;N-ACETYL-LEU-LEU-NORLEUCINAL;MG 101;LLNL;CALPAIN INHIBITOR. CAS No. 110044-82-1. Molecular formula: C20H37N3O4. Mole weight: 383.53. Safty Description: 22-24/25. | |
Calpain inhibitor I Quick inquiry Where to buy Suppliers range | Calpain inhibitor I. Group: Biochemicals. Grades: Highly Purified. CAS No. 110044-82-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C20H37N3O4. US Biological Life Sciences. | Worldwide |
Calpain Inhibitor I Quick inquiry Where to buy Suppliers range | MG-101, also known as Calpain Inhibitor I and ALLN, is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Activities of MG-101 includes: (1) reduce colon injury caused by dinitrobenzene sulphonic acid, (2) overcome acquired resistance to TRAIL, (3) protect against atractyloside-induced toxicity. (4). reduce colon injury caused by dinitrobenzene sulphonic acid. Synonyms: (S)-N-Acetyl-L-leucyl-N-(1-formylpentyl)-L-leucinamide; ALLN; ALLnL; CI-1 (peptide); Calp I; Calpain inhibitor I; MG 101; (S)-N-Acetyl-L-leucinyl-L-leucinyl-L-norleucinal; MG-101. Grades: 98 %. CAS No. 110044-82-1. Molecular formula: C20H37N3O4. Mole weight: 383.52. | |
Calpain Inhibitor II Quick inquiry Where to buy Suppliers range | Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grades: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57. | |
Calpain Inhibitor II Quick inquiry Where to buy Suppliers range | Calpain Inhibitor II. Group: Biochemicals. Grades: Highly Purified. CAS No. 110115-07-6. Pack Sizes: 5mg, 10mg, 25mg. US Biological Life Sciences. | Worldwide |
Calpain Inhibitor III Quick inquiry Where to buy Suppliers range | Calpain Inhibitor III. Group: Biochemicals. Grades: Highly Purified. CAS No. 88191-84-8. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
Calpain Inhibitor IV Quick inquiry Where to buy Suppliers range | The Calpain Inhibitor IV controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 557.65. Catalog: IAR42415257. | |
Calpain Inhibitor V Quick inquiry Where to buy Suppliers range | The Calpain Inhibitor V controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 407.48. Catalog: IAR42415258. | |
Calpain Inhibitor VI Quick inquiry Where to buy Suppliers range | Calpain Inhibitor VI is a cell-permeable peptide aldehyde which functions as a reversible calpain inhibitor. It is an inhibitor of the calcium-dependent cysteine proteases μ-calpain with IC50 of 7.5 nM for calpain-1 and m-calpain with IC50 of 78 nM for calpain-2. Calpain Inhibitor VI can reduce nuclear opacity and proteolysis of crystallins and α-spectrin. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Synonyms: SJA 6017. Grades: ≥95%. CAS No. 190274-53-4. Molecular formula: C17H25FN2O4S. Mole weight: 372.5. | |
Calpain Inhibitor XII Quick inquiry Where to buy Suppliers range | Calpain Inhibitor XII is a cell-permeable, potent, selective, reversible, and active-site-directed inhibitor of calpain-1 with Ki of 19 nM. It has been shown to inhibit calpain-2 with Ki of 120 nM and human cathepsin B with Ki of 750 nM. Calpain inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury. Synonyms: Z-L-Nva-CONH-CH2-2-Py. Grades: ≥90%. CAS No. 181769-57-3. Molecular formula: C26H34N4O5. Mole weight: 482.6. | |
MDL 28170, Z-Val-Phe-CHO, (Carbobenzoxy-valinyl-phenylalaninal, Calpain Inhibitor III) Quick inquiry Where to buy Suppliers range | A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25nm respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Modulates the formation of Ab formation by inhibiting the formation of intermediate Ab46 and protecting Ab from degradation. Group: Biochemicals. Grades: Highly Purified. CAS No. 88191-84-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
12-Amino Minocycline Quick inquiry Where to buy Suppliers range | 12-Amino Minocycline is an impurity of Minocycline. It can be used in the preparation of calpain inhibitors. CAS No. 864073-42-7. Molecular formula: C23H28N4O6. Mole weight: 456.49. | |
(2R,?3R)?-2-Bromo-3-hydroxybutanedioic Acid 1,4-Diethyl Ester Quick inquiry Where to buy Suppliers range | (2R,?3R)?-2-Bromo-3-hydroxybutanedioic Acid 1,4-Diethyl Ester is an intermediate in the synthesis of derivative of E-64 an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. Group: Biochemicals. Grades: Highly Purified. CAS No. 80640-15-9. Pack Sizes: 1g, 5g. Molecular Formula: C8H13BrO5. US Biological Life Sciences. | Worldwide |
(2S, 3S) -3- [ [ [ (1S) -1- [ [ (4-Azidobutyl) amino] carbonyl] -3-methylbutyl] amino] carbonyl] -2-oxiranecarboxylic Acid Ethyl Ester Quick inquiry Where to buy Suppliers range | N3Le is a derivative of E-64 an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1174021-95-4. Pack Sizes: 1mg, 10mg. Molecular Formula: C16H27N5O5. US Biological Life Sciences. | Worldwide |
2-Thiophenebutanoic Acid Quick inquiry Where to buy Suppliers range | 2-Thiophenebutanoic Acid is used to prepare cell-penetrating peptide α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy. it is also used to prepare isochroman carboxylic acid derivatives as potential anti-diabetic agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 4653-11-6. Pack Sizes: 1g, 5 g. Molecular Formula: C8H10O2S, Molecular Weight: 170.23. US Biological Life Sciences. | Worldwide |
3,3-Diphenylpropionic Acid Quick inquiry Where to buy Suppliers range | 3,3-Diphenylpropionic Acid is used in the preparation of steroid 5α-reductase inhibiting acylpiperidines. It can also be used in the preparation of calpain-inhibitory piptidyl α-ketoacids and esters. Group: Biochemicals. Alternative Names: β-Phenylbenzenepropanoic Acid; Diphenylpropionic Acid; NSC 631492; NSC 6797; β-Phenylbenzenepropanoic Acid. Grades: Highly Purified. CAS No. 606-83-7. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C??H??O?, Molecular Weight: 226.27. US Biological Life Sciences. | Worldwide |
Acetyl-Calpastatin (184-210) (human) Quick inquiry Where to buy Suppliers range | Acetyl-Calpastatin (184-210) (human) is a calpain I/II inhibitor and could increase secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio. Grades: ≥95% by HPLC. CAS No. 123714-50-1. Molecular formula: C142H230N36O44S. Mole weight: 3177.65. | |
ALLM - CAS 110115-07-6 Quick inquiry Where to buy Suppliers range | Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 110115-07-6. Pack Sizes: 25MG. Mole weight: 401.56. Catalog: AP110115076. Assay: >95% (HPLC). | |
Aloxistatin Quick inquiry Where to buy Suppliers range | Aloxistatin is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain, which predicted to function against SARS-CoV-2 infection. Synonyms: L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide; L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester; (2S, 3S) -3-[[[ (1S) -3-Methyl-1-[[ (3-methylbutyl) amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic Acid Ethyl Ester; E 64c ethyl ester; E 64d; EP 453; EST; Loxistatin; NSC 694281; (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester. Grades: 98%. CAS No. 88321-09-9. Molecular formula: C17H30N2O5. Mole weight: 342.43. | |
Aureusimine B Quick inquiry Where to buy Suppliers range | It is an inhibitor of the protease Calpain produced by the strain of Streptomyces sp. SC433. It is a small molecular weight monoketopiperazine formed non-ribosomally by the fusion of phenylalanine and valin. Synonyms: Phevalin; 3-(1-Methylethyl)-6-(phenylmethyl)-2(1H)-pyrazinone; 6-Benzyl-3-isopropylpyrazin-2-one. Grades: >95% by HPLC. CAS No. 170713-71-0. Molecular formula: C14H16N2O. Mole weight: 228.29. | |
BAPTA-AM Quick inquiry Where to buy Suppliers range | BAPTA-AM is a lipophilic diester of BAPTA used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE. Group: Biochemicals. Alternative Names: N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]glycine 1,1'-bis[(acetyloxy)methyl] ester; 1,2-Bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid tetraacetoxymethyl ester. Grades: Highly Purified. CAS No. 126150-97-8. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O??, Molecular Weight: 764.68. US Biological Life Sciences. | Worldwide |
Biotin-LLY-FMK Quick inquiry Where to buy Suppliers range | Biotin-LLY-FMK is a biotin-labeled calpain inhibitor that can be used as a probe for detecting calpain II and cathepsin L by biotin ligand. Synonyms: Biotin-Leu-Leu-Tyr-Fluoromethylketone. Grades: ≥95%. Molecular formula: C32H48FN5O6S. Mole weight: 649.82. | |
Calpastatin Peptide Quick inquiry Where to buy Suppliers range | A 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 500μG. Mole weight: 3177.63. Catalog: IAR42415262. Assay: ≥95% (HPLC). | |
Calpeptin Quick inquiry Where to buy Suppliers range | Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Uses: Cysteine proteinase inhibitors. Synonyms: Benzylcarbonyl-leu-nleu-H; Cbz-Leu-Nle-al. Grades: >98%. CAS No. 117591-20-5. Molecular formula: C20H30N2O4. Mole weight: 362.46. | |
Clasto-Lactacystin beta-lactone (Omuralide) Quick inquiry Where to buy Suppliers range | In vitro lactacystin does not react with the proteasome. It rather undergoes a spontaneous conversion (lactonization) to the active metabolite clasto-lactacystin beta-lactone. Potent and selective irreversible and cell permeable proteasome inhibitor. Inhibits the chymotrypsin-like, trypsin-like and caspase-like peptidase activity of the proteasome. The active metabolite of lactacystin with higher potency since it does not require hydrolysis in order to become cell permeable. Calpain and cathepsin inhibitor. Apoptosis inducer. Anticancer compound. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Induces neuritogenesis. Autophagy inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 154226-60-5. Pack Sizes: 100ug. Molecular Formula: C10H15NO4, Molecular Weight: 213.2. US Biological Life Sciences. | Worldwide |
Dihydroeponemycin Quick inquiry Where to buy Suppliers range | Dihydroeponemycin is a natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X. It does not inhibit calpain or trypsin and has minor effects on cathepsin B and chymotrypsin at higher concentrations. It is cell-permeable and induces apoptosis in bovine aortic endothelial cells. Grades: ≥98%. CAS No. 126463-64-7. Molecular formula: C20H36N2O6. Mole weight: 400.5. | |
E-64c Quick inquiry Where to buy Suppliers range | Calpain Inhibitor. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 76684-89-4. Pack Sizes: 5MG. Mole weight: 314.38. Catalog: AP76684894. | |
E-64d Quick inquiry Where to buy Suppliers range | E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats. Group: Biochemicals. Alternative Names: (2S, 3S) -3- [ [ [ (1S) -3-Methyl-1- [ [ (3-methylbutyl) amino] carbonyl] butyl] amino] carbonyl] -2-oxiranecarboxylic Acid Ethyl Ester; Aloxistatin; E 64c ethyl ester; E 64d; EP 453; EST; EST (pharmaceutical); Loxistatin; NSC 694281. Grades: Highly Purified. CAS No. 88321-09-9. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
Fitc-LLY-FMK Quick inquiry Where to buy Suppliers range | FITC-LLY-FMK is a fluorescein isothiocyanate (FITC)-conjugated calpain inhibitor that can be used as a marker for detecting calpain II and cathepsin L in live cells. Synonyms: FITC-Leu-Leu-Tyr-Fluoromethylketone. Grades: ≥95%. Molecular formula: C43H45FN4O9S. Mole weight: 812.91. | |
H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH Quick inquiry Where to buy Suppliers range | H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH is an internally quenched substrate for calpain-1 (μ-calpain) with optimal cleavage motifs flanking the scissile bond. The turnover rate of the enzyme to hydrolysis of this FRET substrate based on the PLFAER amino acid sequence is more than 18 times higher than that of EVYGMM derived from the natural substrate α-spectrin cleavage site. Synonyms: N- ({5-[ (2-Aminoethyl) amino]-1-naphthyl}sulfonyl) -L-α -glutamyl-L-prolyl-L-leucyl-L-phenylalanyl-L-alanyl-L-α -glutamyl-L-arginyl-N6- (4-{[4- (dimethylamino) phenyl]diazenyl}benzoyl) -L-lysine. Grades: ≥95%. CAS No. 1914987-47-5. Molecular formula: C72H97N17O16S. Mole weight: 1488.71. | |
Leupeptin hemisulfate Quick inquiry Where to buy Suppliers range | Leupeptin Hemisulfate is a reversible, competitive inhibitor of serine/cysteine protease, which inhibits cathepsins B, H, L and S, calpain and trypsin. It is used as antioxidant and anti-inflammatory agent. Uses: Peptide Inhibitors. CAS No. 103476-89-7. Product ID: R0896. | |
MDL 28170 Quick inquiry Where to buy Suppliers range | MDL 28170. Group: Biochemicals. Alternative Names: [ (1S) -1-[[ (1-Formyl-2-phenylethyl) amino]carbonyl]-2-methylpropyl]carbamic Acid Phenylmethyl Ester; Calp III; Calpain Inhibitor III. Grades: Highly Purified. CAS No. 88191-84-8. Pack Sizes: 25mg. Molecular Formula: C22H26N2O4, Molecular Weight: 382.45. US Biological Life Sciences. | Worldwide |
MDL 28170 Quick inquiry Where to buy Suppliers range | MDL 28170 is a calpain and cathepsin B inhibitor with Ki values of 10 and 25 nM respectively. It shows neuroprotective effects in vivo. MDL 28170 can attenuate depression in myocardial contractile performance which occurs during reperfusion following cardiac ischemia. Synonyms: benzyl N-[(2S)-3-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]butan-2-yl]carbamate. Grades: ≥ 95 % by HPLC. CAS No. 88191-84-8. Molecular formula: C22H26N2O4. Mole weight: 382.45. | |
MG-132 (Z-Leu-Leu-Leu-CHO) Quick inquiry Where to buy Suppliers range | Potent, cell permeable and selective, reversible proteasome inhibitor. Blocks degradation of short-lived proteins and induces a heat shock response. NF-kB activation inhibitor through IκB degradation. Cell permeable, reversible peptide aldehyde inhibitor. Calpain and cathepsin inhibitor. Has anticancer properties by inducing cell cycle arrest and activating apoptosis in various cancer cell lines. Has adjuvant / chemosensitizer potential. Neurite outgrowth stimulator in PC12 cells. Prevents beta-secretase cleavage. Autophagy activator. Group: Biochemicals. Alternative Names: Z-Leu-Leu-Leu-al; Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal; Proteasome Inhibitor XI). Grades: Highly Purified. CAS No. 133407-82-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C26H41N3O5, Sequence: Z-Leu-Leu-Leu-aldeyhde. US Biological Life Sciences. | Worldwide |
PD 145305 Quick inquiry Where to buy Suppliers range | PD 145305 is an inactive analog of PD 150606, a selective calpain inhibitor. Synonyms: 3-phenyl-2-sulfanylpropanoic acid; Benzylthioglykolsaure. Grades: ≥95%. CAS No. 90536-15-5. Molecular formula: C9H10O2S. Mole weight: 182.2. | |
PD 150606 Quick inquiry Where to buy Suppliers range | PD 150606 is a selective, cell-permeable inhibitor of calpains (Ki = 0.21 μM for μ-calpain (calpain-1) and 0.37 μM for m-calpain (calpain-2)). It targets the calcium binding sites of calpain. PD 150606 demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate. Synonyms: PD-150606; PD150606. Grades: ≥95% by HPLC. CAS No. 179528-45-1. Molecular formula: C9H7IO2S. Mole weight: 306.12. | |
PD 150,606 (3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid) Quick inquiry Where to buy Suppliers range | Cell permeable and selective calpain inhibitor. Interacts with calcium-binding domain of calpain. Neuroprotective. Ca2+-permeable AMPA receptor inhibitor. Apoptosis inhibitor. Group: Biochemicals. Alternative Names: 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid. Grades: Highly Purified. CAS No. 426821-41-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
PD 150606 - CAS 426821-41-2 Quick inquiry Where to buy Suppliers range | A cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 and 370 nM for calpain-2. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 426821-41-2. Pack Sizes: 5MG. Mole weight: 306.12. Catalog: AP426821412. Assay: ≥95% (HPLC). | |
PD 151746 Quick inquiry Where to buy Suppliers range | PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain. Synonyms: PD-151746; PD 151746; PD151746. Grades: >98%. CAS No. 179461-52-0. Molecular formula: C11H8FNO2S. Mole weight: 237.25. | |
Penicillide (Vermixocin A, Antibiotic AS 186A, Antibiotic MC 140) Quick inquiry Where to buy Suppliers range | Plant growth inhibitor. Acyl-CoA-cholesterol acyltransferase (ACAT) inhibitor. Anticancer compound. Cytotoxic. Non-peptidic oxytocin receptor antagonist. Calpain inhibitor. Source:Isolated from Penicillium sp. Group: Biochemicals. Alternative Names: Vermixocin A, Antibiotic AS 186A, Antibiotic MC 140. Grades: Highly Purified. CAS No. 55303-92-9. Pack Sizes: 250ug, 1mg. Molecular Formula: C21H24O6, Molecular Weight: 372.4. US Biological Life Sciences. | Worldwide |
Proteasome Substrate III, Fluorogenic Quick inquiry Where to buy Suppliers range | Proteasome Substrate III, Fluorogenic, is a substrate for proteasome. Also acts as a substrate for calpain, chymotrypsin, and ingensin. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG. Mole weight: 763.88. Catalog: IAR42416016. Assay: ≥98% (HPLC). | |
Q-VD-OPh (Anhydrous) Quick inquiry Where to buy Suppliers range | Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6- difluorophenoxy methyl (OPh) group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies. CAS Number:1135695-98-5 (anhydrous). Group: Biochemicals. Alternative Names: Q-Val-Asp-OPh; pan-Caspase Inhibitor; N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone, (3S) -5- (2, 6-Difluorophenoxy) -3-[[ (2S) -3-methyl-1-oxo-2-[ (2-quinolinylcarbonyl) amino]butyl]amino]-4-oxo-pentanoic Acid. Grades: Highly Purified. CAS No. 1135695-98-5. Pack Sizes: 1mg, 3x1mg, 5mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. | Worldwide |
Suc-Leu-Leu-Val-Tyr-AMC Quick inquiry Where to buy Suppliers range | Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic substrate of calpains and 20S proteasome and used to study the activity of calpains and proteosomal degradation. It is also a substrate for carboxypeptidase Y, proteinase yscE (kexin), ingensin, as well as for porcine calpain isozymes I and II and for papain. Uses: Peptide Inhibitors. CAS No. 94367-21-2. Product ID: R0808. | |
Suc-Leu-Leu-Val-Tyr-AMC Quick inquiry Where to buy Suppliers range | Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic substrate of calpains and 20S proteasome. Synonyms: Suc-LLVY-AMC; Proteasome substrate (fluorogenic); Calpain substrate (fluorogenic). Grades: >97%. CAS No. 94367-21-2. Molecular formula: C40H53N5O10. Mole weight: 763.89. | |
Suc-Leu-Tyr-AMC Quick inquiry Where to buy Suppliers range | Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease), and used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; emission max: 460 nm). Suc-Leu-Tyr-AMC can also be cleaved by the Ti protease from E. coli. Uses: Peptide Inhibitors. CAS No. 94367-20-1. Product ID: R0810. | |
Suc-Leu-Tyr-AMC Quick inquiry Where to buy Suppliers range | Suc-Leu-Tyr-AMC is a fluorescent substrate for calpains I and II and papain (another cysteine protease). Synonyms: Suc-LY-AMC. Grades: >98%. CAS No. 94367-20-1. Molecular formula: C29H33N3O8. Mole weight: 551.6. | |
USP7-USP47 inhibitor Quick inquiry Where to buy Suppliers range | USP7/USP47 inhibitor(compound 14) is a selective USP7 (EC50= 0.42 μM)/USP47 (EC50= 1.0 μM) inhibitor but does not inhibit caspase 3, calpain 1, 20S proteasome, and a panel of representative USPs (USP2, USP5, USP8, USP21, and USP28; EC50 > 31.6 μM Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47. compound 14 exhibits enhanced potency against HCT-116 cells. treatment of cells with compound 14 resulted in an increase in p53 and an appreciable induction of p21 protein over the DMSO control. Thus, compound 14 penetrated the cells and modulated p53 and p21 as expected for a USP7 inhibitor. Synonyms: MDK25371; MDK25371; MDK25371; USP7-USP47 inhibitor; 2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-. Grades: >98%. CAS No. 1247825-37-1. Molecular formula: C18H11Cl2N3O3S3. Mole weight: 484.4. | |
Z-LLY-FMK Quick inquiry Where to buy Suppliers range | Z-LLY-FMK is a cell-permeant and irreversible calpain inhibitor that is selective for calpain II, and also exhibits inhibitory effect against cathepsin L. It was shown to suppress hepatocyte apoptosis after bile duct ligation in rat. Synonyms: Calpain Inhibitor IV; Z-Leu-Leu-Tyr-FMK; Z-Leu-Leu-Tyr-Fluoromethylketone; N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide. Grades: ≥95%. CAS No. 133410-84-1. Molecular formula: C30H40FN3O6. Mole weight: 557.66. |