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AZD-5597 is a potent CDK inhibitor with in vitro anti-proliferative effects against a range of cancer cell lines. AZD-5597 has excellent physiochemical properties and large margins against inhibition of CYP isoforms and the hERG ion channel. Synonyms: AZD 5597; AZD5597; Methanone, [4-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-2-pyrimidinyl]amino]phenyl][(3S)-3-(methylamino)-1-pyrrolidinyl]-; [4-[[5-Fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-2-pyrimidinyl]amino]phenyl][(3S)-3-(methylamino)-1-pyrrolidinyl]methanone; (S)-(4-((5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone. Grades: >98%. CAS No. 924641-59-8. Molecular formula: C23H28FN7O. Mole weight: 437.52.
O-Desmethyl Adapalene
An intermediate in the preparation of Adapalene derivatives. Group: Biochemicals. Alternative Names: 6-(4-Hydroxy-3-tricyclo[3.3.1.13, 7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid; 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic Acid; AHPN; CD 437; CD 437/AHPN. Grades: Highly Purified. CAS No. 125316-60-1. Pack Sizes: 5mg. US Biological Life Sciences.
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Terpendole E
Terpendole E is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Albophoma yamenashiensis. The IC50 that inhibits ACAT in macrophages is 0.29 μmol/L, and the CD50 that causes 50% cell damage is greater than 23.4 μmol/L. Synonyms: (2S, 4R, 4aR, 4bR, 6aS, 12bS, 12cS, 14aS)-2-(2-Hydroxypropan-2-yl)-4a, 12b, 12c-trimethyl-3, 4, 4a, 4b, 5, 6, 6a, 7, 12, 12b, 12c, 13, 14, 14a-tetradecahydro-2H-chromeno[5', 6':6, 7]indeno[1, 2-b]indol-4-ol. Grades: >98%. CAS No. 167427-23-8. Molecular formula: C28H39NO3. Mole weight: 437.61.