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Carfilzomib is an anti-cancer drug acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin. It is a second-generation and peptide epoxyketone class proteasome inhibitor that targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome with IC50 of 5.2 nM. Carfilzomib impurity 13 hydrochloride is a potential impurity found in commercial carfilzomib preparations. Grade: ≥95%. CAS No. 2319881-95-1. Molecular formula: C16H22N2O4·HCl. Mole weight: 342.8.
Carfilzomib Impurity 18
Carfilzomib Impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1541171-67-8. Molecular formula: C40H58ClN5O7. Mole weight: 756.37. Catalog: APB1541171678.
Carfilzomib Impurity 2
Carfilzomib (2R,4S)-Diol is a derivative of Carflizomib , a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Synonyms: (αS)?-α-[[2-(4-Morpholinyl)?acetyl]?amino]?benzenebutanoyl-L-leucyl-N-[(1S,?3R)?-3,?4-dihydroxy-3-methyl-1-(2-methylpropyl)?-2-oxobutyl]?-L-phenylalaninamide. Grade: > 95%. CAS No. 1541172-75-1. Molecular formula: C40H59N5O8. Mole weight: 737.94.
Carfilzomib Impurity 27
Carfilzomib Impurity 27. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide. CAS No. 1672698-88-2. Molecular formula: C40H57N5O7. Mole weight: 719.91. Catalog: APB1672698882.
Carfilzomib Impurity 39
Carfilzomib Impurity 39. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-N-((S)-1-(((2R,4S)-1,2-dihydroxy-2,6-dimethyl-3-oxoheptan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide. CAS No. 1541172-75-1. Molecular formula: C40H59N5O8. Mole weight: 737.93. Catalog: APB1541172751.
Carfilzomib Impurity 39
Carfilzomib Impurity 39. Uses: For analytical and research use. Group: Impurity standards. CAS No. 168154-76-5. Molecular formula: C10H12ClNO3. Mole weight: 229.66. Catalog: APB168154765.
Carfilzomib Impurity 46
Carfilzomib Impurity 46. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1396006-47-5. Molecular formula: C22H33N3O5. Mole weight: 419.52. Catalog: APB1396006475.
Carfilzomib Impurity 7
Carfilzomib Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-3-phenylpropanoate. CAS No. 15136-32-0. Molecular formula: C21H32N2O5. Mole weight: 392.49. Catalog: APB15136320.
Carfilzomib Related Impurity ((S)-2-amino-4-oxo-4-phenylbutanoic acid hydrochloride)
(S)-4-Oxo-homophenylalanine Hydrochloride is a derivative of L-Homophenylalanine; an antitumor agent. Synonyms: (αS)-α-Amino-γ-oxo-benzenebutanoic Acid Hydrochloride; (S)-α-Amino-γ-oxo-benzenebutanoic Acid Hydrochloride. Grade: > 95%. CAS No. 168154-76-5. Molecular formula: C10H11NO3. HCl. Mole weight: 193.20 36.46.
(2R)-2-Amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]pentan-1-one Trifluoroacetate Salt
(2R)-2-Amino-4-methyl-1-(2-methyloxiran-2-yl)pentan-1-one Trifluoroacetate Salt s an impurity of carfilzomib (C183460). Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 50mg. Molecular Formula: C11H18F3NO4, Molecular Weight: 285.26. US Biological Life Sciences.
Worldwide
Boc-Homophe-Leu-Phe-Ome
An impurity of Carfilzomib, which is a second-generation proteasome inhibitor for the treatment of relapsed and refractory multiple myeloma. Synonyms: Boc-HPh-Leu-Phe-Ome; (6S,9S,12S)-Methyl 12-benzyl-9-isobutyl-2,2-dimethyl-4,7,10-trioxo-6-phenethyl-3-oxa-5,8,11-triazatridecan-13-oate; N-[(S)-2-(tert-Butoxycarbonylamino)-4-phenylbutanoyl]-L-leucyl-L-phenylalanine methyl ester. CAS No. 868539-96-2. Molecular formula: C31H43N3O6. Mole weight: 553.70.
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