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| Product | Description | |
|---|---|---|
| caspase-1 | From mammalian monocytes. This enzyme is part of the family of inflammatory caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Cleaves pro-interleukin-1β (pro-IL-1β) to form mature IL-1β, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-γ-inducing factor. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mi...proteinase; ICE. Enzyme Commission Number: EC 3.4.22.36. CAS No. 122191-40-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4211; caspase-1; EC 3.4.22.36; 122191-40-6; interleukin 1β-converting enzyme; protease VII; protease A; interleukin 1β precursor proteinase; interleukin 1 converting enzyme; interleukin 1β-converting endopeptidase; interleukin-1β convertase; interleukin-1β converting enzyme; interleukin-1β precursor proteinase; prointerleukin 1β protease; precursor interleukin-1β converting enzyme; pro-interleukin 1β proteinase; ICE. Cat No: EXWM-4211. |  |
| caspase-10 | Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62). Like caspase-8, caspase-10 contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation. The enzyme has many overlapping substrates in common with caspase-8, such as RIP (the cleavage of which impairs NF-κB survival signalling and starts the cell-death process) and PAK2 (associated with some of the morphological features of apoptosis, such as cell rounding and apoptotic body formation). Bid, a Bcl2 protein, can be cleaved by caspase-3 (EC 3.4.22.56), caspase-8 and caspase-10 at Lys-Gln-Thr-Asp? ...u-Thr-Asp? to yield a p13 fragment that is not N-myristoylated. Belongs in peptidase family C14. Group: Enzymes. Synonyms: FLICE2, Mch4; CASP-10; ICE-like apoptotic protease 4; apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1β-converting enzyme 2. Enzyme Commission Number: EC 3.4.22.63. CAS No. 189088-85-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4239; caspase-10; EC 3.4.22.63; 189088-85-5; FLICE2, Mch4; CASP-10; ICE-like apoptotic protease 4; apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1β-converting enzyme 2. Cat No: EXWM-4239. | |
| caspase-11 | This murine enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide. This enzyme not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to cellular apoptosis under pathological conditions. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CASP-11. Enzyme Commission Number: EC 3.4.22.64. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4240; caspase-11; EC 3.4.22.64; CASP-11. Cat No: EXWM-4240. | |
| Caspase-1 from Human, Recombinant | Caspase 1/Interleukin-1 converting enzyme is an enzyme that proteolytically cleaves other proteins, such as the precursor forms of the inflammatory cytokines interleukin 1β and interleukin 18, into active mature peptides. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages. Studies of a similar protein in mouse suggest a role in the pathogenesis of Huntington's disease. Alternative splicing of the gene results in five transcript variants encoding distinct isoforms. Recent studies implicated caspase 1 in promoting CD4 T-cell death and inflammation by HIV, two signature events that fuel HIV disease progression to AIDS. Recombinant, human caspase-1 fused at the n-terminus to a hisotag sequence and expressed in e. coli useful for the study of enzyme regulation, cleavage of target substrates, and inhibitor screening. Group: Enzymes. Synonyms: CASP1; ICE; IL1BC; P45; Caspase 1; Interleukin-1; IL-1β Converting Enzyme. Purity: >90% by SDS-PAGE. Caspase-1. Mole weight: 10 kDa and 20 kDa. Activity: >25,000 units/mg protein. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: E. coli. Species: Human. CASP1; ICE; IL1BC; P45; Caspase 1; Interleukin-1; IL-1β Converting Enzyme. Cat No: NATE-0813. | |
| Caspase-1/ICE Inhibitor Z-WEHD-FMK | Z-WEHD-FMK is an inhibitor of caspase-1, caspase-5 and cathepsin B, which can inhibit cell apoptosis in a variety of biological systems. Synonyms: CASPASE-1 INHIBITOR TFA SALT; Z-WEHD-FMK-TFA; Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK-TFA. Grades: >99%. CAS No. 210345-00-9. Molecular formula: C37H42FN7O11. Mole weight: 763.78. |  |
| caspase-2 | Caspase-2 is an initiator caspase, as are caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63). Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Two forms of caspase-2 with antagonistic effects exist: caspase-2L induces programmed cell death and caspase-2S suppresses cell death. Caspase-2 is activated by caspase-3 (EC 3.4.22.56), or by a caspase-3-like protease. Activation involves cleavage of the N-terminal prodomain, followed by self-proteolysis between the large and small subunits of pro-caspase-2 and further proteolysis into smaller fragments. Proteolysis occurs at Asp residues and the ...s a substrate of the large isoform of pro-caspase-2 (caspase-2L) but not of the short isoform (caspase-2S). Belongs in peptidase family C14. Group: Enzymes. Synonyms: ICH-1; NEDD-2; caspase-2L; caspase-2S; neural precursor cell expressed developmentally down-regulated protein 2; CASP-2; NEDD2 protein. Enzyme Commission Number: EC 3.4.22.55. CAS No. 182372-14-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4230; caspase-2; EC 3.4.22.55; 182372-14-1; ICH-1; NEDD-2; caspase-2L; caspase-2S; neural precursor cell expressed developmentally down-regulated protein 2; CASP-2; NEDD2 protein. Cat No: EXWM-4230. | |
| caspase-3 | Caspase-3 is an effector/executioner caspase, as are caspase-6 (EC 3.4.22.59) and caspase-7 (EC 3.4.22.60). These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype. Procaspase-3 can be activated by caspase-1 (EC 3.4.22.36), caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63) as well as by the serine protease granzyme B. Caspase-3 can activate procaspase-2 (EC 3.4.22.55). Activation occurs by inter-domain cleavage followed by removal of the N-terminal prodomain. Although Asp-Glu-(Val/Ile)-Asp is thought to be the preferred cleavage sequence, the enzyme can accommodate different residues at P2 and P3 of the substrate. Like caspase-2, a hydrophobic residue at P5 of caspase-3 leads to more efficient hydrolysis, e.g. (Val/Leu)-Asp-Val-Ala-Asp? is a better substrate than Asp-Val-Ala-Asp?. This is not the case for caspase-7. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CPP32; apopain; yama protein. Enzyme Commission Number: EC 3.4.22.56. CAS No. 169592-56-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4231; caspase-3; EC 3.4.22.56; 169592-56-7; CPP32; apopain; yama protein. Cat No: EXWM-4231. | |
| Caspase-3/7 Inhibitor I | Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM). It is a weaker inhibitor of caspase-9 with Ki(app) of 3.1 μM and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki(app)s ≥25 μM). The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue. Grades: ≥98%. CAS No. 1110670-49-9. Molecular formula: C14H16N2O5S. Mole weight: 324.4. | |
| Caspase 3 Human, Recombinant | Caspase 3 is a member of the CED-3 subfamily of caspases and is responsible for the cleavage of many key proteins such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP), the inhibitor of caspase-activated deoxyribonuclease (ICAD), and gelsolin, a protein involved in apoptosis regulation. Caspase 3 is considered to be an effector caspase, activating pro-caspase 6 and pro-caspase 9 in vitro. Caspase 3 can be activated by caspase 8, caspase 6, and granzyme B. Human recombinant c-terminal histidine tagged caspase 3 is a fully active protein consisting of 17 kda and 13.5 kda subunits; the 13.5 kda subunit contains the histidine tag. Applications: Caspase-3 is a caspase prote...ve enzyme. this protein cleaves and activates caspases 6 and 7; and the protein itself is processed and activated by caspases 8, 9, and 10. it is the predominant caspase involved in the cleavage of amyloid-beta 4a precursor protein, which is associated with neuronal death in alzheimer's disease. alternative splicing of this gene results in two transcript variants that encode the same protein. caspase-3 shares many of the typical characteristics common to all currently-known caspases. for example, its active site contains a cysteine residue (cys-163) and histidine residue (his-121) that stabilize the peptide bond cleavage of a protein sequence to the carboxy-terminal side of an | |
| caspase-4 | This enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but, unlike caspase-1, it is very inefficient at generating mature interleukin-1β (IL-1β) from pro-IL-1&beta. Both this enzyme and caspase-5 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17). The caspase-1 inhibitor Ac-Tyr-Val-Ala-Asp-CHO can also inhibit this enzyme, but more slowly. Belongs in peptidase family C14. Group: Enzymes. Synonyms: ICErelII; ICErel-II; Ich-2; transcript X; TX; TX protease; caspase 4; CASP-4. Enzyme Commission Number: EC 3.4.22.57. CAS No. 182762-08-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4232; caspase-4; EC 3.4.22.57; 182762-08-9; ICErelII; ICErel-II; Ich-2; transcript X; TX; TX protease; caspase 4; CASP-4. Cat No: EXWM-4232. | |
| caspase-5 | This enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36) and caspase-4 (EC 3.4.22.57) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but is very inefficient at generating mature interleukin-1β (IL-1β) from pro-IL-1&beta. Both this enzyme and caspase-4 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17). Unlike caspase-4, this enzyme can be induced by lipopolysaccharide. Belongs in peptidase family C14. Group: Enzymes. Synonyms: ICErel-III; Ich-3; ICH-3 protease; transcript Y; TY; CASP-5. Enzyme Commission Number: EC 3.4.22.58. CAS No. 192465-11-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4233; caspase-5; EC 3.4.22.58; 192465-11-5; ICErel-III; Ich-3; ICH-3 protease; transcript Y; TY; CASP-5. Cat No: EXWM-4233. | |
| caspase-6 | Caspase-6 is an effector/executioner caspase, as are caspase-3 (EC 3.4.22.56) and caspase-7 (EC 3.4.22.60). These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype. Caspase-6 can cleave its prodomain to produce mature caspase-6, which directly activates caspase-8 (EC 3.4.22.61) and leads to the release of cytochrome c from the mitochondria. The release of cytochrome c is an essential component of the intrinsic apoptosis pathway. The enzyme can also cleave and inactivate lamins, the intermediate filament scaffold proteins of the nuclear envelope, leading to nuclear fragmentation in the final phases of apoptosis. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CASP-6; apoptotic protease Mch-2; Mch2. Enzyme Commission Number: EC 3.4.22.59. CAS No. 182372-15-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4234; caspase-6; EC 3.4.22.59; 182372-15-2; CASP-6; apoptotic protease Mch-2; Mch2. Cat No: EXWM-4234. | |
| Caspase-6 (Active) from Human, Recombinant | Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Caspase 6 can also undergo self-processing without other members of the caspase family. Alternative splicing of this gene results in two transcript variants that encode different isoforms. Group: Enzymes. Synonyms: CASP6; MCH2; Caspase-6 (Active); Caspase-6. Caspase 6. Appearance: Liquid. Storage: -80°C. Form: Liquid. 5μg in 25μl of 50mM TRIS (pH 8.0) containing 100mM sodium chloride and 50mM imidazole. Source: E. coli. Species: Human. CASP6; MCH2; Caspase-6 (Active); Caspase-6. Cat No: NATE-0814. | |
| caspase-7 | Caspase-7 is an effector/executioner caspase, as are caspase-3 (EC 3.4.22.56) and caspase-6 (EC 3.4.22.59). These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype. Although a hydrophobic residue at P5 of caspase-2 (EC 3.4.22.55) and caspase-3 leads to more efficient hydrolysis, the amino-acid residue at this location in caspase-7 has no effect. Caspase-7 is activated by the initiator caspases [caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63)]. Removal of the N-terminal prodomain occurs before cleavage in the linker region between the large and small subunits. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CASP-7; ICE-like apoptotic protease 3; ICE-LAP3; apoptotic protease Mch-3; Mch3; CMH-1. Enzyme Commission Number: EC 3.4.22.60. CAS No. 189258-14-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4236; caspase-7; EC 3.4.22.60; 189258-14-8; CASP-7; ICE-like apoptotic protease 3; ICE-LAP3; apoptotic protease Mch-3; Mch3; CMH-1. Cat No: EXWM-4236. | |
| Caspase-7 from Human, Recombinant | Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing by upstream caspases (caspase-8, -9) at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme in the form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. Applications: Used to screen caspase inhibitors, study enzyme regulation, determine caspase substrate specificity, or as positive control in caspase activity assays. Group: Enzymes. Synonyms: CASP7; CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3; Caspase-7. Enzyme Commission Number: EC 3.4.22.-. Purity: 90% (SDS-PAGE). Caspase 7. Activity: ~25,000U/mg protein. Appearance: Lyophilized. Storage: -80°C. Source: E. coli. Species: Human. CASP7; CASP-7; CMH-1; ICE-LAP3; LICE2; MCH3; Caspase-7. Cat No: NATE-0815. | |
| caspase-8 | Caspase-8 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63). Caspase-8 is the apical activator of the extrinsic (death receptor) apoptosis pathway, triggered by death receptor ligation. It contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation. This enzyme is linked to cell surface death receptors such as Fas. When Fas is aggregated by the Fas ligand, procaspase-8 is recruited to the death receptor where it is activated. The enzyme has a preference for Glu at P3 and prefers small residues, such as Gly, Ser and Ala, at the P1' position. It has very broad P...ORT1-associated CED-3 homolog; Mch5; mammalian Ced-3 homolog 5; CASP-8; ICE-like apoptotic protease 5; FADD-homologous ICE/CED-3-like protease; apoptotic cysteine protease; apoptotic protease Mch-5; CAP4. Enzyme Commission Number: EC 3.4.22.61. CAS No. 179241-78-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4237; caspase-8; EC 3.4.22.61; 179241-78-2; FLICE, FADD-like ICE; MACH; MORT1-associated CED-3 homolog; Mch5; mammalian Ced-3 homolog 5; CASP-8; ICE-like apoptotic protease 5; FADD-homologous ICE/CED-3-like protease; apoptotic cysteine protease; apoptotic protease Mch-5; CAP4. Cat No: EXWM-4237. | |
| Caspase-8 Inhibitor, Q-IETD-OPh (Q-IE(OMe)-TD(OMe)-OPh, Quinolyl-Ile-Glu(OMe)-Thr-Asp(OMe)-OPh) | A second-generation capase-8 inhibitor that is potent, cell permeable, irreversible and nontoxic. Group: Biochemicals. Grades: Purified. Pack Sizes: 3mg. US Biological Life Sciences. |  Worldwide |
| caspase-9 | Caspase-9 is an initiator caspase, as are caspase -2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-10 (EC 3.4.22.63). Caspase-9 contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. An alternatively spliced version of caspase-9 also exists, caspase-9S, that inhibits apoptosis, similar to the situation found with caspase-2. Phosphorylation of caspase-9 from some species by Akt, a serine-threonine protein kinase, inhibits caspase activity in vitro and caspase activation in vivo. The activity of caspase-9 is increased dramatically upon association with the apoptosome but the enzyme can be activated without proteolytic cleavage. Procaspase-3 is the enzyme's physiological substrate. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CASP-9; ICE-like apoptotic protease 6; ICE-LAP6; apoptotic protease Mch-6; apoptotic protease-activating factor 3; APAF-3. Enzyme Commission Number: EC 3.4.22.62. CAS No. 180189-96-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4238; caspase-9; EC 3.4.22.62; 180189-96-2; CASP-9; ICE-like apoptotic protease 6; ICE-LAP6; apoptotic protease Mch-6; apoptotic protease-activating factor 3; APAF-3. Cat No: EXWM-4238. | |
| Caspase-9 (Active) from Human, Recombinant | The expressed caspase-9 spontaneously undergoes autoprocessing to yield the subunits characteristic of the native enzyme. Active enzyme purified from E. coliThis product is useful in screening caspase inhibitors for pharmaceutical Applications. Group: Enzymes. Synonyms: CASP9; APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56; Caspase-9 (Active); Caspase-9. Purity: 90% (SDS-PAGE). Caspase 9. Activity: ~400 units/mg. Appearance: Lyophilized Powder. Storage: -80°C. Source: E. coli. Species: Human. CASP9; APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56; Caspase-9 (Active); Caspase-9. Cat No: NATE-0816. | |
| Caspase-9 Inhibitor III | Caspase-9 Inhibitor III (Ac-LEHD-cmk) is a caspase-9 inhibitor. Caspase-9 Inhibitor III exhibits protective effects on ischemia-reperfusion-induced myocardial injury [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ac-LEHD-cmk. CAS No. 403848-57-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-136744. |  |
| Caspase-9 Inhibitor III | Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9 with cardioprotective effects. Caspase inhibitors play an important role in investigating biological processes. Caspase-9 can reduce infarct size, lactate dehydrogenase (LDH) and creatine kinase (CK) release, and DNA smearing induced by ischemia and reperfusion in isolated rat hearts. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Synonyms: Ac-LEHD-CMK. Grades: 98%. CAS No. 403848-57-7. Molecular formula: C24H35ClN6O9. Mole weight: 587.02. | |
| Caspase-9 Inhibitor, Q-LEHD-OPh (Q-LE(OMe)-HD(OMe)-OPh, Quinolyl-Leu-Glu(OMe)-His-Asp(OMe)-OPh) | A second-generation capase-9 inhibitor that is potent, cell permeable, irreversible and nontoxic. Group: Biochemicals. Grades: Purified. Pack Sizes: 3mg. US Biological Life Sciences. | Worldwide |
| Caspase Family Group I, Active, Recombinant Set (Caspases-1,4,5), Caspase-1 | Caspase Family Group I, Active, Recombinant Set (Caspases-1,4,5), Caspase-1. Group: Molecular Biology. Pack Sizes: 25 units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group I, Active, Recombinant Set (Caspases-1,4,5), Caspase-4 | Caspase Family Group I, Active, Recombinant Set (Caspases-1,4,5), Caspase-4. Group: Molecular Biology. Pack Sizes: 25 units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group I, Active, Recombinant Set (Caspases-1,4,5), Caspase-5 | Caspase Family Group I, Active, Recombinant Set (Caspases-1,4,5), Caspase-5. Group: Molecular Biology. Pack Sizes: 25 units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group III, Active, Recombinant Caspase-10 | Caspase Family Group III, Active, Recombinant Caspase-10. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group III, Active, Recombinant Caspase-6 | Caspase Family Group III, Active, Recombinant Caspase-6. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group III, Active, Recombinant Caspase 8 | Caspase Family Group III, Active, Recombinant Caspase 8. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group III, Active, Recombinant Caspase-9 | Caspase Family Group III, Active, Recombinant Caspase-9. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group IV, Active, Recombinant, Caspase 1 | Caspase Family Group IV, Active, Recombinant, Caspase 1. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25 units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group IV, Active, Recombinant, Caspase 10 | Caspase Family Group IV, Active, Recombinant, Caspase 10. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25 units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group IV, Active, Recombinant, Caspase 2 | Caspase Family Group IV, Active, Recombinant, Caspase 2. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25 units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group IV, Active, Recombinant, Caspase 3 | Caspase Family Group IV, Active, Recombinant, Caspase 3. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25 units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group IV, Active, Recombinant, Caspase 4 | Caspase Family Group IV, Active, Recombinant, Caspase 4. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25 units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group IV, Active, Recombinant, Caspase 5 | Caspase Family Group IV, Active, Recombinant, Caspase 5. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25 units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group IV, Active, Recombinant, Caspase 6 | Caspase Family Group IV, Active, Recombinant, Caspase 6. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25 units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group IV, Active, Recombinant, Caspase 7 | Caspase Family Group IV, Active, Recombinant, Caspase 7. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25 units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group IV, Active, Recombinant, Caspase 8 | Caspase Family Group IV, Active, Recombinant, Caspase 8. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25 units. US Biological Life Sciences. | Worldwide |
| Caspase Family Group IV, Active, Recombinant, Caspase 9 | Caspase Family Group IV, Active, Recombinant, Caspase 9. Group: Molecular Biology. Grades: Molecular Biology Grade. Pack Sizes: 1x25 units. US Biological Life Sciences. | Worldwide |
| 10Panx | Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1 β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by >70%. Group: Biochemicals. Grades: Highly Purified. CAS No. 955091-53-9. Pack Sizes: 1mg. Molecular Formula: C58H79N15O16, Sequence: WRQAAFVDSY. US Biological Life Sciences. | Worldwide |
| 11-Keto β-Boswellic Acid | A constitutent of frankincense (olibanum) with anti-inflammatory properties. It has been shown to trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Group: Biochemicals. Alternative Names: (3α,4 β)-3-Hydroxy-11-oxours-12-en-23-oic Acid; 3α-Hydroxy-11-oxours-12-en-24-oic Acid; 11-Oxo- β-boswellic Acid; 11-keto- β-Boswellic Acid. Grades: Highly Purified. CAS No. 17019-92-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 14-3-3 Antagonist I, 2-5 ( (S) -2- (2- (4-Azidobenzamido) acetamido) -3- ( (4-hydroxyphenethyl) amino) -3-oxopropyl-dihydrogen Phosphate) | A cell-permeable dipeptidyl-phosphoserine compound that effectively disrupts 14-3-3 interaction with its ligands (IC50=2.6uM against TMR-GG-RLSHpSSLPG binding to human 14-3-3 sigma), including Raf-1 and p53. Shown to induce caspase-3 activation and apoptotic cell death in human lung adenocarcinoma A549 cultures (100uM) in a time-dependent manner. Group: Biochemicals. Grades: Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?P, Molecular Weight: 506.4. US Biological Life Sciences. | Worldwide |
| 1,4:3,6-Dianhydrogalactitol | 2-Hydroxymethylene-4,6-anhydro-galactopyranose, or 1,4:3,6-Dianhydrogalactitol, is a promising antineoplastic molecule with demonstrated efficacy against diverse cancers, such as those afflicting the brain, prostate, and breast tissue. Its chemo-preventive, cytotoxic, and apoptotic functions render it a potent impetus in caspase-3 pathways, effectively preventing malignant cells from proliferating and promoting their programmed death. The multifaceted potential of 1,4:3,6-Dianhydrogalactitol presents a compelling vehicle for cancer treatment that warrants continued exploration. CAS No. 915288-38-9. | |
| 15-Acetoxyscirpenol | 15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3 [1]. Uses: Scientific research. Group: Natural products. CAS No. 2623-22-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6681. | |
| 2,3-DCPE hydrochloride | 2,3-DCPE hydrochloride is a compound that selectively induces apoptosis and downregulates Bcl-XL protein expression in multiple human cancer cells versus normal cells in vitro. It also specifically cleaves caspase-8, caspase-3, caspase-9, and poly(ADP-ribose) polymerase in cancer cells. Uses: Antitumor agent. Synonyms: 2,3-DCPE HCl; 2-((3-(2,3-Dichlorophenoxy)propyl)amino)ethan-1-ol hydrochloride. Grades: ≥99% by HPLC. CAS No. 1009555-55-8. Molecular formula: C11H16Cl3NO2. Mole weight: 300.61. | |
| 2-Bromoaniline-d4 | 2-Bromoaniline-d4 is the labeled analogue of 2-Bromoaniline (B679950), a reagent used in the synthesis of substituted 2-carboxanilides as herbicides and antibacterials. Also used in the synthesis of benzisothiazol-3-one derivatives as caspase-3 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1643564-99-1. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C6H2D4BrN, Molecular Weight: 176.05. US Biological Life Sciences. | Worldwide |
| (2-Bromoethyl)benzene | (2-Bromoethyl)benzene is used in the synthesis of sulforaphane derivatives used as potential antitumor agents. As well, used in the synthesis of 1,2-benzisothiazol-3-one derivatives as potent caspase-3-inhibitors. Group: Biochemicals. Alternative Names: (2-Bromoethyl)benzene; 1-Bromo-2-phenylethane; 1-Phenyl-2-bromoethane; 2-Bromo-1-phenylethane; 2-Phenethyl Bromide; 2-Phenyl-1-bromoethane; 2-Phenylbromoethane; 2-Phenylethyl Bromide; NSC 33926; Phenethyl Bromide; Phenylethyl Bromide; β-Bromoethylbenzene; β-Phenethyl Bromide; β-Phenylethyl Bromide. Grades: Highly Purified. CAS No. 103-63-9. Pack Sizes: 50g. US Biological Life Sciences. | Worldwide |
| 2'-Deoxyadenosine | 2'-Deoxyadenosine is a purine nucleoside composed of Adenine (HY-B0152) and 2'-deoxyribose. 2'-Deoxyadenosine activates Caspase-3 and promotes Apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase. 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. CAS No. 958-09-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W040329. | |
| 2-methoxyestradiol | 2-methoxyestradiol, also known as 2-ME, is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis. Uses: Antineoplastic agents. Synonyms: 2-ME; 2-Methoxy Estradiol. US brand name: Panzem. Abbreviation: 2ME2. Chemical structure name: (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol. Grades: 0.98. CAS No. 362-07-2. Molecular formula: C19H26O3. Mole weight: 302.414. | |
| 3,3'-Diamino-4'-methoxyflavone, DD1 (3-amino-2-(3-amino-4-methoxyphenyl)-4H-chromen-4-one, p76S6 Inhibitor, DD1, Proteasome Inhibitor, DD1) | A cell-permeable flavone derivative that arrests the proliferation of acute myeloid leukemia cells (NB4, U937, HL-60, OCI AML3), in a dose and time-dependent manner (optimum at ~20uM and 96h) and blocks the colony formation in samples from acute myeloid leukemia patients, without affecting normal blood cells. Shown to reduce mitochondrial membrane potential and Bad phosphorylation (at Ser136), induce Bax and caspase 3, 8, and 9 activation in U937 cells. Does not affect the phosphorylation of Akt1, but significantly reduces the expression and phosphorylation of p70S6 kinase in U937 cells. Reported to inhibit the chymotrypsin-like activity of proteasome (IC50 = 2.0uM) and this effect is synergistic with bortezomib. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-(5-Amino-3-methyl-1H-pyrazol-1-yl)-Benzoic Acid-d4 Hydrochloride | Isotope labelled 3-(5-Amino-3-methyl-1H-pyrazol-1-yl)-Benzoic Acid is a reagent used in the synthesis of quinoline derivatives used as caspase-3 inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C11H8D4ClN3O2, Molecular Weight: 257.71. US Biological Life Sciences. | Worldwide |
| 3-(5-Amino-3-methyl-1H-pyrazol-1-yl)-Benzoic Acid Hydrochloride | 3-(5-Amino-3-methyl-1H-pyrazol-1-yl)-Benzoic Acid is a reagent used in the synthesis of quinoline derivatives used as caspase-3 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1620390-43-3. Pack Sizes: 100mg, 1g. Molecular Formula: C11H12ClN3O2, Molecular Weight: 253.68. US Biological Life Sciences. | Worldwide |
| 3-Methoxy-9H-Carbazole | 3-Methoxy-9H-Carbazole induces caspase-3 activities and the cellular generation of eactive oxygen species. 3-Methoxy-9H-Carbazole inhibits cancer cell proliferation and induces apoptosis [1]. Uses: Scientific research. Group: Natural products. CAS No. 18992-85-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W106456. | |
| 4-Benzyl-1-piperazineacetic Acid-d8 Hydrazide | Isotope labelled 4-Benzyl-1-piperazineacetic Acid Hydrazide is an intermediate in the synthesis PAC-1 (P132000), a caspase 3 activator. Group: Biochemicals. Alternative Names: 4-(Phenylmethyl)-1-piperazineacetic Acid-d8 Hydrazide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 4-Benzyl-1-piperazineacetic Acid Hydrazide | 4-Benzyl-1-piperazineacetic Acid Hydrazide is an intermediate in the synthesis PAC-1 (P132000), a caspase 3 activator. Group: Biochemicals. Alternative Names: 4-(Phenylmethyl)-1-piperazineacetic Acid Hydrazide. Grades: Highly Purified. CAS No. 24632-70-0. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| (4-Benzylpiperazin-1-yl)acetic Acid Ethyl Ester-d8 | (4-Benzylpiperazin-1-yl)acetic Acid Ethyl Ester-d8 is an isotope labelled intermediate in the synthesis of PAC-1-d8 (P132002), a caspase 3 activator. Group: Biochemicals. Alternative Names: Ethyl 2-(4-Benzylpiperazin-1-yl)acetate; Ethyl 4-Benzyl-1-piperazineacetate;4-Benzyl-1-piperazineacetic Acid Ethyl Ester; 4-(Phenylmethyl)-1-piperazineacetic Acid Ethyl Ester. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 4-Vinylcyclohexene dioxide | 4-Vinylcyclohexene dioxide is a metabolite of 4-vinylcyclohexene that can specifically destroy oocytes in primordial and primary follicles of rats and mice. 4-Vinylcyclohexene dioxide induces apoptosis in rat cells is associated with activation of a caspase-mediated cascade [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Vinylcyclohexene diepoxide. CAS No. 106-87-6. Pack Sizes: 500 mg; 1 g. Product ID: HY-106591A. | |
| 5,7-Dihydroxychromone | 5,7-Dihydroxychromone, the extract of Cudrania tricuspidata , activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells [1]. Uses: Scientific research. Group: Natural products. CAS No. 31721-94-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N1970. | |
| 7-BIO | 7-BIO is a derivative of indirubin that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation. Furthermore, in contrast to other indirubin derivatives, 7-BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3. Synonyms: 7-Bromoindirubin-3'-oxime; 7-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol. Grades: ≥99%. CAS No. 916440-85-2. Molecular formula: C16H10BrN3O2. Mole weight: 356.2. | |
| AC 187 | AC 187 is a potent amylin receptor antagonist (IC50 = 0.48 nM) displaying 38- and 400-fold selectivity over calcitonin and CGRP receptors respectively. It inhibits amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. It increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo. Synonyms: Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2; N-acetyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide; AC187; salmon calcitonin (8-32) reduced; acetyl-(Asn30,Tyr32)sCT(8-37); AC-187. Grades: >98%. CAS No. 151804-77-2. Molecular formula: C127H205N37O40. Mole weight: 2890.25. | |
| AC 187 acetate | AC 187 acetate is a potent amylin receptor antagonist (IC50 = 0.48 nM) displaying 38- and 400-fold selectivity over calcitonin and CGRP receptors respectively. It inhibits amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. It increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels, and increases food intake in vivo. Synonyms: Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2.CH3CO2H; N-acetyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide acetic acid. Grades: ≥95%. Molecular formula: C129H209N37O42. Mole weight: 2950.26. | |
| Ac-AAVALLPAVLLALLAP-DEVD-CHO trifluoroacetate salt | Ac-AAVALLPAVLLALLAP-DEVD-CHO is a composite of Ac-DEVD-CHO, a peptide inhibitor of caspase-3 and -7, and a cell-permeable hydrophobic sequence derived from K-FGF. Synonyms: Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO; Ac-AAVALLPAVLLALLAP-DEVD-aldehyde; Ac-AAVALLPAVLLALLAPDEVD-CHO; ?Caspase-3 Inhibitor I; DEVD-CHO-CPP 32. Grades: ≥95%. Molecular formula: C94H158N20O27·xCF3COOH. Mole weight: 2000.42. | |
| Ac-AAVALLPAVLLALLAP-IETD-CHO trifluoroacetate salt | Ac-AAVALLPAVLLALLAP-IETD-CHO is a composite of Ac-IETD-CHO, a peptide inhibitor of caspase-8, and a cell-permeable hydrophobic sequence derived from K-FGF. Synonyms: Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO; Caspase-8 Inhibitor I. Grades: ≥95%. Molecular formula: C95H162N20O26·xCF3COOH. Mole weight: 2000.40. | |
| Ac-AAVALLPAVLLALLAP-VAD-CHO trifluoroacetate salt | Ac-AAVALLPAVLLALLAP-VAD-CHO is a composite of Ac-VAD-CHO, a non-selective caspase inhibitor, and a cell-permeable hydrophobic sequence derived from K-FGF. Synonyms: Caspase Inhibitor II; Ac-AAVALLPAVLLALLAP-VAD-aldehyde; Ac-AAVALLPAVLLALLAPVAD-CHO. Grades: ≥95%. Molecular formula: C88H151N19O22·xCF3COOH. Mole weight: 1827.3. | |
| Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde | Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde, a potent and reversible caspase-8 inhibitor, enables cell permeability by linking to a nonpolar CPP corresponding to the Kaposi fibroblast growth factor (FGF) signaling peptide sequence. Synonyms: Caspase-8 Inhibitor I, Cell Permeable; N-Acetyl-L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-isoleucyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-threoninamide; N-Acetyl-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-al; L-Threoninamide, N-acetyl-L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-. Grades: ≥95%. CAS No. 886462-83-5. Molecular formula: C95H162N20O26. Mole weight: 2000.42. | |
| Ac-Asp-Glu-Val-Asp-pNA | Ac-Asp-Glu-Val-Asp-pNA is the caspase-3 chromogenic substrate, and its cleavage can be monitored at 405 nm. Synonyms: Ac-DEVD-pNA; N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-L-valyl-N4-(4-nitrophenyl)-L-asparagine; L-α-Asparagine, N-acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-nitrophenyl)-; (2S,5S,8S,11S)-8-(2-carboxyethyl)-11-(carboxymethyl)-5-isopropyl-2-(2-((4-nitrophenyl)amino)-2-oxoethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecan-1-oic acid. Grades: ≥95%. CAS No. 189684-50-2. Molecular formula: C26H34N6O13. Mole weight: 638.59. | |
| Ac-DEVD-AFC | Ac-DEVD-AFC is a fluorogenic substrate for caspase-3 and related caspases. Caspase activity can be quantified by fluorescent detection of free AFC (7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm. Synonyms: Ac-DEVD-7-amido-4-trifluoroMethylcoumarin; Caspase-3 Substrate ?, Fluorogenic; Ac-Asp-Glu-Val-Asp-AFC; N-acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine. Grades: ≥90%. CAS No. 201608-14-2. Molecular formula: C30H34F3N5O13. Mole weight: 729.61. | |
| Ac-DEVD-AMC | Ac-DEVD-AMC is a fluorogenic substrate for caspase-3. Caspase activity can be quantified by fluorescent detection of free AMC (7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Synonyms: N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Methylcoumarin; N-acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine. Grades: ≥95%. CAS No. 169332-61-0. Molecular formula: C30H37N5O13. Mole weight: 675.64. | |
| Ac-DEVD-CHO | Ac-DEVD-CHO is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2. Uses: Cysteine proteinase inhibitors. Synonyms: N-acetyl-asp-glu-val-asp-al; Ac-Asp-Glu-Val-Asp-Aldehyde; L-Valinamide,N-acetyl-L-a-aspartyl-L-a-glutamyl-N-(2-carboxy-1-formylethyl)-. Grades: 95 %. CAS No. 169332-60-9. Molecular formula: C20H30N4O11. Mole weight: 502.47. | |
| Ac-DEVD-CHO | Ac-DEVD-CHO is a specific Caspase-3 inhibitor with a K i value of 230 pM. Uses: Scientific research. Group: Peptides. CAS No. 169332-60-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1001. | |
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