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Castanospermine is a natural alkaloid that can be extracted from black beans or the Moreton Bay chestnut tree (Castanospermum australae). Castanospermine is an α/ β-glucosidase inhibitor. Castanospermine has anti-inflammatory, antiviral replication and anti-metastatic effects on prostate cancer. Castanospermine can be used as an immunosuppressant to prevent transplant rejection [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 79831-76-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N2022.
Castanospermine
Castanospermine is an inhibitor of all forms of α- and β-glucosidases, especially glucosidase l. It inhibits lysosomal and neutral α-glucosidases with Ki values of 0.1 and 10 μM, respectively. It also inhibits lysosomal and cytosolic β-glucosidases with Ki values of 7 and 40 μM, respectively. It inhibits HIV syncytium formation and replication. It catalyzes the cleavage of individual glucosyl residues from various glycoconjugates, including complex carbohydrates and glycoproteins. It is effective both in vitro and in vivo. It blocks N-linked glycosylation during post-translational modification of proteins, affecting protein trafficking and cell functions, including angiogenesis. It also interferes with viral replication and infection. It is a potent and specific inhibitor of mammalian and plant α-and β-D-glucosidases in vitro. Uses: Castanospermine inhibits hiv syncytium formation and replication. it catalyzes the cleavage of individual glucosyl residues from various glycoconjugates, including complex carbohydrates and glycoproteins. it blocks n-linked glycosylation during post-translational modification of proteins, affecting protein trafficking and cell functions, including angiogenesis. it also interferes with viral replic. Synonyms: (1S,6S,7R,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol; 1,6,7,8-Indolizinetetrol, octahydro-, [1S-(1α,6β,7α,8β,8aβ)]-; (+)-C
Castanospermine
Castanospermine is a plant alkaloid shown to be a potent inhibitor of lysosomal a-or beta- glucosidase. It also inhibits mammalian glucosidase 1 and beta-mannosidase from sweet almonds and fungal beta-xylosidase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
6-Acetamido-6-deoxycastanospermine
6-Acetamido-6-deoxycastanospermine is a potent inhibitor of hexosaminidases. Synonyms: CastNAc; 6-Acetamido-6-Deoxy-Castanospermine; N-[(1S,6S,7R,8R,8aR)-1,7,8-trihydroxyoctahydroindolizin-6-yl]acetamide; Acetamide, N-(1S,6S,7R,8R,8aR)-octahydro-1,7,8-trihydroxy-6-indolizinyl-. Grade: ≥95%. CAS No. 134100-29-1. Molecular formula: C10H18N2O4. Mole weight: 230.26.
6-Epi-castanospermine
6-Epi-castanospermine is a remarkably efficacious suppressant of α-glucosidases and glycosidase, exhibiting unparalleled potential for studying afflictions including cancer, diabetes and viral infections. Synonyms: (1S,6R,7R,8R,8aR)-Octahydroindolizine-1,6,7,8-tetraol; 6-Epicastanospermine; 1,6,7,8-Indolizinetetrol, octahydro-, (1S,6R,7R,8R,8aR)-; (+)-6-Epicastanospermine; (+)-6-epi-Castanospermine; 1,6,7,8-Indolizinetetrol, octahydro-, (1S-(1alpha,6alpha,7alpha,8beta,8abeta))-. Grade: 95%. CAS No. 107244-34-8. Molecular formula: C8H15NO4. Mole weight: 189.21.
6-O-butyl castanospermine
Celgosivir, an effective α-glucosidase I inhibitor, has been found to be related to viral maturation and is still under Phase I/II trial against Dengue. IC50: 16 and 47 umol/L (through plaque assay and a cytopathic assay). Uses: Celgosivir is an effective α-glucosidase i inhibitor that has been found to be related to viral maturation. Synonyms: 60-P-001; MBI-3253; MDL-28574; MX-3253; VIR-222; 60P001; MBI3253; MDL28574; MX3253; VIR222; 60 P 001; MBI 3253; MDL 28574; MX 3253; VIR 222; Celgosivir; BuCast; 6-O-Butanoylcastanospermine; UNII-895VG117HN; B-CAST; AC1L1TTH. Grade: 95%. CAS No. 121104-96-9. Molecular formula: C12H21NO5. Mole weight: 259.30.
Celgosivir
Celgosivir (MBI 3253; MDL 28574; MX3253) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay. Uses: Designed for use in research and industrial production. Additional or Alternative Names: celgosivir;MDL 28574;(1S)-1,2,3,5,6,7,8,8aα-Octahydro-6α-butyryloxyindolizine-1β,7β,8α-triol;6-Butyryl castanospermine;Castanospermine 6-butyrate;BuCast. Product Category: Inhibitors. CAS No. 121104-96-9. Molecular formula: C12H21NO5. Mole weight: 0. Canonical SMILES: O[C@@H]1[C@]2([H])[C@@H](O)[C@H](O)[C@@H](OC(CCC)=O)CN2CC1. Product ID: ACM121104969. Alfa Chemistry ISO 9001:2015 Certified.
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