Carboxyl Methyltransferase Suppliers USA
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Product | Description | |
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2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic Acid Quick inquiry Where to buy Suppliers range | 2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic Acid is a small molecule that has been reported as a novel histone methyltransferase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1374601-41-8. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H21N3O3, Molecular Weight: 399.44. US Biological Life Sciences. | Worldwide |
CAY10677 Quick inquiry Where to buy Suppliers range | Isoprenylcysteine Carboxyl Methyltransferase (ICMT) is a protein coding gene. Diseases associated with ICMT include Hallermann-Streiff syndrome and Legionnaire disease. CAY10677 is an analog of the ICMT inhibitor cysmethynil that was developed for improved solubility and cell permeability. It inhibits ICMT with an IC50 value of 0.86 μM and demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells and human prostate cancer PC3 cells. Synonyms: Icmt Inhibitor 15; CAY 10677; CAY-10677. Grades: ≥98%. CAS No. 1443253-20-0. Molecular formula: C25H37N5. Mole weight: 407.6. | |
Cysmethynil Quick inquiry Where to buy Suppliers range | Cysmethynil is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with antitumor activity in cancer cells. Cysmethynil treatment results in inhibition of cell growth in an Icmt-dependent fashion, demonstrating mechanism-based activity of the compound. Treatment of cancer cells with cysmethynil results in mislocalization of Ras and impaired epidermal growth factor signaling. In a human colon cancer cell line, cysmethynil treatment blocks anchorage-independent growth, and this effect is reversed by overexpression of Icmt. Synonyms: 2-(1-octyl-5-m-tolyl-1H-indol-3-yl)acetamide; 1H-Indole-3-acetamide, 5-(3-methylphenyl)-1-octyl-. CAS No. 851636-83-4. Molecular formula: C25H32N2O. Mole weight: 376.54. | |
(E,E)-Farnesyl Thioacetate Quick inquiry Where to buy Suppliers range | (E,E)-Farnesyl Thioacetate, an acetate derivative of (E,E)-Farnesyl Thiol, has inhibitory activity against human isoprenylcysteine carboxyl methyltransferase (Icmt) protein. Synonyms: Ethanethioic Acid S-[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl] Ester; Ethanethioic Acid S-[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl] Ester; S-[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl] ethanethioate. Grades: ≥95%. CAS No. 340701-35-1. Molecular formula: C17H28OS. Mole weight: 280.47. | |
HMTase Inhibitor VI, BRD4770 (Methyl-2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate) Quick inquiry Where to buy Suppliers range | A cell-permeable analog of the amino-benzimidazolo BIX-01338 and the methylester prodrug of BRD9539 that acts as an SAM-competitive inhibitor against PRC2 and G9a (IC50<6.3uM) histone methyltransferase activities, displaying little effect toward 10 other HMTases, 9 HDACs, and 100 cellular kinases. Selectively reduces H3K9me2 and H3K9me3 (EC50=5uM) histone methylation levels in pancreatic cancer cells (PANC-1) with much less or little effect toward H3K36me3, H3K4me3, H3K27me3, or H3K6me3 levels. Inhibits both anchorage-dependent and -independent PANC-1 proliferation via ATM activation and G2/M cell-cycle arrest, but not apoptosis induction (no caspase3/7 activation; 10uM, 72h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
ICMT Inhibitor (Cysmethynil) Quick inquiry Where to buy Suppliers range | An inhibitor of protein prenylation. Cysmethynil is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with antitumor activity in cancer cells. Cysmethynil treatment results in inhibition of cell growth in an Icmt-dependent fashion, demonstrating mechanism-based activity of the compound. Treatment of cancer cells with cysmethynil results in mislocalization of Ras and impaired epidermal growth factor signaling. In a human colon cancer cell line, cysmethynil treatment blocks anchorage-independent growth, and this effect is reversed by overexpression of Icmt.A cell-permeable indole acetamide that acts as a substrate-competitive and AdoMet-noncompetitive Icmt (isoprenylcysteine carboxyl methyltransferase) inhibitor (Ki=0.02uM; IC50=0.29uM; Substrate=S-farnesyl-L-cysteine), exhibiting no activity against FTase, gernayl geranyl transferase type I, CaaX protease Rce1, AdoMet-dependent DNA methyltransferase, SssI DNA methyltransferase, or PCMT1 protein methyltransferase. Cysmethynil (25uM) induces G1 cell cycle-arrest and autophagy-mediated, but not apoptotic, cell death in prostate cancer PC3 cells with concomitant PI 3-K/Akt and mTOR signaling blockage, consistent with inhibition of Icmt-mediated activation of Ras and Rheb GTPases. Murine PC3 xenograft studies reveal limited in vivo efficacy. Group: Biochemicals. Alternative Names: Cysmethynil; 2-(5-(3-Methylphenyl)-1-octyl-1H-indol-3-yl)acetamide, 2-(1-Octyl-5-m-tolyl-1H-indol-3-yl) acetamide; Isoprenylcysteine Carboxyl Methyltransferase Inhibitor). Grades: Highly Purified. CAS No. 851636-83-4. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C25H32N2O, Molecular Weight: 376.5. US Biological Life Sciences. | Worldwide |
ICMT Inhibitor II, FTPAT ((E)-methyl-3-((5-(4-(2-((1,1-biphenyl]-4-yl)ethyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate) Quick inquiry Where to buy Suppliers range | A cell-permeable triazolo-farnesylthiopropanoate compound that acts as a potent, reversible, and isoprenyl mimetic competitive inhibitor of isoprenylcysteine carboxyl methyltransferase activity (ICMT; IC50=800nM; Ki=400nM). Shown to prevent K-Ras membrane localization in GFP-K-Ras transfected Jurkat T-cells. Exhibits selective toxicity towards wt-Icmt+/+ mouse embryonic fibroblasts (MEFs) over Icmt-/- MEFs (IC50=33 and >100uM). Also shown to arrest the proliferation of PaTu-8902, a highly metastatic pancreatic cancer cells (IC50=8uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
S-Adenosyl-L-methionine p-toluenesulfonate Quick inquiry Where to buy Suppliers range | S-(5?-Adenosyl)-L-methionine (SAM) is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells. Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury. Group: Biochemicals. Alternative Names: (3S) -5'-[ (3-Amino-3-carboxylatopropyl) methylsulphonio]-5'-deoxyadenosine) ; SAMe p-toluenesulfonate; S-Adenosylmethionine Tosylate; Adomet; Ademetionine. Grades: Highly Purified. CAS No. 17176-17-9. Pack Sizes: 10g, 25g, 50g, 100g. US Biological Life Sciences. | Worldwide |