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| Product | Description | |
|---|---|---|
| calpain-1 | In peptidase family C2. Requires Ca2+ at micromolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53, calpain-2. Group: Enzymes. Synonyms: μ-calpain; calcium-activated neutral protease I. Enzyme Commission Number: EC 3.4.22.52. CAS No. 78990-62-2. Calpain 1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4227; calpain-1; EC 3.4.22.52; 78990-62-2; μ-calpain; calcium-activated neutral protease I. Cat No: EXWM-4227. |  |
| Calpain-1, Human Erythrocytes | Calpain-1, Human Erythrocytes, is a native calpain-1. A heterodimeric cysteine proteinase with low Ca2+ requirement (EC?? = 2 μM). Group: Fluorescence/luminescence spectroscopy. |  |
| Calpain-1, Porcine Erythrocytes | Calpain-1, Porcine Erythrocytes, is a native calpain-1. A heterodimeric cysteine proteinase with low Ca2+ requirement (EC?? = 2 μM). Group: Fluorescence/luminescence spectroscopy. | |
| calpain-2 | Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52, calpain-1. Group: Enzymes. Synonyms: calcium-activated neutral protease II; m-calpain; milli-calpain. Enzyme Commission Number: EC 3.4.22.53. CAS No. 702693-80-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4228; calpain-2; EC 3.4.22.53; 702693-80-9; calcium-activated neutral protease II; m-calpain; milli-calpain. Cat No: EXWM-4228. | |
| Calpain Inhibitor VI | Calpain Inhibitor VI is a cell-permeable peptide aldehyde which functions as a reversible calpain inhibitor. It is an inhibitor of the calcium-dependent cysteine proteases μ-calpain with IC50 of 7.5 nM for calpain-1 and m-calpain with IC50 of 78 nM for calpain-2. Calpain Inhibitor VI can reduce nuclear opacity and proteolysis of crystallins and α-spectrin. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Synonyms: SJA 6017. Grades: ≥95%. CAS No. 190274-53-4. Molecular formula: C17H25FN2O4S. Mole weight: 372.5. |  |
| Calpain Inhibitor XII | Calpain Inhibitor XII is a cell-permeable, potent, selective, reversible, and active-site-directed inhibitor of calpain-1 with Ki of 19 nM. It has been shown to inhibit calpain-2 with Ki of 120 nM and human cathepsin B with Ki of 750 nM. Calpain inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury. Synonyms: Z-L-Nva-CONH-CH2-2-Py. Grades: ≥90%. CAS No. 181769-57-3. Molecular formula: C26H34N4O5. Mole weight: 482.6. | |
| Calpeptin - CAS 117591-20-5 | A cell-permeable calpain inhibitor (ID?? = 52 nM for calpain-1; ID?? = 34 nM for calpain-2; ID?? = 138 nM for papain). Group: Fluorescence/luminescence spectroscopy. | |
| H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH | H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH is an internally quenched substrate for calpain-1 (μ-calpain) with optimal cleavage motifs flanking the scissile bond. The turnover rate of the enzyme to hydrolysis of this FRET substrate based on the PLFAER amino acid sequence is more than 18 times higher than that of EVYGMM derived from the natural substrate α-spectrin cleavage site. Synonyms: N- ({5-[ (2-Aminoethyl) amino]-1-naphthyl}sulfonyl) -L-α -glutamyl-L-prolyl-L-leucyl-L-phenylalanyl-L-alanyl-L-α -glutamyl-L-arginyl-N6- (4-{[4- (dimethylamino) phenyl]diazenyl}benzoyl) -L-lysine. Grades: ≥95%. CAS No. 1914987-47-5. Molecular formula: C72H97N17O16S. Mole weight: 1488.71. | |
| PD 150606 | PD 150606 is a selective, cell-permeable inhibitor of calpains (Ki = 0.21 μM for μ-calpain (calpain-1) and 0.37 μM for m-calpain (calpain-2)). It targets the calcium binding sites of calpain. PD 150606 demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate. Synonyms: PD-150606; PD150606. Grades: ≥95% by HPLC. CAS No. 179528-45-1. Molecular formula: C9H7IO2S. Mole weight: 306.12. | |
| PD 150606 - CAS 426821-41-2 | A cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 and 370 nM for calpain-2. Group: Fluorescence/luminescence spectroscopy. | |
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